• Molecular & Cellular Toxicology
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• 제4권1호
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• pp.5-10
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• 2008

The effect of obesity on the drug-metabolizing enzymes remains an important issue for clinician since obesity is a world wide epidemic problem. However, little is known about the effects of obesity on flavincontaining monooxygenase (FMO) production and activity. We show here for the first time that in vivo FMO activity determined by urinary ranitidine (RA) metabolites ratio in human, was higher in subjects with a high body mass index (BMI, kg/$m^2$, 21.97-30.32) than in those with an intermediate BMI (range 19.38-21.83). Moreover, there was a significant correlation between FMO activity and BMI in 209 subjects. In high fat diet-induced obese mice, we also observed that the hepatic expression of FMO (225% of lean mice) and the activity measured by the RA Noxidation rate ($513{\pm}58.1$ vs. $349{\pm}66.0$ pmol/hr per mg protein) were significantly higher than in lean mice fed a control diet. Unknown factors rather than leptin or insulin appeared to regulate the hepatic FMO production. Thus, FMO activity may be increased in obese or overweight individuals. Moreover, the regulation of FMO activity in subjects with morbid obesity, with or without complications and its clinical implications, should be investigated further.

• Food Science and Biotechnology
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• 제17권2호
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• pp.336-342
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• 2008

The aim of the present study was to assess the anti-obesity effects of fermented kochujang supplement in C57BL/6J mice. Thirty mice were divided into 3 groups; normal diet control group (ND), high fat diet control group (HD), and high fat diet plus kochujang supplemented group (HDK). Results were as follows: 1. Fennented kochujang supplement in high fat diet decreased body weight and epidydimal and back fat weight compared to non-supplement in HD group. 2. Lipid content and blood glucose level were lower in HDK group than HD group. 3. Fermented kochujang supplement increased mRNA level of lipolytic genes such as acyl-CoA synthetase (ACS), carnitine palmitoyltransferase-1 (CPT-1), and uncoupling proteins-1 (UCP-1) expression, whereas decreased mRNA level of adipogenic genes such as acetyl CoA carboxylase (ACC) expression. These findings suggest that fermented kochujang supplement in high fat diet normalized body weight, epididymal and back fat weight, lipid content, and blood glucose levels through controlling lipid metabolism and provides basic information on the control of obesity.

• Korean Journal of Acupuncture
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• 제24권1호
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• pp.59-63
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• 2007

Objectives : To discuss the biocompatibility of stainless steel for using acupuncture needles. Results and Conclusions : It is widely assumed that stainless steel is one of the good corrosion-resistant materials and is safe for human body, Most of metal acupuncture needles are made of STS304 and STS316 in light of human body safety: STS304 in more differences between STS304 and STS316 in light of human body safety: STS304 is more vulnerable to oxidation than STS316. A variety of literature survey showed that although STS316 is more corrosion-resistant than STS304 there is no evidence supporting the hypothesis that STS304 has the potential danger to human body, Further study would be necessary to draw more decisive conclusion.

• 한국가구학회지
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• 제22권3호
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• pp.151-159
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• 2011

This study is to suggest versatile chair designs that are organically shaped to take individual orientation. This study intends to provide design method to ensure the face of the chair that contacts the body of its user is transformed flexibly to support the body. The movement of human body is not just a behavior but the ways and tools that reflexively express against external stimuli that are sensed and identified by the person. The versatile chair whose users' sitting position is fixed is made by covering the lump form with a piece of cloth ensuring that the content is firmly fixed and by placing the beads-woven wood fabric according to the shape. And then, it is covered with the external cover. The proposed versatile chair designs assume specific forms as follows: First, it is a versatile chair whose user's sitting position can fix. The organically-shaped form that can accept varying postures is made as a mass, which changes into different shapes when human body touches the form so that users can lie down or sit. Due to such transformation, body posture is determined and individual differences in shape changing are all acceptable. Second, it is a versatile chair that reflects the user's position in a fixed chair, where a cloth-wrapper feature is applied to the form a sifit wrapped postures so that a variety of body postures can be accepted. Finally, a versatile chair that reflects the user's position by changing the shape of is covered with forms so that it will be transformed and used in accordance with situations and chair shapes and reflect multiple shapes including round or square ones.

• 한국전자파학회논문지
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• 제24권3호
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• pp.239-246
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• 2013

본 논문에서는 MICS(Medical Implant Communication Service, 402~405 MHz)와 ISM(The Industrial, Scientific and Medical, 2.40~2.485 GHz) 대역에서 동작하는 의료용 무선 중계 시스템을 위한 이중 대역 인체 부착형 안테나를 제안하고, 인체의 영향을 고려한 안테나 성능에 대한 분석을 하였다. 제안된 안테나는 ISM 대역에서 동작하는 윗면의 패치와 MICS 대역에서 동작하는 바닥면의 패치로 구성되어 있다. 안테나가 실제 인체에 착용되어 사용되는 상황을 고려하고, 인체가 안테나에 미치는 영향을 분석하기 위하여 모의 인체를 이용하여 시뮬레이션과 측정을 수행하였다. 제안된 안테나의 반사 손실은 MICS 대역과 ISM 대역에서의 요구 대역폭을 만족하였고, 측정된 최대 이득은 MICS 대역과 ISM 대역에서 각각 -12.47 dBi, 1.71 dBi이었다. 제안된 안테나의 방사 패턴은 MICS 대역에서 인체 내부 지향성, ISM 대역에서 인체 외부 지향성을 가지며, 반사 손실 특성은 인체의 영향에 매우 둔감하므로 의료용 무선 중계 시스템용 인체 부착형 안테나로 활용되기에 적절할 것으로 사료된다.

• 사상체질의학회지
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• 제15권2호
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• pp.124-128
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• 2003

Background: Sasang Constitutional Medicine (SCM) is a component of Korean traditional medicine that classifies humans into four categories, according to their constitution (Taeyangin, Taeumin, Soyangin and Soeumin). We are unaware of previous assessments of SCM in non-Asian race groups. Objectives: To quantify body composition components in three race groups and to determine whether SCM has an independent effect on body composition components. Design: A cross-sectional evaluation of 76 adults (28 Caucasian, 21 African-American, 27 Asian). Body composition was estimated using dual energy x-ray absorptiometry. Results: SCM component had a significant effect on weight, fat, and lean mass regardless of race group (p <0.001).

• 대한약침학회지
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• 제14권2호
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• pp.81-91
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• 2011

Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.

• 한국전자파학회논문지
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• 제16권8호
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• pp.790-796
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• 2005

본 논문에서는 캡슐 내시경의 무선통신이 이루어지기 위한 환경 연구와 더불어 그에 적합한 수신 안테나를 설계하였다. 제안된 안테나는 인체와 같은 multi-loss layer환경에서 전파 손실을 최소화 하고 magnetic field를 이용하기 위해 루프 안테나로 설계했다. 주파수 대역은 인체 내 전파 손실을 고려하여 $400\~500$ MHz이고 FCC 규정에 따라 인체 각각의 조직에 대한 유전율과 도전율을 추출했다. 이를 하나의 등가 모델로 설정하고 그에 따른 유전율과 도전율을 계산해서 인체를 대신할 수 있는 수용액을 제조하였다. 전파 손실이 심한 인체 내에서 캡슐이 이동함에 따라 수신 레벨이 급격히 감소하기 때문에 배열 안테나가 요구된다. 1 mW의 신호를 송신하는 송신 안테나 위치에 상관없이 배열 안테나의 신호 레벨은 평균 -60 dBm 정도로 충분한 신호 검출이 가능한 것을 확인했다.

• Toxicological Research
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• 제9권1호
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• pp.83-98
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• 1993

LBD-007, a newly developed recombinant human interferon alpha A, was at dose levels of 0, 3 $\times$ $10^6$, 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subctaneously to pregnant Sprague-Dawley rats during the organogenetic period. Ethylenethiourea was used as a positive control. 2/3 of dams per group were subjected to caesarean section on day 20 of pregnancy and the remaining 10 dams per group were allowed to deliver. Effects of test substance on dams, embryonal development development of F1 fetuses, as well as growth, behaviour and mating performance of F1 offspring were examined. 1. No treatment-related changes in clinical signs, food consumption, body weight and necropsy findings of dams were observed.

• 복식
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• 제58권2호
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• pp.162-180
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• 2008

The purpose of this study is to find the basic design factors that affect the changes in body surface lines caused by lower limb movements, thereby resulting in slacks that fit well regardless of whether the human form is static or in motion. Using unmarried female university students aged 18-24 as subjects, a total of 32 body surface lines (15 body surface total lines and 17 body surface segment lines) were measured in one static and 9 movement poses, The analysis first involved the calculation of the expansion and contraction rates per body part in body surface line in 9 lower limb movements, Second, a factor analysis was conducted using the expansion and contraction rates of these changes in body surface line. The results of this study are as follows, According to the factor analysis, basic design factors that affect changes in body surface lines comprised 8 types of factors as illustrated in fig, 2-fig, 9, which explained 79.2% of total variate for the variables studied, Factor 1, comprising the lower segment of center back leg line, center front leg line and inner leg line, and lower limb girth except midway thigh girth and ankle girth below hip girth, accounted for 30.3% of total variance, Factor 2, comprising waist girth, the total and upper segment of center back leg line and center tront leg line, and front and back segment of crotch length, explained 17.4% of total variance, Factor 3, the total and upper segment of lateral leg line at the center, accounted for 56.5% of total variance in accordance with Factors 1, 2, and 3, Factor 4 was the contracting upper part of lower leg between legscye girth and midway thigh girth, Factor 5 comprised the total and upper segment of inner leg line and posterior knee girth, Factor 6 was the total crotch length, Factor 7 was the ankle girth, Factor 8 was the abdomen girth.