Fermented Kochujang Supplement Shows Anti-obesity Effects by Controlling Lipid Metabolism in C57BL/6J Mice Fed High Fat Diet
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Koo, Bon-Sun
(Research Institute Center of Bioactive Material, Chonbuk National University)
Seong, So-Hui (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University) Kown, Dae-Young (Food Functional Research, Division Korean Food Research Institutes) Sohn, Hee-Sook (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University) Cha, Youn-Soo (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University) |
1 | Bosello O, Cominacini L, Zocca I, Garbin U, Compri R, Davoli A, Brunetti L. Short- and long-term effects of hypocaloric diets containing proteins of different sources on plasma lipids and apoproteins of obeses subjects. Ann. Nutr. Metab. 32: 206-214 (1998) DOI |
2 | Jenkins AJ, Lyons T, Zheng DY, Otvos JD, Lackland DT, Mcgee D, Garvey WT, Klein RL. Serum lipoprotein in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort-associations with gender and glycemia. Diabetes Care 26: 810-818 (2003) DOI ScienceOn |
3 | Pushparaj PN, Tan BH, Tan CH. The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa billimbi in streptozotocin-diabetic rats. Life Sci. 70: 535-547 (2001) DOI ScienceOn |
4 | Iritani N, Sugimoto T, Fukuda H. Dietary soybean protein increases insulin receptor gene expression in male Wistar fatty rats when dietary polyunsaturated fatty acid level is low. J. Nutr. 127: 1077- 1083 (1997) |
5 | Achouri Y, Hegarty BD, Allanic D, Becard D, Hainault I, Ferre P, Foufelle F. Long chain fatty acyl-CoA synthetase expression is induced by insulin and glucose: Involvement of sterom.l regulatory element-binding protein-1c. Biochimie 87: 1149-1155 (2005) DOI ScienceOn |
6 | Dyck JRB, Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the ischemic heart. J. Mol. Cell. Cardiol. 34: 1099-1109 (2002) DOI ScienceOn |
7 | Engelgau MM, Frank Vinicor, Simionescu M, King GL, Meininger C, Mensah GA. Summary statement IV: Obesity and diabetes: Opportunities for translation of basic research. Vascul. Pharmacol. 46: 324-326 (2007) DOI ScienceOn |
8 | Tsuzuki T, Kawakami Y, Nakagawa K, Miyazawa T. Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. J. Nutr. Biochem. 17: 518-524 (2006) DOI ScienceOn |
9 | Choi HJ, Eo HK, Park KC, Jin MR, Park EJ, Kim SH, Park JE, Kim SY. A water-soluble extract form Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model. Biochem. Bioph. Res. Co. 359: 419-425 (2007) DOI ScienceOn |
10 | Watanabe T, Kawada T, Kato T, Harada T, Iwai K. Effects of capsaicin analogs on adrenal catecholamine secreation in rats. Life Sci. 54: 369-374 (1994) DOI ScienceOn |
11 | Sites CK, Cooper BC, Toth MJ, Gastaldelli A, Arabshahi A, Barnes S. Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women. Fertil. Steril. 88: 1609-1617 (2007) DOI ScienceOn |
12 | Masashi M, Chiaki S, Katsum S. Dietary soya protein intake and exercise training have an additive effect on skeletal muscle fatty acid oxidation enzyme activities and mRNA levels in rats. Brit. J. Nutr. 96: 469-475 (2006) |
13 | Kim YS, Kwon DJ, Koo MS, Oh HI, Kang TS. Changes in microflora and enzyme activities of traditional kochujang during fermentation. Food Sci. Biotechnol. 25: 502-509 (1993) 과학기술학회마을 |
14 | Weissman C. Nutrition in the intensive care unit. Crit. Care 3: R67-R75 (1999) DOI ScienceOn |
15 | Kim SJ, Jung KO, Park KY. Inhibitory effect of kochujang extracts on chemically induced mutagenesis. J. Food Sci. Nutr. 4: 38-42 (1999) |
16 | Barter PJ, Rye KA. High density lipoproteins and coronary heart disease. Atherosclerosis 121: 1-12 (1996) DOI ScienceOn |
17 | Mynatt RL, Lappi MD, Cook GA. Myocardial carnitine palmitoyltransferase of the mitochondrial outer membrane is not altered by fasting. Biochim. Biophys. Acta 1128: 105-111 (1992) DOI ScienceOn |
18 | Herdt TH. Ruminat adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Vet. Clin. N. Am.-Food A. 16: 215-230 (2000) DOI |
19 | Wagner JD, Cefalu WT, Anthony MS, Litwak KN, Zhang L, Clarkson TB. Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteolester content in ovariectomized cynomologus monkeys. Metabolism 46: 698-705 (1997) DOI ScienceOn |
20 | Fujita H, Yoshikawa M. LKPNM: A prodrug type ACE-inhibitory derived from fish protein. Immunopharmacology 44: 123-127 (1999) DOI ScienceOn |
21 | Heim M, Frank O, Kampmann G, Sochodky N, Pennimpded T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I. The phytoestrogen genistein enhances osteogenesis and suppresses adipogenic differentiation of human primary bone marrow cells. Endocrinology 145: 848-859 (2004) DOI ScienceOn |
22 | Oh JY, Kim YS, Shin DH. Changes in microorganisms, enzyme activities, and gas formation by the addition of mustard power on kochujang with different salt concentration. Food Sci. Biotechnol. 15: 298-302 (2006) 과학기술학회마을 |
23 | Wang J, Armour T, Geiss LS, Engelgau MM. Obesity and diabetes: Dual epidemics on the rise. Curr. Opin. Endocrinol. Diabetes 12: 174-180 (2005) DOI ScienceOn |
24 | Ascencio C, Torres N, Isoard-Acosta F, Gomez-Perez FJ, Hernandez-Pando R, Tavar AR. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J. Nutr. 134: 522-529 (2004) |
25 | Himms-Hagen J, Cui J, Danforth E, Taatjes DJ, Lang SS, Water BL, Claus TH. Effects of CL-316,243, thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266: R1371-R1379 (1994) |
26 | Choo JJ. Anti-obesity effects of kochujang in rats fed on a high fed diet. Korean J. Nutr. 33: 787-793 (2000) |
27 | Folch J, Lees M, Sloane-Stanley GHS. Simple method of the isolation of total lipids from animal tissues. J. Biol. Chem. 22: 497-509 (1983) |
28 | Kuriyama H, Shimomura I, Kishia K, Kondo H, Furuyama N, Nishizawa H, Maeda N, Matsuda M, Nagaretani H, Kihara S, Akamura T, Tochino Y, Fundhashi T, Matsuzawa Y. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes 51: 2915-2921 (2002) DOI ScienceOn |
29 | Saad MF, Grec S, Osei K, Lewin AJ, Edwards C, Nunez M, Reinhardt RR. Ragaglitazone improves glycemic control and lipid profile in type 2 diabetic subjects: A 12-weeks, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm. Diabetes Care 27: 1324-1329 (2004) DOI |
30 | Tovar AR, Torre-Villalvazo I, Ochoa M, Elias AL, Ortiz V, Aguliar- Salinas CA, Torres N. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. J. Lipid Res. 46: 1823- 1832 (2005) DOI ScienceOn |
31 | Chio BG, Vilahur G, Viles-Gonzalez JF, Badimon JJ. The role of high-density lipoprotein cholesterol in atherothrombosis. Mt. Sinai J. Med. 73: 690-701 (2006) |
32 |
Choo JJ, Shin HJ. Body-fat suppressive effects of capsaicin through |
33 | Champe PC, Harvey RA, Ferrier DR. Lippincott's Illustrated Reviews: Biochemistry. 3rd ed. Lippincott Williams & Wilkins, New York, NY, USA. pp. 181-187 (2006) |
34 | Mandard S, Muller M, Kersten S. PPAR a target genes. Cell. Mol. Life Sci. 61: 393-416 (2004) DOI |
35 | Jing Y, Waxman S. Structural requirements for differentiationinduction and growth-inhibition of mouse erythro-leukemia cells by isoflavones. Anticancer Res. 15: 1147-1152 (1995) |
36 | Nazz A, Yellayi S, Zakroczymski M, Bunick D, Doerge DR, Lubahn DB, Helferich WG, Cooke PS. The soy isoflavone genistein decrease adipose deposition in mice. Endocrinology 144: 3315-3320 (2003) DOI ScienceOn |
37 | Ryu MH, Sohn HS, Heo YR, Naima M, Cha YS. Differential regulation of hepatic gene expression by starvation versus refeeding following a high-sucrose or high-fat diet. Nutrition 21: 543-552 (2005) DOI ScienceOn |
38 | Rhee SH, Kong KR, Jung KO, Park KY. Decreasing effects kochujang on body weight and lipid levels of adipose tissues and serum in rats fed a high-fat diet. J. Food Sci. Nutr. 32: 882-886 (2003) 과학기술학회마을 DOI |
39 | Pushparaj P, Tan CH, Tan BKH. Effects of Averrhoa billimbi leaf extract on blood glucose and lipid in streptozotocin-diabetic rats. J. Ethnopharmacol. 72: 69-76 (2000) DOI ScienceOn |
40 | Boss O, Mussin P, Giacobino JP. The uncoupling proteins, a review. Eur. J. Endocrinol. 139: 1-9 (1998) DOI |
41 | Yoshida T. Umdkawa T, Kumamoto K, Sakane N, Kogure A, Kondo M, Wakabayashi Y, Kawada T, Nagase I, Saito M. P3- Adrenergic agonist induces a functionally active uncoupling protein in fat and low-twitch muscle fibers. Am. J. Physiol. 274: E469-E475 (1998) |
42 | Park KY, Kong KR, Jung KO, Rhee SH. Inhibitory effects of kochujang extracts on the tumor formation. J. Food Sci. Nutr. 6: 187-191 (2001) |
43 | Fasshauer M, Pasche R. Regulation of adipocytokines and insulin resistance. Diabetologia 46: 1594-1603 (2003) DOI |
44 | Blandino A, Al-Aseeri ME, Pandiella SS, Cantero D, Webb C. Cereal-based fermented food and beverages. Food Res. Intern. 36: 527-543 (2003)erpo DOI ScienceOn |
45 | Kawada T, Hagihara K, Iwai K. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J. Nutr. 116: 1272 (1986) DOI |
46 | Fukutake M, Takahashi M, Ishida K, Kawamura H, Sugimura T, Wakabayashi K. Quantification of genistein and genistin in soybeans and soybean products. Food Chem. Toxicol. 34: 457-461 (1996) DOI ScienceOn |
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