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Fermented Kochujang Supplement Shows Anti-obesity Effects by Controlling Lipid Metabolism in C57BL/6J Mice Fed High Fat Diet  

Koo, Bon-Sun (Research Institute Center of Bioactive Material, Chonbuk National University)
Seong, So-Hui (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University)
Kown, Dae-Young (Food Functional Research, Division Korean Food Research Institutes)
Sohn, Hee-Sook (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University)
Cha, Youn-Soo (Department of Food Science and Human Nutrition, College of Human Ecology, Chonbuk National University)
Publication Information
Food Science and Biotechnology / v.17, no.2, 2008 , pp. 336-342 More about this Journal
Abstract
The aim of the present study was to assess the anti-obesity effects of fermented kochujang supplement in C57BL/6J mice. Thirty mice were divided into 3 groups; normal diet control group (ND), high fat diet control group (HD), and high fat diet plus kochujang supplemented group (HDK). Results were as follows: 1. Fennented kochujang supplement in high fat diet decreased body weight and epidydimal and back fat weight compared to non-supplement in HD group. 2. Lipid content and blood glucose level were lower in HDK group than HD group. 3. Fermented kochujang supplement increased mRNA level of lipolytic genes such as acyl-CoA synthetase (ACS), carnitine palmitoyltransferase-1 (CPT-1), and uncoupling proteins-1 (UCP-1) expression, whereas decreased mRNA level of adipogenic genes such as acetyl CoA carboxylase (ACC) expression. These findings suggest that fermented kochujang supplement in high fat diet normalized body weight, epididymal and back fat weight, lipid content, and blood glucose levels through controlling lipid metabolism and provides basic information on the control of obesity.
Keywords
kochujang; body weight; lipid content; blood glucose; gene expression;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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