• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.5-10
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• 2008

The effect of obesity on the drug-metabolizing enzymes remains an important issue for clinician since obesity is a world wide epidemic problem. However, little is known about the effects of obesity on flavincontaining monooxygenase (FMO) production and activity. We show here for the first time that in vivo FMO activity determined by urinary ranitidine (RA) metabolites ratio in human, was higher in subjects with a high body mass index (BMI, kg/$m^2$, 21.97-30.32) than in those with an intermediate BMI (range 19.38-21.83). Moreover, there was a significant correlation between FMO activity and BMI in 209 subjects. In high fat diet-induced obese mice, we also observed that the hepatic expression of FMO (225% of lean mice) and the activity measured by the RA Noxidation rate ($513{\pm}58.1$ vs. $349{\pm}66.0$ pmol/hr per mg protein) were significantly higher than in lean mice fed a control diet. Unknown factors rather than leptin or insulin appeared to regulate the hepatic FMO production. Thus, FMO activity may be increased in obese or overweight individuals. Moreover, the regulation of FMO activity in subjects with morbid obesity, with or without complications and its clinical implications, should be investigated further.

• Food Science and Biotechnology
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• v.17 no.2
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• pp.336-342
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• 2008

The aim of the present study was to assess the anti-obesity effects of fermented kochujang supplement in C57BL/6J mice. Thirty mice were divided into 3 groups; normal diet control group (ND), high fat diet control group (HD), and high fat diet plus kochujang supplemented group (HDK). Results were as follows: 1. Fennented kochujang supplement in high fat diet decreased body weight and epidydimal and back fat weight compared to non-supplement in HD group. 2. Lipid content and blood glucose level were lower in HDK group than HD group. 3. Fermented kochujang supplement increased mRNA level of lipolytic genes such as acyl-CoA synthetase (ACS), carnitine palmitoyltransferase-1 (CPT-1), and uncoupling proteins-1 (UCP-1) expression, whereas decreased mRNA level of adipogenic genes such as acetyl CoA carboxylase (ACC) expression. These findings suggest that fermented kochujang supplement in high fat diet normalized body weight, epididymal and back fat weight, lipid content, and blood glucose levels through controlling lipid metabolism and provides basic information on the control of obesity.

• Korean Journal of Acupuncture
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• v.24 no.1
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• pp.59-63
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• 2007

Objectives : To discuss the biocompatibility of stainless steel for using acupuncture needles. Results and Conclusions : It is widely assumed that stainless steel is one of the good corrosion-resistant materials and is safe for human body, Most of metal acupuncture needles are made of STS304 and STS316 in light of human body safety: STS304 in more differences between STS304 and STS316 in light of human body safety: STS304 is more vulnerable to oxidation than STS316. A variety of literature survey showed that although STS316 is more corrosion-resistant than STS304 there is no evidence supporting the hypothesis that STS304 has the potential danger to human body, Further study would be necessary to draw more decisive conclusion.

• Journal of the Korea Furniture Society
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• v.22 no.3
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• pp.151-159
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• 2011

This study is to suggest versatile chair designs that are organically shaped to take individual orientation. This study intends to provide design method to ensure the face of the chair that contacts the body of its user is transformed flexibly to support the body. The movement of human body is not just a behavior but the ways and tools that reflexively express against external stimuli that are sensed and identified by the person. The versatile chair whose users' sitting position is fixed is made by covering the lump form with a piece of cloth ensuring that the content is firmly fixed and by placing the beads-woven wood fabric according to the shape. And then, it is covered with the external cover. The proposed versatile chair designs assume specific forms as follows: First, it is a versatile chair whose user's sitting position can fix. The organically-shaped form that can accept varying postures is made as a mass, which changes into different shapes when human body touches the form so that users can lie down or sit. Due to such transformation, body posture is determined and individual differences in shape changing are all acceptable. Second, it is a versatile chair that reflects the user's position in a fixed chair, where a cloth-wrapper feature is applied to the form a sifit wrapped postures so that a variety of body postures can be accepted. Finally, a versatile chair that reflects the user's position by changing the shape of is covered with forms so that it will be transformed and used in accordance with situations and chair shapes and reflect multiple shapes including round or square ones.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.3
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• pp.239-246
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• 2013

In this paper, a dual-band on-body antenna operating at MICS and ISM band for a wireless medical repeater system is proposed and the antenna performance including the human body effect is investigated. The designed dual-band antenna is comprised of a top patch for ISM band and bottom patch for MICS band. Simulation and measurement was carried out in order to analyze the effects of human body on antenna performance considering real use. The proposed antenna has required impedance bandwidth enough to cover both MICS and ISM bands. The measured peak gains were -12.47 dBi and 1.71 dBi at the each center frequency of MICS and ISM bands, respectively. Furthermore, the antenna has the maximum radiation directed toward the inside of the human body in the MICS band and directed toward the outside in the ISM band. In addition, the return loss property of the antenna is insensitive to human body effects so that the proposed antenna is well suited for the on-body wireless medical repeater system.

• Journal of Sasang Constitutional Medicine
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• v.15 no.2
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• pp.124-128
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• 2003

Background: Sasang Constitutional Medicine (SCM) is a component of Korean traditional medicine that classifies humans into four categories, according to their constitution (Taeyangin, Taeumin, Soyangin and Soeumin). We are unaware of previous assessments of SCM in non-Asian race groups. Objectives: To quantify body composition components in three race groups and to determine whether SCM has an independent effect on body composition components. Design: A cross-sectional evaluation of 76 adults (28 Caucasian, 21 African-American, 27 Asian). Body composition was estimated using dual energy x-ray absorptiometry. Results: SCM component had a significant effect on weight, fat, and lean mass regardless of race group (p <0.001).

• Journal of Pharmacopuncture
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• v.14 no.2
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• pp.81-91
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• 2011

Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.8 s.99
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• pp.790-796
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• 2005

In order to accomplish a wireless communication of capsule endoscopy, an environment study in the human body and receiving antenna design have been performed. The proposed antenna is the loop antenna designed to minimize the propagation loss in multi-loss layer such as the human body and utilize the magnetic field. Considering the propagation loss in the human body, the frequency range is from 400 MHz to 500 MHz. Acorrrding to the FCC regulations, the permittivity and conductivity for each human tissue were extracted. We set up an equivalent model and make an aqueous solution which is replaced with the human body. Due to movement of capsule in the human body which propagation loss is extremly severe, an array antenna is required. Irrespective of the location of transmission antenna transmitting a signal of 1 mW, we confirme what it is possible for the enough signal detection as the average signal level of array antenna is -60 dBm.

• Toxicological Research
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• v.9 no.1
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• pp.83-98
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• 1993

LBD-007, a newly developed recombinant human interferon alpha A, was at dose levels of 0, 3 $\times$ $10^6$, 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subctaneously to pregnant Sprague-Dawley rats during the organogenetic period. Ethylenethiourea was used as a positive control. 2/3 of dams per group were subjected to caesarean section on day 20 of pregnancy and the remaining 10 dams per group were allowed to deliver. Effects of test substance on dams, embryonal development development of F1 fetuses, as well as growth, behaviour and mating performance of F1 offspring were examined. 1. No treatment-related changes in clinical signs, food consumption, body weight and necropsy findings of dams were observed.

• Journal of the Korean Society of Costume
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• v.58 no.2
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• pp.162-180
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• 2008

The purpose of this study is to find the basic design factors that affect the changes in body surface lines caused by lower limb movements, thereby resulting in slacks that fit well regardless of whether the human form is static or in motion. Using unmarried female university students aged 18-24 as subjects, a total of 32 body surface lines (15 body surface total lines and 17 body surface segment lines) were measured in one static and 9 movement poses, The analysis first involved the calculation of the expansion and contraction rates per body part in body surface line in 9 lower limb movements, Second, a factor analysis was conducted using the expansion and contraction rates of these changes in body surface line. The results of this study are as follows, According to the factor analysis, basic design factors that affect changes in body surface lines comprised 8 types of factors as illustrated in fig, 2-fig, 9, which explained 79.2% of total variate for the variables studied, Factor 1, comprising the lower segment of center back leg line, center front leg line and inner leg line, and lower limb girth except midway thigh girth and ankle girth below hip girth, accounted for 30.3% of total variance, Factor 2, comprising waist girth, the total and upper segment of center back leg line and center tront leg line, and front and back segment of crotch length, explained 17.4% of total variance, Factor 3, the total and upper segment of lateral leg line at the center, accounted for 56.5% of total variance in accordance with Factors 1, 2, and 3, Factor 4 was the contracting upper part of lower leg between legscye girth and midway thigh girth, Factor 5 comprised the total and upper segment of inner leg line and posterior knee girth, Factor 6 was the total crotch length, Factor 7 was the ankle girth, Factor 8 was the abdomen girth.