• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2005년도 2005 Annual Meeting & International Symposium
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• pp.54-62
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• 2005

While genomics (the set of experimental and computational tools that allows the blueprints of life to be read) opens the doors to a more rational approach to the design and use of living cells to bring about desirable chemical transformations, genomics is, by itself, insufficient. We need tools that allow us to relate genomic and molecular information to cellular physiology and then to the response of a population of cells. We propose the development of hybrid computer cellular models. In such models genomics and chemical detail for a cellular subsystem (e.g. pathogenesis) is embedded in a coarse-grain cell model. Such a construct allows the quantitative and explicit linkage of genomic detail to cell physiology to the extracellular environment. To illustrate the principles involved we are constructing a model for a minimal cell. A minimal cell is a bacterial cell with the fewest number of genes necessary to sustain life as a free living microbe.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 B
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• pp.1374-1376
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• 2003

The output of solar cell or array depends on the weather conditions such as cell temperature and insolation level. If the output of the photovoltaic system would be regularly generated under any weather conditions, it is so easy to develop the inverter, its related system, and also control algorithm. This can be performed by the VISC(virtual-implemented solar cell) system studied in this paper. And a few I-V curves are provided by the manufacturers, and so any I-V value between the given curves is unknown. The new model for solar cell is proposed which is based on the interpolation. Both simulation and experiment are executed to show the validity of the proposed VISC system.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2010년 춘계학술대회논문집
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• pp.556-561
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• 2010

This paper proposes a three-dimensional haptotaxis model to simulate the migration of the population of cancer cells. The invasion of the cancer cells relates with the hapto- and the effect of the energy between cells and (ECM). The diffuse interface model is employed, which incorporates haptotaxis mechanism and interface energies. The semi-implicit Fourier spectral scheme is adopted for efficient complications. The simulation results reveal rich dynamics of cancer cells migration.

• 대한의용생체공학회:의공학회지
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• 제5권1호
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• pp.33-38
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• 1984

Biological rhythms are very important phenomena to generate, grow a living thing. However, the origin of rhythms are not disclosed completely until now. Eack myocardial cell has a natural rhythm of itself, and synchronization is happened when two cells are come in contact with each other. In this research, a simple synchronization model has been proposed and studied, refering to the physiological model. The changes of the synchronization rhythms in experimental results are compared with that of the model.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2006년도 하계종합학술대회
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• pp.525-526
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• 2006

A macro model for Savtchenko switching mode MRAM (toggling MRAM) cells which can be utilized to develop the core architecture and the peripheral circuitry is proposed, and a writing scheme suitable to the toggling characteristic is developed. The sensing and writing operations of the toggling MRAM adopting the macro model are verified by Spectre simulations.

• 한국식품영양학회지
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• 제7권4호
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• pp.399-405
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• 1994

Some method was introduced to explain oxygen transfer from broth to cell during aerobic microbe cultivation. It is explained by 5 steps that how desolved oxygen can reach to cell. Among these steps film resistance was the most important factor to describe oxygen transfer. Lumped model and distributed model was introduced to explain oxygen diffusion rate and oxygen consumption rate which occurs in the microbe pellet.

• 한국태양에너지학회 논문집
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• 제32권5호
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• pp.118-123
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• 2012

Water balance has a significant impact on the overall fuel cell performance. Maintenance of proper water management should provide an adequate membrane hydration and avoidance of water flooding in the catalyst layer and gas diffusion layer. Considering the important of advanced water management in PEM fuel cell, this study proposes a simple one dimensional water transportation model of PEM fuel cell for use in a dynamic condition. The model has been created by assumption that the output is the water liquid saturation difference. The liquid saturation change is the total difference between the additional water and the removal water on the system. The water addition is obtained from fuel cell reaction and the electro osmotic drag. The water removal is obtained from capillary transport and evaporation process. The result shows that the capillary water transport of low temperature fuel cell is high because the evaporation rate is low.

• 전력전자학회논문지
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• 제14권5호
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• pp.372-378
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• 2009

태양광 발전시스템의 설치 용량이 증가함에 따라 시스템 효율을 개선하기 위한 연구가 활발히 진행되고 있다. 고성능 시스템의 설계 및 시험을 위해서는 태양전지의 모델링을 바탕으로 태양전지의 물리적 특성에 관해 정확히 이해하는 것이 중요하다. 그러나 태양전지의 모델은 다수의 파라미터가 얽힌 비선형 형태이며, 모델식의 파라미터 값을 얻기 위한 기존의 방식에서는 오차를 동반하는 실제와 다른 가정을 전제로 하므로 결과적으로 추출된 파라미터의 정확도가 저하되게 되는 단점이 있다. 따라서 본 논문에서는 제조사가 표준상태에서 측정하여 공개하는 태양전지의 I-V 커브로부터 다이오드의 이상계수와 역포화 전류를 구하고 이로부터 저항 성분이 없는 이상적인 태양전지의 I-V 커브를 도출한 뒤, 실측된 I-V 커브와 차이를 최소화하는 직·병렬 저항값을 추출하는 새로운 방식을 제안한다. 기존의 방식과 제안된 방식의 모델링을 통하여 얻은 파라미터를 이용해 구현한 I-V 커브와 실측 I-V 커브와의 상관관계를 최소자승법을 통해 계산함으로써 제안된 방법의 유용함을 증명하였다.

• International Journal of Stem Cells
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• 제11권2호
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• pp.177-186
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• 2018

Background and Objectives: Glial scarring and inflammation after spinal cord injury (SCI) interfere with neural regeneration and functional recovery due to the inhibitory microenvironment of the injured spinal cord. Stem cell transplantation can improve functional recovery in experimental models of SCI, but many obstacles to clinical application remain due to concerns regarding the effectiveness and safety of stem cell transplantation for SCI patients. In this study, we investigated the effects of transplantation of human mesenchymal stem cells (hMSCs) that were genetically modified to express Olig2 in a rat model of SCI. Methods: Bone marrow-derived hMSCs were genetically modified to express Olig2 and transplanted one week after the induction of contusive SCI in a rat model. Spinal cords were harvested 7 weeks after transplantation. Results: Transplantation of Olig2-expressing hMSCs significantly improved functional recovery in a rat model of contusive SCI model compared to the control hMSC-transplanted group. Transplantation of Olig2-expressing hMSCs also attenuated glial scar formation in spinal cord lesions. Immunohistochemical analysis showed that transplanted Olig2-expressing hMSCs were partially differentiated into Olig1-positive oligodendrocyte-like cells in spinal cords. Furthermore, NF-M-positive axons were more abundant in the Olig2-expressing hMSC-transplanted group than in the control hMSC-transplanted group. Conclusions: We suggest that Olig2-expressing hMSCs are a safe and optimal cell source for treating SCI.

• 한국환경과학회지
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• 제5권5호
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• pp.593-603
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• 1996

용응탄산염 연료전지의 산소전극성능모사를 위한 이중기공구조의 filmed agglomerate model을 연구하였다. 이 모델에서는 전극과 전해질 계면의 물리, 화학적인 현상 및 전극반응기구를 고려하여 정상상태 에서 전극의 특성을 조업조건에 따라 표시할 수있다. 기존의 연구에서 기하학적인 구조를 가정하여 전극반응면적을 이론적으로 계산한 반면에 본 연구에서는 porosimeter를 이용한 기공도와 기공구조 분포 측정자료를 이용한 방법을 제시하였다. 계산결과는 전극재질, 기체조성, 전극두께, agglomerate 기공도 및 전해질 막의 두께에 따른 영향을 전류밀도와 과전압의 관계로 표시하였다. 또한 전극 재질로 perovskite (La0.8Sr0.2CoO3)와 NiO를 사용하여 실제전지를 이용한 성능을 측정하여 이론치와 비교하였다. 두전 극의 반쪽전지 실험에서 유사한 성능을 나타내었다. Perovskite 전극은 전극 기공도 65%, agglomerate 기공도 12% 그리고 전극두께 1.5~2mm에서 최적의 결과를 보여주었다. NiO전극의 경우 peroxide 반응기구에서 superoxide 반응기구의 계산결과보다 실험치와 일치하는 좋은 결과를 보였다.