• Spatial Information Research
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• 제3권2호
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• pp.135-146
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• 1995

본 연구의 목적은 소유역 지표유출의 시각적.공간적 재현을 위한 GIS의 응용 및 호환 모형 GISCELWAB을 개발하는 것이다. 이 모형은 세가지의 모형으로 구성되었다. 분포형 수문모형인 격자 물수지 모형 CELWAB과 CELWAB 모형의 입력자료를 자동으로 추출하는 입력자료 추출모형GISINDATA 와 CELWAB모형의 계산결과를 도형화하여 도시하도록 구성된 출력자료처리 모형GISOUTDISP로 구성되었다. GISINDATA는 모형의 입력자료 구성에 소모되는 시간을 절약하고 자료의 객관적 정확성을 갖도록 하기 위하여 개발되었으며, GISOUTDISP는 CELWAB 모형의 결과르 도형화하고 도시하여 유역전체에 대한 유출현상을 시간적, 공간적으로 재현하는 것을 가능하게 하였다.

• 한국전자통신학회논문지
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• 제17권3호
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• pp.483-490
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• 2022

말라리아는 기생충에 의해 발생하는 질병으로 전 세계에 퍼져있다. 말라리아 셀을 인식하는데 일반적으로 두꺼운 혈흔과 얇은 혈흔 검사 방법이 사용되지만 이러한 방법은 많은 수작업 계산이 필요하여 효율성과 정확성이 매우 낮을 뿐만 아니라 빈민국에는 병리학자가 부족하여 말라리아 치명율이 높다. 본 논문에서는 특징 추출기, 잔류 구조와 완전 연결층으로 구성되고, 전이 학습을 이용한 말라리아셀 이미지를 인식하는 모델을 제안한다. VGG-19 모델의 사전 학습된 파라미터가 사용될 때 일부 컨볼루션층의 파라미터는 고정되고, 모델의 데이터에 맞추기 위하여 미세조정이 사용된다. 그리고 제안된 모델과 비교하기 위하여 잔류 구조가 없는 말라리아셀 인식 모델을 구현한다. 실험 결과 잔류 구조를 사용한 모델이 잔류 구조가 없는 모델에 비하여 성능이 우수 하였으며, 최신 논문과 비교하여 가장 높은 97.33%의 정확도를 보여주었다.

• Biomolecules & Therapeutics
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• 제30권2호
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• pp.151-161
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• 2022

This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we used diverse experimental methods such as cell viability assay, colony formation assay, tumor spheroid formation assay, cell cycle analysis, TUNEL assay, Western blot analysis, xenograft mouse model and histological analysis. Treatment with GA inhibited cell proliferation in dose-dependent manner as measured by cell viability assay at 48 h. GA and cisplatin (CDDP) also inhibited colony formation and tumor spheroid formation. In addition, GA and CDDP induced apoptosis, as determined by the distribution of early and late apoptotic cells and DNA fragmentation. Western blot analysis revealed that inhibition of the PI3K/Akt pathway induced upregulation of p53 (tumor suppressor protein), which in turn regulated cell cycle related proteins such as p21, p27, Cyclin D1 and E1, and intrinsic apoptotic proteins such as Bax, Bcl-2 and cleaved caspase-3. The anti-cancer effect of GA was further confirmed in an in vivo mouse model. Intraperitoneal injection with GA for 4 weeks in an A549-derived tumor xenograft model reduced the size of tumor mass. Injection of them downregulated the expression of proliferating cell nuclear antigen and p-Akt, but upregulated the expression of cleaved caspase-3 in tumor tissues. Taken together, these results indicated that GA hindered lung cancer progression by inducing cell cycle arrest and apoptosis, suggesting that GA would be a potential therapeutic agent against non-small cell lung cancer.

• 한국경영과학회지
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• 제28권3호
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• pp.67-79
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• 2003

An efficient mobility management for mobile stations plays an important role in mobile communication networks. Even though many a mobility management schemes have been proposed, most of mobile communication networks adopt the mobility scheme based on zone-based registration. This paper studies the mobility management scheme that combines zone-based registration and 2-step selective paging. We assume cell by cell registration area, not ring by ring registration area of previous studies, and set up a new mobility model based on 2-dimensional random walk model considering the characteristic of zone-based registration to evaluate its performance exactly. We provide numerical results using proposed model to demonstrate the performance of zone-based registration and 2-step selective paging under various circumstances.

• 대한산업공학회지
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• 제23권3호
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• pp.581-595
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• 1997

The procedure of grouping the machines and parts to form cells is called manufacturing cell design. The manufacturing cell design is an important step in the development and implementation of advanced manufacturing systems. For the successful implementation of the manufacturing systems, identification of independent manufacturing cells, i.e., cells where parts are completely processed in the cell and no intercell movements, is necessary in the design phase. In this paper, we developed a mixed integer programming model and genetic algorithm based procedure to solve the independent manufacturing cells design problem considering the alternative process plans and machines duplication. Several manufacturing parameters such as, production volume, machine capacity, processing time, number of cells and cell size, are considered in the process. The model determines the process plan for parts, port families and machine cells simultaneously. The model has been verified with the numerical examples.

• 한국경영과학회지
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• 제23권3호
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• pp.123-133
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• 1998

A cell design model based on operation sequence is proposed for maximizing the total parts flow within cells considering the data of Process plans for parts, Production volume, and cell size. A relationship between machines is calculated on the basis of the process plans for parts obtained from process plan sheets. Then the machines are classified into machine cells using the relationship. The model is formulated as a 0-1 integer programming and a genetic algorithm approach is developed to solve the model. The developed approach is tested and Proved using actual industrial data. Experimental results indicate that the approach is appropriate for large-size cell design problems efficiently.

• 한국CDE학회논문집
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• 제12권4호
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• pp.245-254
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• 2007

This research proposed feature extraction algorithms as an input of STEP Ap214 data, and feature parameterization process to simplify further design change and maintenance. The procedure starts with suppression of blend faces of an input solid model to generate its simplified model, where both constant and variable-radius blends are considered. Most existing cell decomposition algorithms utilize concave edges, and they usually require complex procedures and computing time in recomposing the cells. The proposed algorithm using reference features, however, was found to be more efficient through testing with a few sample cases. In addition, the algorithm is able to recognize depression features, which is another strong point compared to the existing cell decomposition approaches. The proposed algorithm was implemented on a commercial CAD system and tested with selected industrial product models, along with parameterization of recognized features for further design change.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.281-286
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• 2002

In this study, we intended to get a preliminary data for establishing rat tracheal surface epithelial(RTSE) cell culture system as an experimental model for physiology and pharmacology of tracheal epithelial cells. Primary culture on the membrane support and application of the air-liquid interface system at the level of cell layer were performed. The cell growth rate and mucin production rate were measured according to the days in culture. The results were as follows: this culture system was found to manifest mucocilliary differentiation of rat tracheal epithelial cells, the cells were confluent and the quantity of produced and released mucin was highest on culture day 9, the mucin was mainly released to the apical side and tbe free $^3{H}$-glucosamine which was not incorporated to process of synthesis of mucin was left on the basolateral side. Taken together, we suggest that air-liquid interface culture system can be used as a substitute for immersion culture system and as an experimental model for in vivo mucus-hypersecretory diseases.

• 한국수소및신에너지학회논문집
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• 제34권5호
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• pp.490-496
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• 2023

Unmanned aerial vehicles (UAVs) research is recently actively underway. Especially, fuel cell battery hybrid systems are widely used to overcome the limitations of continuous operation. However, fuel cell systems must be operated in combination with a battery due to their low specific output characteristics. Therefore, a hybrid power system model for UAVs is developed. The rule-based strategy is applied to the model to properly distribute power to batteries and fuel cells. As a result, the designed rule-based power distribution control operates UAVs while maintaining battery state of charge(SOC) at an appropriate level.

• Journal of Electrical Engineering and Technology
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• 제10권2호
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• pp.641-646
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• 2015

In this paper, a zinc electrowinning cell is fully optimized to achieve a uniform current distribution at electrode surfaces. To effectively deal with an electromagnetically coupled problem with multi-dimensional design variables, a sampling-based sensitivity approach is combined with a highly tuned multiphysics simulation model. The model involves the interrelation between electrochemical reactions and electromagnetic phenomena so as to predict accurate current distributions in the electrowinning cell. In the sampling-based sensitivity approach, Kriging-based surrogate models are generated in a local window, and accordingly their sensitivity values are extracted. Such unique design strategy facilitates optimizing very complicated multiphysics and multi-dimensional design problems. Finally, ten design variables deciding the electrolytic cell structure are optimized, and then the uniformity of current distribution in the optimized cell is examined through the comparison with existing cell designs.