• 대한방사선치료학회지
• /
• 제12권1호
• /
• pp.20-25
• /
• 2000

The accuracy of the target localization was evaluated by conventional and spiral CT in stereotactic radiosurgerv. Conventional and spiral CT images were obtained with geometrical phantom, which was designed to produce exact three-dimensional coordinates of several objects within 0.1mm error range. Geometrical phantom was attached by BRW headframe, intermediate head ring, and CT localizer. Twentv-seven slices of conventional CT image were scanned at 3 mm slice thickness. Spiral CT images were scanned at 3 mm slice thickness from the pitch value 1 to 3, and twenty-seven slices of image were obtained per each the pitch value. These CT images were transferred to a treatment planning system(X-knife, Radionics) by ethernet, Three-dimensional coordinates of these images measured from the treatment planning system were compared to known values of geometrical phantom. The mean localization error of the target localization of conventional CT was 1.4mm. In case of spiral CT, the error of the target localization was within 1.6mm from the pitch value 1 to 1.3, but was more than 30mm above the pitch value 1.5. In conclusion, as the localization error of spiral CT was increased in high pitch value compared to conventional CT, the application of spiral CT will be with caution in stereotactic radiosurgery.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2007년도 춘계학술대회B
• /
• pp.2026-2031
• /
• 2007

Hydrogen is receiving much research attention as an alternative substitute for hydrocarbon fuels these days due to its cleanliness and renewability. However, hydrogen should be used with caution because of its high propensity for leak and wide flammable range. This study deals with a situation that hydrogen leaks and then forms a flammable mixture inside 1kW class residential fuel cell. The residential fuel cell was modeled as a box-shaped chamber with vent openings at the top and bottom, filled with various components such as reformer, desulfurizer, fuel cell stack and humidifier. Computational fluid dynamics (CFD) was used to simulate the diffusion, buoyant flow and accumulation of leaked hydrogen in the modeled chamber. From the simulation, the risk region vulnerable to flame was identified and the methods to minimize such hazardous region was discussed. When the vent openings are 1% of the total surface, as the quantity of hydrogen leakage increases the risk regions increases accordingly. As the vent openings of the total surface increased from 1% to 2.3%, averaged hydrogen mole fraction is under 1% in the system.

• Biomolecules & Therapeutics
• /
• 제21권2호
• /
• pp.173-179
• /
• 2013

Objective of present study was to prepare and characterize self-nanoemulsifying drug delivery system (SNEDDS) of lutein and to evaluate its effect on bioavailability of warfarin. The SNEDDS was prepared using an oil, a surfactant, and co-surfactants with optimal composition based on pseudo-ternary phase diagram. Effect of the SNEDDS on the bioavailability of warfarin was performed using Sprague Dawley rats. Lutein was successfully formulated as SNEDDS for immediate self-emulsification and dissolution by using combination of Peceol as oil, Labrasol as surfactant, and Transcutol-HP or Lutrol-E400 as co-surfactant. Almost complete dissolution was achieved after 15 min while lutein was not detectable from the lutein powder or intra-capsule content of a commercial formulation. SNEDDS formulation of lutein affected bioavailability of warfarin, showing about 10% increase in $C_{max}$ and AUC of the drug in rats while lutein as non-SNEDDS did not alter these parameters. Although exact mechanism is not yet elucidated, it appears that surfactant and co-surfactant used for SNEDDS formulation caused disturbance in the anatomy of small intestinal microvilli, leading to permeability change of the mucosal membrane. Based on this finding, it is suggested that drugs with narrow therapeutic range such as warfarin be administered with caution to avoid undesirable drug interaction due to large amount of surfactants contained in SNEDDS.

• 대한임상독성학회지
• /
• 제15권1호
• /
• pp.60-64
• /
• 2017

Nicotine-poisoning related to the electronic cigarettes (e-cigarette) is increasing worldwide. Moreover, the American Association of Poison Control Centers has advised the public to use caution with e-cigarette devices and highly concentrated liquid nicotine after a surge in related poisonings. We report here the first case of nicotine poisoning from self-injected e-cigarette fluid in Korea. A 17-year-old male patient subcutaneously injected himself with 0.5 ml of nicotine solution for an electronic cigarette via the dorsum of his hand, after which he complained of nausea, vomiting, dizziness and dyspnea. His vital signs were within the normal range, but his mental status was drowsy. He was admitted for observation and the symptoms disappeared the following day. Sinus bradycardia with a rate of 45/min was observed on the third hospital day, but improved after 6 hours. He was discharged without complications.

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
• /
• pp.600-603
• /
• 2009

We compared relative importance of thermal conductivity and initial ground temperature in designing borehole heat exchanger network and also we test accuracy of ground temperature estimation in thermal response test using a proven 3-D T-H modeler. The effect of error in estimating ground temperature on calculated total length of borehole heat exchanger was more than 3 times larger than the case of thermal conductivity in maximum 20% error range. Considering 10% of error in estimating thermal conductivity is generally acceptable, we have to define the initial ground temperature within 5% confidence level. Utilizing the mean annual ground surface temperature and the geothermal gradient map compiled so far can be a economic way of estimating ground temperature with some caution. When performing thermal response test for estimating ground temperature as well as measuring thermal conductivity, minimum 100 minutes of ambient circulation is required, which should be even more in case of very cold and hot seasons.

• 대한한방소아과학회지
• /
• 제24권2호
• /
• pp.31-39
• /
• 2010

Objectives The recent prevalence rate of obesity in children is increasing, but so far the majority of ongoing research is focused on obesity in adults. Even comparison studies between obesity in adults and in children are insufficient at this stage. Thus, our research will investigate the characteristics of obesity in children based on the comparison with adults. Methods The blood levels including glucose, cholesterol, AST, ALT of obese children and obese adults were compared and analyzed. Results From comparison studies, the levels of glucose, cholesterol, ALT in adults were higher than in children. In order to take account the age differences, only the rate of abnormal levels based on the reference range were compared. As a result, the abnormal rate in blood cholesterol level was higher in children. Conclusions Childhood obesity may develop complications at early age and has high potential risk to result in adult obesity as well. Therefore, child obesity needs to be treated with more caution and careful attention.

• Asian-Australasian Journal of Animal Sciences
• /
• 제25권1호
• /
• pp.22-27
• /
• 2012

The experiment involved observations of 2,514 Holstein-Friesian cows to determine the effects of environmental factors (cow's age, calving season, weight and sex of calves, housing system) and genetic factors on gestation length in dairy cattle and the correlation between gestation length and other reproductive traits (calving ease, stillbirth rates and placental expulsion). Genetic parameters were estimated based on the sires of calved cows (indirect effect) and the sires of live-born calves (direct effect). The following factors were found to contribute to prolonged gestation: increasing cow's age, male fetuses and growing fetus weight. Optimal gestation length was determined in the range of 275-277 days based on calving ease and stillbirth rates. The heritability of gestation length was estimated at 0.201-0.210 by the direct effect and 0.055-0.073 by the indirect effect. The resulting genetic correlations suggest that the efforts to optimize (prolong) gestation length could exert an adverse influence on the breeding value of bulls by increasing perinatal mortality and calving difficulty. The standard errors of the investigated parameters were relatively high, suggesting that any attempts to modify gestation length for the purpose of improving calving ease and reducing stillbirth rates should be introduced with great caution.

• Biomolecules & Therapeutics
• /
• 제22권3호
• /
• pp.254-259
• /
• 2014

The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and OA on platelet aggregation was examined on the basis that alteration of platelet activity is a potential process contributing to cardiovascular events. Treatment of UA enhanced platelet aggregation induced by thrombin or ADP, which was concentration-dependent in a range of $5-50{\mu}M$. Quite comparable results were obtained with OA, in which OA-treated platelets also exhibited an exaggerated response to either thrombin or ADP. UA treatment potentiated aggregation of whole blood, while OA failed to increase aggregation by thrombin. UA and OA did not affect plasma coagulation assessed by measuring prothrombin time and activated partial thromboplastin time. These results indicate that both UA and OA are capable of making platelets susceptible to aggregatory stimuli, and platelets rather than clotting factors are the primary target of them in proaggregatory activity. These compounds need to be used with caution, especially in the population with a predisposition to cardiovascular events.

• 한국산학기술학회논문지
• /
• 제11권5호
• /
• pp.1814-1819
• /
• 2010

본 연구에서는 현재 OCR(과압밀비) 값 결정을 위하여 실용적으로 많이 활용되고 있는 경험적 방법인 정규화 콘팁저항치과 과압밀비의 관계상수법에 대하여 분석하였다. 이를 위하여 창원 북면 및 인천 서북면 지역의 연약점 토지반에 대하여 관계상수를 산정하고 고찰하였다. 연구결과, 관계상수 값은 창원북면의 경우 0.28~0.33, 인천 서북면의 경우 0.49~0.6으로, 해외의 기존 연구결과 보다 최대 90% 크게 비안전측으로 산정되어 향후 콘팁저항치와 과압밀비의 관계상수법 사용에 주의가 필요하다 하겠다.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제5권3호
• /
• pp.195-203
• /
• 2005

Recently, a novel multi-bit nonvolatile memory based on double gate (DG) MOSFET is proposed to overcome the short channel effects and to increase the memory density. We need more complex voltage schemes for DG MOSFET devices. In view of peripheral circuits driving memory cells, one should consider various voltage sources used for several operations. It is one of the key issues to minimize the number of voltage sources. This criterion needs more caution in considering a DG nonvolatile memory cell that inevitably requires more number of events for voltage sources. Therefore figuring out the permissible range of operating bias should be preceded for reliable operation. We found that reliable operation largely depends on the depletion conditions of the silicon channel according to charge amount stored in the floating gates and the negative control gate voltages applied for read operation. We used Silvaco Atlas, a 2D numerical simulation tool as the device simulator.