• The Korean Society of Law and Medicine
• /
• v.12 no.2
• /
• pp.65-117
• /
• 2011

This article analyzes the case (2008Da16776) which has the issue how patients have to prove causal relationship when patients claim against pharmaceutical companies alleging that patients were infected with virus due to contaminated blood products. The Supreme court held that: (1) if patients prove that they didn't have symptoms suggesting virus infection before administration of blood products, the virus infection had been confirmed after administration of blood products, and there were significant potential of contamination of the blood products with the virus, the defect in blood products or the negligence of pharmaceutical company in making blood products shall be presumed to cause the infection of the victim. (2) The pharmaceutical companies could reverse the presumption by proving the blood products were not contaminated, but the fact that the victims were treated with the blood products manufactured by other companies or had received blood transfusions is not enough to reverse the presumption. The case is the first decision whether the burden of proof about causal relationship could be reduced in pharmaceutical product liability lawsuit. Hereafter pharmaceutical product liability cases, it would be necessary to reduce the burden of proof about causal relationship in order to make substantive equality between patients and pharmaceutical companies.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.14 no.7
• /
• pp.557-561
• /
• 2001

Chemical mechanical polishing (CMP) process has been widely used to planarize dielectric layers, which can be applied to the integraded circuits for sub-micron technology. Despite the increased use of CMP process, it is difficult to accomplish the global planarization of in the defect-free inter-level dielectrics (ILD). Especially, defects such as micro-scratch lead to severe circuit failure which affect yield. CMP slurries can contain particles exceeding 1㎛ in size, which could cause micro-scratch on the wafer surface. The large particles in these slurries may be caused by particles agglomeration in slurry supply line. To reduce these defects, slurry filtration method has been recommended in oxide CMP. In this work, we have studied the effects of filtration and the defect trend as a function of polished wafer count using various filters in inter-metal dielectrics(IMD)-CMP process. The filter installation in CMP polisher could reduce defects after IMD-CMP process. As a result of micro-scratch formation, it is shown that slurry filter plays an important role in determining consumable pad lifetime. The filter lifetime is dominated by the defects. We have concluded that slurry filter lifetime is fixed by the degree of generating defects.

• Journal of Korean Society for Quality Management
• /
• v.38 no.3
• /
• pp.340-353
• /
• 2010

Properly designed and well-executed services enable e-commerce companies to capture the unique needs and preferences of customers, help them build customer loyalty, and thereby, strengthen their competitiveness in the marketplace. An object of this study is the new open-market company and it has only 3 percent of the market share. Therefore, it is needed to raise the market share by improving the service qualities. This article presents a six sigma project for service quality improvement in the open-market company. This study was carried out based on five steps of DMAIC which is six sigma technique. First, a defect rate was defined as unsatisfaction rate. In addition, 50-people data was analyzed and it was shown that the defect level was 2.5 sigma level. In this study, in order to raise the sigma level, novel eight action items were determined based on SIPOC, FDPM, cause and effect diagram, matrix chart, Pareto chart and statistical analysis.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.46 no.1
• /
• pp.76-83
• /
• 2023

Recently, the development of computer vision with deep learning has made object detection using images applicable to diverse fields, such as medical care, manufacturing, and transportation. The manufacturing industry is saving time and money by applying computer vision technology to detect defects or issues that may occur during the manufacturing and inspection process. Annotations of collected images and their location information are required for computer vision technology. However, manually labeling large amounts of images is time-consuming, expensive, and can vary among workers, which may affect annotation quality and cause inaccurate performance. This paper proposes a process that can automatically collect annotations and location information for images using eXplainable AI, without manual annotation. If applied to the manufacturing industry, this process is thought to save the time and cost required for image annotation collection and collect relatively high-quality annotation information.

• Journal of Veterinary Clinics
• /
• v.26 no.1
• /
• pp.76-80
• /
• 2009

A Maltese was presented with a subcutaneous mass at right flank, depression and hyperthermia. Ultrasonography revealed a hypoechoic mass with hyperechoic foci, a defect of abdominal wall and peritonitis. In cytology, fat necrosis was found. This dog was diagnosed as chronic suppurative steatitis secondary to pancreatitis and pancreatic herniation through surgery and histopathologic examination. Steatitis is recurrent inflammation and necrosis of adipose tissue. Also steatitis associated with pancreatic diseases such as pancreatitis and pancreatic tumor was reported and direct fat necrosis by pancreatic enzyme was supposed as the etiology. Steatitis secondary to pancreatitis was rarely reported in dogs and there was difficulty in diagnosis and treatment. This case has a limitation that pancreatitis was not diagnosed as underlying cause to steatitis before surgery. However, a defect of abdominal wall and peritonitis were observed on ultrasonography. Good prognosis could be achieved through prompt surgery and medical treatment.

• Nuclear Engineering and Technology
• /
• v.52 no.11
• /
• pp.2678-2685
• /
• 2020

The pipe bends and elbows in nuclear power plants (NPPs) are vulnerable to degradation mechanisms and can cause wall-thinning defects. As it is difficult to detect both the defects generated inside the wall-thinned pipes and the preliminary signs, the wall-thinning defects should be accurately estimated to maintain the integrity of NPPs. This paper proposes a deep fuzzy neural network (DFNN) method and estimates the collapse moment of wall-thinned pipe bends and elbows. The proposed model has a simplified structure in which the fuzzy neural network module is repeatedly connected, and it is optimized using the least squares method and genetic algorithm. Numerical data obtained through simulations on the pipe bends and elbows with extrados, intrados, and crown defects were applied to the DFNN model to estimate the collapse moment. The acquired databases were divided into training, optimization, and test datasets and used to train and verify the estimation model. Consequently, the relative root mean square (RMS) errors of the estimated collapse moment at all the defect locations were within 0.25% for the test data. Such a low RMS error indicates that the DFNN model is accurate in estimating the collapse moment for wall-thinned pipe bends and elbows.

• Journal of Veterinary Clinics
• /
• v.25 no.1
• /
• pp.58-63
• /
• 2008

Peritoneopericardial diaphragmatic hernia(PPDH) is uncommon and congenital disease in dogs and cats. In PPDH, the peritoneal organs such as liver, small intestine, stomach and omentum are displaced into the congenital defect between pericardial sac and diaphragm and cause the abnormal round and enlarged cardiac silhouette. Abnormal cardiac silhouette contacts with the cranial diaphragmatic border consistently and soft tissue- and/or gas- density structures are summated over the cardiac density in radiography. The contrast medium flows from peritoneal cavity into the pericardial sac and demonstrates the herniated abdominal organs and the abnormal defect in positive peritoneography. In this study, 4 dogs was diagnosed as PPDH using radiography, peritoneography and thoracic ultrasonography and showed various clinical signs according to the kind, amount and clinical state of herniated abdominal organs.

• The KIPS Transactions:PartB
• /
• v.17B no.6
• /
• pp.445-458
• /
• 2010

A Cold Cathode Fluorescent Lamp(CCFL) is used as a LCD Monitor's backlight widely. The most common way to check CCFL's defects is an examination with the naked eye. This naked eye examination can cause examination inconsistencies and industrial disasters. A shooting environment and detection algorithms are important for finding CCFL defects automatically. This paper presents CCFL defect detection algorithms using images captured under the shooting environment with sidelight which is one of the shooting environment we have suggested. The experimental result shows 4.65% of overdetection and 5.37% of unsuccessful defect detection of CCFL.

• The Korean Journal of Physiology and Pharmacology
• /
• v.23 no.6
• /
• pp.539-547
• /
• 2019

Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane chloride channel. It has been recognized that mutations in the ANO5 gene cause many skeletal muscle diseases such as limb girdle muscular dystrophy type 2L (LGMD2L) and Miyoshi muscular dystrophy type 3 (MMD3) in human. However, the molecular mechanisms of the skeletal myopathies caused by ANO5 defects are poorly understood. To understand the role of ANO5 in skeletal muscle development and function, we silenced the ANO5 gene in C2C12 myoblasts and evaluated whether it impairs myogenesis and myotube function. ANO5 knockdown (ANO5-KD) by shRNA resulted in clustered or aggregated nuclei at the body of myotubes without affecting differentiation or myotube formation. Nuclear positioning defect of ANO5-KD myotubes was accompanied with reduced expression of Kif5b protein, a kinesin-related motor protein that controls nuclear transport during myogenesis. ANO5-KD impaired depolarization-induced $[Ca2^{+}]_i$ transient and reduced sarcoplasmic reticulum (SR) $Ca^{2+}$ storage. ANO5-KD resulted in reduced protein expression of the dihydropyridine receptor (DHPR) and SR $Ca^{2+}-ATPase$ subtype 1. In addition, ANO5-KD compromised co-localization between DHPR and ryanodine receptor subtype 1. It is concluded that ANO5-KD causes nuclear positioning defect by reduction of Kif5b expression, and compromises $Ca^{2+}$ signaling by downregulating the expression of DHPR and SERCA proteins.

• Archives of Reconstructive Microsurgery
• /
• v.6 no.1
• /
• pp.56-62
• /
• 1997

Latissimus dorsi(LD) muscle is the largest transplantable block of vascularized tissue. Since LD free flap was introduced in 1970's, this flap has been widely used for the reconstruction of large soft tissue defect of the limb. From 1981 to 1996, we had experienced 37 cases of LD free flap. Serratus anterior muscle was combined with LD in three of them whose defects were very large. The average age of the patients was 31 years(range : 4-74 years), and thirty one patients were male. Trauma was cause of the defect in every case. For the recipient sites, the foot and ankle was the most common(22 cases); and the knee and lower leg(11 cases), the elbow and forearm(2 cases), the hand(2 cases) were the next. The duration of follow-up was averaged as 16 months(range: 6 months-12 years). Thirty one cases(84%) out of 37 were successful transplantations. In one case the failure of the flap was due to heart attack and subsequent death of the patient. One failure was caused by sudden violent seizure of the patient who had organic brain damage. Immediate reexploration of the flap was performed in 4 patients, and the flap survived in three of them. There was one necrosis of the grafted split-thickness skin on the survived LD flap. LD free flap was considered as one of the good methods, for the reconstruction of the large soft tissue defect of the limb.