• Title/Summary/Keyword: case-controlled study

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Systematic Review and Meta-Analysis on Herbal Medicine for Generalized Anxiety Disorder: Focusing on Clinical Studies over the Past 5 Years (범불안장애의 한약 치료에 관한 체계적 문헌고찰 및 메타분석: 최근 5년 임상연구를 중심으로)

  • Min-Jae Kim;Hyun-Seob Park;Chan-Young Kwon
    • Journal of Oriental Neuropsychiatry
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    • v.34 no.4
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    • pp.403-420
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    • 2023
  • Objectives: This study investigated the effectiveness of herbal medicine for generalized anxiety disorder (GAD) based on recent clinical studies. Methods: Studies were searched through four databases. Clinical research studies on herbal medicine treatment for GAD patients were included. The studies were analyzed according to study design, diagnostic criteria, population, and intervention. A risk of bias assessment was performed to assess the quality of the included randomized controlled trials (RCT). If the intervention applied to the treatment and control groups was the same and two or more studies were reporting the same items as outcome indicators, a meta-analysis was performed. Results: A total of 19 studies, including 12 RCTs were selected. The most common pattern identification was 'Phlegm fire disturbing upward' (痰熱上擾), and the most used herb for therapeutic purposes was 'Rhizome of Poria cocos' (茯苓). Meta-analysis results of three studies showed that there were no significant differences in effectiveness between the herbal medicine intervention and the Western medicine intervention. Meta-analysis results of five studies showed that the Hamilton Anxiety Rating Scale was significantly reduced in the case of herbal medicine intervention compared to Western medicine intervention. Conclusions: The results of our study demonstrated that herbal medicine treatment for GAD is effective in alleviating anxiety symptoms and chief symptoms of GAD. However, this study has several limitations; there was a lack of placebo-controlled RCT and an absence of objective diagnostic criteria in case reports. Therefore, further well-designed clinical studies, conducted based on the results of this study, are recommended.

A Study on the ALS Method of System Identification (시스템동정의 ALS법에 관한 연구)

  • Lee, D.C.
    • Journal of Power System Engineering
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    • v.7 no.1
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    • pp.74-81
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    • 2003
  • A system identification is to estimate the mathematical model on the base of input output data and to measure the output in the presence of adequate input for the controlled system. In the traditional system control field, most identification problems have been thought as estimating the unknown modeling parameters on the assumption that the model structures are fixed. In the system identification, it is possible to estimate the true parameter values by the adjusted least squares method in the input output case of no observed noise, and it is possible to estimate the true parameter values by the total least squares method in the input output case with the observed noise. We suggest the adjusted least squares method as a consistent estimation method in the system identification in the case where there is observed noise only in the output. In this paper the adjusted least squares method has been developed from the least squares method and the efficiency of the estimating results was confirmed by the generating data with the computer simulations.

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Ruptured Aneurysm of Sinus Valsalva (대동맥 동맥루 파열 9례 보고)

  • Yoon, Yu-Joon;Cho, Bum-Koo;Hong, Seung-Nok
    • Journal of Chest Surgery
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    • v.11 no.4
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    • pp.373-377
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    • 1978
  • Aneurysmal rupture of sinus Valsalva is known as one of rare cardiac disease and not controlled with medical treatment. We experienced 9 cases which were composed with 7 case of male and 2 cases of female during last 15 years. 7 cases were ruptured into right ventricle from right. coronary sinus and 2 cases were ruptured into right atrium from non-coronary sinus. The diagnosis was made with cardiac catheteriza1icn and cineangiccardicgram but 2 cases were misdiagnosed with only cardiac catheterization. All cases were corrected under cardiopulmonary bypass with means of direct suture with tdlon pledget by transatrial or transventricular approach. All were not confirmed in it's origin because of no history, no evidences of syphilis, TB, or bacterial endocarditis and only fibrosis in pathologic report. In postoperative course, 1 case had postoperative bleeding and 1 case was sufferd from left hemiplegia due to may be air embolism. Follow up study revealed all patient go on their usual life well with good improvement at this present time.

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The effects of dual-task training on ambulatory abilities of stroke patients: Review of the latest trend

  • Lee, Gyu Chang;Choi, Won Jae
    • Physical Therapy Rehabilitation Science
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    • v.1 no.1
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    • pp.1-5
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    • 2012
  • Objective: Dual-task walking deficits impact functional daily life, which often requires walking while performing simultaneous tasks such as talking, thinking or carrying an object. This study is to find out the latest trend of dual-task training's influence on ambulatory abilities of a stroke patient. Design: Systematic review of randomized controlled trials. Methods: This literature review was conducted in Pubmed and Sciencedirect with the follwing key words:stroke, cerebro-vascular accident, hemiplegia, gait, rehabilitation, exercise. 7 studies were chosen in findings by search tool. 3 studies were case study, 3 studies were cross sectional observational study and 1 study was randomized controlled trial. Results: It was found that stroke patients have difficulties in doing 2 motor tasks simultaneously and when they do 2 tasks, one is done in a naturally preferred activity areas. Moreover, when simply applying dual-tasks, the walking speed decreased. Meanwhile, when applying them through training, the speed increased. This showed the improvement of effective task-implementation abilities after dual-task training using task-integration models. Conclusions: In the beginning of the 2000s, dual-tasks were implemented by simply combining walking and cognition or exercise task, and the results of this study suggest that subjects with stroke have difficulty performing dual task. However, the latest trend is to let patients do the dual-task training by combining it with virtual reality. Therefore, dual task training could be performed in a safe in the environment such as virtual reality or augment reality.

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Recent Research Trends in Moxibustion Treatment in Korea

  • Lee, Ju-Hyeon;Hwang, Doo-ree;Hong, Seung-Hyo
    • Journal of Acupuncture Research
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    • v.37 no.1
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    • pp.1-12
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    • 2020
  • A total of 1,235 studies were retrieved on June 23, 2019, from 3 databases. Selected 59 studies were evaluated by year of publication, study type, subject condition/disease, acupoint, standards for reporting interventions in clinical trials of moxibustion (STRICTOM), Cochrane risk of bias (RoB), and risk of bias assessment tool for non-randomized study (RoBANS). Most studies were conducted in 2011, after which the number of studies decreased. The most common study type was 25 case reports (CR), 16 uncontrolled clinical trials (UCT), 11 randomized controlled trials (RCT), and 7 controlled clinical trials (CCT). Moxibustion treatment was mainly used for musculoskeletal and circulatory diseases/conditions. A total of 83 acupoints were used, A-shi points being the most used. As for STRICTOM, an average of 7.4 items were satisfactory for UCT and CR without a control group, and an average of 9.4 items were satisfactory for RCT and CCT. RCT was assessed using the RoB, and many items were rated as uncertain. In this study, the need for RCT of moxibustion treatment in Korea was identified. The detailed description of study methods and results will provide evidence for the efficacy of moxibustion treatment in preventive and therapeutic aspects of Korean traditional medicine.

A Study on the Flowable Backfill with Waste Foundry Sand for Retaining Wall (유동특성을 이용한 폐주물사 혼합물의 옹벽뒷채움재 연구)

  • 조재윤;이관호;이인모
    • Journal of the Korean Geotechnical Society
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    • v.16 no.4
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    • pp.17-30
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    • 2000
  • The objective of this study is to evaluate the lateral earth pressure and the stability of small scale retaining wall with waste foundry sand(WFS) mixtures as a controlled low strength materials (CLSM). Three different types of WFS, like Green WFS, Hurane WFS and Coated WFS, were used in this study, and fly ash of Class F type was adopted. To evaluate the lateral earth pressure and the stability of retaining wall, two different samll scale retaining wall tests, which are called an artificially controlled strain method and a natural strain method, were carried out. In case of an artificially controlled strain method, the coefficient of lateral earth pressure, just after backfilling of WF mixtures, was around 0.8 to 1.0, and most of earth pressure was dissipated within 12 hours. In case of a natural strain method, two steps of stage constructions were employed. The mixtures of Hurane WFS and Coated WFS showed fast decrease of earth pressure due to a relatively good drainage. Judging from the sta bility of retaining wall for overturning and sliding, two steps of stage construction for 2 days were enough to finish the backfill of 6-m height of retaining wall. Also, considering the curling effect of WFS mixtures, the stability of retaining wall increased as curling time increased.

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A Systematic Review of Chuna Manual Therapy for Adolescent Idiopathic Scoliosis

  • Jung, Ga Hyeon;Lee, Hyun;Kong, Hae Jin;Ryu, Hwa Yeon;Ku, Yong Ho;Kang, Jae Hui
    • Journal of Acupuncture Research
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    • v.36 no.3
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    • pp.119-130
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    • 2019
  • This study analyzed randomized controlled trials (RCTs) and case studies investigating Chuna manual therapy and variations of this term, for adolescent idiopathic scoliosis. On June $15^{th}$, 2019, 6 online databases were used to retrieve studies. A total of 527 articles were retrieved, and 14 RCTs and 20 case studies were selected for review. Typically, the frequency of Chuna therapy was 1-2 times/week. The most common period of treatment was 12 months in RCTs and 3-6 months in case studies. Cobb's angle was the most frequent evaluation index used (11 RCTs and 20 case studies). In control groups, brace treatment was used in 8 RCTs. In 6 RCTs and 20 case studies, Cobb's angle significantly decreased after Chuna therapy, and in 4 RCTs, Chuna therapy was as effective as brace treatment, with no significant difference between groups. Adverse events were not reported except for minor reactions in only 3 case studies. This review suggested that Chuna therapy for adolescent idiopathic scoliosis was more advantageous than and as effective as brace treatment in most cases, although the risk of bias in 13 RCTs was unclear.

A Case Report of Symptomatic Epilepsy (수면중 간질발작을 주소로 하는 증후성 간질 환아 증례 보고)

  • Kim, Yoon-Young;Min, Sang-Yeon;Kim, Jang-Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • v.23 no.1
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    • pp.85-93
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    • 2009
  • Objectives The purpose of this study is to report a case which gave various remarkable epilepsy treatment results by using oriental medicine. Methods We treated the patient with acupuncture as a main treatment and herbal medicine. We also recommended to the patient and patient's parents to continue oriental medical treatment for 2 years from now because symptomatic epilepsy is a type of disease which needs long term care. Results The epileptic seizure has been well controlled for 12 months so far, and the results was recorded by EEG. The EEG level was in normal range. Conclusions Even though this is only one case of the study but this case has an important meaning because the epilepsy was treated by oriental medicine, especially acupuncture treatment. The control of the symptomatic epileptic seizure was effective by means of increasing patient's quality of life. Further studies about effective treatment of symptomatic epilepsy would be needed with more various cases.

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The Sharing Economy Business Model per the Analysis of Value Attributes (공유경제 비즈니스 모델의 가치 요인 분석)

  • Lee, Junmin;Hwang, Junseok;Kim, Jonglip
    • Journal of Information Technology Services
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    • v.15 no.4
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    • pp.153-174
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    • 2016
  • On account of multiple causes, including prolonged global economic crisis, addressing environmental pollution and the advent of hyper-connected society, a new paradigm called 'sharing economy' has rapidly emerged. Many startups have attempted to build promising business model based on the sharing economy concept. Nevertheless, successful cases are still very rare in the global level, except for Uber and Airbnb cases. Therefore, this study analyzes necessary causes and sufficient causes for successful settlements in the market through a comparative case analysis on digital matching firms in the sharing economy businesses. For the case study, we compare five successful cases (Uber, Airbnb, Kickstarter, TaskRabbit and DogVacay), three failure cases (Homejoy, Ridejoy and Tuterspree) and a platform cooperativism case (Juno) in accordance with six value attributes of business model including value proposition, market segment, value chain, cost structure and profit potential, value network and competitive strategy. We apply Boolean method to support controlled comparison and eliminate unnecessary attributes. The Boolean analysis result shows that value proposition, cost structure and profit potential, value network and competitive strategy are the essential attributes. Furthermore, the result indicates that each attribute is a necessary condition, where all four conditions should be met simultaneously in order to be successful. With this result, we discuss essential consideration for those who are planning startup based on the sharing economy business model.

A Clinical Analysis to Study Effectiveness of Korean Medicine for Medial Collateral Ligament Injury of the Knee (무릎 내측측부인대 손상의 한의학적 치료에 대한 국내외 임상연구 동향 분석)

  • Oh, Tae Young;Han, Si Hoon;Oh, Min Seok
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.17 no.1
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    • pp.35-46
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    • 2022
  • Objectives This study aimed to review clinical studies on traditional Korean medicine treatment for medial collateral ligament injury of the knee. Methods Clinical studies on Korean traditional medicine treatment of medial collateral ligament injury were conducted. We used five Korean online databases (OASIS, KISS, RISS, DBPia, and ScienceOn) and three foreign databases (PubMed, Cochrane Library, and CNKI). Out of 99 studies that were found, we excluded repeated articles, studies that were not related to Korean medicine, and those not relevant to the topic of the study. Results Ten randomized controlled trials and 20 case studies were selected. Eight traditional Korean medicine treatments, including acupuncture, herbal medicine, chuna, and herbal ointment, were used in these studies. The most commonly used treatment was found to be acupuncture. Conclusions Our study showed that traditional Korean medicine for medial collateral ligament injuries was effective. However, there were some limitations. Further clinical studies and randomized controlled clinical trials are needed for more evidence on Korean traditional medicine.