• 제목/요약/키워드: case-control studies

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국제판례상 실효적 지배의 개념과 독도에 관한 고찰 (Reviews on the Concept of Effective Control in International Legal Cases and with Regard to Dokdo)

  • 이용희
    • Ocean and Polar Research
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    • 제35권4호
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    • pp.313-322
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    • 2013
  • The concept of effective control is a crucial element for the acquisition as well as maintenance of territorial title. The general meaning of the concept has been described as 'an intentional display of power and authority over the territory, by the exercise of jurisdiction and State functions, on a continuous and peaceful basis'. The concept has been developed through some significant international cases such as the Island of Palmas case (1928), Legal Status of Eastern Greenland (1933), Minquiers and Ecrehos case (1953), Burkina Faso/Mali case (1986) and Nicaragua/Colombia case (2012). In relation to Dokdo, the concept has an important bearing in regard to Korea's claims of territorial sovereignty over the island. This paper reviews the definition, components and ramifications of the effective control with regard to the acquisition and maintenance of territorial title through analyzing the relevant judgements of international courts and tribunals. Furthermore, it exams the legal ramifications of the current effective control on Dokdo and makes some suggestions for the strengthening of Korea's position on the island.

직업적 트리클로로에틸렌 노출과 비호지킨림프종의 연관성 (Occupational Exposure to Trichloroethylene and Non-hodgkin Lymphoma Risk)

  • 전재범;한소희;윤형석;이은정;이경무
    • 한국환경보건학회지
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    • 제37권5호
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    • pp.358-368
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    • 2011
  • Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.

Are Beta Blockers New Potential Anticancer Agents?

  • Akbar, Shahid;Alsharidah, Mansour Saleh
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권22호
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    • pp.9567-9574
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    • 2014
  • ${\beta}$-Blockers have been one of the most widely used and versatile drugs for the past half a century. A new potential for their use as anti-cancer drugs has emerged in the past few years. Various retrospective case control studies have been suggestive that use of ${\beta}$-blockers before the diagnosis of cancer could have preventive and protective effects against non-small cell lung carcinoma, melanoma, and breast, pancreatic and prostate cancers. Experimental and clinical observations are still inconclusive with some inconsistent findings. However, indications are pointing toward a positive role of some ${\beta}$-blockers against certain forms of cancers. This mini review is an effort to present the up to date published results of case-control studies and experimental findings.

사시의 침치료에 대한 최근 임상 연구 동향 (Recent Clinical Research on Effect of Acupuncture for Strabismus)

  • 이지나;이선행;이진용
    • 대한한방소아과학회지
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    • 제30권2호
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    • pp.23-30
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    • 2016
  • Objectives The purpose of this study is to investigate recent clinical studies on effect of acupuncture for strabismus in Korea and other countries. We have analyzed 10 years (from 2006 to 2015) of case studies and randomized controlled trials (RCT) on effect of acupuncture for strabismus. Methods The search database includes Oasis, KTKP (Korean Traditional Knowledge Portal), Medline, Embase, and Cochrane library. To narrow the search, the following key search terms were used: 'strabismus, acupuncture'. The search was limited to the publication date from 2006 to 2015. 7 case studies and 5 control studies were selected for analysis. Results and Conclusions 1. The acupuncture treatment is effective for paralytic strabismus 2. The studies used BL1, GB1, ST2, TE23, GB15, EX-HN5, ST1, and LI4 acupoints and also an electroacupuncture treatment, which is 15 minutes of extraocular muscle stimulation, was used. 3. Degree of strasbismus was tested by Ocular motor range test, Corneal light reflex test, Ocular abducent scale test (Scott and Kraft, Diploptic range test).

Evaluation of Economic Damage Caused by Drought in Central Region Vietnam: A Case Study of Phu Yen Province

  • Truong, Dinh Duc;Tri, Doan Quang
    • 자원환경지질
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    • 제54권6호
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    • pp.649-657
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    • 2021
  • This paper aims to study the impact of natural disasters on per capita income in Vietnam both the short and long-term, specifically impact loss of income caused by the extreme drought 2013 for agriculture, forestry and fishery in Phu Yen Province, Central Vietnam. The study valued economic damage by applying the synthetic control method (SCM), which is a statistical method to evaluate the effect of an intervention (e.g. natural disasters) in different case studies. It estimates what would have happened to the treatment group if it had not received the treatment by constructing a weighted combination of control units (e.g. control provinces). The results showed that the 2013 drought caused a decrease in income per capita, mainly in the agriculture, forestry, and fishery sector in Phu Yen. The reduced income was estimated to be VND 160,000 (1 USD = 23,500 VND (2021)) for one person per month, accounting for 11% of total income per capita and continued to affect the income 6 years later. Therefore, authorities need to invest in preventive solutions such as early and accurate warnings to help people to be more proactive in disaster prevention.

The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review

  • Jae-Hee Park;Yunjung Lee;Mijoo Choi;Eunju Park
    • Clinical Nutrition Research
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    • 제12권1호
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    • pp.77-89
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    • 2023
  • This study aimed to find out the effect of vitamins on respiratory-related viral infections, including coronavirus disease 2019 (COVID-19), through the literature reviews. From January 2000 to June 2021, the studies (cohort studies, cross-sectional studies, case-control studies, randomized control trials) related to vitamins (vitamin A, D, E, C, B6, folate, and B12) and COVID-19/severe acute respiratory syndrome/Middle East respiratory syndrome/cold/influenza were selected from the PubMed, Embase, and Cochrane libraries and analyzed. The relationship between vitamins and virus-related respiratory diseases was identified. Through the review, 39 studies were selected on vitamin D, one study on vitamin E, 11 studies on vitamin C, and 3 studies on folate. Regarding COVID-19, 18 studies on vitamin D, 4 studies on vitamin C, and 2 studies on folate showed significant effects of the intake of these nutrients in preventing COVID-19. Regarding colds and influenza, 3 studies on vitamin D, 1 study on vitamin E, 3 studies on vitamin C, and 1 study on folate demonstrated that the intake of these nutrients significantly prevents these diseases. Therefore, this review suggested the intake of vitamins D, E, C, and folate is important for preventing respiratory diseases related to viruses, such as COVID-19, colds, and influenza. The relationship between these nutrients and virus-related respiratory diseases should be continuously monitored in the future.

No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

  • Hu, Zheng-Hui;Lin, Yi-Wei;Xu, Xin;Chen, Hong;Mao, Ye-Qing;Wu, Jian;Xu, Xiang-Lai;Zhu, Yi;Li, Shi-Qi;Zheng, Xiang-Yi;Xie, Li-Ping
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권3호
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    • pp.1691-1695
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    • 2013
  • Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma. Methods: We searched PubMed, Web of Science and Scopus between 1970 and November 2012. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Twelve epidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. In a meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overall relative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidence interval [CI] 0.89-1.21). In subgroup meta-analyses by study design, there was no significant association between tea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI 0.84-1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95, 95% CI 0.81-1.12). Conclusion: Our findings do not support the conclusion that tea consumption is related to decreased risk of renal cell carcinoma. Further prospective cohort studies are required.

섬유근통에 대한 국내 임상 연구 동향 및 중재 방향 (Korean Domestic Trends of Clinical Research and Direction of Intervention for Fibromyalgia)

  • 이정한;금지혜;우현준;이창훈;정종혁;이명수
    • 척추신경추나의학회지
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    • 제15권2호
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    • pp.43-54
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    • 2020
  • Objectives The purpose of this review was to analyze the trend of clinical research related to fibromyalgia and to suggest the direction of intervention Methods We reviewed the clinical research by searching seven Korean web databases and classified the studies by the year of publication, academic field, and study design. Results A total of 75 clinical studies were selected. Except for 2002, more than one study was annually published; however, the number was below 10. In the academic field, there were 34 in the medical field, 21 in the Korean medicine field, and 15 in the nursing science field. By study design, there were 62 observational studies, mostly case reports and case-control studies. There were 13 experimental studies, including non-random control studies and one group pre and post-test design studies. Conclusions Fibromyalgia-related clinical research requires a greater number of studies, and a study design with a high level of evidence should be conducted along with various observational and intervention studies. Additionally, multidisciplinary and integrated intervention plans and research are needed.

Breast Cancer and Modifiable Lifestyle Factors in Argentinean Women: Addressing Missing Data in a Case-Control Study

  • Coquet, Julia Becaria;Tumas, Natalia;Osella, Alberto Ruben;Tanzi, Matteo;Franco, Isabella;Diaz, Maria Del Pilar
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권10호
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    • pp.4567-4575
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    • 2016
  • A number of studies have evidenced the effect of modifiable lifestyle factors such as diet, breastfeeding and nutritional status on breast cancer risk. However, none have addressed the missing data problem in nutritional epidemiologic research in South America. Missing data is a frequent problem in breast cancer studies and epidemiological settings in general. Estimates of effect obtained from these studies may be biased, if no appropriate method for handling missing data is applied. We performed Multiple Imputation for missing values on covariates in a breast cancer case-control study of $C{\acute{o}}rdoba$ (Argentina) to optimize risk estimates. Data was obtained from a breast cancer case control study from 2008 to 2015 (318 cases, 526 controls). Complete case analysis and multiple imputation using chained equations were the methods applied to estimate the effects of a Traditional dietary pattern and other recognized factors associated with breast cancer. Physical activity and socioeconomic status were imputed. Logistic regression models were performed. When complete case analysis was performed only 31% of women were considered. Although a positive association of Traditional dietary pattern and breast cancer was observed from both approaches (complete case analysis OR=1.3, 95%CI=1.0-1.7; multiple imputation OR=1.4, 95%CI=1.2-1.7), effects of other covariates, like BMI and breastfeeding, were only identified when multiple imputation was considered. A Traditional dietary pattern, BMI and breastfeeding are associated with the occurrence of breast cancer in this Argentinean population when multiple imputation is appropriately performed. Multiple Imputation is suggested in Latin America's epidemiologic studies to optimize effect estimates in the future.

A design of discrete time nonlinear control system with disturbances using model following method

  • Zhang, Yuan-Sheng;Okubo, Shigenori
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
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    • pp.239-242
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    • 1996
  • A model following control system(MFCS) can give general output signals following desired ones. In previous studies, a method of nonlinear MFCS was proposed by S.Okubo[1]. In this paper, the method of nonlinear MFCS will be extended to discrete time nonlinear systems. It is easy to extend the method to discrete time systems. But in the case .gamma.=1 discrete time systems, the proof becomes difficult, because the transfer function from f(v(k)) to v(k) can't be a positive real function. In this case, to ensure that internal states are stable, a new criterion is proposed.

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