• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9241-9247
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• 2014

Background: Rs31489 in the cleft lip and palate transmembrane1-like gene (CLPTM1L) has been identified to be associated with lung cancer through genome-wide association studies (GWAS). However, some recent replication studies yielded inconclusive results. Thus, we undertook this study to investigate the precise effect of rs31489 on lung cancer susceptibility. Materials and Methods: A hospital-based case-control study in 1,673 Chinese subjects (611 individuals with lung cancer and 1,062 controls) and a meta-analysis among 32,199 subjects (16,364 cases and 15,835 controls) were performed in this study. Results: In our case-control study, rs31489 was inversely associated with lung cancer (AC versus CC: OR=0.68, 95%CI=0.52-0.88; additive model: OR=0.68, 95%CI=0.54-0.85; dominant model: OR=0.65, 95%CI =0.51-0.84). Stratification analysis by smoking status showed a significant association and strong genetic effect in non-smokers but not in smokers. Our meta-analysis further confirmed the association, although with significant heterogeneity contributed by study design and source of controls, as shown by stratified analysis. Sensitive and cumulative analyses both indicated robust stability of our results. In addition, there was no observable publication bias in our meta-analysis. Conclusions: Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5407-5413
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• 2015

Background: Published data regarding associations between the P275A polymorphism in the macrophage scavenger receptor 1 (MSR1) gene and prostate cancer (PCa) risk are inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of P275A polymorphism in MSR1 gene for PCa. Materials and Methods: A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 27, 2015). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software. Results: A total of 5,017 cases and 4,869 controls in 12 case-control studies were included in this meta-analysis. When all groups were pooled, there was no evidence that the P275A polymorphism had a significant association with PCa under dominant (OR=0.93, 95%CI=0.81-1.06, and p=0.28), co-dominant (homogeneous OR=0.97, 95%CI=0.56-1.68, and p=0.92; heterogeneous OR=0.93, 95%CI=0.74-1.15, and p=0.49), recessive (OR=1.10, 95%CI=0.65-1.87, and p=0.73), over-dominant (OR=0.93, 95%CI=0.75-1.15, and p=0.50), and allelic (OR=0.95, 95%CI=0.77-1.16, and p=0.61) genetic models. For stratified analyses by ethnicity and study design, no significant associations were found in the white race, the yellow race, the black race and mixed ethnicity, and the population-based case-control (PCC) and hospital-based case-control (HCC) studies under all genetic models. Conclusions: Based on our meta-analysis, the P275A polymorphism in the MSR1 gene is unlikely to be a risk factor for PCa.

• Nutrition Research and Practice
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• v.17 no.1
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• pp.122-134
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• 2023

BACKGROUND/OBJECTIVES: Consumption of certain protective foods may help inhibit Helicobacter pylori (H. pylori) associated gastric pathologies. However, studies conducted to assess the efficacy of protective foods in H. pylori-infected subjects are either limited or inconsistent. This study evaluated the association of individual or a combination of protective foods on the incidence of gastric cancer (GC) in H. pylori-positive subjects through a case-control study. MATERIALS/METHODS: Subjects aged 20-79 years were selected from 2 hospitals between December 2002 and September 2006. In total, 134 patients and 212 controls tested positive for H. pylori infection. Among these, we included 82 pairs of cases and controls matched by sex, age (± 5 years), enrollment period (± 1 years), and hospital. RESULTS: A higher intake of soy products was associated with a significantly lower risk of GC than a lower intake of soy products (odds ratio [OR] = 0.37, 95% confidence interval [CI] = 0.14-0.96). Additionally, a higher fruit intake resulted in a significantly lower risk of GC than a lower fruit intake (OR = 0.35, 95% CI = 0.13-0.94). A combination of food groups was evaluated, and a lower risk of GC was observed with a high intake of both soy products and fruits (OR = 0.20, 95% CI = 0.06-0.67), high intake of soy and dairy products (OR = 0.28, 95% CI = 0.10-0.78) and high intake of fruits and dairy products (OR = 0.28, 95% CI = 0.09-0.83). CONCLUSIONS: A high intake of soy products or fruits was associated with a lower risk of GC. A combination of soy products or fruits with dairy products was associated with a lower risk of GC. A balanced intake of soy products, fruits, and dairy products may help reduce GC risk.

• Proceedings of the Korea Multimedia Society Conference
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• 2001.11a
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• pp.260-264
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• 2001

This paper presents virtual reality using 6-DOF Haptic interface. It is proposed reappearance of force using 6-DOF Haptic device that was designed by previous studies and 3D image considered time delay. The performance of conventional control is excellent in the case of the exactly known dynamic model of the robot, but degrades seriously as the uncertainty of the model increases. The virtual reality using 6-DOF Haptic interface is presented here to overcome such that, and verified through the experiment.

• 전기의세계
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• v.26 no.3
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• pp.84-91
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• 1977

A modified version of algorithm and computer program is proposed to improve the currently available contingency analysis methode for the security control of power system. The underlying principle is based upon the reasonable modification of the current methods suggested by Stagg, Tinny, Alsac, and Stott in consideration of speed, aceuracy, reliability and convergency characteristics. The algorithm and program are desirgned especially for On-Line operation, although Off-Line applications are readily available. Several case studies on the Koren Power Company's 48-bus, 91-line system have shown that the method proposed is efficiently powerful in a sense of practical applicability.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10a
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• pp.87-92
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• 1991

A naphtha reforming process treats the feed naphtha for the production of BTX and high octane gasoline. In this paper, the development of NAFOS (Naphtha Reformer Steady-State Simulator), which is the efficient tool for the wide range of reforming process studies, is presented. NAFOS system is based on the sequential modular approach and composed of unit computation routines, physical properties data base, numerical routines, flowsheet convergence routine and user interfaces for input-output control. The developed NAFOS system has been tested by computation of the UOP Platforrming process. Simulation results of NAFOS corresponded with that of established general purpose simulator (ASPEN PLUS), and faster for the same simulation case.

• 제어로봇시스템학회:학술대회논문집
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• 1986.10a
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• pp.560-565
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• 1986

For the control of chemical process, optimal value of the process should be known at first. And process simulation is the previous step of optimal value calculation. However it is not a simple work to analyze chemical process system. Especially for the large scale chemical process system, many difficulties such as non-linearity and complexity caused by recycle streams should be overcome. In this paper, three strategies of large scale chemical process analysis were explained and discussed with case studies.

• International Journal of Control, Automation, and Systems
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• v.6 no.3
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• pp.320-326
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• 2008

This paper studies the problem of fault estimation using adaptive fault diagnosis observer. A fast adaptive fault estimation (FAFE) approximator is proposed to improve the rapidity of fault estimation. Then based on linear matrix inequality (LMI) technique, a feasible algorithm is explored to solve the designed parameters. Furthermore, an extension to sensor fault case is investigated. Finally, simulation results are presented to illustrate the efficiency of the proposed FAFE methodology.

• Journal of the Korean Chemical Society
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• v.13 no.1
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• pp.13-15
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• 1969

This investigation is to make comparative evaluation of the corrosion inhibiting effects of quinoline, oxine and 7-nitroso 8-hydroxy quinoline (7NHQ). In case of quinoline, and oxine, since the N atom in them functions as cation, the process involved is assumed to be cathode control. On the other hand 7-NHQ was found to form a stable chelate compound with $Fe^{++}$ ion in acidic solution and shows as anode control predominantly. After plotting polarization curves, Tafel parameters were calculated in each solution involving the inhibitors, at the same time corrosion inhibiting effects were separately measured and compared from data of both corrosion current and analytical method.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.1
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• pp.25-42
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• 2017

Objectives The goal of this review was to investigate clinical, experimental and literature studies of Korean medicine on atopic dermatitis (AD) of Korean children in Korean medicine literature, seeking for the better research methods for more effective treatments. Methods Electronic investigations were practiced on AKOP (The Association of Korean Oriental Pediatrics, http://www.akop.or.kr) to collect theses which were published by J Pediatr Korean Med. The key word 'Atopy' was used for searching to ensure that every related thesis was collected. The publication date was limited from 1996 to 2016. The selected literatures were assessed mainly according to distributions of study type, publication year, scale, treatment and its efficacy. Results 55 papers were selected from 59 studies. In these collected 55 related theses, there were 29 experimental studies (52.73%), 18 clinical studies (32.73%), 8 review studies (14.55%). In the 29 experimental studies, there were 20 studies (68.97%) using NC/Nga mouse as subjects. The mite antigen was used to trigger AD by 8 studies (27.59%). The studies have been utilizing DNCB and DNFB instead of mite antigen since 2011. All the experimental studies showed that the Korean medicine was effective in AD. In total 18 clinical studies, 3 studies (16.67%) were case reports, only 1 thesis (5.56%) was conducted by case control study and the rest were case series studies. 7 studies (38.89%) of 18 studies diagnosed AD according to Hanifin and Rajka's diagnostic criteria (1980), only 1 study (5.56%) according to the Korean standard and the rest 10 studies (55.56%) didn't mention diagnostic criteria. 12 clinical studies (66.67%) showed efficacy in treating AD. There were 10 studies (55.56%) only employing internal treatments and 1 thesis (5.56%) didn't mention the exact prescription. Naesowhajungtang-kamibang, Saenghyeoryunbue-um were used 3 times (16.67%) as the internal medicine respectively. 5 theses (27.78%) were combined with acupuncture therapy. Hegu (LI4), Sanyinjiao (SP6) were used in 4 theses, and Taichong (LR3), Quchi (LI11), Zusanli (ST36) in 3 theses. The number of acupoints chosen from The Spleen meridian of Foot-Taiyin was the largest. There were 8 review theses. 2 were about the foreign oriental medicine, 3 were about the external medicine or external treatment methods, and 3 other studies were about severity scoring systems, the methodological study in the latest clinical study, overview for pattern and results of herbal medicine-derived AD clinical researches. Conclusions The experimental studies and clinical studies showed the effectiveness of Korean medicine treatments. However, this study still needs improving by conducting more comparative studies and using better research methods, in order to find more effective treatments to improve clinical efficacy.