• Journal of the Korean Society for Precision Engineering
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• v.22 no.8 s.173
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• pp.57-63
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• 2005

Development of a locomotive mechanism fer the capsule type endoscopes will largely enhance the ability to diagnose disease of digestive organs. In connection with it, most of researches have focused on an installable locomotive mechanism in the capsule. In this paper, it is introduced that the movement of a capsule type endoscope in digestive organ can be manipulated by magnetic force produced outside human body. Since the magnetic force is provided by permanent magnets, no additional power supply to the capsule is required. Using a robotic manipulator for locating the external magnet, the capsule motion control system can cover the whole human digestive organs. This study is particularly concentrated on dither motion effect to improve the mobility of capsule type endoscope. It was experimentally found out that the friction coefficient between the capsule and digestive organ can be remarkably reduced by superposing yawing or rolling dither motion on the translatory motion. In this paper, the experimental results obtained with the direction, amplitude and frequency of sinusoidal dither motion changed is reported.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.11
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• pp.964-971
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• 2002

A numerical investigation of the constrained melting of phase change materials within spherical-like capsule is presented. A single-domain enthalpy formulation is used for simulation of the phase change phenomenon. The solution methodology is verified with the melting process inside an isothermal spherical capsule. Especially, the effect of capsule shape on the heat storage is emphasized. Two shape parameters are considered from the real capsule shape showing good characteristics of heat storage and the effect of these parameters is examined. Early during the melting process, the conduction mode of heat transfer is dominant. Thus the capsule shape with large surface area is desirable. However, the capsule shape with large surface area plays negative role on the strength of buoyancy-driven convection that becomes more important as melting continues.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.2
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• pp.313-318
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• 1997

Effects of the concentration of NaCl, the concentration and the molecular weight of chitosan on the permeability of capsule type fertilizer and herbicide were investigated. The encapsulating process was based on the electrostatic interaction between chitosan (a polycationic polymer) and sodium alginate (an anionic polysaccharide). Sodium alginate solution $(1\%)$ was dropped into chitosan solution $(1\%)$ in which various amounts of NaCl was added. The capsule strength was increased with the addition of NaCl and the maximum value of capsule strength was observed at 0.3M NaCl. Capsule type fertilizer and herbicide were immersed in deionized water to determine its permeability, and it was affected by the concentration of NaCl and chitosan, and the molecular weight of chitosan. As the concentration of NaCl in chitosan solution increased, permeability of the capsule increased and marked the maximum value of $ 88\%$(fertilizer), $87\%$ (herbicide) at 0.75M NaCl. As concentration of chitosan solution increased, permeability tended to decreased; it showed the maximum value of $90\%$ (fertilizer) and $90.3\%$ (herbicide) at $0.25\%$ chitosan and the minimum value of $83\%$ (fertilizer) and $82\%$ (herbicide) at $1\%$ chitosan. Permeability of fertilizer and herbicide also decreased, as the molecular weight of chitosan (material of capsule) was decreased; it was showed $86\%$ (fertilizer) and $83\%$ (herbicide) at M.W 330,000 (sonication time 0min) and $52\%$ (fertilizer) and $51\%$ (herbicide) at M.W 119,000 (sonication time 180 min). The chitosan-alginic acid capsule was manufactured (defined as prepared capsule), dried for 6 hrs and immersed in deionized water (defined as restored capsule) to examine restoration of capsule. Restoration of capsule was good, and capsule strength was slightly decreased form $20g/cm^2$ (prepared capsule) to $17g/cm^2$ (restored capsule)

• KSBB Journal
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• v.16 no.4
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• pp.321-326
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• 2001

The change of molecular weight inside and outside a capsule produced using coencapsulating technology was investigated. Chitosan and chitosanase were enveloped in this membrane and product released was a loaded the medium by the principle of size exclusion. The leakage of substrate corresponding to the agitation speed was controlled by adjusting the alginate and CaCO$_3$ concentrations. The optimal condition of alginate concentration and agitation speed were 0.5% and 40rpm, respectively. Membrane thickness and capsules diameter were 10 $\mu$m and approx. 3.0 - 1.5 mm, respectively. Molecular weight difference by concentration and alginate viscosity were of little significance. In accordance with the molecular weight distribution versus enzyme concentration relationship, low concentration of enzyme produced high molecular weight oligosaccharides. At a 1.5 mm capsule size the product diffusion rate to outer surface highest. The molecular weight distribution of the released oligosaccharides was ranged from 1000 to 6000 Da. More than 80% of the initial activity of encapsulated enzyme retained after 8hrs of reaction.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1068-1073
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• 2005

Development of a locomotive mechanism for the capsule type endoscopes will largely enhance the ability to diagnose disease of digestive organs. In connection with it, most of the researches have focused on an installable locomotive mechanism in the capsule. In this paper, it is introduced that the movement of a capsule type endoscope in digestive organ can be manipulated by magnetic force produced outside human body. Since the magnetic force is provided by permanent magnets, no additional power supply to the capsule is required. Using a robotic manipulator for locating the external magnet, the capsule motion control system can cover the whole human digestive organs. This study is particularly concentrated on dither motion effect to improve the mobility of capsule type endoscope. It was experimentally found out that the friction coefficient between the capsule and digestive organ can be remarkably reduced by superposing yawing or rolling dither motion on the translatory motion. In this paper, the experimental results obtained while the direction, amplitude and frequency of sinusoidal dither motion were changed are reported.

• Journal of Applied Reliability
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• v.18 no.3
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• pp.260-270
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• 2018

Purpose: The purpose of this study is to evaluate the life of the capsule, which is a core part of the heat storage cooling system. This paper will develop a life test mode that can reproduce environment conditions through the analysis of capsule shrinkage and expansion characteristics. Methods: In order to determine the life test mode of the capsule, this paper analyzed the case of field failures and analyzed the deformation characteristics according to the pressure fluctuation of the capsule. The method to find out whether the field failure and deformation analysis results are consistent is the testing with the construction of the repetition pressure test equipment and the thermal cycle test to reproduce the freezing and thawing characteristics. Results: In this study, failure mode analysis and analysis of freezing and thawing characteristics regarding to the capsule positions were completed. Based on this test & analysis results, this paper have been able to determine the main parameters for determining the life test mode, the freezing and thawing time. Conclusion: Determining the lifetime mode of the capsule can be used to improve the life and performance of the thermal storage system.

• Journal of Mechanical Science and Technology
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• v.20 no.7
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• pp.1012-1018
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• 2006

Diagnosis and treatment using the conventional flexible endoscope in gastro-intestinal tract are very common since advanced and instrumented endoscopes allow diagnosis and treatment by introducing the human body through natural orifices. However, the operation of endoscope is very labor intensive work and gives patients some pains. As an alternative, therefore, the capsule endoscope is developed for the diagnosis of digestive organs. Although the capsule endoscope has conveniences for diagnosis, it is passively moved by the peristaltic waves of gastro-intestinal tract and thus has some limitations for doctor to get the image of the organ and to diagnose more thoroughly. As a solution of these problems, various locomotive mechanisms for capsule endoscopes are introduced. In our proposed mechanism, the capsule-type microrobot has synchronized multiple legs that are actuated by a linear actuator and two mobile cylinders inside of the capsule. For the feasibility test of the proposed microrobot, a series of in-vitro experiments using small intestine without incision were carried out. From the experimental results, our proposed microrobot can advance along the 3D curved and sloped path with the velocity of about $3.29\sim6.26mm/sec$ and $35.1\sim66.7%$ of theoretical velocity. Finally, the proposed locomotive mechanism can be not only applicable to micro capsule endoscopes but also effective to advance inside of gastro-intestinal tract.

• International Journal of Industrial Entomology and Biomaterials
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• v.33 no.2
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• pp.50-53
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• 2016

The size of head capsule is one of the most important factors for identifying developmental stage. In order to understand the developmental characteristics of the butterfly Atrophaneura alcinous, we examined fluctuations in larval head capsule size under three different temperature conditions (20, 25, and $30^{\circ}C$) and 60% humidity. As a result, larvae developed to the fifth instar at all three temperatures. The head capsule size of larvae tended to be larger at the lowest temperature and smaller at the highest temperature. The development rate showed a regular change, consistent with Dyar's rule regarding head capsule size development. Furthermore, the development of head capsule size was found to correspond to a second degree polynomial regression better than to a linear regression. On the basis of these results, it would appear to be possible to perform an accurate assessment of instar status during the development of A. alcinous.

• Nuclear Engineering and Technology
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• v.29 no.2
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• pp.148-157
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• 1997

A new capsule that has a unique structure in which the test environments including neutron flux and fluence, and irradiation temperature can be controlled precisely during irradiation, was conceptually designed. The capsule structure and instrumentation were successfully designed according to the JMTR's standard procedures of capsule design. Based on the target irradiation, the details of the irradiation such as neutron fluence and irradiation temperature ore calculated and the related capsule safety was evaluated. In addition, the effects of design parameters including the changes in inner-capsule configuration, heater capacity, and Helium gas pressure on the specimen temperature were analyzed with a computer program. Through these thermal and strength evaluations, this capsule was proved to be safe during the irradiation in the JMTR.

• KSBB Journal
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• v.10 no.4
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• pp.358-369
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• 1995

A mathematical model using local thermodynamic equilibrium isotherms for adsorption in encapsulated adsorbent is proposed in order to optimize the design parameters in situ bioproduct separation process. The model accurately follows the experimental data on the adsorption of berberine, secondary metabolite produced in Thaictrum rugosum plant cell culture. The adsorption rate on encapsulated adsorbent is compared with that on alginate-entrapped adsorbent. The result shows that the higher loading capacity in encapsulated adsorbent is mainly due to the increase in the maximum solid phase concentration. Based on the adsorption rate and loading capacity, the encapsulated adsorbent would be more useful than the entrapped adsorbent when used in situ bioproduct separation process. Design parameters in situ bioproduct separation process, such as the size of the capsule, membrane thickness, the ratio of capsule volume to bulk volume, the ratio of single capsule volume to total capsule volume and the adsorbent content in the capsule, are evaluated by using the model. The ratio of single capsule volume to total capsule volume is the most effective parameter for adsorption of berberine on encapsulated adsorbent.