통합 검색 | Korea Science

M.H. Rhee;Kim, S.K.
- 한국수정란이식학회:학술대회논문집
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- 한국수정란이식학회 2002년도 국제심포지엄
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- pp.96-96
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- 2002
We examined the role of SR 144528 (N-[-(1S-endo-1,3,,3-trimethyl-bicycle[2, 2, 1 ] heptan-2-y1]-5-(-4-chloro-3-mothyl-phenyl)-(4-methylbenzyl)-pyrazole-3- carboxamide) in the modulation of certain AC isoforms in transiently transfected COS-7 cells. We found that CB2 in COS cells has a constitutive activity, and thus leading to inhibition of AC-V activity even in the absence of agonist. In addition, this constitutive modulation of AC is reversed by SR144528. It is now well established that several G protein-coupled receptors can signal without agonist stimulation(constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive G protein-coupled receptor signaling. Agonist activation of the G$\_$i/o/-coupled peripheral cannabinoid receptor CB2 normally inhibits adenylyl cyclase type V and stimulates adenylyl cyclase type II. Using transfected COS cells, we show here that application of SR144528, an inverse agonist of CB2, leads to a reverse action (stimulation of adenylyl cyclase V and inhibition of adenylyl cyclase II). This inverse agonism of SR144528 is dependent on the temperature, as well as on the concentration of the cDNA of CB2 transfected. Pertussis toxin blocked the regulation of adenylyl cyclase activity by SR 144528.
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김무준;신정언;김현기;신동욱
- 대한화장품학회지
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- 제50권2호
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- pp.95-102
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- 2024
최근 의료용 대마의 합법화 추세와 규제가 완화되고 있는 상황 속에서 대마의 다양한 효능이 과학적으로 입증되고 있기 때문에 여러 분야에서 대마추출물이 차세대 유망 성분으로 떠오르고 있다. 대마에서 추출한 성분인 cannabinoid (CB), cannabidiol (CBD), phytocannabinoid (pCB), hemp seed hexane extracts (HSHE)은 피부 염증을 감소시키며 피부 보습, 강력한 항산화 효과가 있고 여러 피부질환 개선에 효능을 가지고 있다. 본 논문에서는 대마추출물들의 피부에서의 효능을 종합하여 소재로서의 잠재적 역할에 대해 살펴보고자 한다.
https://doi.org/10.15230/SCSK.2024.50.2.95 인용 PDF