• Journal of the korean veterinary medical association
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• v.43 no.6
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• pp.536-542
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• 2007

국내뿐만 아니라, 전세계적으로 관심을 가지고 있는 인플루엔자 바이러스(influenza virus)는 일반적으로 고열과 기침을 동반한 독감을 일으키는 원인체로서, 사람을 포함한 포유동물과 조류 등에 감염되고 전염될 수 있기 때문에 많은 문제를 유발 하고 있습니다. 또한 이미 많이 알려진 조류 인플루엔자(avain influenza; AI)의 경우 조류에서 뿐만 아니라, 사람에게 전염될 경우 치명적인 결과를 초래하는 경우가 많아 때로는 공포의 대상이 되기도 합니다. 더욱이 조류 인플루엔자(AI)는 보건상의 문제를 해결하기 위해 많은 노력을 기울이고 있음에도 불구하고, 현재까지도 국내.외 여러 산업에 영향을 주거나 사람이 사망에 까지 이르고 있는 실정입니다. 이러한 현실에서 인플루엔자 바이러스가 사람을 비롯한 여러 동물에서 감염 혹은 전염이 확인될 경우 많은 걱정을 할 수 밖에 없으며, 만약 동물에서의 바이러스 감염 사실이 과장되거나 잘못된 정보가 대중에게 알려질 경우에는 사회적으로 엄청난 파장을 일으킬 수 밖에 없는 것이 현실입니다. 더욱이, 근래 미국에서는 개의 독감(canine flu)이라고 불리는 개의 인플루엔자 바이러스(canine influenza virus; CIV) 감염이 전역으로 확산되고 있는 상황이기 때문에, 국내에서도 예의주시하면서 지켜보고 있을 뿐만 아니라, 수의사를 비롯한 보호자를 개의 인플루엔자 바이러스에 대해서 많은 관심을 가지고 있는 상황입니다.

• Journal of the korean veterinary medical association
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• v.44 no.9
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• pp.842-847
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• 2008

국내에서 개 인플루엔자는 2007년에 공식보고가 되기 시작한 Canine influenza virus, H3N2가 원인인 것으로 알려져 있다. 이에 최근에 발생한 개 인플루엔자 발생 예를 소개하고자 한다.

• Journal of Microbiology and Biotechnology
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• v.26 no.6
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• pp.1109-1114
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• 2016

H3N2 canine influenza virus emerged in South Korea in 2007 and subsequently spread to China and Thailand, causing epidemic or endemic respiratory diseases in dogs. Through intermammalian species transmission, the virus has also infected cats. However, no direct evidence of significant genetic evolution has been reported since its first emergence. Here, we describe in depth the genetic and molecular characteristics of the ancestral strain (i.e., the first virus isolate from South Korea) of the H3N2 canine influenza virus currently circulating in East Asia.

• Journal of Veterinary Clinics
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• v.34 no.3
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• pp.165-171
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• 2017

A cross-sectional study was conducted to investigate the prevalence of canine influenza (CI) infection in pet dogs and canine parvovirus (CPV) infection in street dogs of different age and sex by collecting rectal and nasal swab samples from three districts, Dhaka, Mymensingh and Sirajgonj, in Bangladesh using a RapiGEN$^{(R)}$ Canine Influenza Virus Ag Test kit and RapiGEN$^{(R)}$ Canine Parvovirus Ag Test Kit. Out of 114 rectal swabs and 115 nasal swab samples, the overall prevalence of CI and CPV was found to be 11.30% and 32.45%, respectively. The prevalence of parvovirus infection was found to be significantly higher in puppies and dogs 6 months of age (50.0%) than those > 24 months of age (p = 0.005). The prevalence was also higher in males (34.42%) than females (30.18%). The prevalence of CI was higher (30.43%) in dogs up to 6 months of age (p = 0.011) than 6-12 month (7.93%) and 12-18 month (6.66%) old dogs. Moreover, the prevalence of CI was found to be higher in males (16.10%) than females (5.66%). The prevalence of CPV infection also varied significantly in different study areas (p = 0.0029), with 12.72%, 12.5% and 7.14% of dogs found to be CI positive in Dhaka, Mymensingh and Sirajgonj, respectively. Overall, the highest prevalence of CI was found in local breeds (6.08%) followed by German shepherds and Keeshonds (1.73%), and Bloodhounds and Terriers (0.86%). Additionally, there were more positive CI found in unvaccinated dogs (14.81%) than vaccinated (2.94%) dogs. Dogs with flu-like symptoms were more positive (19.23%) for CI relative to those without flu-like symptoms (4.76%) samples. Overall, the results of this study indicate that canine vaccination should be initiated to prevent the occurrence of diseases and that regular monitoring should be continued in Bangladesh.

• Korean Journal of Veterinary Service
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• v.37 no.4
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• pp.297-305
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• 2014

Animals and disease frequency of the rescued dogs were investigated in Incheon Veterinary Medical Association Animal Shelter from January in 2012 to December in 2013. Three zoonoses (rabies, brucellosis, and dirofilariosis) and three infectious diseases (canine distemper, canine parvoviral enteritis, and canine influenza) were examined for stray dogs. Among 5,603 heads, 647 (11.5%) went back to their owner and 969 (17.3%) were adopted to new families. Prevalence of dirofilariosis, canine distemper and canine parvoviral enteritis were 2.2% (16/718), 6.0% (24/399) and 6.1% (24/396), respectively. Positive antibody rates against rabies, B. canis and canine influenza virus were 20.5% (41/200), 0.1% (1/718) and 2.0% (4/200), respectively. Protective antibody for canine distemper virus and canine parvovirus were shown in 47.0% (94/200). The data indicate that control measures including facility standards and disease control program are one of the important aspects of the shelter management because stray dogs are exposed to various infectious agents.

• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.465-480
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• 2009

Objective : Lonicerae Flos has detoxifying properties and been used as antipyretic, antibacterial and antitumor. Fermentation of herbal medicine is known to increase the absorption, enhance effectiveness, decrease herbal toxicity and reduce side-effects. This study was performed to measure the effects of fermented Lonicerae Flos on influenza A/WSN (H1N1) virus replication. Material and Methods : Lonicerae Flos was fermented by Lactobacillus casei PM1. Fermented Lonicerae Flos was treated for 12 hours to MDCK (Mardin Darby canine kidney) cells, then cell-virulence was observed by MTT assay for 12 hours, 24 hours, and 36 hours after treatment. Following cases were conducted for 0, 10, 100, and $1000{\mu}g/ml$ concentrations of fermented Lonicerae Flos under the same time-frame; the fermented Lonicerae Flos was treated to MDCK cells before and after contamination by A-type influenza virus. The fermented Lonicerae Flos and the virus were mixed directly. The influence was observed by MTT assay and plaque assay. Results : These findings suggest that the fermented Lonicerae Flos inhibited the virulence of influenza A virus in MDCK cells and suppressed the plaque forming colonies induced by influenza A virus. Furthermore, pretreatment with fermented Lonicerae Flos was more effective than post-treatment. The titer of influenza virus was reduced for all before and after influenza A virus inoculation.

• Journal of Veterinary Science
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• v.24 no.6
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• pp.78.1-78.6
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• 2023

Avian-origin H3N2 canine influenza A viruses (CIVs) have become enzootic in China and Korea and have sporadically transmitted to North America, causing multiple epidemics. We isolated six CIVs in Korea from CIV-infected patients during 2014-2017 and conducted whole genome sequencing and phylogenetic analyses. Results revealed that CIVs have circulated and evolved in Korea since the early 2000s and then diversified into a new clade, probably contributing to multiple epidemics in China, the USA, and Canada. Our findings bridge an evolutionary gap for understanding the global transmission of CIVs, emphasizing the significance of continuous monitoring of CIVs.

• Korean Journal of Veterinary Service
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• v.43 no.4
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• pp.217-225
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• 2020

This study was conducted to survey pathogens of canine coronavirus (CCV), canine distemper virus (CDV), canine influenza virus (CIV), canine parvovirus (CPV), severe fever with thrombocytopenia syndrome virus (SFTSV), Dirofilaria (D.) immitis, Giardia and antibodies against Anaplasma (A.) phagocytophilum, Borrelia (B.) burgdorferi, Brucella (B.) canis and Ehrlichia (E.) canis among stray dogs in Gyeonggi province. We collected 271 feces, 291 bloods, 311 nasal and ocular swab samples from 311 of dogs in the Gyeonggi province assistance dogs sharing center from January to December, 2019. Among canine infectious disease pathogens, Giardia was highly detected in 46/271 (17.0%) samples. Subsequently, CCV 10.3% (28/271), D. immitis 8.2% (24/291), CPV 4.1% (11/271), CDV 1.0% (3/311), A. phagocytophilum (antibody) 0.3% (1/291), E. canis (antibody) 0.3% (1/291) were detected. Based on the results, this study is expected to provide a useful reference for disease control and management of stray dogs.

• Korean Journal of Veterinary Service
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• v.36 no.4
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• pp.333-340
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• 2013

Canine influenza virus (CIV) is an emerging pathogen that causes severe and acute respiratory disease in dogs. In 2006, the H3N2 CIV was first identified in dogs from Guangdong province in China. The nine isolates were grouped together with the canine H3N2 viruses isolated from dogs and cats in Korea. The possible interspecies transmission of influenza A virus is very important. We carried out a serological retrospective study using invited canine serum. The hospital invited 123 dogs, first vaccination group were revealed with CIV antibody positive rate of 81.8%. the second vaccination group were detected a positive rate of 91.2%. Antibody generation rate was higher in 3~10 years dogs. Protective antibody titers were detected from 2 weeks to 12 months. thereafter below the protective antibody. The results indicate that H3N2 CIV may have been consistently circulating in dog populations. Recently. These findings showed that H3N2 CIV has the capacity to replicate in and transmit among cohoused dogs and underscore the need for continued public health surveillance. Considering the result continuous management and prevention system against CIV is required at the concentrated animal care centers. The importance of CIV surveillance in this region for understanding the genesis of this virus, and it is important to remain aware of the potential of H3N2 CIV to be transmitted from dogs to the human population.

• Journal of Microbiology and Biotechnology
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• v.24 no.7
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• pp.921-924
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• 2014

C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.