• Journal of Veterinary Science
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• 제23권4호
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• pp.61.1-61.10
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• 2022

Background: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection. Objectives: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease. Methods: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis. Results: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner's satisfaction were very good Conclusions: Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects.

• Journal of Oral Medicine and Pain
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• 제16권1호
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• pp.95-102
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• 1991

The purpose of this study carried into the Electric pulp test for having knowledge of the difference of each one's stimulant threshold in normal teeth, the stimulant threshold at 10:00 A.M. and 3:00 P.M. in the same teeth, the differendce of the stimulant threshold between dental caries and normal contralateral teeth. In this study, 27 students aged between 22 and 24 years were selected from a pool of students who are sttending school of dentistry, chosun university who did not possessed dental disease like the dental caries, periodontal disease and restoration etc., and 30 outpatients who possessed dental caries(++). The obtained results were as follows : 1. The stimulant thresholds of the premolars and canine were higher than that of the incisors. 2. The stimulant thresholds of the carious teeth were lower than that normal contralateral teeth. 3. There were no difference stimulant threshold at 10:00 A.M. and 3:00 P.M.

• 치과방사선
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• 제2권1호
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• pp.41-46
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• 1972

The author had measured the alveolar bone level of periodontal disease on 50 cases of orthopantomogram to detect the degree of alveolar bone resorption of both sexes of Korean. The results were obtained as follows; 1. Alveolar bone resorption of mesial and distal portion was similiar in same patient. 2. The order of alveolar bone resorption was mandibular anterior region, posterior region, canine and premolar region of both jaws. 3. The degree of alveolar bone destruction was severe in shorter root length than longer. 4. The degree of alveolar bone resorption was severe in forth decades.

• 한국임상수의학회지
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• 제19권1호
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• pp.103-106
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• 2002

Specific diagnosis of orthopedic disease can be diffcult in canine practice. Failure to detect the clinical signs of a disorder during physical examination of dogs with acute or chronic lameness is the most common reason for failure to make specific diagnosis. A 6-month-old, female doberman with history of swelling and non-weight-bearing lameness in the left forelimb was referred to Beterinary Teaching Hospital of Chungbuk National University. Physical examination, plain radiography, and conventional three-phase radionuclide bone scan were performed in the patient. Based on the physical exam and radiography, this case was diagnosed as elbow strain and subluxation. Conventional three-phase bone scan detected soft tissue inflammation and osteochondral lesions of elbow joint, and revealed good agreement with clinical findings. Therefore, conventional three-phase bone scan was able to provide the precise information about inflammation of soft tissue and osteochondral lesions of joint.

• Journal of Veterinary Science
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• 제22권5호
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• pp.60.1-60.9
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• 2021

Background: Echocardiography is a primary tool used by veterinarians to evaluate heart diseases. In recent years, various studies have targeted standard echocardiographic values for different breeds. Reference data are currently lacking in Maltese dogs and it is important to fill this gap as this breed is predisposed to myxomatous mitral valve disease, which is a volume overload disease. Objectives: To establish the normal echocardiographic parameters for Maltese dogs. Methods: In total, 23 healthy Maltese dogs were involved in this study. Blood pressure measurements, thoracic radiography, and complete transthoracic echocardiography were performed. The effects of body weight, age and sex were evaluated, and the correlations between weight and linear and volumetric dimensions were calculated by regression analysis. Results: The mean vertebral heart size was 9.1 ± 0.4. Aside from the ejection fraction, fractional shortening, and the left atrial to aorta root ratio, all the other echocardiographic parameters were significantly correlated with weight. Conclusion: This study describes normal echocardiographic parameters that may be useful in the echocardiographic evaluation of Maltese dogs.

• Journal of Veterinary Science
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• 제24권2호
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• pp.25.1-25.6
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• 2023

An eight-year-old Maltese dog presented with diarrhea and anorexia. Ultrasonography revealed marked focal wall thickening with loss of layering in the distal ileum. Contrast-enhanced computed tomography (CT) revealed a preserved wall layer with hypoattenuating middle wall thickening. In some segments of the lesion, small nodules protruding toward the mesentery from the outer layer were observed. Histopathology revealed focal lipogranulomatous lymphangitis (FLL) with lymphangiectasia. This is the first report to describe the CT features of FLL in a dog. CT features of preserved wall layers with hypoattenuating middle wall thickening and small nodules can assist in diagnosing FLL in dogs.

• 한국동물위생학회지
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• 제41권3호
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• pp.211-216
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• 2018

Heat stroke in a dog is a life-threatening syndrome characterized by a high body temperature over $41^{\circ}C$, by the central nervous system dysfunction, and by multiple organ dysfunction. A 11-month-old male American Pit Bull Terrier was presented to clarify the cause of death to diagnostic laboratory. This dog showed clinical signs such as high body temperature ($42^{\circ}C$), severe tachypnea, hematochezia, epistaxis and hemoptysis after transportation at hot summer time. At necropsy, there were hemorrhages in skin, serosa of stomach and small intestine, and also dark red fluid in lumen of intestine. Histopathologic examination revealed extensive hemorrhages in stomach, muscle, skin, and tongue. In microbiology, pathologic bacteria such as Pasteurella, Boedetella, Salmonella, Clostridium, and circulating virus in Korea such as CDV, CIV, CAV, CHV, CCV, CPIV were negative except CPV. There were many gross and microscopic lesions suggesting hest stroke while pathologic agents and related lesions were not detected. Therefore we diagnosed this case as heatstroke.

• 한국임상수의학회지
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• 제32권3호
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• pp.235-238
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• 2015

서울에서 개의 안과질환에 대한 역학적인 특징에 대해 2009년 1월부터 2013년 12월까지우성동물메디칼센터에 안과질환으로 내원한 초진환자들의 자료를 분석하였다. 총 1253두의 안과환자들이 초진 내원하였으며, 평균나이는 7.93년령 (SD, 4.06)이었다. 환자중에 Shih Tzu (29.4%)가 가장 많았으며, Maltese, Yorkshire Terrier, Cocker Spaniel, toy Poodle (P < 0.01)이 뒤를 따랐다. 눈에서 질병이 호발하는 곳은 수정체 관련 질환이 가장 많았으며 (28.3%), 안검질환, 망막질환, 비루관질환, 포도막질환, 유리체질환, 시신경계 질환이 그 뒤를 따랐다(P < 0.01). 수정체, 안검, 망막, 비루관, 포도막, 유리체, 시신경계 질환들은 주로 양측성 질환(P < 0.01)으로 발생하는 경향을 보였다. Shih Tzu에서는 각막질환이 가장 많이 발생하였으며, 수정체, 안검, 망막, 녹내장 질환이 그 뒤를 따랐다. Maltese에서는 수정체, 안검, 망막, 각막질환의 순으로 질병이 발생했다. Yorkshire Terrier, Cocker Spaniel, 그리고 toy Poodle 종은 수정체 질환이 가장 많았다(P < 0.01). 안과질환으로 병원에 내원하는 주된 환자들은 Shih Tzu, Maltese, Yorkshire Terrier등과 같은 소형견들이었고, 대부분 수정체 질환과 같은 품종소인이 있는 질환이 대부분이었다.

• 대한기계학회논문집B
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• 제38권9호
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• pp.739-745
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• 2014

심장 질환 환자에게 약물 치료를 시행하고 있으나, 통상의 약물 치료만으로는 심장질환을 치료하기에는 부족하다. 그러나 LVAD 를 이식한다면 심장기능을 보조하여 심장 이식까지의 가교 역할로서 효과가 있다고 보고되고 있다. 본 연구에서는 선행 연구로 개발된 곡관형 LVAD 인 LibraHeart-I(LH-1)을 이용하여, 대동물(Bovine model, Holstein)과 소동물(canine model, Labrador-retriever)을 대상으로 장기간 동물실험 및 응급상황에서의 생체적합성을 평가하고자 한다. 대동물을 대상으로 실시한 장기간의 동물 실험에서 49 일 생존하였으며, 실험기간 동안 실시한 혈액 검사 및 생징후에서 특이 소견을 관찰되지 않았다. 소동물을 대상으로 한 단기간의 동물 실험에서는 외부 구동부의 동력 지원 없이도 LH-I 내에 혈액이 머무르지 않는 것으로 관찰되었다. 본 연구에서는 장기간 동물실험 및 응급상황에서의 박출 성능을 통해 선행 연구로 개발된 LH-I의 생체적합성을 검증하였다.

• 한국임상수의학회지
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• 제39권5호
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• pp.207-216
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• 2022

Canine babesiosis has been scarcely investigated in the Republic of Korea (ROK). Although it is known that Babesia gibsoni is its primary causative agent, its clinical presentation has not been completely clarified in the ROK. Consequently, the aim of this study was to evaluate the clinical appearance of this parasitic infection based on the anamnesis of the patient and compare of hematological and biochemical test results. Four hundred whole blood samples from patients with a presumptive diagnosis of tick-borne disease were analyzed by polymerase chain reaction (PCR) to amplify the Babesia spp. 18S rRNA gene and by a rapid diagnostic test kit (VetAll Laboratories^®) to detect B. gibsoni seroreactive animals. Thirty-six (9.0%) dogs were PCR-positive but only 24 (6.0%) were seropositive. The investigation revealed that all the courses of the disease are present in the ROK, with the acute course being predominant. The acute course tends to consist of inappetence, lethargy, pyrexia, gastrointestinal symptoms, and occasionally hematuria. It also occurs with common hematological abnormalities, such as thrombocytopenia and anemia, and to a lesser extent biochemical abnormalities, such as hyperbilirubinemia, hypoalbuminemia, and elevated liver enzymes. This research shows that B. gibsoni is an endemic hemoparasite capable of producing a variety of clinical manifestations in dogs. For its accurate diagnosis, a descriptive history of the clinical signs, hematology, and biochemical profile of the patient, along with a well-performing PCR assay, are essential. These findings will help in planning pragmatic preventive strategies against this potent threat in the ROK.