• Journal of Korean Society of societal Security
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• v.1 no.2
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• pp.53-59
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• 2008

The lack of water resources is becoming a serious issue throughout the world. The water shortage in Korea is expected to increase. Groundwater can be a solution to this matter in some places. Especially, bank filtrations are known to be advantageous over conventional reserviors, even if they have some drawbacks such as their limited location for development and small sizes. The AHP(Analytic Hierarchy Process) is an analytical tool, supported by simple mathematics, which enables one to explicitly rank tangible and intangible factors against each other for the purpose of resolving conflicts or setting priorities. In order to check the applicability of AHP to the evaluation of bank filtration sites, four candidate locations were chosen. They have suffered from problems like water-supply shortage and delayed dam construction. The analysis results are compared with those of the previous study using a conventional method. It is believed that the developed method can a basis for reasonable decision-making regarding bank filtration development.

• Journal of Soil and Groundwater Environment
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• v.8 no.4
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• pp.36-44
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• 2003

The lack of water resources is becoming a serious issue throughout the world. The water shortage in Korea is expected to increase dramatically through 2020. The amount of water shortage could amount to 1.8 and 2.6 billion cubic meters in 2011 and 2020, respectively. Groundwater can be a solution to this matter in some places. Especially, underground dams are known to be advantageous over conventional dams, evert if they have some drawbacks such as their limited location for development and small sizes. The analytic hierarchy process(AHP) is an analytical tool, supported by simple mathematics, which enables one to explicitly rank tangible and intangible factors against each other for the purpose of resolving conflicts or setting priorities. In order to check the applicability of AHP to the evaluation of underground dam sites, lour candidate locations were chosen. They have suffered from problems like water-supply shortage and delayed dam construction. The analysis results are compared with those of the previous study using a conventional method. It is believed that the developed method can provide central or local government with a basis for reasonable decision-making regarding underground dam development.

• Journal of the Korean Geotechnical Society
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• v.19 no.2
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• pp.39-48
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• 2003

Previous analytical models for key blocks have been based on the assumption of infinite persistent discontinuities. In this paper, a key block analysis method considering the finite persistence of discontinuities is proposed as a stability evaluation method in tunnel constructions, and then applied to an actual example site. Three-dimensional rock block identification with consideration of the persistence of discontinuities is performed by using discontinuity disk model. The removability and stability analyses of rock blocks formed by the identification method are performed. The identification method can handle convex and concave shape blocks. In order to demonstrate the applicability of this developed numerical method to the stability evaluation in tunnel constructions, the analytical results are examined and compared one another.

• Korean Journal of Environmental Biology
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• v.41 no.2
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• pp.109-125
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• 2023

This study was conducted to select target fish species as baseline research for accumulation analysis of major hazardous chemicals entering the aquatic ecosystem in Korea and to analyze the impact on fish community. The test bed was selected from a sewage treatment plant, which could directly confirm the impact of the inflow of harmful chemicals, and the Geum River estuary where harmful chemicals introduced into the water system were concentrated. A multivariable metric model was developed to select target candidate fish species for hazardous chemical analysis. Details consisted of seven metrics: (1) commercially useful metric, (2) top-carnivorous species metric, (3) pollution fish indicator metric, (4) tolerance fish metric, (5) common abundant metric, (6) sampling availability (collectability) metric, and (7) widely distributed fish metric. Based on seven metric models for candidate fish species, eight species were selected as target candidates. The co-occurring dominant fish with target candidates was tolerant (50%), indicating that the highest abundance of tolerant species could be used as a water pollution indicator. A multi-metric fish-based model analysis for aquatic ecosystem health evaluation showed that the ecosystem health was diagnosed as "bad conditions". Physicochemical water quality variables also influenced fish feeding and tolerance guild in the testbed. Eight water quality parameters appeared high at the T1 site, indicating a large impact of discharging water from the sewage treatment plant. T2 site showed massive algal bloom, with chlorophyll concentration about 15 times higher compared to the reference site.

• Korean Journal of Ecology and Environment
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• v.43 no.1
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• pp.44-54
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• 2010

In this study, a comprehensive exploration and evaluation of washland candidate locations by means of field monitoring as well as spatial analysis in six major river system (Han, Nakdong, Nam, Geum, Youngsan, and Seomjin Rivers). Washland(in other words, river detention basin) is an artificial wetland system which is connected to streams or rivers likely to riverine wetlands. Major purpose of washland creation is to control floodings, water supply and purification, providence of eco-cultural space to human and natural populations. Characteristics and functions of riverine wetlands can be expected as well, thus it is believed to be an efficient multi-purpose water body that is artificially created, in terms of hydrology and ecology. Geographical information and field monitoring results for the washland candidate locations were evaluated in 2009, with respect to optimal location exploration, ecosystem connectivity and educational-cultural circumstances. A total of $269\;km^2$ washland candidate locations were found from spatial analysis (main channel of Rivers South Han, 71.5; Nakdong 54.1; Nam, 2.3; Geum, 79.0; Youngsan 46.4; Seomjin 15.7), and they tended to be distributed in mid- to lower part of the rivers to which tributaries are confluent. Field monitoring at 106 sites revealed that some sites located in the Rivers Nam and Geum is appropriate for restoration or artificial creation as riverine wetlands. Several sites in the Nakdong and Seomjin Rivers were close to riverine wetlands (e.g., Upo), habitats of endangered species (e.g., otters), or adjacent to educational facility (e.g., museums) or cultural heritages (e.g., temples). Those sites can be utilized in hydrological, ecological, educational, and cultural ways when evidence of detailed hydrological evaluation is provided. In conclusion, determination of washland locations in the major river basins has to consider habitat expansion as well as hydrological function (i.e. flood control) basically, and further utility (e.g. educational function) will increase the values of washland establishment.

• Nuclear Engineering and Technology
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• v.26 no.2
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• pp.168-178
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• 1994

Accident Management involves all measures to prevent core damage and retain the core within the reactor vessel, maintain containment integrity and minimize off-site releases. The accident management approach includes : (1) advanced evaluation of candidate strategies, (2) development of procedures to execute appropriate actions efficiently, and (3) identification and provision for materials, tools, and possible modifications to the plant system that may be needed for such execution. When assessing accident management strategies it effectiveness, adverse effect and its feasibility, including information needs and compatibility with existing procedures, must be considered. The objective of this paper is to introduce analytical tools of decision trees and influence diagrams to develop a framework for modeling and assessing severe accident management strategies. The characteristics associated with these took are presented. Based on decision trees and influence diagrams, the framework is applied to a simple example associated with a single decision.

• Genomics & Informatics
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• v.21 no.1
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• pp.7.1-7.11
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• 2023

The gram-positive bacterium Listeria monocytogenes is an important foodborne intracellular pathogen that is widespread in the environment. The functions of hypothetical proteins (HP) from various pathogenic bacteria have been successfully annotated using a variety of bioinformatics strategies. In this study, a HP Imo0888 (NP_464414.1) from the Listeria monocytogenes EGD-e strain was annotated using several bioinformatics tools. Various techniques, including CELLO, PSORTb, and SOSUIGramN, identified the candidate protein as cytoplasmic. Domain and motif analysis revealed that the target protein is a PemK/MazF-like toxin protein of the type II toxin-antitoxin system (TAS) which was consistent with BLASTp analysis. Through secondary structure analysis, we found the random coil to be the most frequent. The Alpha Fold 2 Protein Structure Prediction Database was used to determine the three-dimensional (3D) structure of the HP using the template structure of a type II TAS PemK/MazF family toxin protein (DB ID_AFDB: A0A4B9HQB9) with 99.1% sequence identity. Various quality evaluation tools, such as PROCHECK, ERRAT, Verify 3D, and QMEAN were used to validate the 3D structure. Following the YASARA energy minimization method, the target protein's 3D structure became more stable. The active site of the developed 3D structure was determined by the CASTp server. Most pathogens that harbor TAS create a crucial risk to human health. Our aim to annotate the HP Imo088 found in Listeria could offer a chance to understand bacterial pathogenicity and identify a number of potential targets for drug development.

• Journal of Bio-Environment Control
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• v.24 no.4
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• pp.287-295
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• 2015

This study was conducted to find the suitability site selection for the construction of Saemangeum horticulture complex taking into account cost-effective environmental management by analyzing and comparing meteorological conditions. The study sites were regions around the Saemangeum area in which the development of an industrial complex extending 28,300 ha is planned. We collected meteorological data in 12 candidate sites and established a rating scheme and thematic maps. We selected ten themes by consulting experts using a questionnaire. Selected ten themes is Summer, 20 days max. temp. mean, Winter, 20 days min. temp. mean, Summer, 90 days temp. mean, Winter, 90 days temp. mean, Year-round, max. wind velocity, Year-round, wind velocity mean, Winter, 90 days solar radiation mean, Year-round, number of foggy days, Year-round, 1 day max. rainfall and Spring. 90 days humidity mean. And we set ratio-based weights for the evaluation parameters.

• Journal of Korea Water Resources Association
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• v.55 no.2
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• pp.159-170
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• 2022

As the severity of water-related disasters increases in urban watersheds due to climate change, reducing flood damage in urban watersheds is one of the important issues. This study focuses on prioritizing the optimal site for permeable pavement to maximize the efficiency of reducing flood damage in urban watersheds in the future climate environment using multi-criteria decision making techniques. The Mokgamcheon watershed which is considerably urbanized than in the past was selected for the study area and its 27 sub-watersheds were considered as candidate sites. Six General Circulation Model (GCM) of Coupled Model Intercomparison Project 6(CMIP6) according to two Shared Socioeconomic Pathway (SSP) scenarios were used to estimate future monthly precipitation for the study area. The Driving force-Pressure-State-Impact-Response (DPSIR) framework was used to select the water quantity evaluation criteria for prioritizing permeable pavement, and the study area was modeled using ArcGIS and Storm Water Management Model (SWMM). For the values corresponding to the evaluation criteria based on the DPSIR framework, data from national statistics and long-term runoff simulation value of SWMM according to future monthly precipitation were used. Finally, the priority for permeable pavement was determined using the Fuzzy TOPSIS and Minimax regret method. The high priorities were concentrated in the downstream sub-watersheds where urbanization was more progressed and densely populated than the upstream watersheds.

• Journal of Gastric Cancer
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• v.21 no.2
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.