• 한국안전학회지
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• 제27권1호
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• pp.76-85
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• 2012

This paper proposes a robust damper design technique for adjacent structures against model uncertainty. This approach introduces multi-objective optimization based system identification using measurement information which enables reasonable selection of the perturbation range in the robust design. Moreover, in order to improve the numerical efficiency in sampling the structural models required for the robust design of large structures, we define new objective functions which enable us to minimize the number of candidate models suitable to the purpose of the robust design. In addition, the performance index is newly employed to evaluate the robust performance of the sampled structural models, and the robust design has been performed according to the performance index. As a numerical example to demonstrate the efficiency of the proposed method, 5-story and 10-story two adjacent buildings are taken into account, and the existing and newly proposed robust design approaches are compared with each other. The results demonstrate that the proposed approach can guarantee more robust damper system only using small number of samples of the structural models because of using the measurement information which leads to improvement in the numerical efficiency, compared with the existing robust design methods.

• Asian-Australasian Journal of Animal Sciences
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• 제28권7호
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• pp.926-935
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• 2015

The efficiency of genome-wide association analysis (GWAS) depends on power of detection for quantitative trait loci (QTL) and precision for QTL mapping. In this study, three different strategies for GWAS were applied to detect QTL for carcass quality traits in the Korean cattle, Hanwoo; a linkage disequilibrium single locus regression method (LDRM), a combined linkage and linkage disequilibrium analysis (LDLA) and a $BayesC{\pi}$ approach. The phenotypes of 486 steers were collected for weaning weight (WWT), yearling weight (YWT), carcass weight (CWT), backfat thickness (BFT), longissimus dorsi muscle area, and marbling score (Marb). Also the genotype data for the steers and their sires were scored with the Illumina bovine 50K single nucleotide polymorphism (SNP) chips. For the two former GWAS methods, threshold values were set at false discovery rate <0.01 on a chromosome-wide level, while a cut-off threshold value was set in the latter model, such that the top five windows, each of which comprised 10 adjacent SNPs, were chosen with significant variation for the phenotype. Four major additive QTL from these three methods had high concordance found in 64.1 to 64.9Mb for Bos taurus autosome (BTA) 7 for WWT, 24.3 to 25.4Mb for BTA14 for CWT, 0.5 to 1.5Mb for BTA6 for BFT and 26.3 to 33.4Mb for BTA29 for BFT. Several candidate genes (i.e. glutamate receptor, ionotropic, ampa 1 [GRIA1], family with sequence similarity 110, member B [FAM110B], and thymocyte selection-associated high mobility group box [TOX]) may be identified close to these QTL. Our result suggests that the use of different linkage disequilibrium mapping approaches can provide more reliable chromosome regions to further pinpoint DNA makers or causative genes in these regions.

• Journal of Animal Science and Technology
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• 제57권3호
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• pp.7.1-7.7
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• 2015

To meet the increasing demands of specific pathogen free (SPF) minipigs in biomedical researches, 8 pregnant Chinese Wuzhishan minipigs (WZSP) sows with clear background were chosen to obtain SPF WZSP by hysterectomy. At $111{\pm}days2$ of the pregnancy, piglets were aseptically taken out from the sows and artificially suckled for 40 to 45 days in the positive isolators. Then, the piglets defined as F0 were transferred to barrier environment and fed with standard feeds. The original SPF colony was formed for breeding by selected piglets from F0 group of 6-8 months old. Biological characteristics of SPF WZSP were collected and further compared to those of conventional (CV) WZSP, including growth performance, reproductive performance, hematology and blood biochemistry, and major pathogens detection. As a result, 61 F0 piglets were obtained from 8 candidate sows, and 55 out of them survived. After strictly selection, 35 F0 piglets were used to form the original SPF colony, which produced 14 litters of SPF piglets defined as F1. Piglet survival rates, growth performance, and reproductive performance of SPF WZSP were similar to CV WZSP. Some hematology and blood biochemistry parameters showed significant differences between SPF and CV WZSP. Eighteen kinds of pathogens were identified to be free in F0 and F1 SPF colony by repeated pathogen detections. In conclusion, we established a satisfied SPF WZSP colony maintaining original characteristics, free of controlled diseases, and being proved to be a suitable laboratory animal.

• Fisheries and Aquatic Sciences
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• 제19권4호
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• pp.21.1-21.11
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• 2016

Background: The evaluation of suitable reference genes as normalization controls is a prerequisite requirement for launching quantitative reverse transcription-PCR (RT-qPCR)-based expression study. In order to select the stable reference genes in abalone Haliotis discus hannai tissues (gill and hepatopancreas) under heavy metal exposure conditions (Cu, Zn, and Cd), 12 potential candidate housekeeping genes were subjected to expression stability based on the comprehensive ranking while integrating four different statistical algorithms (geNorm, NormFinder, BestKeeper, and ${\Delta}CT$ method). Results: Expression stability in the gill subset was determined as RPL7 > RPL8 > ACTB > RPL3 > PPIB > RPL7A > EF1A > RPL4 > GAPDH > RPL5 > UBE2 > B-TU. On the other hand, the ranking in the subset for hepatopancreas was RPL7 > RPL3 > RPL8 > ACTB > RPL4 > EF1A > RPL5 > RPL7A > B-TU > UBE2 > PPIB > GAPDH. The pairwise variation assessed by the geNorm program indicates that two reference genes could be sufficient for accurate normalization in both gill and hepatopancreas subsets. Overall, both gill and hepatopancreas subsets recommended ribosomal protein genes (particularly RPL7) as stable references, whereas traditional housekeepers such as ${\beta}-tubulin$ (B-TU) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes were ranked as unstable genes. The validation of reference gene selection was confirmed with the quantitative assay of MT transcripts. Conclusions: The present analysis showed the importance of validating reference genes with multiple algorithmic approaches to select genes that are truly stable. Our results indicate that expression stability of a given reference gene could not always have consensus across tissue types. The data from this study could be a good guide for the future design of RT-qPCR studies with respect to metal regulation/detoxification and other related physiologies in this abalone species.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10325-10328
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• 2015

RASSF1A, regarded as a candidate tumor suppressor, is frequently silenced and inactivated by methylation of its promoter region in many human tumors. However, the association between RASSF1A promoter methylation and lung cancer risk remains unclear. To provide a more reliable estimate we conducted a meta-analysis of cohort studies to evaluate the potential role of RASSF1A promoter methylation in lung carcinogenesis. Relevant studies were identified by searches of PubMed, Web of Science, ProQest and Medline databases using the following key words: 'lung cancer or lung neoplasm or lung carcinoma', 'RASSF1A methylation' or 'RASSF1A hypermethylation'. According to the selection standard, 15 articles were identified and analysised by STATA 12.0 software. Combined odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association between RASSF1A promoter methylation and lung cancer risk. A chi-square-based Q test and sensitivity analyses were performed to test between-study heterogeneity and the contributions of single studies to the final results, respectively. Funnel plots were carried out to evaluate publication bias. Overall, a significant relationship between RASSF1A promoter methylation and lung cancer risk (OR, 16.12; 95%CI, 11.40-22.81; p<0.001) with no between-study heterogeneity. In subgroup analyses, increased risk of RASSF1A methylation in cases than controls was found for the NSCLC group (OR, 13.66, 95%CI, 9.529-19.57) and in the SCLC group (OR, 314.85, 95%CI, 48.93-2026.2).

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.700-705
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• 2005

The purpose of this project is the derivation and development of techniques for the new estimation of robustness for the systems having uncertainties. The basic ideas to analyze the system which is the originally nonlinear is Lyapunov direct theorems. The nonlinear systems have various forms of terms inside the system equations and this investigation is confined in the form of bounded uncertainties. Bounded means the uncertainties are with same positive/negative range. The number of uncertainties will be the degree of freedoms in the calculation of the stability region. This is so called the robustness bounds. This proposition adopts the theoretical analysis of the Lyapunov direct methods, that is, the sign properties of the Lyapunov function derivative integrated along finite intervals of time, in place of the original method of the sign properties of the time derivative of the Lyapunov function itself. This is the new sufficient criteria to relax the stability condition and is used to generate techniques for the robust design of control systems with structured perturbations. Using this relaxing stability conditions, the selection of Lyapunov candidate function is of various forms. In this paper, the quadratic form is selected. this generated techniques has been demonstrated by recent research interest in the area of robust control design and confirms that estimation of robustness bounds will be improved upon those obtained by results of the original Lyapunov method. In this paper, the symbolic algebraic procedures are utilized and the calculating errors are reduced in the numerical procedures. The application of numerical procedures can prove the improvements in estimations of robustness for one-and more structured perturbations. The applicable systems is assumed to be linear with time-varying with nonlinear bounded perturbations. This new techniques will be extended to other nonlinear systems with various forms of uncertainties, especially in the nonlinear case of the unstructured perturbations and also with various control method.

• 컴퓨터교육학회논문지
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• 제13권1호
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• pp.53-64
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• 2010

본 논문에서는 모바일 그리드 환경에서 안정적인 자원을 선택하고 활용하는 자원 관리 방법을 제안한다. 모바일 그리드에서 이동 기기를 작업 처리에 이용하고자 하는 연구들이 많이 이루어지고는 있지만 모바일 장치의 불규칙한 이동성, 서비스 탐색, 자원 공유, 기기의 다양성, 제한적인 배터리 용량 등의 제약으로 인하여 기존 유선 그리드 환경에서의 작업 처리에 비해 신뢰성이 매우 낮다. 이러한 문제점을 해결하기 위하여 다양한 연구가 진행되었고 대표적으로 프록시 기반 모바일 그리드 구조와 에이전트 기반 모바일 그리드 구조를 들 수 있다. 본 논문에서는 IP 페이징을 프록시 기반 모바일 그리드 구조에 적용하여 보다 쉽게 유휴 자원 탐색과 그리드 자원 정보를 관리하고자 한다. 그리고 모바일 기기의 작업 관리를 위하여 SIP(Session Initiation Protocol)를 이용하여 지속적으로 모바일 기기의 이동성을 관리하고 페이징 캐쉬를 이용하여 모바일 기기의 자원 변화와 배터리 용량을 관리하여 자원 예약을 통해 진행 중인 작업의 이주를 허용하고자 한다. 시뮬레이션을 통하여 제안하는 모바일 그리드 구조가 효율적이고 안정적임을 보여준다.

• 한국정보통신학회논문지
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• 제14권6호
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• pp.1409-1415
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• 2010

본 논문에서는 웨이블릿 변환 영역에서 구성한 부대역간의 트리구조와 공간 영역에서의 영상 형태 정보를 이용하여 워터마크의 삽입 위치를 결정한 후에 워터마크를 삽입하는 기법을 제안하였다. 웨이블릿 영역에서 높은 주파수를 가지는 부대역을 다수의 영역으로 나누고 각 블록에 대한 에너지와 전체 에너지의 평균값 등을 이용하여 워터마킹을 위한 후보영역을 얻는다. 또한 공간 영역에서 얻어진 영상의 경계 정보를 이용하여 워터마크가 삽입될 후보 영역을 구한다. 무작위 난수와 웨이블릿 영역에서 이웃 웨이블릿 계수간의 관계를 이용하여 워터마킹 후보영역 내에 워터마크를 삽입한다. 마지막으로 역 웨이블릿 변환을 수행하여 워터마크가 삽입된 영상을 생성한다. 제안된 워터마킹 알고리즘은 JPEG과 같은 압축과 블러링, 선명화, 그리고 가우시안 잡음 등의 공격에 대해서 우수한 특성을 보였다.

• Journal of the Korean Data and Information Science Society
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• 제28권1호
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• pp.131-142
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• 2017

매년 폐렴 입원 환자 수는 증가하는 추세이며, 국내 질환 중 입원율 1위이기도 하다. 주로 박테리아와 바이러스가 주된 원인인 폐렴은 날씨의 영향을 받기도 한다. 본 연구에서는 날씨 변수로는 습도, 일조량, 일교차, 평균온도, 미세먼지 농도를 각각 1일 전부터 27일 전까지의 총 135개 변수를 고려하였다. 날씨와 입원 환자 수에 잠재적으로 영향을 미치는 위험 요인으로 연도 효과, 휴일 효과, 계절 효과를 추가적으로 고려하였다. 벌점화 일반화 선형 모형을 이용하여 폐렴 입원 환자 수와 관련된 변수를 선택하였다.

• 생물환경조절학회지
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• 제25권1호
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• pp.1-8
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• 2016

본 연구에서는 새만금 개발구역에서 환경조절 비용이 적게 들 수 있도록 기상환경을 분석하여 조성 적지를 선정하는 연구를 진행하였다. 작성된 10개의 주제도를 도면중첩하여 50~59점 지역을 적지로 도출하였다. 그 중 농업생명용지 계획지역을 중첩하여 최종적인 시설원예단지 조성 적지로 선정하였다. 본 연구는 시설원예의 환경조절 비용을 낮추어 부가가치를 상승 시킬 수 있다. 새만금에서 시설원예의 대규모를 통해 우리 농업의 국제 경쟁력 도움이 될 수 있다.