• Biomedical Science Letters
• /
• v.15 no.4
• /
• pp.327-333
• /
• 2009

Heterotrimeric GTP binding proteins, G-proteins, mediate signal transduction generated by neurotransmitters and hormones. Among G-proteins, Go proteins are the most abundant in brain and classified as a member of Gi family. Ras-like protein in all tissues (Rit), one of the small GTPases, is a member of a Ras superfamily and identified as an important regulator of neuronal differentiation and cell transformation. Recently, we have reported that Rit functioned as a candidate downstream effector for alpha subunit of Go proteins ($Go{\alpha}$) and regulated neurite outgrowth triggered by $Go{\alpha}$ activation. In this study, we showed that the GTPase domain of $Go{\alpha}$ contributed to the direct interaction with Rit. We also demonstrated that $Go{\alpha}$ could lead to an increase of Rit activity suggesting that Rit play a role as a downstream effector of $Go{\alpha}$.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.1
• /
• pp.35.3-35.3
• /
• 2017

Neutrinos play an important role in astronomy and therefore they need to be observed as well as other astronomical messengers. The first observation of astronomical neutrinos is from the SN1987a by the Kamiokande neutrino telescope in Japan. Unlike other astronomical messengers neutrinos can cover all energy range of astronomical phenomena due to their weak interactions and neutrality. Multi messenger astronomy including optical, neutrino, and cosmic ray observations, provides more information on astronomical phenomena and thus such collaborational works are ongoing worldwide. A future Korean neutrino telescope consisting of huge (260 kiloton) water Cherenkov detector under a mountain was proposed in 2016 and the sensitivity studies on various topics are in progress with international collaborators. In this talk I will introduce the future Korean neutrino telescope and its science as well as the potential candidate sites in Korea. We invite all of you to work together for the future Korean neutrino telescope that will operate more than 30 years.

• International Journal of Oral Biology
• /
• v.34 no.2
• /
• pp.49-52
• /
• 2009

Perception of sweet compounds is important for animals to detect external carbohydrate source of calories and plays a crucial role in feeding behavior of animals. Recent progress in molecular genetic studies provides evidence for a candidate receptor (heterodimers with taste receptor type 1 member 2 and 3: T1R2/T1R3), and major downstream transduction molecules required for sweet taste signaling. Several studies demonstrated that the sweet taste signal can be modulated by a satiety hormone, leptin, through its receptors expressed in a subset of sweet-sensitive taste cells. Increase of internal energy storage in the adipose tissue leads to increase in the plasma leptin level which can reduce activities of sweet-sensitive cells. In human, thus, diurnal variation of plasma leptin level parallels variation of taste recognition thresholds for sweet compounds. This leptin modulation of sweet taste sensitivity may influence individuals' preference, ingestive behavior, and absorption of nutrients, thereby plays important roles in regulation of energy homeostasis.

• Journal of Communications and Networks
• /
• v.7 no.2
• /
• pp.135-143
• /
• 2005

This paper presents an investigation of satellite radio access technology for beyond IMT-2000 systems. Although we could not see any active role of a satellite system in the 3G networks, satellite system will provide strong advantages in future systems for certain applications. Because a satellite link has longer round trip delay than a terrestrial link, we need technologies that would make the satellite component especially efficient. After presenting the satellite radio interface of the 3G system, we suggest several points which need to be considered in the beyond 3G systems. We also suggest a few candidate technologies with various simulation results.

• Vacuum Magazine
• /
• v.2 no.4
• /
• pp.16-26
• /
• 2015

Carbon nanomaterials including nanocrystalline diamond and graphene films are expected to play a core role in $21^{st}$ century industries due to their amazing physicochemical properties. To achieve their practical utilization and industrialization, the development of their mass production technologies is strongly required. Recently, a surface wave excited plasma (SWP) which is produced using microwaves has been attracting special attentions as a candidate for the mass production technology of carbon nanomaterials. SWP can allow a low-temperature large-area plasma chemical vapor deposition (CVD) system. Here, this article introduces the promising SWP-CVD technology. Plasma characteristics in a SWP will be introduced in detail to help understanding how to use and control a SWP as a plasma source for CVD applications.

• YAKHAK HOEJI
• /
• v.48 no.1
• /
• pp.75-81
• /
• 2004

Bone mineral density (BMD) is influenced by genetic and environmental factors. Among genetic study; calcitonin receptor (CTR) gene is a good candidate influencing the inter-individual difference in BMD because CTR is involved in calcium and bone metabolism. Thus, we investigated the distribution of C1377T polymorphism in the CTR gene among male Korean elite athletic and control groups, respectively and also an association with BMD in lumbar spine and femoral neck. Our results suggested that this polymorphism of CTR gene was not significantly associated with lumbar spine or femoral neck BMDs in the both groups, respectively. However, we found that there was the racial difference in genotype distribution of this polymorphism between Caucasian and Asian populations. Though we could not detect the significant association between C1377T polymorphism of CTR gene and lumbar spine or femoral neck BMDs, further studies using other ethnic groups are necessary to clarify the precise role in BMD of CTR gene.

• The Korean Journal of Health Service Management
• /
• v.5 no.3
• /
• pp.1-11
• /
• 2011

The objective of this study is to identify the relationship between nursing organizational culture and job satisfaction and turnover intention. Furthermore this study analyzed the mediating effect of empowerment on the relationship between two variables. Data were collected by self-administered questionnaires. Structural Equation Modeling(SEM) analysis was conducted. The major findings of this study are as follows: nursing organizational culture having a positive effect on empowerment and organizational effectiveness. The empowerment as a mediating role between nursing organizational culture and job satisfaction and turnover intention was statistically significant. This finding showed that desirable organizational culture and improvement of empowerment is necessary to maintain nursing staff's organizational loyalty and eventually to improve total organizational performance.

• Animal cells and systems
• /
• v.7 no.3
• /
• pp.249-253
• /
• 2003

Abnormalities in fibrinolysis system is associated with risk of hypertension. In this report, the Alu repeat insertion/deletion (I/D) polymorphism of tissue plasminogen activator (t-PA) and the Hind III RFLP of plasminogen activator inhibitor-1 (PAI-1) genes were investigated in 115 normotensives and 83 patients with hypertension, and their association with anthropometrical data and plasma biochemical parameters were analyzed. There were no significant differences in the gene frequencies of the two candidate genes between normotensives and hypertensives, respectively. Our results indicate lack of associations between the two polymorph isms in t-PA and PAI-1 genes and risk of hypertension in the population under study. However, the Hind III RFLP of PAI-1 gene was significantly associated with plasma glucose level, suggesting its role in glucose metabolism. It needs to be tested whether this RFLP of PAI-1 gene is associated with insulin resistance syndrome or non-insulin dependent diabetes mellitus (NIDDM) in the Korean population.

• International Journal of Internet, Broadcasting and Communication
• /
• v.6 no.1
• /
• pp.5-8
• /
• 2014

Social networking services that connect a person to other people are attracting our attention and various types of on-the-network services are provided. Library has been playing a role of social media by providing with materials such as books and magazines, and with a place for reading, studying, getting lectures, etc. In this paper, we present a method for finding candidates of groups of the library's patrons who share interest areas by utilizing the loan records, which are obtainable by every library. Such a homogeneous group can become a candidate for a study group, a community for exchange ideas, and other activity group. We apply the method to a collection of loan records of a university library, find some problem to be solved, and propose measures for more detailed solutions. Even though the potential group finding problem still remains a lot of problems to be solved, its potential importance is very high and thus to be studies even more for future applications.

• Proceedings of the EASDL Conference
• /
• 2010.11a
• /
• pp.47-47
• /
• 2010

Chilliness is a complaint among menopausal women in Japan, but increasing evidence indicates that young women also suffer from chilliness. However, neither diagnostic criteria nor drug therapies exist for treating chilliness. We noticed it and recently elucidated methodological issues related to identifying women with chills. Using a discriminant analysis, we demonstrated that four parameters were important determinants of chilliness. On the other hand, after repeated reports of serious adverse effects with hormone replacement therapy, much attention has been given to the development of new remedies to alleviate menopausal depressive state in women, but methods for their preclinical evaluation have not been clarified. We previously developed a procedure to predict the effect of candidate substance on the menopausal depressive-like state in female mice. Since either chilliness or mood disorder is known to disturb a quality of life in women, in this symposium, the efficacy of Korean red ginseng on chilliness in women and depressive-like state will be discussed.