Browse > Article

Detection, modulation, and transmission of sweet taste in regulation for energy homeostasis  

Jyotaki, Masafumi (Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences)
Ninomiya, Yuzo (Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences)
Publication Information
International Journal of Oral Biology / v.34, no.2, 2009 , pp. 49-52 More about this Journal
Abstract
Perception of sweet compounds is important for animals to detect external carbohydrate source of calories and plays a crucial role in feeding behavior of animals. Recent progress in molecular genetic studies provides evidence for a candidate receptor (heterodimers with taste receptor type 1 member 2 and 3: T1R2/T1R3), and major downstream transduction molecules required for sweet taste signaling. Several studies demonstrated that the sweet taste signal can be modulated by a satiety hormone, leptin, through its receptors expressed in a subset of sweet-sensitive taste cells. Increase of internal energy storage in the adipose tissue leads to increase in the plasma leptin level which can reduce activities of sweet-sensitive cells. In human, thus, diurnal variation of plasma leptin level parallels variation of taste recognition thresholds for sweet compounds. This leptin modulation of sweet taste sensitivity may influence individuals' preference, ingestive behavior, and absorption of nutrients, thereby plays important roles in regulation of energy homeostasis.
Keywords
sweet taste; leptin; modulation; energy homeostasis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Finger TE, Danilova V, Barrows J, Bartel DL, Vigers AJ, Stone L, Hellekant G, Kinnamon SC. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 2005;310:1495-99   DOI   PUBMED   ScienceOn
2 Heck GL, Mierson S, DeSimone JA. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science. 1984;223:403-5   DOI   PUBMED
3 Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA. 2006;103:12569-74   DOI   ScienceOn
4 Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem. 2002;277:1-4   DOI   ScienceOn
5 Margolskee RF, Dyer J, Kokrashvili Z, Salmon KSH, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. T1R3 and gustducin in gut sense sugars to regulate expression of $Na^{+}$-glucose cotranspoter 1. Proc Natl Acad Sci USA. 2007;104:15075-81   DOI   ScienceOn
6 Ninomiya Y, Shigemura N, Yasumatsu K, Ohta R, Sugimoto K, Nakashima K, Lindemann B. . Vitam Horm. 2002;64:221-48   DOI   PUBMED
7 Ugawa S, Minami Y, Gup W, Saishin Y, Takatsuji K, Yamamoto T, Tohyama M, Shimada S. Receptor that leaves a sour taste in the mouth. Nature. 1998;395:555-6   DOI   ScienceOn
8 Wong GT, Gannon KS, Margolskee RF. Transduction of bitter and sweet taste by gustducin. Nature. 1996;381:796-800   DOI   ScienceOn
9 Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Ninomiya Y. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology. 2004;145:839-43   DOI   ScienceOn
10 Tomchik SM, Berg S, Kim JW, Chaudhari N, Roper SD. Breadth of tuning and taste coding in mammalian taste buds. J Neurosci. 2007;27:10840-48   DOI   ScienceOn
11 Saladin R, Vos DP, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 1995;377:527-9   DOI   ScienceOn
12 Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature. 2005;438:1022-25   DOI   ScienceOn
13 Sinha MK, Sturis J, Ohannesian J, Magosin S, Thomas S, Heiman ML, Polonsky KS, Caro JF. Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun. 1996;228:733-8   DOI   ScienceOn
14 Yoshida R, Shigemura N, Sanematsu K, Yasumatsu K, Ishizuka S, Ninomiya Y. Taste responsiveness of fungiform taste cells with action potentials. J Neurophysiol. 2006;96:3088-95   DOI   ScienceOn
15 Huang YJ, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper SD. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci USA. 2007;104:6436-41   DOI   ScienceOn
16 Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci. 2002;5:1169 -76   DOI   ScienceOn
17 Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y: Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA. 2000;97:11044-9   DOI   ScienceOn
18 Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11   DOI   ScienceOn
19 Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM.Weightreducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-6   DOI   PUBMED
20 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32   DOI   ScienceOn
21 Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA. 2002;99:4692-6   DOI   ScienceOn
22 Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS. Mammalian sweet taste receptors. Cell. 2001;106: 381-90   DOI   ScienceOn
23 Schoeller DA, Cella LK, Sinha MK, Caro JF. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest. 1997;100:1882-87   DOI   ScienceOn
24 Hisatsune C, Yasumatsu K, Takahashi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K. Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem. 2007;282:37225-31   DOI   ScienceOn
25 Medler KF, Margolskee RF, Kinnamon SC. Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice. J Neurosci. 2003;23:2608-17
26 Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, MaratosFlier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250-2   DOI   ScienceOn
27 Lyall V, Heck GL, Vinnikova AK, Ghosh S, Phan TH, Alam RI, Russell OF, Malik SA, Bigbee JW, DeSimone JA.The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. J Physiol. 2004; 558:147-59   DOI   ScienceOn
28 Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y. Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin level. Diabetes. 2008;57:2661-65   DOI   ScienceOn
29 Romanov RA, Rogachevskaja OA, Bystrova MF, Jiang P, Margolskee RF, Kolesnikov SS. Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J. 2007;26:657-67   DOI   ScienceOn
30 Flier JS. Obesity wars: molecular progress confronts an expanding epidemic.Cell. 2004;116:337-50   DOI   PUBMED   ScienceOn
31 Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab. 1996;81:3419-23   DOI   ScienceOn