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AluI RFLP Analysis of the Calcitonin Receptor Gene in the Korean Athletic Men  

장대호 (삼육대학교 생명과학과)
황영철 (삼육대학교 약학과)
강병용 (삼육대학교 생명과학연구소)
최성숙 (삼육의명대학 식품과학과)
강진양 (삼육대학교 약학과)
하남주 (삼육대학교 약학과)
Publication Information
YAKHAK HOEJI / v.48, no.1, 2004 , pp. 75-81 More about this Journal
Abstract
Bone mineral density (BMD) is influenced by genetic and environmental factors. Among genetic study; calcitonin receptor (CTR) gene is a good candidate influencing the inter-individual difference in BMD because CTR is involved in calcium and bone metabolism. Thus, we investigated the distribution of C1377T polymorphism in the CTR gene among male Korean elite athletic and control groups, respectively and also an association with BMD in lumbar spine and femoral neck. Our results suggested that this polymorphism of CTR gene was not significantly associated with lumbar spine or femoral neck BMDs in the both groups, respectively. However, we found that there was the racial difference in genotype distribution of this polymorphism between Caucasian and Asian populations. Though we could not detect the significant association between C1377T polymorphism of CTR gene and lumbar spine or femoral neck BMDs, further studies using other ethnic groups are necessary to clarify the precise role in BMD of CTR gene.
Keywords
bone mineral density; calcitonim receptor and Korean;
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