• Asian-Australasian Journal of Animal Sciences
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• v.19 no.4
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• pp.459-462
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• 2006

Prolactin (PRL) plays an important role in promoting mammalian mammary gland development, and milk production during lactation. Therefore the PRL gene was chosen as a candidate gene for milk traits in Holstein dairy cows. PCR-SSCP and PCR-RFLP were used to analyze genetic variations in the 5' regulation region of the PRL gene. In this part of the gene, two new polymorphic sites were detected in the Chinese Holstein dairy cows. One was a XbaI-RFLP locus, and the other was an SSCP locus. Statistical analysis showed that the XbaI-RFLP locus and the SSCP locus had a significant positive effect on milk traits.

• Environmental Mutagens and Carcinogens
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• v.22 no.3
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• pp.183-186
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• 2002

Hypertension is a multifactorial disease. Both genetic and environmental factors have been implicated in its etiology. Since the impairment of nitric oxide (NOS) production plays an important role in the pathogenesis of hypertension, endothelial nitric oxide synthase (ecNOS) gene is supposed to be a candidate gene of hypertension. Our study group investigated the 27 bp insertion/deletion (Ins/Del) polymorphism of ecNOS gene in 99 Korean normotensives and 98 hypertensives, respectively. There was no significant association with any cardiovascular risk factors as well as hypertension in Koreans. The Ins/Del polymorphism of the ecNOS gene indicated the similar allele distribution among ethnic groups studied. Further studies using larger sample size and subject information is required to describe the general picture of the association between the ecNOS gene polymorphic loci and hypertension

• Journal of Information Technology Applications and Management
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• v.19 no.2
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• pp.197-215
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• 2012

SNS has been recognized as a means of expanding social capital by promoting interaction and efficient communication among users. On the other hand, there are serious concerns on negative side of social network which is often called epidemics. Trust plays a critical role in controlling the spread of distorted information and vicious rumor as well as reducing uncertainties and risk from unreliable users in social network. This study focuses on what the antecedents of interpersonal trust are in social network. We performed online survey from 252 Twitter users and tested candidate antecedents which are chosen from previous literature. As a result, propensity to trust of trustor, ability and sincerity of trustee, intimacy between trustor and trustee significantly affected to the interpersonal trust in Twitter.

• Journal of Marine Bioscience and Biotechnology
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• v.1 no.1
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• pp.34-39
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• 2006

Molecular biology and microalgal biotechnology have the potential to play a major role in improving the production efficiency of a vast variety of products including functional foods, industrial chemicals, compounds with therapeutic applications and bioremediation solutions from a virtually untapped source. Microalgae are a source of natural products and have been recently studied for biotechnological applications. Efficient genetic transformation systems in microalgae are necessary to enhance their potential to be used for human health. A microalga such as Chlarella is a eukaryotic organism sharing its metabolic pathways with higher plants. This microalga is capable of expressing, glycosylating, and correctly processing proteins which normally undergo post-translational modification. Moreover, it can be cultured inexpensively because it requires only limited amount of sunlight and carbon dioxide as energy sources. Because of these advantages, Chlarella may be of great potential interest in biotechnology as a good candidate for bioreactor in the production of pharmaceutical and industrial compounds for human functional foods. Here, we briefly discuss recent progress in microalgal transgenesis that has utilized molecular biology to produce functional proteins and bioactive compounds.

• Journal of Food Hygiene and Safety
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• v.30 no.4
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• pp.376-382
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• 2015

Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.

• Journal of Korea Multimedia Society
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• v.21 no.10
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• pp.1131-1141
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• 2018

Motion Estimation which is used to reduce the redundant data plays an important role in video compressions. However, it requires huge computational complexity of the encoder part. And therefore many fast motion estimation methods has been developed to reduce complexity. Multi-view video is obtained by using many cameras at different positions and its complexity increases in proportion to the number of cameras. In this paper, we proposed a fast motion estimation method for multi-view video. The proposed method predicts a search start point by using correlated candidate vectors of the current block. According to the motion size of the start search point, a search start pattern of the current block is decided adaptively. The proposed method proves to be about 2 ~ 5 times faster than existing methods while maintaining similar image quality and bitrates.

• Natural Product Sciences
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• v.15 no.3
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• pp.125-129
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• 2009

Neurodegenerative diseases such as Alzheimer's disease, stroke, and Parkinson's disease, are caused by neuronal cell death. Apoptosis, oxidative stress, inflammation, excitotoxicity or ischemia are discussed to play a role of neuronal cell death. In order to find the candidate of neuroprotective agent, neuroprotective activity of some medicinal plants was investigated with in vitro assay system using glutamate-induced neurotoxicity in primary cultures of rat cortical cells. The aqueous methanolic extracts of twenty-seven medicinal plants were evaluated the protective effects against glutamate-injured excitotoxicity in rat cortical cells at the concentration of 50 $\mu$g/ml and 100 $\mu$g/ml, respectively. Among them, extracts of Lonicera japonica, Taraxacum platycarpum, Polygonum aviculare, Gardenia jasminoides, Forsythia viridissima, Lygodium japonicum, Panax notoginseng, Akebia quinata, Anemarrhena asphodeloides and Phellodendron amurense showed significantly neuroprotective activities against glutamate-induced neurotoxicity in primary rat cortical cells.

• Journal of Microbiology and Biotechnology
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• v.19 no.10
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• pp.1103-1108
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• 2009

The human immunodeficiency virus (HIV)-l protein Tat acts as a transcription transactivator that stimulates expression of the infected viral genome. It is released from infected cells and can similarly affect neighboring cells. The nucleocapsid is an important protein that has a related significant role in early mRNA expression, and which contributes to the rapid viral replication that occurs during HIV-1 infection. To investigate the interaction between the Tat and nucleocapsid proteins, we utilized cDNA micro arrays using pTat and flag NC cotransfection in HEK 293T cells and reverse transcription-polymerase chain reaction to validate the micro array data. Four upregulated genes and nine downregulated genes were selected as candidate genes. Gene ontology analysis was conducted to define the biological process of the input genes. A proteomic approach using PathwayStudio determined the relationship between Tat and nucleocapsid; two automatically built pathways represented the interactions between the upregulated and downregulated genes. The results indicate that the up- and downregulated genes regulate HIV-1 replication and proliferation, and viral entry.

• Proceedings of the KIEE Conference
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• 2000.07a
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• pp.558-560
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• 2000

The role of power line is not limited to providing electrical power. Power line fumed out to be an candidate to cope with the existing communication channels. It is need to be measured the properties of power line as communication channels, before successful communication system is possible. This paper presents the characteristics of power line noise and attenuation measurements in the frequency range of $0{\sim}10$ MHz, and then suggests applicable communication techniques in brief. Power line channel is configured in our laboratory and the length of it is 250 meters.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.983-984
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• 2008

This paper proposes a variable break that can offset prediction error as well as a pre-selection methods, based on the variable break, for enhanced unit selection. In Japanese, a sentence consists of several APs (Accentual phrases) and MPs (Major phrases), and the breaks between these phrases must predicted to realize text-to-speech systems. An MP also consists of several APs and plays a decisive role in making synthetic speech natural and understandable because short pauses appear at its boundary. The variable break is defined as a break that is able to change easily from an AP to an MP boundary, or from an MP to an AP boundary. Using CART (Classification and Regression Trees), the variable break is modeled stochastically, and then we pre-select candidate units in the unit-selection process. As the experimental results show, it was possible to complement a break prediction error and improve the naturalness of synthetic speech.