• 제목/요약/키워드: cancer units

검색결과 151건 처리시간 0.021초

측정과 ADAC 치료계획 시스템에서 계산된 고에너지 전자선의 Monitor Unit Value 비교 (Comparison of Monitor Units Obtained from Measurements and ADAC Planning System for High Energy Electrons)

  • Lee, Re-Na;Choi, Jin-Ho;Suh, Hyun-Suk
    • 한국의학물리학회지:의학물리
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    • 제13권4호
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    • pp.202-208
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    • 2002
  • 본 논문에서는 표면조직에 있는 종양 치료 시 사용되고 있는 고에너지 전자선의 monitor unit을 다양한 방법에 의해 계산하여 평가 하고자 한다. 본 병원에서 6, 9, 그리고 12 MeV 전자선으로 치료한 33명의 유방암 환자가 선택되었다. 각 환자마다 모의 치료기에서 얻어진 시뮬레이션 필름에 불규칙한 모양의 전자선 블록이 제작되었다. 이러한 불규칙한 모양의 블록을 이용하여 최대선량 깊이에 100 cGy의 선량을 주기 위해 필요한 monitor unit 이 3차원 치료계획 시스템 (Pinnacle 6.0, ADAC Lab)을 사용하여 계산되었고 측정되었다. 선원과 표면 거리(SSD)가 100 cm 인 곳에서 plane parallel (PP) 이온전리함(Roos, OTW Germany) 을 사용하여 고체 물 팬텀 내에서 측정하였다. 불균등 조직에 대한 효과를 평가하기 위해 CT 데이터를 사용하였고 monitor unit을 균등조직 및 비균등조직 내에서 계산하였다. 균등조직으로 계산하기 위해 CT의 밀도를 1 g/㎤로 지정하였다. 이러한 방법에 의해 구해진 monitor unit 값들을 비교하였다. 한 지점에서 측정된 선량과 RTP에서 구해진 선량을 비교 할 때 측정된 값이 치료계획에 의해 계산된 값보다 조금 높았다. 평평한 고체 물 표면에 조사된 경우 측정된 값과 계산된 값에는 6 MeV 전자선의 경우 4%, 그리고 9 및 12 MeC 전자선의 경우 2%의 차이가 있었다. 또한 다양한 조사방향에서 CT 데이터를 사용하여 monitor unit을 계산한 경우 불균등한 조직의 밀도를 고려하여 계산된 값과 고려하지 않고 계산된 값은 모든 에너지에서 3% 이내의 차이가 있었다. 이러한 결과는 전자선을 사용하여 유방암 치료 시 조직내의 불균등한 밀도를 고려하지 않고 monitor unit을 계산해도 큰 차이가 발생하지 않는다는 것을 의미한다.

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대장균의 내열성장독소 측정법개발을 위한 단세포군항체의 생산 (Production of the Monoclonal Antibodies to the Escherichia coli Heat-Stable Enterotoxin)

  • 장우현;이우곤;김석용;박정범
    • 대한미생물학회지
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    • 제22권4호
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    • pp.377-392
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    • 1987
  • Monoclonal antibody to the Escherichia coli heat-stable enterotoxin(ST) was produced to develop a rapid and convenient diagnostic method to the ST. The toxin was purified from culture supernatant of enterotoxigenic E. coli O148H28($ST^+/LT^+$) and conjugated to bovine serum albumin(BSA). The ST-BSA conjugate was used to immunize BALB/c mice and the immune spleen cells from these mice were fused with $P3{\times}63$ Ag8.V653 plasmacytoma cells. Hybridomas were screened by ELISA and positive hybridomas were cloned by limiting dilution. Finally, one stable clone (AS36) specific to ST was selected for further growth and characterization. Antibody titers of culture supernatant and ascitic fluid from BALB/c mice were 1:1,024 and 1:20,480 respectively in ELISA. The isotype and subclass of monoclonal antibody was IgG1 in sandwich ELISA. To test the neutralizing effect of monoclonal antibody on toxin activity of ST, mixture of ascitic fluid and ST was assayed by infant mouse assay and this monoclonel antibody was proved to be a neutralizing antibody. The titer of ascitic fluid which completely neutralized biological activity of 4 units of ST was 1:4. Purified ST was quantitatively measured by competitive ELISA and minimum amount of ST detectable by this assay was 250pg, which was an amount six-fold smaller than that detectable by infant mouse assay. Four reference strains of enterotoxigenic E. coli from WHO were detected by competitive ELISA and highly specific, sensitive and reproducible result was obtained.

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간호·간병 통합서비스 병동 간호사의 역할 모호성 개념분석 (Role Ambiguity of Comprehensive Nursing Care Unit Nurses: A Concept Analysis)

  • 이지선;김윤아;문세미;정은영;박하영
    • 보건행정학회지
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    • 제29권4호
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    • pp.502-512
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    • 2019
  • Background: The purpose of this study was to identify role ambiguity of comprehensive nursing care unit nurses. Methods: A concept analysis method by Walker and Avant was used to understand role ambiguity of comprehensive nursing care unit nurses. Results: The antecedents of role ambiguity of nurses at comprehensive nursing units were shortage of nurses, unclear admission criteria, and demands for customized nursing care according to severity. Attributes include ambiguity in role delegation, patient placement ambiguity, and professional ambiguity among nursing staff. The consequences were diminished job satisfaction due to excessive workload, difficulty in resolving role ambiguity due to the lack of work analysis studies, and poor outcome of nursing indicators. Conclusion: Improvement of nationwide awareness for comprehensive nursing care unit is required. Clear division at scope of practice for nursing staff in accordance of each medical institution's characteristics is essential. Nurses at comprehensive nursing care unit should understand nature of role ambiguity that occurs as they work in large groups. Nurses should promote communications between nursing staff and they must have volition to improve status quo. An additional research of comprehensive nursing care on the causes of role ambiguity in the practice of nursing care for ward nurses is needed, and management measures should be sought at the organizational level.

암 환아 부모의 경험에 대한 질적 연구 (The Experience of Parents Whose Child is Dying with Cancer)

  • 조영숙;김수지
    • 대한간호학회지
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    • 제22권4호
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    • pp.491-505
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    • 1992
  • The purpose of this research was to understand the structure of the lived experience of parents of a child terminally ill with cancer The research question was “What is the structure of the experience of parents of a child terminally ill with cancer\ulcorner” The sample consisted of 17 parents of children admitted to the cancer units of two university hospitals in Seoul. The unstructured interviews were carried out from October 10, 1991 through January 10, 1992. They were audio-recorded and analysed using Van Kaam's method. Parents ascribed the cause of the cancer to the mother's emotional imbalance during pregnancy, the mother's stress, failure to observe religious rites, food, the parent's sin, misfortune and pollution. The theme clusters were tension, fear and depression experienced during pregnancy, stress that children suffer from abusive parents, failure to observe religious activites, bad luck, and sins committed during a previous life. When the child suffered a recurrence of cancer, the parents experienced negative emotions, nervousness, sorrow. depression and death. The theme clusters were feelings of despair, helplessness, regret, guilt, insecurity, emptyness and apathy. The long struggle with cancer resulted in the loss of economic security, loss of psychological and physical well being, and social withdrawal. The theme clusters were the economic burden of medical cost, giving up treatment, debt, limited medical insurance coverage and blood transfusion. The loss of psychological well being included stress, lack of support systems, inability to carry out responsibilities, lack of trust of the medical ten family breakdown, inappropriate expression of emotion and not disclosing the diagnosis to the child. Physically the parents suffered fatigue, insomnia, loss of appetite, loss of weight, dizzness, headache, psychosomatic symptoms, and increased consumption of liquor and cigarettes. Social withdrawal was manifested by taking time off from work to look after the child, decrease of outside social activities and feelings of isolation. Influences on family life were spousal conflicts, negative response of siblings, separation of the family members and economic hardship. The theme clusters were blaming a spouse for the cause of the illness and disagreements, maladjustment, lonliness, hostility and depression of siblings. The high price of medical care over the long period was a major factor influencing the life of the family. Positive experiences during the child's long illness were the strengthening of support systems and religious beliefs and financial help from social organizations. The support of one's spouse primarily helped to overcome the stress of the long illness. In addition, support was received from parents of other children with cancer and from nurses and religious leaders. The nurse, by providing empathetic support, should be a person with whom parents can express their feelings and share their experiences.

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호스피스완화의료서비스 성과평가 도구개발 (Development and Validation of the Hospice Palliative Care Performance Scale)

  • 권소희
    • 대한간호학회지
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    • 제41권3호
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    • pp.374-381
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    • 2011
  • Purpose: The purpose of this study was to develop and validate a hospice palliative care performance measure which would cover more than just physical symptoms or quality of life. Methods: Through an intensive literature review, the author chose questions that measured aspects of physical, emotional, spiritual, social, or practical domains pertinent to hospice palliative care for inclusion in the scale. Content validation of the questions was established by 15 hospice palliative care professionals. A preliminary Hospice Palliative Care Performance Scale (HPCPS) of 20 questions was administered to 134 pairs of terminal cancer patients from 5 hospice palliative care units and their main family caregiver. A validation study was conducted to evaluate construct validity and internal consistency. Results: Factor analysis showed 14 significant questions in five subscales; Physical, Emotional, Spiritual, Social, and Patient' rights. There were no significant differences between the ratings by patients and family members except for three out of the 14 questions. The measure demonstrated construct validity, and Cronbach's ${\alpha}$ of the subscales ranged from .73 to .79. Conclusion: The HPCOS demonstrated acceptable validity and reliability. It can be used to assess effectiveness of hospice palliative care for terminal cancer patients in practice and research.

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

  • Xu, Ping;Zhang, Wen-Bo;Cai, Xin-Hua;Lu, Dan-Dan;He, Xiao-Yang;Qiu, Pei-Yong;Wu, Jiao
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권19호
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    • pp.8171-8175
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    • 2014
  • Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of $30{\mu}g/mL$. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

Automatic Electronic Cleansing in Computed Tomography Colonography Images using Domain Knowledge

  • Manjunath, KN;Siddalingaswamy, PC;Prabhu, GK
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권18호
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    • pp.8351-8358
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    • 2016
  • Electronic cleansing is an image post processing technique in which the tagged colonic content is subtracted from colon using CTC images. There are post processing artefacts, like: 1) soft tissue degradation; 2) incomplete cleansing; 3) misclassification of polyp due to pseudo enhanced voxels; and 4) pseudo soft tissue structures. The objective of the study was to subtract the tagged colonic content without losing the soft tissue structures. This paper proposes a novel adaptive method to solve the first three problems using a multi-step algorithm. It uses a new edge model-based method which involves colon segmentation, priori information of Hounsfield units (HU) of different colonic contents at specific tube voltages, subtracting the tagging materials, restoring the soft tissue structures based on selective HU, removing boundary between air-contrast, and applying a filter to clean minute particles due to improperly tagged endoluminal fluids which appear as noise. The main finding of the study was submerged soft tissue structures were absolutely preserved and the pseudo enhanced intensities were corrected without any artifact. The method was implemented with multithreading for parallel processing in a high performance computer. The technique was applied on a fecal tagged dataset (30 patients) where the tagging agent was not completely removed from colon. The results were then qualitatively validated by radiologists for any image processing artifacts.

내.외과계 간호사의 통증 관리에 대한 지식 및 태도 (Pain Management Knowledge and Attitude of Internal Medicine and Surgery Stream Nurses)

  • 송승순;박재순
    • 가정간호학회지
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    • 제17권1호
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    • pp.55-62
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    • 2010
  • Purpose: This study investigated the sought to identify the pain management knowledge and attitude of nurses in internal medicine and surgery stream wards and intensive care units to obtain basic information needed for improved pain control. Method: Data was collected through self-reported questionnaires and analyzed by descriptive statistics, t-test and ANOVA using SPSS Win 12.0. Results: Pain management knowledge score averaged 51.1 out of 100, with significant differences evident depending on age, marital status, educational level, position, total work career, working department and cancer care-giving experience. Pain management attitude score averaged 2.9 out of 4, and significant differences were evident depending on age, marital status, educational level, position, total work career, working department, cancer care-giving experience, education experience and number of patients treated. Conclusion: Further studies are necessary to develop effective nursing knowledge and attitude education programs and evaluation such as discussion by cases, workshops, system of expert help for uncontrollable pain or a multi-disciplinary pain management task force. In addition, patient satisfaction level with pain management should be assessed and the responses reflected practically.

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위분문부 및 식도암 환자에서 경열공 식도절제술 (Transhiatal Esophagectomy in Cardia and Esophageal Cancer)

  • 최동휘;정경원;김동헌
    • Journal of Gastric Cancer
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    • 제5권1호
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    • pp.1-9
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    • 2005
  • 목적: 현재 위분문부 및 식도암에 대한 근분 치로 원칙은 수술적 치료이며, 이에 대한 방법으로는 기존에는 주로 개흉을 요하는 McKeown술식(transthoracic esophagectomy, TTE)을 시행하였으나 최근에는 개흉술을 시행하지 않고 경열공을 통한 식도절제술(transshiatal esophagectomy, THE)도 많이 시행하고 있다. 이에 최근 본원에서 시행한 TTE와 THE의 임상 및 병리 결과를 분석하여 봄으로써 기존의 TTE에 대한 THE의 유용성에 대해 고찰해 보고자 한다. 상 및 방법: 최근 10년간 부산대학교병원에서 식도 및 위분문부암으로 진단 받고 수술적 치료를 받은 52예를 대상으로 후향적으로 자료를 수집, 분석하였다. 결과: 총 52예 중 20예에서 TTE를 32예에서 THE를 시행하였다. TTE는 중간부식도암 12예, 하부식도암 8예에서 시행되었고, THE는 중간부식도암 7예, 하부식도암 15예, 위분문부암 10예에서 시행되었다. TTE 후 식도대체장기로는 17예에서 위를, 3예에서 대장을 사용했으며, THE에서는 29예에서 위를, 3예에서 대장을 사용하였다. 술 후 합병증은 TTE를 시행한 13예(폐렴, 흉수 등 호흡기게 합병증 5예, 문합부유출 3예, 간병증 2예, 창상감염 1예, 패혈증 1예)에서, THE를 시행한 19예(문합부협착 13예, 흉수 3예, 문합부유출 1예, 창상감염 1예, 회귀후두신경마비 1예)에서 발생했다. 술 후 치료기간 동안 사망한 예는 TTE에서 1예 있었다. 수술 후 입원기간은 TTE에서 평균 25.6일, THE에서 20.6일 이었다. 결론: THE가 수술 이환율(morbidity)과 사망률(mortality)이 낮고 술식이 간편하여 시행하기가 용이하여 기존의 개흉을 통한 TTE 술식과 비교했을 때 식도절제를 요하는 대부분의 암환자들에게 유용한 술식이라 하겠다.

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Self-organized Pullulan/Deoxycholic Acid Nanogels: Physicochemical Characterization and Anti-cancer Drug-releasing Behavior

  • Na, Kun;Park, Kyong-Mi;Jo, Eun-Ae;Lee, Kwan-Shik
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제11권3호
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    • pp.262-267
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    • 2006
  • The objective of this study was to develop new self-organized nanogels as a means of drug delivery in patients with cancer. Pullulan (PUL) and deoxycholic acid (DOCA) were conjugated through an ester linkage between the hydroxyl group in PUL and the carboxyl group in DOCA. Three types of PUL/DOCA conjugates were obtained, differing in the number of DOCA substitutions (DS; 5, 8, or 11) per 100 PUL anhydroglucose units. The physicochemical properties of the resulting nanogels were characterized by dynamic light scattering, transmission electron microscopy, and fluorescence spectroscopy. The mean diameter of DS 11 was the smallest (approx. 100 nm), and the size distribution was unimodal. To determine the organizing behavior of these conjugates, we calculated their critical aggregation concentrations (CACs) in a 0.01-M phosphate buffered saline solution. They were $10.5{\times}10^{-4}mg/mL,\;7.2{\times}10^{-4} mg/mL,\;and\;5.6{\times}10^{-4} mg/mL$ for DS 5, 8, and 11, respectively. This indicates that DOCA can serve as a hydrophobic moiety to create self-organized nanogels. To monitor the drug-releasing behavior of these nanogels, we loaded doxorubicin (DOX) onto the conjugates. The DOX-loading efficiency increased with the degree of DOCA substitution. The release rates of DOX from PUL/DOCA nanogels varied inversely with the DS. We concluded that the PUL/DOCA nanogel has some potential for use as an anticancer drug carrier because of its low CAC and satisfactory drug-loading capacity.