• 대한간호학회지
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• 제49권4호
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• pp.472-485
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• 2019

Purpose: This study aimed to develop and evaluate the effectiveness of an adapted health literacy self-management intervention for elderly cancer patients undergoing chemotherapy. Methods: The intervention in this study was systematically developed through the six stages of Intervention Mapping Protocol and was based on Fransen et al's causal pathway model. A quasi-experimental trial was conducted on a total of 52 elderly patients (26 in an experimental group and 26 in a control group) undergoing chemotherapy in Korea. The intervention consisted of seven sessions over 5 weeks. The experimental tool for this study was an adapted health literacy self-management intervention, which was designed to promote a reduction in the symptom experience and distress of elderly cancer patients through the promotion of self-management behavior. To develop efficient educational materials, the participants' health literacy was measured. To educate participants, clear communication and the teach-back method were used. In addition, for the improvement of self-efficacy, four sources were utilized. For the promotion of self-management behavior, five self-management skills were strengthened. Data were collected before and after the intervention from June 4 to September 14, 2018. The data were analyzed with SPSS/WIN 21.0. Results: Following the intervention, self-management knowledge and behavior and, self-efficacy significantly improved in experimental group. Symptom experience and distress decreased in the experimental group compared to the control group. Conclusion: The self-management intervention presented in this study was found to be effective in increasing self-management knowledge and behavior and, self-efficacy, and ultimately in reducing symptom experience and distress for elderly patients undergoing chemotherapy.

• 한국정보통신학회논문지
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• 제15권7호
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• pp.1573-1582
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• 2011

흉부의 폐질환으로 폐암발생은 꾸준히 증가하고 있다. 일차적인 폐암진단 방법에는 흉부X선영상이다. 흉부X선영상 이용하여 폐암진단을 하기 위해서는 임상경험이 풍부한 의사가 필요하다. 그러나 풍부한 경험을 가진 의사라도 오진이 발생할 수 있고 이한 폐암의 조기진단과 생존률을 낮게 한다. 본 논문에서는 주성분분석을 이용하여 학습영상의 데이터베이스와 질병이 있는 흉부영상을 진단함으로써 컴퓨터보조진단의 기반을 마련하고자 한다. 이를 의사가 진단하기 전의 예비판독의 단계로 이용한다면 오진으로 인한 환자의 조기 진단률의 감소를 줄일 수가 있다. 실험은 정상흉부X선영상과 악성폐암인 기관지암(Bronchogenic Carcinoma)과 양성종양인 육아종(Granuloma)으로 실험하였다. 영상은 주성분분석 후 정상영상과 질환 영상의 고유영상을 추출하고 상호 비교한 뒤 인식효율을 비교하였다. 결과로는 정상영상과 질환영상간의 인식률은 높았으나 질환간의 인식효율은 정상에 비해 다소 떨어지는 것으로 나타났다. 흉부질환간의 인식효율을 높이기 위해서 관련 알고리즘에 관한 연구가 계속 이어진다면 컴퓨터보조진단에 좋은 연구기반이 되리라 생각한다.

• Journal of Hospice and Palliative Care
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• 제11권2호
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• pp.99-105
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• 2008

목적: 본 연구에서는 호스피스 병동에 입원한 말기 암 환자들을 대상으로 임상적으로 보다 정확한 잔여 수명을 예측하고자 임종의 시기에 객관적으로 임상적 증상 및 징후들의 변화를 관찰하였다. 방법: 강남성모병원 호스피스센터를 방분한 말기 암 환자를 대상으로 입원 시부터 임종까지 말기에 흔히 나타나는 증상과 신체적 징후의 변화를 관찰하였다. 증상의 정도는 $0{\sim}3$점수화하였으며 신체적 징후는 있다 또는 없다로 구분하였다. 이밖에 활력증후와 통증 정도, 진통제 사용을 관찰하였다. 결과: 호흡곤란, 혼수의 증상은 입원 시와 비교해서 임종 $1{\sim}2$일 전에 악화되었다. 대상자의 활동 수행 능력은 임종 시간이 가까워질수록 점진적으로 감소하였고, 섭취량과 소변 배설량도 줄어들었다. 특히 임종 $1{\sim}2$2일 전부터 현저하게 혈압이 감소하였다. 임종 시점을 기준으로 시기에 따라 증상의 변화가 유의하게 나타난 임상 지표는 활동수행 능력, 수축기 혈압, 구강건조증, 식욕저하, 쇠약감, 변비, 황달, 부종, 욕창, 호흡곤란, 진정, 혼수, 청색증, 호흡이상, 가래 끓는 소리, 눈을 뒤로 젖힘 등이었다. 결론: 말기 암 환자에서 수축기 혈압의 감소, 호흡곤란, 진정, 혼수, 청색증, 호흡이상, 가래 끓는 소리, 눈을 뒤로 젖힘 등의 증상이 나타나면 임종이 임박했음을 예상하여 가족들과 환자가 준비할 수 있도록 해야 하며, 의료진도 임종에 관한 돌봄을 시행하도록 해야 한다.

• Toxicological Research
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• 제32권1호
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• pp.21-33
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• 2016

Dichlorodiphenyltrichloroethane (DDT) is still used in certain areas of tropics and subtropics to control malaria and other insect-transmitted diseases. DDT and its metabolites have been extensively studied for their toxicity and carcinogenicity in animals and humans and shown to have an endocrine disrupting potential affecting reproductive system although the effects may vary among animal species in correlation with exposure levels. Epidemiologic studies revealed either positive or negative associations between exposure to DDT and tumor development, but there has been no clear evidence that DDT causes cancer in humans. In experimental animals, tumor induction by DDT has been shown in the liver, lung, and adrenals. The mechanisms of hepatic tumor development by DDT have been studied in rats and mice. DDT is known as a non-genotoxic hepatocarcinogen and has been shown to induce microsomal enzymes through activation of constitutive androstane receptor (CAR) and to inhibit gap junctional intercellular communication (GJIC) in the rodent liver. The results from our previously conducted 4-week and 2-year feeding studies of p,p'-DDT in F344 rats indicate that DDT may induce hepatocellular eosinophilic foci as a result of oxidative DNA damage and leads them to hepatic neoplasia in combination with its mitogenic activity and inhibitory effect on GJIC. Oxidative stress could be a key factor in hepatocarcinogenesis by DDT.

• Journal of Hospice and Palliative Care
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• 제10권2호
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• pp.67-73
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• 2007

인간에게 있어서 자신의 삶을 의미 있게 만드는 것은 인생의 가장 중요한 목표이다. 하지만 죽음을 앞둔 호스피스 환자들에게 이러한 목표의 달성은 신체적, 심리적, 사회적 어려움으로 인하여 위협받는다. 여기에 음악치료는 호스피스 환자나 그 가족들의 신체적 심리적 사회적 필요를 여러 가지 방법으로 채워줄 수 있는 효과적인 방법으로 사용될 수 있다. 창조적 예술 형태로서의 음악치료는 호스피스 환자의 통증과 긴장 완화에 효과적일 뿐 아니라, 심리적 안정감을 제공하여 남아있는 삶을 돌아보며 의미를 찾을 수도록 도와주는 역할을 한다. 또한 음악은 그 자체로 언어적/비언어적 의사소통의 도구가 되기 때문에 환자와 가족들을 연결시키고 공감하며 이해하도록 한다. 본 논문은 호스피스 처치에서 음악치료의 필요와 호스피스 분야에서 음악치료가 담당해야 할 역할에 대해 고찰하는데 목적을 둔다.

• 한국간호교육학회지
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• 제12권2호
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• pp.143-150
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• 2006

Purpose: The purposes of this study were to identify the actual conditions and needs of the health care utilization and health information in deafs. Methods: Forty-one deaf volunteers were interviewed by suwha nursing students. The semi-structured interviews were conducted in sign language at homes and community centers. The instrument developed by researchers consisted of 22 items including demographic information, health care utilization, and open-ended questions. Data were analyzed using content analysis, frequency and percentage. Results: The most discomfort problems were communication difficulty and expression of symptom. The deaf people wanted to learn about diseases and symptoms. The deaf wanted to get information about cancer. Conclusions: Further studies focusing on educational intervention are needed to increase the knowledge level on disease of deaf. The sign language translators are needed to help communication for deaf in health care facilities.

• 한국전자통신학회논문지
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• 제15권4호
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• pp.733-738
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• 2020

최근에는 연안 지역의 개발이 진행됨에 따라 해변 근처에서 레저 활동을 하고 있는 사람들이 증가 하고 있다. 하지만, 오존층의 파괴로 지표면에 도달하는 자외선의 양은 증가하였다. 인체는 자외선에 의한 피부암과 눈 손상 등으로 유해한 영양을 받는다. 특히, 해변에서 자외선의 영향은 모래 표면으로 부터의 반사로 인해 내륙 지역보다 높다. 본 연구는 원격탐사를 이용한 동해안 해변의 자외선 반사 측정 방법의 기초자료로 활용할 수 있을 것으로 기대된다.

• Journal of information and communication convergence engineering
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• 제16권2호
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• pp.130-134
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• 2018

Wireless capsule endoscopy (WCE) is considered as recent technology for the detection cancer cells in the human digestive system. WCE sends the captured information from inside the body to a sensor on the skin surface through a wireless medium. In WCE, the design of low-power consumption devices is a challenging topic. In the Shannon-Nyquist sampling theorem, the number of samples should be at least twice the highest transmission frequency to reconstruct precise signals. The number of samples is proportional to the power consumption in wireless communication. This paper proposes compressive sensing as a method to reduce power consumption in WCE, by means of a trade-off between samples and reconstruction accuracy. The proposed scheme is validated under channel constraints, expressed as the realistic human body path loss. The results show that the proposed scheme achieves a significant reduction in WCE power consumption and achieves a faster computation time with low signal error reconstruction.

• Journal of Hospice and Palliative Care
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• 제24권3호
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• pp.135-143
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• 2021

End-of-life patients experience physical, mental, social, and existential distress. While medical personnel provide medication and care to alleviate patients' distress, listening to and interacting with patients remains essential for understanding their psychological condition. The most important tool, though difficult to implement in practice, is end-of-life discussion (EOLD). EOLD has been shown to have positive effects on end-of-life treatment choices, achievement of patients' life goals, improvements in the quality of life of patients and their families, and the prevention of depression and complicated grief among bereaved family members. EOLD is not often undertaken in clinical practice, however, due to hesitancy among medical personnel and patients for various reasons. In order to conduct an EOLD, the patient's judgment, psychiatric illnesses such as delirium and depression, and psychological issues such as the side effects of psychotropic drugs, denial, and collusion must be evaluated. Open and honest conversation, treatment goal setting, the doctor's familiarity with the patient's background, and attentiveness when providing information are important elements for any dialogue. Meaning-centered psychotherapy was developed to alleviate the existential distress of cancer patients, and its application may promote EOLD. The future development of meaning-centered psychotherapy in practice and in research is expected to further promote EOLD.

• Archives of Pharmacal Research
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• 제20권4호
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• pp.297-305
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• 1997

A new serum-free defined medium was developed that supports the growth of normal rat mammary epithelial cells. Mammary organoids from the glands of female F344 rats were cultured in a serum-free medium. Monolayer culture colonies developed within a week and remained viable for months in culture. Upon subculture of one-week-old primary colonies, almost the same morphology of colonies was developed. The scrape loading/dye transfer technique showed that most of colonies that developed in a serum-free medium containing EGF, human transferrin, insulin, and hydrocortisone (basal serum-free medium, BSFM) failed to show cell-cell communication. However, colonies cultured in BSFM supplemented with prolactin, $E_2$, and progesterone (complete hormone serum-free medium, CHSFM) showed cell-cell communication at 14 days of primary culture or of subculture. By flow cytometry with FITCPNA and PE-anti-Thy-1.1 monoclonal antibody, we distinguished four RMEC subpopulations in cultures in both media: Thy-1.1+ cells, PNA+ cells, cells negative to both reagents and cells positive to both reagents. It is likely that combined prolactin, cortisol, and insulin in CHSFM stimulate terminal differentiation of clonogenic cells.