• 한국간호교육학회지
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• 제4권1호
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• pp.7-14
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• 1998

The use and need of health and nutrition information on the PC communication and internet among university students at Chungbuk area were investigated. The data from 167 students from two different universities were collected and analyzed from March to May, 1998. The results are as follows. 1. Male students were 27.5% and female students were 72.5%. 2. Sixty percent and 74.7% of the students had ever used PC communication and internet, respectively. Higher proportions of male students had experiences in PC communication and internet use than fe male students. The main reasons to use PC communication and internet were 1)to obtain information and knowledge(67.4%) 2)to enjoy(10.5%), 3)to make friends or to talk(5.3%) 3. About 40% of the experienced students of the PC communication of internet obtained health or nutrition information. However, only 25% of the experienced students obtained the nutrition information from the internet. Only 10% of the students agreed that the information from the PC communication and internet was very useful. The reasons not to use the information from the PC communication and internet were 'lack of expertise of the information' and 'long response time'. Many students thought that the information provided through the computer should be improved in terms of variety and applicability to the real situation. 4. Among the 33 topics of the health and nutrition information given on the questionnaire, both male and female students had the greatest interest in stress management. The next topics in which female students had interests were diet for weight control, health problems related to menstration, dietary assessment, and cancer prevention. In male students, dietary assessment, infant nutrition management, hypertention diet were the main interests. On the basis of these results an information system on health and nutrition management during the lifecycle for Korean women will be constructed on the internet.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7789-7794
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• 2015

Background: This study aimed to evaluate the impact of a community-based health education and communication programme on reducing liver fluke infections caused by the consumption of uncooked fish among people in a high-risk area of Thailand. Materials and Methods: The study was quasi-experimental in nature, with three-stages. Stage 1 involved a situational and capacity analysis of designated communities in Khon Kaen province. This was followed by the development of a model for community-based health education and communication to prevent liver fluke infections among high-risk people, and, lastly, implementation and evaluation of the model were performed. Data were collected using both qualitative and quantitative methods. In total, 390 people were surveyed, and quasi-experimental and comparison groups, each with 90 people, were assessed between May 2011 and April 2012. Analysis was using statistical OR, 95 % CI, the Willcoxon matched pairs signed ranks test, the chi-square test, and the Mann-Whitney U test. Results: The findings showed that most respondents had a high level of knowledge and understanding of liver fluke disease (89.5%, 95% CI:86.0-92.4), and positive attitudes toward the prevention of the disease (94.4%, 95% CI:91.6-96.4). However, with regard to changes in consumption of uncooked fish, most respondents were still in the pre-contemplation phase (55.1%, 95% CI:50.0-60.1), followed by the contemplation phase, 22.6%. Furthermore, four factors were found to be associated with the consumption of uncooked fish - the consumption of alcohol (OR 4.16, 95% CI:1.79-9.65), gender (OR 3.17, 95% CI:1.53-6.54), smoking (OR 3.03, 95% CI:1.31-7.05), and age 40 years and above (OR 2.68, 95% CI:1.02-7.05). After nine months of the health education and communication programme using local media based on local wisdom, culture and persons, the results showed that, compared to the control group, members of the experimental group had a higher level of knowledge, a better attitude and lower levels of ill-advised consumption behaviour. Also, it was found that consumption of uncooked fish, by an assessment of the level of stage of change, was reduced. (p-value 0.002). Conclusions: The health education and communication programme developed as part of the study was effective in changing the consumption of uncooked fish. Therefore, this approach should be promoted in other high-risk areas in Thailand in the future.

• 한국식품위생안전성학회지
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• 제22권1호
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• pp.1-14
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• 2007

The term, "food safety", has traditionally been viewed as a practical science aimed at assuring the prevention acute illnesses caused by biological microorganisms, and only to a minor extent, chronic diseases cause by chronic low level exposures to natural and synthetic chemicals or pollutants. "food safety" meant to prevent microbiological agents/toxins in/on foods, due to contamination any where from "farm to Fork", from causing acute health effects, especially to the young, immune-compromised, genetically-predisposed and elderly. However, today a broader view must also include the fact that diet, perse (nutrients, vitamins/minerals, calories), as well as low level toxins and pollutant or supplemented synthetic chemicals, can alter gene expressions of stem/progenitor/terminally-differentiated cells, leading to chronic inflammation and other mal-functions that could lead to diseases such as cancer, diabetes, atherogenesis and possibly reproductive and neurological disorders. Understanding of the mechanisms by which natural or synthetic chemical toxins/toxicants, in/on food, interact with the pathogenesis of acute and chronic diseases, should lead to a "systems" approach to "food safety". Clearly, the interactions of diet/food with the genetic background, gender, and developmental state of the individual, together with (a) interactions of other endogenous/exogenous chemicals/drugs; (b) the specific biology of the cells being affected; (c) the mechanisms by which the presence or absence of toxins/toxicants and nutrients work to cause toxicities; and (d) how those mechanisms affect the pathogenesis of acute and/or chronic diseases, must be integrated into a "system" approach. Mechanisms of how toxins/toxicants cause cellular toxicities, such as mutagenesis; cytotoxicity and altered gene expression, must take into account (a) irreversible or reversal changes caused by these toxins or toxicants; (b)concepts of thresholds or no-thresholds of action; and (c) concepts of differential effects on stem cells, progenitor cells and terminally differentiated cells in different organs. This brief Commentary tries to illustrate this complex interaction between what is on/in foods with one disease, namely cancer. Since the understanding of cancer, while still incomplete, can shed light on the multiple ways that toxins/toxicants, as well as dietary modulation of nutrients/vitamins/metals/ calories, can either enhance or reduce the risk to cancer. In particular, diets that alter the embryo-fetal micro-environment might dramatically alter disease formation later in life. In effect "food safety" can not be assessed without understanding how food could be 'toxic', or how that mechanism of toxicity interacts with the pathogenesis of any disease.

• 한국정보전자통신기술학회논문지
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• 제16권2호
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• pp.87-96
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• 2023

최근 의학계에서도 딥러닝 기술을 이용한 질병의 치료결과 예측 연구가 활발하다. 그러나, 소규모 환자 데이터와 특정한 딥러닝 알고리즘을 선택·활용, 연구를 진행하여 특정 조건 아래에서 의미 있는 결과를 보여주었다. 본 연구에서는 연구 결과의 일반화를 위하여 환자 대상을 좀 더 확대·세분화하여 80대·90대·100대 남녀 대상으로 폐암 진단 후 사망률 예측 연구 결과를 도출하였다. 건강보험심사평가원의 대규모 진료 정보와 다종의 딥러닝 알고리즘을 제공하는 AutoML을 이용, 80대·90대·100대 남녀의 폐암 진단 후 84개월간의 사망률 예측을 위해 Decision Tree, Random Forest, Gradient Boosting, XGBoost, Logistic Regression 등 5개 알고리즘별 모델을 생성하고 이를 통해 예측 성능을 비교하고 사망률에 영향을 미치는 요인에 대한 분석도 추진하였다. 연구 결과, 80대와 90대에서 남성이 여성보다 사망 예측률이 더 높았으며 100대에서는 여성의 사망 예측률이 남성보다 높게 나타났다. 그리고 사망률에 가장 큰 영향을 미치는 요인으로는 치료기간으로 분석되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.219-223
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• 2016

Background: Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and is one of the hallmarks of the disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation of promoter methylation has been reported in various cancers. Objectives: The objectives of this study were to investigate the CELSR3 hypermethylation level in oral squamous cell carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) and to correlate CELSR3 methylation with patient demographic and clinicopathological parameters. Materials and Methods: Frozen tissue samples of healthy subjects' normal mucosa and OSCCs were examined with regard to their methylation levels of the CELSR3 gene using MS-HRM. Results: MS-HRM analysis revealed a high methylation level of CELSR3 in 86% of OSCC cases. Significant correlations were found between CELSR3 quantitative methylation levels with patient ethnicity (P=0.005), age (P=0.024) and pathological stages (P=0.004). A moderate positive correlation between CELSR3 and patient age was also evident (R=0.444, P=0.001). Conclusions: CELSR3 promoter hypermethylation may be an important mechanism involved in oral carcinogenesis. It may thus be used as a biomarker in OSCC prognostication.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5901-5904
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• 2013

Objective: To compare the effectiveness of different methods of recall for repeat Pap smear among women who had normal smears in the previous screening. Design: Prospective randomized controlled study. Setting: All community clinics in Klang under the Ministry of Health Malaysia. Participants: Women of Klang who attended cervical screening and had a normal Pap smear in the previous year, and were due for a repeat smear were recruited and randomly assigned to four different methods of recall for repeat smear. Intervention: The recall methods given to the women to remind them for a repeat smear were either by postal letter, registered letter, short message by phone (SMS) or phone call. Main Outcome Measures: Number and percentage of women who responded to the recall within 8 weeks after they had received the recall, irrespective whether they had Pap test conducted. Also the numbers of women in each recall method that came for repeat Pap smear. Results: The rates of recall messages reaching the women when using letter, registered letter, SMS and phone calls were 79%, 87%, 66% and 68%, respectively. However, the positive responses to recall by letter, registered letter, phone messages and telephone call were 23.9%, 23.0%, 32.9% and 50.9%, respectively (p<0.05). Furthermore, more women who received recall by phone call had been screened (p<0.05) compared to those who received recall by postal letter (OR=2.38, CI=1.56-3.62). Conclusion: Both the usual way of sending letters and registered letters had higher chances of reaching patients compared to using phone either for sending messages or calling. The response to the recall method and uptake of repeat smear, however, were highest via phone call, indicating the importance of direct communication.

• 한국병원경영학회지
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• 제12권3호
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• pp.1-19
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• 2007

This study focused on finding the variation of medical service utilization and medical payments of the patients died by three, cancers, stomach, breast, and colon cancer. For this study, data of the one-year episodes of the health insurance subscribers died in 2004 were selected. The frequency of medical visits, the lengths of slays, the days of outpatient visits, the total period of medical services and the total medical payments were compared by the characteristics of the suppliers and utilizers. The data of the patients died by cerebrovascular diseases and cancer in 2004 were selected. To select the dead by cerebrovascular diseases and cancer in 2004, were matched the 2004 reimbursement data of all medical institutions to the data of funeral fee payment by the National Health Insurance Corporation from January 2004 to May 2005 for the death in 2004. The results of the analysis were as follow. The variation of medical service utilization of the dead by cancers were not small in Korea. The current study found that the variation of medical care utilization was influenced by the factors of suppliers, such as types and locations of medical institutions and the factors of users, such as sex and age. It was suspected that the reimbursement by fee-for-service contributed to the variation quite a lot, but we could not compare the variation between the different reimbursement systems in Korea. The results of the study suggested that tile factors of suppliers and utilizers should he reviewed to reduce the under use and over use expressed by variations of medical service utilization. The processes of care, effective communication and management system should be investigated for the equity of medical service utilization. Additionally, prospective payment could he recommended to reduce the high variation of medical service Use. To find the variation caused by under use and over use, further study need to control the severity of diseases, socio-economic status of the users and the system factors.

• 한국정보통신학회논문지
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• 제6권1호
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• pp.76-82
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• 2002

본 연구에서는 계층적 신경회로망을 사용하여 정상, 후두질환(polyp, nodule, palsy 등), 후두질환 중 성문암 시기별 감별진단이 가능한 후두질환 감별진단 분류기를 구현하였다. 후두질환을 가진 환자군과 정상군, 그리고 성문암의 각 시기별에 해당되는 환자군으로부터 /a/, /e/, /i/, /o/, /u/ 모음에 따른 분류작업을 수행하였다. 각 모음별 분류 실험을 수행한 결과 모든 입력 파라미터에 대해서 /a/모음이 다른 모음에 비해 우수한 분류율을 나타내므로, /a/모음만을 사용하여 후두질환을 감별진단하기 위한 계층적 신경회로망을 구현하였다. 구현된 계층적 신경회로망은 각 계층별로 서로 다른 파라미터들을 적용하여 여러 후두질환을 감별진단하도록 구성되었다.

• Toxicological Research
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• 제17권
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• pp.1-9
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• 2001

Some would argue that the search for the origin and treatment of this disease will continue over the next quarter century in much the same manner as it has in the recent past, by adding further layers of complexity to a scientific literature that is already complex almost beyond measure. But we anticipate otherwise: those researching the cancer problem will be practicing a dramatically different type of science than we have experienced over the past 25 years. Surely much of this change will be apparent at the technical level. But ultimately, the more fundamental change will be conceptual.

• BMB Reports
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• 제40권6호
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• pp.895-898
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• 2007

The oxygen dependent regulation of DNA replication is an essential property of proliferating mammalian cells. In human T24 bladder cancer cells, several hours of hypoxia leads to reversible DNA replication arrest and re-entry of oxygen induces a burst of replication initiation. This short communication provides strong evidence that PD184352 initiates DNA replication in living hypoxic cells without elevating the oxygen level. PD184352 releases the regular hypoxic replicon arrest, however, at a low intensity compared to the effect of reoxygenation. Moreover, PD184352 shows no effect on normoxically incubated as well as reoxygenated T24 cells.