• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.207-215
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• 2008

Drug approval-patent linkage is the practice of linking drug marketing approval to the patent status of the originator's product and not allowing the grant of marketing approval to any third party prior to the expiration of the patent term unless by consent of the patent owner. Article 18.9.5 of Korea-US Free Trade Agreement requires that Korea introduce the linkage system in drug marketing approval. However, Korea is unfamiliar with the linkage system. In addition, there have been lots of arguments over the impacts of this system on Korean pharmaceutical industry and pharmaceutical market in the future. This report investigated the linkage systems of the US and Canada. The US and Canada have implemented drug approval-patent linkage system since 1984 and 1993, respectively. Both countries have patent lists for drug approvalpatent linkage on which originators are required to list patents on substance, product, and use of their drugs. Generic or follow-on drug applicants must contain a certification regarding each patent listed that relates to the referenced drug. If the patent holder files suit for patent infringement within 45 days of notice of application, drug approval is not allowed for several months - 30 months in the US and 24 months in Canada. Both countries have amended their systems after having experienced unexpected results such as listing improper and additional patents, multiple patent litigations and delayed generic entries. After reviewing the US and Canada's experiences, we suggested three principles needed in implementing the system: protecting patent holder's right; promoting generic drug development and marketing; monitoring the process and the effect of the system.

• Korean Journal of Clinical Pharmacy
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• v.25 no.1
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• pp.1-8
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• 2015

A newly-structured Korean pharmacist license exam has been launched in 2015, reflecting upon the changes in the pharmacy curriculum from a 4 year program to a 6 year program in 2009. In order to provide new ideas to ensure that the new exam is one of the most effective pharmacist evaluations that have taken place thus far, this study was done to compare the pharmacy exams in Korea and Canada. One of the major differences noted between the two countries' exams is that along with paper based MCQ portion of the exam, Canada's exam also includes a performance-based section, known as OSCE, which the Korean Pharmacy Exam (KPE) does not have. Furthermore, with the MCQ portion of the exam, the Canadian exam asks about 300 questions, with 450 minutes of test time allocated and taken during a period of two consecutive days, the KPE asks 350 questions, with 325 minutes of test time allocated in one day. Although, similarly, many of the questions in both exams place emphasis on clinical or patient care, Canada's exam puts significantly more emphasis (50.5% of exam questions) on these types of questions than Korea (29.7% of exam questions). However, this percentage does not reflect the exact weight placed for the specific areas of knowledge it requires to answer these questions, since the types of questions asked in this section in Canada could be placed in another section on the KPE. Canada's exam also has more questions (10% +150 questions for BC) on the topics of law and ethics compared to the KPE (5.7%). The reason for this may be that the Canadian society puts emphasis on the legal and ethical duties of pharmacists as a leader. However, since each country is unique in their social, economical, and cultural points of view, comparing the KPE to the Canadian licensing exam and applying these differences to the new KPE may not be appropriate. One last thing to consider is that, as WHO/FIP mentioned, in good pharmacy practice, continually updating and developing an appropriate pharmacy exam with consideration of societal changes, is key to success in developing the scope of practice for current and future pharmacists.

• BMB Reports
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• v.38 no.4
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• pp.420-431
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• 2005

The differentially virulent race T1 of common bunt (Tilletia tritici) was used to inoculate the wheat lines Neepawa (compatible) and its sib BW553 (incompatible) that are nearly isogenic for the Bt-10 resistance gene. Inoculated crown tissues were used to construct a suppression subtractive hybridization (SSH) cDNA library. Of the 1920 clones arrayed from the SSH cDNA library, approximately 10% were differentially regulated. A total of 168 differentially up-regulated and 25 down-regulated genes were identified and sequenced; 71% sequences had significant homology to genes of known function, of which 59% appeared to have roles in cellular metabolism and development, 24% in abiotic/biotic stress responses, 3% involved in transcription and signal transduction responses. Two putative resistance genes and a transcription factor were identified among the up regulated sequences. The expression of several candidate genes including a lipase, two non-specific lipid transfer proteins (ns-LTPs), and several wheat pathogenesis-related (PR)-proteins, was evaluated following 4 to 32 days post-inoculation in compatible and incompatible interactions. Results confirmed the higher overall expression of these genes in resistant BW553 compared to susceptible Neepawa, and the differential up-regulation of wheat lipase, chitinase and PR-1 proteins in the expression of the incompatible interaction.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.549-557
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• 2019

The purpose of this study is to investigate the parallelism and volatility with Korea by using the Export Volume Index of Korea, Canada, Brazil, UK and Australia. The analysis period was prepared for indicator analysis, numerical analysis and model analysis using annual data for a total of 28 years from 1990 to 2017. In the correlation analysis, Korea showed high correlation in Canada, UK and Brazil, but low in Australia. In the coefficient of regression analysis, Brazil, Canada and UK are moving in a positive direction with their dependent variables (Korea), but appear to be almost unaffected by Australia. In order to increase Korea's exports in the future, Australia, Brazil, India, Vietnam and Singapore are emerging as new markets, which requires continuous attention. Although this study selected Canada, UK, Brazil, and Australia, it is expected that an objective and reliable study will be produced if more diverse countries are selected and analyzed in the future.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.156-162
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• 2021

Background: It is estimated that 20-30% of ginseng crops in Canada are lost to root rot each harvest. This disease is commonly caused by fungal infection with Ilyonectria, previously known as Cylindrocarpon. Previous reports have linked the virulence of fungal disease to the production of siderophores, a class of small-molecule iron chelators. However, these siderophores have not been identified in Ilyonectria. Methods: High-resolution LC-MS/MS was used to screen Ilyonectria and Cylindrocarpon strain extracts for secondary metabolite production. These strains were also tested for their ability to cause root rot in American ginseng and categorized as virulent or avirulent. The differences in detected metabolites between the virulent and avirulent strains were compared with a focus on siderophores. Results: For the first time, a siderophore N,N',N"-triacetylfusarinine C (TAFC) has been identified in Ilyonectria, and it appears to be linked to disease virulence. Siderophore production was suppressed as the concentration of iron increased, which is in agreement with previous reports. Conclusion: The identification of the siderophore produced by Ilyonectria gives us further insight into the root rot disease that heavily affects ginseng crop yields. This research identifies a molecular pathway previously unknown for ginseng root rot and could lead to new disease treatment options.

• Journal of Convergence for Information Technology
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• v.11 no.7
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• pp.128-135
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• 2021

Although the comprehensive school report system which was renamed from the admission officer system has been stably implemented in Korea, the fairness of the college admission system concerning the evaluation on the extra-curricular domain has still been a controversial issue. Thus, it has been the main topic in the educational policy to consider the desirable college admission system and investigate the problems of current changes in the admission system. On the other hand, the college admission system has not been the problem for students and people concerned in Canada. The completion of higher education is more important than the admission itself in Canada due to the standardization of higher education institutions such as universities in quality. In this regard, this study aims to examine the education and college admission system in Canada in general focusing on the cases of the province of Quebec.

• Journal of the Korean Home Economics Association
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• v.46 no.1
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• pp.47-61
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• 2008

The purpose of this study is to provide information about domestic living of Korean immigrants in Australia and Canada who have the same cultural background for comparative study. For this, usage of domestic space and living style in housing of 52 Korean households in Melbourne of Australia and 32 Korean households in the region of Waterloo of Canada were analyzed. Ethnographic research with questionnaire were used. Results of the research were as follows. 1. Korean immigrants in each countries were living in houses which was built by company of Australia and Canada. 44.2% of Korean immigrants in Australia were using L+D K and 53.1% of Korean immigrants in Canada were using L D K. 2. Laundry was indispensable for Korean immigrants in both countries and they all wanted to use the laundry as a utility room which could dry, ironing and so on. 3. Drain hole on the floor of the bathroom was not indispensable for most Korean immigrants in both countries for hygienic reason. 4. Korean immigrants in both countries were ironing in master bedroom and they all wanted to separate it from there through renovation and extension and so on. 5. Korean immigrants in Canada were more active to use the formal lounge which has been planned as a traditional element of western house. 6. The seating style of Korean immigrants in both countries belong to chair-seating style mostly. But it was clear that they were making Kimchi with floor seating style in both countries. 7. A level of satisfaction about using carpet was not high for Korean immigrants in both countries cause of uneasiness to clean and it was considered to relate to the floor seating style of them. 8. Almost Korean immigrants were took off the shoes inside of the house and they had shoes cabinet beside the entrance or basement usually. 9. The most popular heating system was ducted heating in both countries. The level of satisfaction about this was different for Korean immigrants in Australia and Canada but most desirable heating system was Ondol for them in both countries commonly.

• Journal of radiological science and technology
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• v.32 no.2
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• pp.225-234
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• 2009

This study attempts to provide basic information on overseas employment to the radiological technologists and students majoring in radiology in Korea who consider the overseas employment by investigating the job consciousness for radiological technologists in Canada and Australia which have a high level of interest for overseas employment and want to compare their status with that of Korean radiological technologists. This study was performed by visiting hospitals such as Prince George Regional Hospital, 1475 Edmonton Street, Prince George, BC, Canada on August 13, 2007, Alfred Hospital, Commercial Road Melbourne 3004, Australia on August 4, 2008, and other Korea hospitals that show the similar scale as Canada and Australia on September 10, 2007. The results were summarized as follows : 1. Differences were observed in this sexual composition, such as 18 males (90%) in Korea, 14 females (73.7%) in Canada, and 25 females in Australia (86.2%). 2. The item of 'aptitude' which is one of the most important criteria, showed the highest level in Korea, Canada, and Australia, and the second most considered item was 'salary'. 3. In the values in jobs, the items of 'economic self-sufficiency', 'recognized by others', and 'establishing a social position' represented high levels in Korea, and the items of 'like the job itself', 'establishing self-actualization', 'feel the meaning of life', and 'make new friends' showed high levels in Canada and Australia. 4. Regarding the item of 'a job is important as much as a marriage', 'Yes' showed high level in Korea, and 'No' showed high levels in Canada and Australia. 5. Radiological technologists in Korea demonstrated a low level in the job consciousness compared to those of Canada and Australia. Although this study shows some limitations for showing whole idea of radiological technologists due to the lack of the scope in samples for each country as a practical manner, this study can be regarded significant to compare some countries that have interests in overseas employment.

• Proceedings of the Korean Aquaculture Society Conference
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• 2006.05a
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• pp.308-309
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• 2006

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2004.05a
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• pp.128-128
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• 2004