• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제42권5호
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• pp.243-250
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• 2016

Objectives: Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). Materials and Methods: This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival. We then compared five inflammation-based prognostic scores, CRP/alb ratio, modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI), based on receiver operating characteristic (ROC) curves. Results: The optimal cut-off value for the CRP/alb ratio was 0.085. The group with a high CRP/alb ratio had a high TNM clinical stage (P=0.002) and larger primary tumors (P=0.029), with statistically significant differences in lymph node metastasis and distant metastasis. In addition, when the CRP/alb ratio was high, multivariate analysis showed a lower survival rate (P=0.002; hazard ratio=6.078), and the ROC curve showed more outstanding discriminatory ability regarding overall survival compared to other inflammation-based prognostic scores. Conclusion: The CRP/alb ratio can be an independent prognostic factor when predicting prognosis in OSCC and has good prognostic ability.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5735-5740
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• 2013

Background: A number of studies have investigated the association between increased pretreatment serum C-reactive protein (CRP) levels and the prognosis of gastric cancer. However, due to the inconsistent results, whether the serum CRP level can be a prognostic factor in primary gastric cancer remains controversial. Methods: We searched Medline, PubMed, Embase and the Cochrane Central Register of Controlled Trials for relevant high-quality reports. A meta-analysis was carried out using the included studies to assess the association between pretreatment serum CRP level and overall survival (OS) in patients with gastric cancer. Correlation analyses were conducted to evaluate the relationship between serum CRP and tumor characteristics such as tumor node metastasis (TNM) stage and recurrence. Results: Twelve reports involving 2,597 patients with gastric cancer were included. Primary meta-analysis indicated a significant association between elevated CRP level and poor OS (HR 1.77, 95% CI 1.56-2.00). Subgroup analyses showed no single factor could alter the primary results when we divided the included studies by "number of patients", "max follow-up period", "TNM stage", "treatment" and "cut-off value". Correlation analyses showed that serum CRP level was significantly related to TNM stage (OR 2.96, 95% CI 2.22-3.93) and tumor recurrence (OR 1.81, 95% CI 1.21-2.71). Conclusions: We demonstrated that increased pretreatment serum CRP level (${\geq}10mg/L$) was significantly associated with poor prognosis in gastric cancer patients, either in early or advanced stages.

• KSBB Journal
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• 제22권6호
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• pp.443-446
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• 2007

관상심장질환 바이오마커의 하나인 CRP를 batch형 수정진동자 면역센서에 의하여 다음과 같이 분석하였다. 센서시스템의 작동은 직접결합방식에 의하여 행하였으며 CRP에 대한 항체의 최적 고정화농도는 $50{\mu}g/ml$이었다. 시스템의 반응완충용액으로 0.1 M 인산완충용액 (pH 7.0)을 사용하였고 시스템 작동은 baseline 안정화, 시료첨가 및 측정, 10 mM NaOH에 의한 센서 칩 재생의 순으로 행하였다. 이중로그척도로 표시하였을 때 0.27-106.00 nM 범위의 쥐 유래 CRP에 대하여 센서반응과 직선상의 관계를 이루었으며 센서의 검출한계는 0.53 nM이었고 재사용성도 양호하였다.

• Clinical Nutrition Research
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• 제12권1호
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• pp.7-20
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• 2023

Creating a complex balance between dietary composition, circadian rhythm, and the hemostasis control of energy is important for managing diseases. Therefore, we aimed to determine the interaction between cryptochrome circadian clocks 1 polymorphism and energy-adjusted dietary inflammatory index (E-DII) on high-sensitivity C-reactive protein in women with central obesity. This cross-sectional study recruited 220 Iranian women aged 18-45 with central obesity. The 147-item semi-quantitative food frequency questionnaire was used to assess the dietary intakes, and the E-DII score was calculated. Anthropometric and biochemical measurements were determined. By polymerase chain response-restricted length polymorphism method, cryptochrome circadian clocks 1 polymorphism was assigned. Participants were categorized into three groups based on the E-DII score, then categorized according to cryptochrome circadian clocks 1 genotypes. The mean and standard deviation of age, BMI, and high-sensitivity C-reactive protein (hs-CRP) were 35.61 ± 9.57 years, 30.97 ± 4.16 kg/m², and 4.82 ± 5.16 mg/dL, respectively. The interaction of the CG genotype and E-DII score had a significant association with higher hs-CRP level compared to GG genotype as the reference group (β, 1.19; 95% CI, 0.11-2.27; p value, 0.03). There was a marginally significant association between the interaction of the CC genotype and the E-DII score with higher hs-CRP level compared to the GG genotype as the reference group (β, 0.85; 95% CI, -0.15 to 1.86; p value, 0.05). There is probably positive interaction between CG, CC genotypes of cryptochrome circadian clocks 1, and E-DII score on the high-sensitivity C-reactive protein level in women with central obesity.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2663-2667
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• 2014

Background: Single nucleotide polymorphisms of C-reactive protein (CRP) have been shown to be related to circulating CRP level, risk and prognosis in cancer patients. However, accumulating evidence of rs1800947 involvement in risk of cancer is inconsistent. Thus, a meta-analysis was performed to obtain a more precise relationship. Materials and Methods: The pooled odds ratio (OR) and its 95% confidence interval were assessed in 10 eligible articles with 12 studies containing 5,601 cancer cases and 8,669 cancer-free controls. Results: No significant association was observed overall and in subgroups in comparison of genotype GC vs GG ($P_H$=0.847, OR=0.939, 95%CI=0.810-1.087), GC/CC vs GG ($P_H$=0.941, OR=1.021, 95%CI=0.901-1.157) and allele C vs G ($P_H$=0.933, OR=1.026, 95%CI=0.909-1.159). However, statistically significance was evident in comparison of genotype CC vs GG in cancer risk ($P_H$=0.586, OR=2.854, 95%CI= 1.413-5.763), especially in colorectal cancer ($P_H$=0.481, OR=4.527, 95%CI= 1.664- 12.315). Conclusions: Genotype CC of rs1800947 in the CRP gene is strongly associated with increased cancer risk, particularly in colorectal cancer.

• Journal of Yeungnam Medical Science
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• 제18권2호
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• pp.215-225
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• 2001

동맥경화증의 생성 및 진행과정의 병태생리에 있어서 염증이 중요한 기전으로 여겨지고 있으며, 혈중에 이러한 염증반응을 나타내는 표식자들 중의 하나인 혈중 C-reactive protein(CRP) 농도가 동맥경화증의 중증도와 관계 있으며 심혈관사고와도 밀접한 연관이 있는 것으로 알려지고 있다. 본 연구는 협심증 환자에서 관동맥중재술에 의한 혈중 CRP의 변화가 단기간 임상경과에 미치는 영향을 알아보기 위해 시행하였다. 1999년 12월부터 2000년 1월까지 협심증으로 영남대학교 의과대학 부속병원 순환기내과에 입원하여 관상동맥확장술을 시행받은 36명의 환자를 대상으로 하였다. 환자는 내원직후 임상적 병력을 청취하였고 혈중 troponin-T, CRP를 측정하였다. 관동맥확장술 12시간，24시간，48시간 그리고 72시간 후에 혈중 CRP를 측정하였으며, 24시간 후에 혈중 troponin-T를 측정 하였다. 퇴원 6개월 후에 외래에서 환자의 임상증상 유무를 측정하였다. 1) 단일혈관질환이 $0.33{\pm}0.20$ mg/dL, 2혈관질환이 $0.36{\pm}0.14$ mg/dL, 그리고 3혈관질환이 $0.56{\pm}0.38$ mg/dL로 병변 혈관수가 증가할수록 CRP가 유의하게 증가하였다(p<0.05). 2) 내원시 안정형 협심증 환자의 CRP가 $0.30{\pm}0.01$ mg/dL, 불안정형 협심증 환자가 $0.46{\pm}0.28$ mg/dL로 불안정형 협심증 환자에서 유의하게 높았다(p<0.05). 3) 시술전 CRP는 $0.38{\pm}0.20$ mg/dL 였으며 시술 후 12시간 $0.56{\pm}0.36$ mg/dL(p<0.05), 24시간 $0.91{\pm}0.66$ mg/dL(p<0.01), 48시간 $0.87{\pm}0.62$ mg/dL(p<0.01), 72시간 $0.63{\pm}0.41$ mg/dL(p<0.01)로 시술전에 비해 시술후 증가하는 양상을 보였으며, 특히 시술 24시간 후에 가장 많이 증가하였다. 이러한 변환의 양상은 안정형 협심증 보다 불안정형 협심증에서 증가량이 많고 상승기간이 오래 유지되었으며, 시술 후 24시간에 절대적인 증가량은 안정형 협심증이 $0.32{\pm}0.31$ mg/dL, 불안정형 협심증이 $0.79{\pm}0.73$ mg/dL로 불안정형 협심증에서 유의하게 높았다(p<0.05). 4) 시술 후 troponin-T의 변화량과 CRP의 변화량에는 상관관계가 없었다(r=0.135. p=0.04). 5) 초기 CRP가 0.6미만인 군 32명 중 4명(13%)에서 재협착을 보였으며, 0.06이상인 군 4명 중 2명에서 재협착을 보였다(50%, p<0.05). 시술후 24시간 CRP가 1.0미만인 군 25명 중 3명(12%)에서 재협착을 보였으며, 1.0이상인 군 11명 중 3명(27%)에서 재협착을 보였다(p=0.257). 안정형 협심증 환자에서는 초기 CRP가 0.6이상인 환자가 없어 통계적인 분석을 하지 못하였고, 불안정형 협심증 환자에서 초기 CRP가 0.6미만인 군 13예 중 1예(8%)에서 재협착을 보였고 0.6이상인 환자 4명 중 2명(50%) 에서 재협착을 보였다(p<0.05). 이상의 결과로 불안정형 협심증 환자에서 안정형 협심증보다 증가된 염증반응을 보이며, 초기에 증가된 염증반응은 관동맥확장술 후 재협착에 영향을 미치는 것으로 사료된다.

• Journal of Nutrition and Health
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• 제57권1호
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• pp.88-104
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• 2024

본 연구는 국민건강영양조사 2015년부터 2018년도 자료를 활용하여 우리나라 만 19세 이상 성인의 KHEI와 복부비만의 관련성 및 hs-CRP의 매개 효과를 분석한 연구이다. 한국 성인 남성의 경우 허리둘레 90 cm 이상, 여성은 허리둘레 85 cm 이상인 경우에 복부비만군으로 정의하였다. 남성에서 복부비만군은 2,587명, 정상군은 5,007명이였고 여성의 복부비만군은 2,869명, 정상군은 7,307명이였다. KHEI, hs-CRP, 복부비만의 연관성 분석에서는 모든 공변량을 보정하였을 때 남성의 KHEI는 복부비만과 유의한 연관이 없었지만, hs-CRP와 음의 연관성이 있었다. 여성의 경우, 복부비만과 hs-CRP 모두 음의 연관성이 관찰되었다. 또한, 남성과 여성에서 hs-CRP 위험군 (> 1.0 mg/L) 이 hs-CRP 정상군 (≤ 1.0 mg/L)보다 복부비만 유병률이 유의하게 높았다. Bootstrapping을 이용한 매개효과 분석에서는 KHEI와 복부비만 관계에서 hs-CRP가 매개 효과를 가지는 것으로 나타났으며 공변량을 단계적으로 보정하였을때 증가하는 양상이 나타났다. 결론적으로, 본 연구 결과는 균형잡힌 식생활를 통한 높은 식사의 질이 hs-CRP에 영향을 미쳐 복부비만 예방에 중요한 영향을 미칠 수 있음을 시사한다.

• Journal of Korean Neurosurgical Society
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• 제54권4호
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• pp.289-295
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• 2013

Objective : Cerebral vasospasm is a common and potentially devastating complication of aneurysmal subarachnoid hemorrhage (aSAH). Inflammatory processes seem to play a major role in the pathogenesis of vasospasm. C-reactive protein (CRP) constitutes a highly sensitive inflammatory marker. Elevation of serum CRP levels has been demonstrated in patients with aSAH. The purpose of the current study was to evaluate the possible relationship between CRP levels in the serum and transcranial Doppler (TCD) and the development of vasospasm in patients with aSAH. Methods : A total of 61 adult patients in whom aSAH was diagnosed were included in the study from November 2008 to May 2011. The patients' demographics, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on days 1, 3, 5, 7, 9, 11 and 13 and TCD was measured on days 3, 5, 7, 9, 11 and 13. All patients underwent either surgical or endovascular treatment within 24 hours of their hemorrhagic attacks. Results : Serum CRP levels peaked on the 3rd postoperative day. There were significant differences between the vasospasm group and the non-vasospasm group on the 1st, 3rd and 5th day. There were significant differences between the vasospasm group and the non-vasospasm group on the 3rd day in the mean middle cerebral artery velocities on TCD. Conclusion : Patients with high levels of CRP on the 1st postoperative day and high velocity of mean TCD on the 3rd postoperative day may require closer observation to monitor for the development of vasospasm.

• Journal of Korean Neurosurgical Society
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• 제38권3호
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• pp.206-210
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• 2005

Objective : Our aim is to evaluate the early changes of biologic markers such as white blood cell[WBC] count, erythrocyte sedimentation rate[ESR] and C-reactive protein[CRP] in early diagnosis of postoperative infection and to differentiate infection from inflammatory reaction in lumbar spine surgery. Methods : We reviewed 330patients who had undergone spinal operations between May 1999 and October 2001. For this study, the patients were classified into two groups, which include a group that underwent spinal decompressive surgery without instrumentation[SD], and the other group that underwent fusion surgery with spinal instrumentation[SI]. And each group was also subdivided into two groups respectively, one with infection and the other without infection. We retrospectively analyzed the WBC count, ESR and CRP preoperatively and postoperatively, according to their operation type and postoperative infection history. Results : Inflammatory indices were physiologically affected by instrumentation itself. But ESR and CRP elevations were more prolonged and sustained under infection. In SD patients without infection, ESR and CRP were stabilized 5 days after surgery. In SI patients without infection, CRP was stabilized about 7days after surgery, but ESR showed sustained and variously elevated. In both SD and SI groups, the stabilization of CRP was the most reliable behavior of surgery without infection. Conclusion : C-reactive protein is most sensitive parameter for postoperative spine infection. The knowledge of the inflammatory indices and their relatively uniform patterns with or without infection offers surgeons the ability to infer the state of surgical wound.

• 대한수의학회지
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• 제59권1호
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• pp.9-15
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• 2019

In canine acute pancreatitis (AP), inappropriate release and activation of zymogen proteases within the pancreas results in the consumption of serum antiproteases. The aim of this study was to examine whether the serum concentrations of ${\alpha}_2$-macroglobulin (A2MG), ${\alpha}_1$-antitrypsin (A1AT), and C-reactive protein (CRP) differ between dogs with AP and healthy dogs. Twenty healthy dogs and 20 dogs with AP were included in this study. Concentrations of A2MG, A1AT, and CRP were measured in the sera of healthy dogs and dogs diagnosed with AP. Serum A2MG and A1AT concentrations were significantly lower in dogs with AP than in healthy dogs, whereas the serum CRP concentration was significantly higher. In addition, the concentrations of A2MG and A1AT were significantly higher in AP survivors than in AP non-survivors, while the CRP concentration was significantly lower. However, in both AP survivors and non-survivors, the CRP concentrations showed a negative correlation with A2MG concentrations but not with A1AT. These findings indicate that serum antiproteases and CRP concentrations might be associated with the mortality rate of AP in dogs.