• Title/Summary/Keyword: bull

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Synthesis of Selective Butyrylcholinesterase Inhibitors Coupled between α-Lipoic Acid and Polyphenols by Using 2-(Piperazin-1-yl)ethanol Linker

  • Yeun, Go Heum;Lee, Seung Hwan;Lim, Yong Bae;Lee, Hye Sook;Won, Moo-Ho;Lee, Bong Ho;Park, Jeong Ho
    • Bulletin of the Korean Chemical Society
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    • v.34 no.4
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    • pp.1025-1029
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    • 2013
  • In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between ${\alpha}$-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2-aminoethoxy)ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy)ethanol (linker 1) was switched to the cationic 2-(piperazin-1-yl)ethanol linker (linker 2). The $IC_{50}$ values of the linker-2 hybrid molecules for BuChE inhibition were lower than those of linker-1 hybrid molecules (except 9-2) and they also had the same great selectivity for BuChE over AChE (> 800 fold) as linker-1 hybrid molecules. ALA-acetyl caffeic acid (10-2, ALA-AcCA) was shown as an effective inhibitor of BuChE ($IC_{50}=0.44{\pm}0.24{\mu}M$). A kinetic study using 7-2 showed that it is the same mixed type inhibition as 7-1. Its inhibition constant (Ki) to BuChE is $4.3{\pm}0.09{\mu}M$.

Epidemiological study for infection route of brucellosis in a infected dairy farms (Brucella 감영농장에서 감염경로의 역학적 연구)

  • 윤여백;김영진;김추철;노영선;권미순;김철민;임채웅
    • Korean Journal of Veterinary Service
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    • v.27 no.2
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    • pp.159-164
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    • 2004
  • A dairy farm that has been suffered continuously(more than 2 years) from brucellosis in Korea in spite of repeated legal test-and-slaughter was investigated the main source of infection in the farm. All cattle(22 milking cows, 44 heifers, 60 calves, 8 bull), dogs(3 mixed breed), feces from wild birds(3 samples), drinking water(3 sites), and soil in the paddocks(14 sites) inside the farm were examined with serological and/or bacteriological methods including specific DNA detection with PCR method. Brucella spp in the milk and blood were detected in 12/22 and 5/22 milking cows, respectively, although all of them were negative with conventional tube agglutination test. The number of serologically positive heifer was 15(15/44), but the isolation of Brucella spp was succeeded in the only 11(11/15) of them. Brucella were detected in vagina 1(1/11) and nasal(3/12) excretion in serologically positive heifers. All the three dogs were serologically positive, and Brucella spp were isolated from their blood. However, Brucella spp were not detected in the drinking water, soil in the paddocks, nor the feces of wild birds. The results suggest that milking cow secrete Brucella spp through milk, genital tract and nasal cavity, which are the major source of infection in this farm, The main infection route of Brucella spp is contact to contact with Brucella spp excreting animals rather than environmental contamination. The animals, living together with infected cow such as dogs, are the readily susceptible and are required to be examined for Brucella spp.

Sensing Characteristics of Tyrosinase Immobilized and Tyrosinase, Laccase Co-immobilized Platinum Electrodes

  • Quan, De;Kim, You-Sung;Shin, Woon-Sup
    • Bulletin of the Korean Chemical Society
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    • v.25 no.8
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    • pp.1195-1201
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    • 2004
  • Tyrosinase was covalently immobilized on platinum electrode according to the method we developed for laccase (Bull. Korean Chem. Soc. 2002, 23(7), 385) and p-chlorophenol, p-cresol, and phenol could be detected with sensitivities of 334, 139 and 122 nA/ ${\mu}M$ and the detection limits of 1.0, 2.0, and 2.5 ${\mu}M$, respectively. The response time ($t_{90\%}$) is 3 seconds for p-chlorophenol, and 5 seconds for p-cresol and phenol. The optimal pHs of the sensor are in the range of 5.0- 6.0. This sensor can tolerate at least 500 times repeated injections of p-chlorophenol with retaining 80% of initial activity. In case of tyrosinase and laccase co immobilized platinum electrode, the sensitivities are 560 nA/ ${\mu}M$ for p-phenylenediamine (PPD) and 195 nA/ ${\mu}M$ for p-chlorophenol, respectively. The sensitivity of the bi-enzyme sensor for PPD increases 70% compared to that of only laccase immobilized one, but the sensitivity for p-chlorophenol decreases 40% compared to that of only tyrosinase immobilized one. The sensitivity increase for the bi-enzyme sensor for PPD can be ascribed to the additional catalytic function of the co-immobilized tyrosinase. The sensitivity decrease for p-chlorophenol can be explained by the “blocking effect” of the co-immobilized laccase, which hinders the mass transport through the immobilized layer. If PPD was detected with the electrode that had been used for p-chlorophenol, the sensitivity decreased 20% compared to that of the electrode that had been used only for PPD. Similarly, if p-chlorophenol was detected with PPD detected electrode, the sensitivity also decreased 20%. The substrate-induced conformation changes of the enzymes in a confined layer may be responsible for the phenomena.

Implementation of RFID-based Information Management System for Bullfights (싸움소를 위한 RFID 기반 정보 관리시스템의 구현)

  • Cho, Yong-Hyun
    • Journal of the Korean Institute of Intelligent Systems
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    • v.18 no.6
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    • pp.768-774
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    • 2008
  • This paper implements a information management system for a bullfights using RFID technology in which the objects containing electronic tag are automatically identified by using radio frequency wave. The presented system is composed of the information systems for career and train, and the real-time informant system to provide various informations to remote bull breeders and administers. As the first step for implementation, we analyze the requirements for information management systems based on the RFID and suggests design considerations. Based on the analysis, we implement an efficient RFID middleware system for tracking a tag location based on antenna transfer method and managing an intelligent tag information which efficiently manages a bullfight informations in field. And we also implement the web-based integrated management system for managing and providing a bullfight informations. The career management system sequentially recognizes a tags, and the training system concurrently recognizes the man tags.

Finite Element Analysis on Buckling Pressure by the Lamination of Composite Pressure Bull (복합재 내압선체의 적층에 따른 좌굴하중 변화에 관한 유한요소 해석)

  • Son J. Y.;Cho J. R.;Bae W. B.;Kwon J. H.;Choi J. H.;Cho Y. S.;Kim T. K.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2005.05a
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    • pp.458-462
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    • 2005
  • This paper deal with the optimal lamination condition of cylindrical shell applied new composite URN300 for a study of composite empirical formula. Finite element analyses for isotropic materials considered element numbers and boundary conditions are compared with existing empirical formulas to apply FE analysis for composite. And composite tensile test is done to know the composite material applied FE analysis for composite. The results of FE analyses for isotropic materials have indicated that Optimal element number and boundary condition were 1600 and both simple support. These conditions were applied in composite FE analyses. Ply orientations and lamination patterns in FE analyses for composite were considered. Ply orientations are $0^{\circ},\;15^{\circ},\;30^{\circ},\;45^{\circ},\;60^{\circ},\;75^{\circ},\;and\;90^{\circ}$. Lamination patterns are $[\pm\theta/0/90]_{14s]$ and $[\pm\theta_{14}/0_{14}/90_{14}]_s$ in FE analysis. Lamination pattern $[\pm\theta_{14}/0_{14}/90_{14}]_s$ is the equivalent model of $[\pm\theta/0/90]_{14s}$. At the result of this study, the FE analyses for composite have indicated that the optimized ply orientation $75^{\circ}$ is and real model must use in FE analysis for accurate results.

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Analysis of Binodal Structures of Final State Distributions in Vibrational Predissociations of Triatomic van der Waals Molecules

  • 이천우
    • Bulletin of the Korean Chemical Society
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    • v.16 no.12
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    • pp.1193-1203
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    • 1995
  • In this work, we focused on the setup of the tools for the analysis of the final rotational state distribution of photofragments in vibrational predissociations of triatomic van der Waals molecules A-B2. We found that reflection principle used for the direct photodissociation processes can also be applied to find out the final rotational state distributions for indirect photodissociation processes. The quantity which represents the strength of rovibrational coupling between the quasi-bound state and the final state is reflected into the mirror of the classical angular momentum function, instead of the initial state before light absorption used in the reflection principle of direct processes. The sign change in the first derivative of the interaction potential with respect to the bond distance of B2 is found to be the source of the binodal structures in the final rotational distributions of photofragments in the model system studied in this work. In MQDT analysis, short range eigenchannel basis functions were found to be localized in angle, in the previous work [Lee, C.W. Bull. Korean Chem. Soc. 1995, 16, 957.] and may be called angle functions. Angle functions enjoy simple geometrical structures which have simple functional relations with the final state distributions of photofragments. Two processes take place along the angle functions which resemble the quasi-bound state and dominate over other processes. Two such angle functions are found to be not only localized angularly but also localized either one of ends of B2 in motions along the bond of B2. These dominating photodissociation processes, however, cancel each other. This cancellation causes photodissociation to depend sensitively on the interaction potential at other angles than the dominant one. Part of potential surface where much larger torque exists can now play an important role in photodissociation. MQDT also enables us to see which processes play important roles after cancellation. This is done by examining the amounts of time delayed by asymptotic eigenchannels.

Taxonomic consideration and Ecological Characteristics of Xylariaceae

  • Lee, Yang-Soo;Han, Sang-Sub
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2003.10a
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    • pp.43-49
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    • 2003
  • The Xylariaceae Tul. & C. Tul is a family of sphaeriaceous genera with obscure but apparently common ancestry (Rogers, 1979). A central core of genera - Xylaria, Hypoxylon, Rosellinia, Poronia, Podosordaria, Hypocopra, Daldinia, Biscogniauxia, Kretzschmaria, Camillea, Penzigia - are obviously related, regardless of the fact that the generic limits are arguable (Rogers, 1979; Barr, 1990; Eriksson & Hawksworth, 1991; Laessoe, 1994). In general, the family Xylariaceae is primarily defined as a group of stromatic pyrenomycetes with unitunicate asci characterized by a typical apical apparatus and pigmented ascospores having a germ slit (Rogers, 1979). Since Winter (1887) circumscribed the family to include Pyrenomycetes with predominately a dark stroma, dark unveiled spores containing 5 geners: Nummularia Tul, & C. Tul., Hypoxylon Bull., ustulina Tul. & C.Tul., Poronia Willd. and XylariaHill ex Schrank, many more genera has been added to the family (Dennis, 1961; Eriksson & Hawksworth, 1993; Whalley, 1996). In the absence of the clear circumscription of the family (Rogers, 1994) the agreed number of accepted genera is governed by individual views and there are therefore difference between the proposals for the ascomycetes recognized 35 genera and indicated a further 3 which might belong there. Laessore reviewed the family and included 37 genera but a few of these were listed as uncertain (Laessoe, 1994). In the most recent accounts Whalley (1996) listed 41 genera but again a number of these were considered uncertain and Ju and Rogers (1996) accepted 39 genera in their interpretation of the family. Since Laessoe (1994) merged Daldinia and Versiomyces with Hypoxylonand Ju and Rogers (1996) combined Astrocystis with Resellinia and Helicogermslita, which can be argued strongly against, it is likely that a realistic number of genera will be close to 40(Whalley, 1996; table 1).

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The Effect of Increasing The Third Party Liability and Expansion of Mandatory Insurance in South Korea

  • KWAK, Young-Arm
    • The Journal of Industrial Distribution & Business
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    • v.12 no.11
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    • pp.33-50
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    • 2021
  • Purpose: In South Korea, two kinds of mandatory insurance, Fierce Liability Insurance and Outdoor Advertising Liability Insurance sells as of February 2021 according to relevant codes. This study analyzed third party liability and personal living liability insurance in terms of various risks not corporation side but personal side arising from normal living and life. Research design, data and methodology: Some cases of drone accident hit man and fierce dog accident were taken into analysis to verify blame ratio and insurance claim money. The former case is that on the way down the elevator, the dog, American pit bull terrier rushed in and bit the lower part of the knee against the visitor. The latter case is that while flying in the sky as usual, the drone suddenly crashed, fell, and hit the head of a young child while walking on the street. Further previous studies such as third party liabilities, liability insurance, mandatory insurance were deeply analyzed. Results: Based on some case studies and previous studies, the author suggested valuable comments in turn realization of insurer as provider, exhaustive creation and operation of mandatory insurance, realization of insured as demanded, and arrangements of laws and systems in special consideration of amendment of companion animal and exhaustive execution of mandatory insurance by the government. Conclusions: This study was about third party liability, personal living liability insurance and expansion of mandatory insurance caused by relevant laws by the government. In this study the author verified what issues were observed from two cases drone accident and fierce dog accident and then suggested some valuable comment as above both systemic plans and practical plans. First of all, the individual should get Comprehensive Property Insurance(CPI) that covers the risks of his/her own property arising from the everyday life. And then the individual should further buy Personal Living Liability Insurance(PLLI) in order to prepare 'accidents that may happen when, where, or how' and overcome the said accidents. Moreover, the individual should take a look every single insurance contract whether he/she has a special terms and conditions of Personal Living Liability Insurance(PLLI) or not.

Estimation of the genetic milk yield parameters of Holstein cattle under heat stress in South Korea

  • Lee, SeokHyun;Do, ChangHee;Choy, YunHo;Dang, ChangGwon;Mahboob, Alam;Cho, Kwanghyun
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.3
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    • pp.334-340
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    • 2019
  • Objective: The objective of this study was to investigate the genetic components of daily milk yield and to re-rank bulls in South Korea by estimated breeding value (EBV) under heat stress using the temperature-humidity index (THI). Methods: This study was conducted using 125,312 monthly test-day records, collected from January 2000 to February 2017 for 19,889 Holstein cows from 647 farms in South Korea. Milk production data were collected from two agencies, the Dairy Cattle Genetic Improvement Center and the Korea Animal Improvement Association, and meteorological data were obtained from 41 regional weather stations using the Automated Surface Observing System (ASOS) installed throughout South Korea. A random regression model using the THI was applied to estimate genetic parameters of heat tolerance based on the test-day records. The model included herd-year-season, calving age, and days-in-milk as fixed effects, as well as heat tolerance as an additive genetic effect, permanent environmental effect, and direct additive and permanent environmental effect. Results: Below the THI threshold (${\leq}72$; no heat stress), the variance in heat tolerance was zero. However, the heat tolerance variance began to increase as THI exceeded the threshold. The covariance between the genetic additive effect and the heat tolerance effect was -0.33. Heritability estimates of milk yield ranged from 0.111 to 0.176 (average: 0.128). Heritability decreased slightly as THI increased, and began to increase at a THI of 79. The predicted bull EBV ranking varied with THI. Conclusion: We conclude that genetic evaluation using the THI function could be useful for selecting bulls for heat tolerance in South Korea.

Muscle-specific color stability in fresh beef from grain-finished Bos indicus cattle

  • Salim, Ana Paula A.A.;Suman, Surendranath P.;Canto, Anna C.V.C.S.;Costa-Lima, Bruno R.C.;Viana, Fernanda M.;Monteiro, Maria Lucia G.;Silva, Teofilo J.P.;Conte-Junior, Carlos A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.7
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    • pp.1036-1043
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    • 2019
  • Objective: To investigate the color and oxidative stabilities of longissimus lumborum (LL) and psoas major (PM) muscles from grain-finished Bos indicus cattle in Brazil. Methods: The LL and PM muscles were obtained 24 h post-mortem from eight (n = 8) Nellore bull carcasses, fabricated into 1.5-cm steaks, aerobically packaged, and stored at $4^{\circ}C$ for nine days. Steaks were analyzed for myoglobin concentration, pH, instrumental color, metmyoglobin reducing activity (MRA) and lipid oxidation. Results: The LL steaks exhibited greater (p<0.05) redness, color stability, and MRA than their PM counterparts on days 5 and 9. The LL and PM steaks demonstrated similar (p>0.05) lightness and yellowness on days 0, 5, and 9. On the other hand, PM steaks exhibited greater (p<0.05) myoglobin concentration, pH, and lipid oxidation than their LL counterparts. Conclusion: These results indicated that muscle source influenced the color and oxidative stabilities of beef from grain-finished Bos indicus animals. These results highlighted the necessity of muscle-specific strategies to improve the color stability of beef from grain-fed Bos indicus cattle.