• Journal of Pharmaceutical Investigation
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• v.35 no.6
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• pp.417-422
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• 2005

This study was aimed to design and formulate the moisture-activated patches containing ofloxacin and lidocaine for antibacterial and local anesthetic action. The solubility of lidocaine at $32^{\circ}C$ in various vehicles decreased in the rank order of PG $759.5{\pm}44.5\;mg/mL$ > PGL > IPM > PEG 300 > PEG 400 > Ethanol > PGMC > DGME > PGML > OA > $Captex^{\circledR}\;300$ > $Captex^{\circledR}\;200$ > water $(4.0{\pm}0.1\;mg/mL)$. Ofloxacin revealed very low solubility, which the highest solubility was obtained from PEG 400 $(18.7{\pm}6.3\;mg/mL)$ among the vehicles used. The addition of lactic acid increased the solubility of ofloxacin dramatically; the solubility at 5% lactic acid was $133.7{\pm}9.7\;mg/mL$. As $2-hydroxypropyl-{\beta}-cyclodextrin$ was added at the concentrations of 40, 80, 120, 160 and 200 mM, the solubilities of lidocaine and ofloxacin were enhanced up to three and two times, respectively, with concentration-dependent pattern. Gel intermediates for filmtype patches were prepared with mucoadhesive polymer, viscosity builders, lidocaine or ofloxacin at pH values from 5 to 7. Gels were cast onto a release liner and dried at room temperature. Dried patch was attached onto an adhesive backing layer, thus forming a patch system. Patches containing a single drug component were characterized by in vitro measurement of drug release rates through a cellulose barrier membrane. The release study was carried out at $37^{\circ}C$ using a Franz-type cell. Receptor solutions were isotonic phosphate buffers (pH 7.4). Samples $(100\;{\mu}L)$ were taken over 24 hours and quantitated by a verified HPLC method. The releases from all tested were proportional to the square root of time. The release rates were 0.9, 157.3 and $281.7\;{\mu}g/cm^{2}/min^{1/2}$ for the lidocaine patches and 19.8,37.2 and $50.7\;{\mu}g/cm^{2}/min^{1/2}$ for the ofloxacin patches at the concentrations of 0.3, 0.5 and 1 %, respectively. The release rates were dose dependent in both drug patches $(R^{2}\;=\;0.9077\;for\;lidocaine;\;R^{2}\;=\;0.9949\;for\;ofloxacin)$ and those were also thickness-dependent $(R^{2}\;=\;0.9246\;for\;lidocaine;\;R^{2}\;=\;0.9512\;for\;ofloxacin)$.

• Journal of architectural history
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• v.13 no.2 s.38
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• pp.57-70
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• 2004

Since Korea disclaimed to open the ports, Korean architecture has met the impetuous transformation. Although there would be various factors of this transformation, the new-coming architecture by missionary seemed to be a significant one, and many researches have been carried out on this theme in diverse viewpoints. However, because these researches have preponderated on the Catholic tradition, it is deficient for clarify the whole history of mission architecture. Therefore, this research has the meaning to enrich the history of Korean modern architecture by making balance. First of all, this paper is focused on the activities of one missionary, Graham Lee. He is a practical missionary at the beginning, his architecture made a critical influence in Korean traditional architecture. Graham Lee was born in Rock Island, Illinois, 1861, and he determined to become a missionary through grown up. He spent his boyhood by working as a plumber for his purpose and studied in a university afterward. Graduating of McComick Theological Seminary, he was nominated as a pioneer of Pyeng Yang Mission Station and set foot in Korea, September of 1892. Since then he started to erect missionary facilities in Pyeng Yang, such as Well House(1898), Pyeng Yang Central Church(1900-1901), Pyeng Yang Academy(1902). These all his works are designed with eclectic style which shows western and Korean traditional style intermingled. This unique characteristic made a profound influence to the Korean mission architecture afterwards. Especially, the L-type plan of Pyeng Yang Central Church, which is first shown by him, is recognized very unique, and this plan type had been spread all over the country. Therefore the L-type plan became the peculiar feature of the early Korean churches. Furthermore, working with Korean carpenters, he taught them new skills of modem buildings. After that, they were expanded out northern part of Korea and took the roles of master builders. According to this expansion, his particular style had got spread and had been settled as a unique eclectic style in Korean modern architecture. In the conclusion, he is evaluated to be a critical pioneer missionary, who left a big influence on the frame work of Korean modern architecture in the transitional times.

• KOMUNHWA
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• no.68
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• pp.7-24
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• 2006

This article is the critical review of the methods and assumptions with which the Korean archaeologists have tried to approach to the Bronze age society. It was not until the 1980s' that there had been any attempt to define the relevant units for the study of past societies. Before the archaeological records of megalithic builders in the Bronze age began to be analyzed to find out the general traits of chiefdom society, Korean archaeologists had described the variations in the cultural, rather than the social, entities. From the 1990s' , some scholars have attempted to reconstruct the scale and organization of the social groups and explain the growth of polities in evolutionary view, analyzing the hierarchical distributions of settlement data. In the concluding remarks of the review, I would like to indicate the some problems in the conceptualization of the material culture patterning in the regional and/or inter-regional level. First, the conceptual problem which appeared when the Bronze archaeologists define the distribution of artifact assemblages, composed of the specific artifact traits , beyond the instrumental categories that are efficient for the establishments of regional chronologies. It is evidently erroneous conceptualization that we define the artifact assemblages as the socio-cultual entities which came into being in specific time and place, geographically expanded, and finally disappeared based on the view of essentialism. Second, the interpretative problems about wide distributions of certain bronze artifacts must be indicated. I would like to suggest that the wide distributions of the specific bronze dagger or mirror types should be explained not by the cultural area concept related to the ethnicity assumptions, but by the world system or the inter-regional interaction models.

• Journal of architectural history
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• v.20 no.3
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• pp.7-22
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• 2011

With the accumulations of outcomes from archaeological excavations of mountain fortress of three kingdoms period, there have been studies about time-periodic territory range of mountain fortress, difference in the way(method) of construction, defence system and so on from various points of view. This is an empirical study on the construction method of the valley part of stone fortress. First of all, it is required to secure large quantity of fresh water for those who lived at mountain fortress. Especially when builders of fortress construct a fortification at the valley part of stone fortress, in advance they must sufficiently consider several options including the establishment of sustainable water resources. First, when it comes to build a fortification on a ridge[or a slope] of a mountain, you have only to consider a vertical stress. However, when it comes to build a fortification at the valley part of a mountain, You must have more sufficient preparations for the constructing process. Because there are not only a vertical stress but also a horizontal pressure simultaneously. Second, a fortification of mountain fortress built by using unit building stone is a structure of masonry construction like brick construction, and the valley part of it is where the construction of the fortification begins. Third, when it comes to build a fortification at the valley part of a mountain, it seems that they use a temporary method such as coffer dam in oder to prevent the collapse of the fortification due to heavy rain. Furthermore, in response to a horizontal pressure a fortification is built by the way of its plane make an arch, or by piling up the soil with the plate method(類似版築) and earthen wall harder method(敷葉) they increase cross-sectional area of the fortification and its cutoff capacity. In front direction they put the reservoir facility for the fear that the hydraulic pressure and earth pressure are directly transmitted to the fortification. The process of constructing the fortification at the valley part of a mountain is done in the same oder as follows; leveling of ground(整地) ${\Rightarrow}$ construction of coffer dam ${\Rightarrow}$ construction of the fortification between the both banks of the valley ${\Rightarrow}$ construction of the fortification at bottom part of spill way(餘水路) between the both banks of the valley ${\Rightarrow}$ construction of spill way(餘水路) & reservoir facility ${\Rightarrow}$ construction of the fortification at upper part of spill way between the both banks of the valley. Coffer dam facility seems to be not only the protection device on occasion of flood but also an important criterion to measure the proper height of spill way or tailrace(放水路). This study has a meaningful significance in that it empirically examines the method of reduction of the horizontal pressure which the fortification at the valley part of a mountain takes, the date the construction was done, and wether the changes in climate such as heavy rainfall influence the process of construction.

• The KIPS Transactions:PartA
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• v.8A no.3
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• pp.189-200
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• 2001

This paper proposes a memory allocation model for Real-Time Linux. The proposed model allows users to create several continuous memory regions in an application, to specify an appropriate region allocation policy for each memory region, and to request memory blocks from a necessary memory region. Instead of using single memory management module in order to support the proposed model, we adopt two-layered structure that is consisted of region allocators implementing allocation policies and a region manager controlling regions and region allocator modules. This structure separates allocation policy from allocation mechanism, thus allows system developers to implement same allocation policy using different algorithms in case of need. IN addition, it enables them to implement new allocation policy using different algorithms in case of need. In addition, it enables them to implement new allocation policy easily as long as they preserver predefined internal interfaces, to add the implemented policy into the system, and to remove unnecessary allocation policies from the system, Because the proposed model provides various allocation policies implemented previously, system builders can also reconfigure the system by just selecting most appropriate policies for a specific application without implementing these policies from scratch.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.32 no.3
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• pp.21-31
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• 2014

This study aims to comparison of spatial composition that Okhojeong garden and Seokpajeong garden. Construct background and space structure in both of Okhojeong garden and Seokpajeong garden is analyzed. The results were as follows. First, Okhojeong garden and Seokpajeong garden of the nobles gardens in late Joseon dynasty. They had the advanced techniques of contemporary based on their political power and wealth, and therefore could built garden and enjoy the garden culture of the upper layer. Furthermore, composition of the Okhojeong garden can be assumed that it is related to construction of the Seokpajeong garden through analysis of the relationship between builders. Secondly, Space structure of Okhojeong garden and Seokpajeong garden is divided into pavilion unit of small gardens with living space as the center. Construction pavilion in each garden space imbues certain landscape theme. In addition, authorization of characteristics of a place in each area is attempted through boundary establishment and selective garden culture of varied seasonal landscape. Thirdly, In Seokpajeong garden, most of construction characteristics of Okhojeong garden are appeared. This indicates that Seokpajeong garden was affected by space-configuration-technique of Okhojeong garden such as acceptation or modification recreation. Fourth, In many cases, fanciers regarding floriculture are expanded to enthusiasts in late Joseon dynasty. In Okhojeong garden and Seokpajeong garden, herbaceous ornamental is considered to be precious and garden materials such as water tray, stone couch, oddly shaped stone, potted plant, artificial hill, wisteria trellis are diversified at the time.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.3 s.39
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• pp.115-135
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• 1990

The purpose of this study was to suggest an improvement proposal for colors in urban environment with special regard to the surface color and their situations of apartment buildings in Seoul. For this goal, 167 cases of different color types of apartment buildings were surveyed. And, the survey was performed in the view of color by areas, by localtion, by builder, by paint year, by built year, by appearance of building, and by surface texture to prove the influencing factors on the surface colors. These collected data analyzed and compared with the existing studies to find out the changing trend of colors. The results are as follows : 1) The use of neutral gray($26.4{\%}$) and warm color(YR, Y, GY; 56.4%) were dominant and the usage trend of higher 'value'(87.4%) and lower 'saturation'(73.0%) was obvious. Especially, the use of PB and P was noticeable. 2) In comparing the existing studies, the changing trend in the surface color pattern was found. That is, neutral gray was used dominantly in 1970's, warm color(YR, Y)in the middle of 1980's. In the end of 1980's, warm color were also used dominantly same as before and GY, PB, P were used noticeably with some rising tendency of higher 'value' and lower 'saturation' was obvious. 3) The results of analysis by localtion shows that the different color groups might exist in Seoul city. Neutral gray and YR were dominant in zone I. Warm colors(YR, Y, GY)were prevailed in zone II, III, IV. In zone V, many colors were evenly used. In zone VI, middle values at warm color were dominant. Progressively, these color groups with further study could be considered in the color management in urban environment possibly. 4) Surface color of apartment buildings were different from their builders. 5) Concerned with the painted year, the use of higher 'value' and lower 'saturation' was increased gradually with the change of times. 6) the analysis by the built year revealed that the 'value' of surface colors on the old buildings was lower than that of the new ones. 7) The 'value' of colors on the surface with texture was higher than that of the surface without texture. 8) In the combination of two colors, the use of 'value' with difference at the same 'hue' was found harmonions in many cases, but the 'saturation' in usage was included in the ambiguity (Moon & Spencer's term). The ambiguity in color harmony should be improved in the near future.

• The Korean Journal of Soil Zoology
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• v.5 no.1
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• pp.21-32
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• 2000

A faunistic study on the spiders (Arachnida: Araneae) from Mt. Jumbong Kangwon-do was carried out from 1996 to 1999. During the survey period, 144 species of 88 genera belonging to 27 families including 5 undetermined species were identified from 900 collecting individuals. The dominant families were Linyphiidae 21 species; 14.6% of total species), Araneidae (20 species, 13.9%), Theridiidae (16 species, 11.1%), and Salticidae 12 species, 8.3%). The composition of the species of web builders was richer than that of hunters. As for species commonness with adjacent countries, the numbers of common species between Mt. Jumbong and Japan, Mt. Jumbong and China, and Mt. Jumbong and Russia were 15 species (80.4%), 98 species (68.5%), and 48 species (33.6%), respectively. The number of common species among these four regions were 39 species (27.3%). So, the spider species composition in Mt. Jumbong seemed being much similar to those in neighbor countries. An outline of biogeographical distribution of spiders can be summarized as 1 Cosmopolitan species (0.7%), 16 Palearctic species (11.2%), 7 Holarctic species (4.9%), 25 Korean endemic species (17.4%) and no Oriental species. In the spider fauna at Mt. Jumbong, therefore, there are high level of occurrence of Korean endemic species with northern spiders as Palearctic and Holarctic species. The level and direction of man-made development may have negative effect on regional biota.

• Korean Journal of Construction Engineering and Management
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• v.12 no.2
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• pp.3-11
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• 2011

There are several causes to recalculate the contract amount in public construction projects. Among them, the escalation clause was introduced in 1969 and now the condition to recalculate the cost is effective after 90 days from the date of contract and the rate of fluctuation should be more than 3% from the date of bidding. The two calculation methods for the rate of fluctuation are item-adjustment and index-adjustment. According to the results of investigation into 4 public institutions and 163 projects, all of them have used the method of index-adjustment and the rate of projects that spend over 6 months obtaining the approval of contract amount adjustment is more than 90%. The reason for spending lots of time is caused by problems of the calculation method on the price fluctuation rate. Therefore, it is necessary that the calculation method should be diversified to cope with the problems and a option of the builder should be expanded as well. Furthermore, if the way to apply correction factors to construction price index and average index based on the producer and consumer price index made by the bank of Korea is added, then the duration will be reduced without additional expenses. This study proposed the diversification of the calculation method using price fluctuation rate and builders' expanded options as improvement on the managerial method of Price Fluctuation System for the prompt and efficient contract amount adjustment.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.1019-1022
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• 2007

Recent construction projects are becoming larger, more complex and higher rising. Accordingly, necessity of the VE is emphasized as more suitable for expense, function and quality. However, the VE is not functional because of difficulty of application process or of the methods in use in the field of construction. One of the alternative is to introduce the incentive system to activate the VE in the field of construction. By using the incentive system, employers can reduce the relevant project's prime cost and builders will maximize profit creation. In domestic case, they presented the systematic support policy 'Technical development compensation system' which is similar to the 1992 American's VE incentive system about builder's technical development effort but the result was not positive. This study investigates both domestic and other country's construction VE incentive system and reported problems in the construction VE incentive system to executives and construction VE experts. From this survey, conclusions were drawn about problems in the domestic construction VE incentive system's similarity system: 'Insufficiency of the construction VE incentive's article and standards', 'Insufficiency of the appraiser of the construction VE and of the full charge department' etc. I had interviews with the experts of the construction VE which were based on the above-mentioned problems and then presented 'Improvement of the construction VE's incentive system relevant law and system', 'Construction VE experts and construction formation' etc. for ways to bring acceptance of the construction VE in the construction industry.