• Journal of Microbiology and Biotechnology
• /
• v.29 no.8
• /
• pp.1193-1203
• /
• 2019

We investigated the protective effects of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) from Polysiphonia morrowii Harvey against hydrogen peroxide ($H_2O_2$)-induced apoptosis in Vero cells. BDB exhibited scavenging activity for DPPH, hydroxyl, and alkyl radicals. BDB also inhibited $H_2O_2$-induced lipid peroxidation, cell death, and apoptosis in Vero cells by inhibiting the production of ROS. To evaluate the molecular mechanisms of apoptosis inhibition, the expression of Bax/Bcl-xL and $NF-{\kappa}B$ was assessed by western blot assay. BDB significantly suppressed the cleavage of caspase-9 and PARP and reduced Bax levels in $H_2O_2$-induced Vero cells. Besides, BDB suppressed the phosphorylation of $NF-{\kappa}$B and the translocation of p65 in $H_2O_2$-induced cells. Furthermore, we evaluated the effect of BDB on ROS production, cell death, and lipid peroxidation in an $H_2O_2$-stimulated zebrafish embryo model. Taken together, these results indicated that ROS generation and cell death were significantly inhibited by BDB in zebrafish embryos, thereby proving that BDB exerts excellent antioxidant activity in vitro and in vivo.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.11
• /
• pp.4067-4070
• /
• 2011

• Journal of the Korean Chemical Society
• /
• v.20 no.3
• /
• pp.244-247
• /
• 1976

• Journal of the Korean Chemical Society
• /
• v.61 no.5
• /
• pp.286-290
• /
• 2017

• Proceedings of the PSK Conference
• /
• 2000.04a
• /
• pp.169.3-170
• /
• 2000

• Proceedings of the Korean Society of Potoscience Conference
• /
• spring
• /
• pp.73-74
• /
• 1999

• Bulletin of the Korean Chemical Society
• /
• v.23 no.7
• /
• pp.1021-1022
• /
• 2002

• Archives of Pharmacal Research
• /
• v.4 no.2
• /
• pp.137-139
• /
• 1981

Reaction of olefinic acids with N-bromophthalimide in dry N, N-dimethylf-ormamide at room temperature gives bromolactones in good yields.

• Bulletin of the Korean Chemical Society
• /
• v.16 no.12
• /
• pp.1212-1218
• /
• 1995

An efficient synthesis of 6,8-dioxa-1,4-diazacyclopenta[b]phenanthren-5-one (Pyrazinopsoralen) (4) has been carried out by the Suzuki coupling reaction as a key step starting from 5-bromo-6-methoxybenzofuran (6) and methyl 2-iodo-3-pyrazinecarboxylate (8).

• Bulletin of the Korean Chemical Society
• /
• v.21 no.6
• /
• pp.611-612
• /
• 2000

A facile synthetic route for the preparation of 4-halobutyl benzoates has been developed. 4-Chloro-, bromo-and iodobutyl benzoates can be easily prepared from the reaction of benzoyl chloride and metal halides in THF under extremely mild conditions. 4-Halo groups were easily controlled by selecting suitable metal halides.