• 대한수의학회지
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• 제44권4호
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• pp.621-624
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• 2004

A 13-year-old female Miniature Pincher was euthanized after suffering from respiratory insufficiency and seizure. At necropsy, firm tan masses approsimately 4 to 5 cm in diameter were noted at the right caudal love and left cranial lobe of the lung. On cross sections of the cerebellum and the verebrum, several compressive firm round masses, 0.5 to 1 cm in diameter, were noted. similar looking nodules were also present in the mediastinal lymph nodes. Histopathologically, the neoplastic masses consisted of cuboidal shape epithelial cells that form glandular structure. The neoplastic cells have hyperchromatic nuclei with prominent nucleoli and moderate amount of cytoplasm. The degree of mitosis was high (4-6/400X). Multiple areas of necrosis, hemorrhage, and tumor emboli were also noted. Metastasis to the mediastinal lymph nodes, pancreas, and brain was confirmed. Based on the gross and histopathologic examinations, a diagnosis of primary metastatic pulmonary adenocarcinoma was made. Clinicaly recognized neurological signs were therefore due to brain metastasis.

• Journal of Veterinary Science
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• 제22권6호
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• pp.86.1-86.13
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• 2021

Background: Conditioned medium is the medium obtained from certain cultured cells and contained secretome from the cells. The secretome, which can be in the form of growth factors, cytokines, exosomes, or other proteins secreted by the cells, can induce the differentiation of cells that still have pluripotent or multipotent properties. Objectives: This study examined the effects of conditioned medium derived from E17 rat brain cells on cells with pluripotent properties. Methods: The conditioned medium used in this study originated from E17 rat brain cells. The CM was used to induce the differentiation of primary colonies of mice blastocysts. Primary colonies were stained with alkaline phosphatase to analyze the pluripotency. The morphological changes in the colonies were examined, and the colonies were stained with GFAP and Neu-N markers on days two and seven after adding the conditioned medium. Results: The conditioned medium could differentiate the primary colony, beginning with the formation of embryoid-body-like structure; round GFAP positive cells were identified. Finally, neuron-like cells testing positive for Neu-N were observed on the seventh day after adding the conditioned medium. Conclusions: Conditioned medium from different species, in this case, E17 rat brain cells, induced and promoted the differentiation of the primary colony from mice blastocysts into neuron-like cells. The addition of CM mediated neurite growth in the differentiation process.

• 수면정신생리
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• 제27권2호
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• pp.67-76
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• 2020

목 적 : 뇌가 성숙해감에따라, 비대칭과 편측성역시 기능적, 효율적인 관점에서 볼 때, 성숙과 더불어 정보처리를 효과적으로 하기 위한 과정이라 할 수 있다. 인지적 복잡성이 높아지는 시기인 6~9세와 14~17세 사이의 뇌의 변화를 휴지기 뇌파를 주파수 분석을 하여 알아 본다. 방 법 : 본 연구는 6~9세(n = 24)와 14~17세(n = 26)의 피험자들의 뇌파는 공개된 자료(Multimodal Resource for Studying Information Processing in the Developing Brain, MIPDB)를 분석하였고, 정신과적 질환이 있거나, 잡파가 심한 뇌파의 피험자는 제외하여 최종적으로 6~9세(n = 14)와 14~17세(n = 11)을 대상으로, EEGlab을 이용하여 뇌파를 분석하였고, 적어도 2분이상의 휴지기 뇌파 중 눈을 감은 상태의 뇌파를 이용하여 주파수 분석을 하였다. 뇌의 구역을 총 9구획으로 나눠서 주파수 분석을 하여, 주파수별 비대칭성과 편측성을 측정하였다. 결 과 : 전반적으로 서파의 파워는 나이가 어릴수록 높았으며, 이 현상은 절대파워와 상대파워에 상관없이 나타났다. 베타밴드의 상대파워는 좌우 편측성없이 14~17세 그룹이 높았다. 비대칭성의 경향은 휴지기 뇌파에서 세타밴드와 알파밴드의 상대파워에서만 두 그룹간의 차이가 관찰되었으며, 세타파는 왼쪽 전두엽 구획에서 14~17세군이 오른쪽 전두엽구획에 비해서 높게 측정되었고, 이 현상은 두정엽 구획으로 갈 수록 반대의 경향, 즉 두정엽 구획에서는 오른쪽 세타밴드파워가 왼쪽의 세타밴드파워에비해서 높게 측정되었다. 알파밴드의 상대파워는 두정엽구획에서 왼쪽의 파워가 오른쪽의 파워보다 높게 측정되었다. 편측성을 보이는 주파수는 알파밴드였으며, 절대파워와 상대파워 모두에서 왼쪽의 알파밴드파워가 오른쪽에 비해서 높게 나타났으며 그 차이가 통계적으로 유의미하였다. 결 론 : 6~9세의 피험자들에 비해서 14~17세의 피험자들은 성장기를 거치며 비교적 수준이 높은 인지기능 및 수행기능을 하게 되고, 이 기능과 관련하여 베타밴드와 알파밴드가 이 변화를 반영한다고 볼 수 있다.

• Smart Structures and Systems
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• 제15권3호
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• pp.807-830
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• 2015

When a building structure requires both health monitoring system and vibration control system, integrating the two systems together will be cost-effective and beneficial for creating a smart building structure with its own sensors (nervous system), processors (brain system), and actuators (muscular system). This paper presents a real-time integrated procedure to demonstrate how health monitoring and vibration control can be integrated in real time to accurately identify time-varying structural parameters and unknown excitations on one hand, and to optimally mitigate excessive vibration of the building structure on the other hand. The basic equations for the identification of time-varying structural parameters and unknown excitations of a semi-active damper-controlled building structure are first presented. The basic equations for semi-active vibration control of the building structure with time-varying structural parameters and unknown excitations are then put forward. The numerical algorithm is finally followed to show how the identification and the control can be performed simultaneously. The results from the numerical investigation of an example building demonstrate that the proposed method is feasible and accurate.

• 한국ITS학회 논문지
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• 제11권3호
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• pp.112-123
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• 2012

교차로는 일반 도로와 달리 서로 다른 기하구조 및 교통운영을 가진 도로가 결합되는 지점으로 매우 복잡한 도로 환경적 요인을 내포하고 있다. 특히, 교차로 접근도로에서 진입하는 차량 간의 상충과 정지 신호시 급정지, 녹색 등화시 급출발 등 다양한 주행패턴의 변화로 인해 교통사고는 지속적으로 발생되며, 교통사고의 주요 발생원인은 인적요인으로 알려져 있다. 이에 본 연구에서는 교차로 영향권 내에서의 운전자 행동에 영향을 주는 요인을 도출하기 위해 최첨단 계측장비를 활용한 뇌파, 시각, 주행속도 등의 생리적 반응을 측정하였다. 개별 교차로의 집중도 뇌파는 보조 간선도로에 비해서 주 간선도로, 사고다발 교차로에서 피실험자의 생체적 반응 뇌파가 높게 출현되고 있음을 규명하였다. 또한, 사고다발 교차로에 서 운전자의 시각활동은 넓게 분포함으로써 주변 차량으로부터의 주의운전을 강화하고 있는 것으로 분석되었다. 또한, 운전자 부하를 유발하는 주요 요인으로 감속과 가속, 주변 차량의 차로변경, 주행속도 변화 등의 요인이 운전자 부하에 직접적인 요인으로 나타나 교차로의 교통사고의 발생원인과 매우 밀접한 관계가 있음을 규명하였다. 본 연구의 결과는 향후 운전자의 생체반응을 고려한 교차로의 안전성 평가를 위한 기초자료로 할용이 가능할 것으로 판단된다.

• Investigative Magnetic Resonance Imaging
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• 제23권1호
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• pp.34-37
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• 2019

Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic systemic fibrosis (NSF). Furthermore, recently the long-term retention of $Gd^{3+}-based$ CAs in brains patients with normal renal function raised another possible safety issue. The safety concerns of $Gd^{3+}-based$ CAs have been based on the ligand structure of $Gd^{3+}-based$ CAs, and findings that $Gd^{3+}-based$ CAs with linear ligand structures showed much higher incidences of NSF and brain retention of CAs than $Gd^{3+}-based$ CAs with macrocyclic ligand structure. In the current study, we report the in vivo biodistribution profile of a new highly stable multifunctional $Gd^{3+}-based$ CA, with macrocyclic ligand structure (HNP-2006). MR imaging using HNP-2006 demonstrated a significant contrast enhancement in many different organs. Furthermore, the contrast enhanced tumor imaging using HNP-2006 confirmed that this new macrocyclic CA can be used for detecting tumor in the central nervous system. Therefore, this new multifunctional HNP-2006 with macrocyclic ligand structure shows great promise for whole-body clinical application.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.707-712
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• 1998

This paper presents several softcomputing techniques such as neural networks, fuzzy logic and genetic algorithms : Neural networks as brain metaphor provide fundamental structure, fuzzy logic gives a possibility to utilize top-down knowledge from designer, and genetic algorithms as evolution metaphor determine several system parameters with the process of bottom up development. With these techniques, we develop a pattern recognizer which consists of multiple neural networks aggregated by fuzzy integral in which genetic algorithms determine the fuzzy density values. The experimental results with the problem of recognizing totally unconstrained handwritten numeral show that the performance of the proposed method is superior to that of conventional methods.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1991년도 하계학술대회 논문집
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• pp.892-895
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• 1991

In this study, it has been refering that disposal of rapidly international information society and artificial intelligence neural networks of the vanguard software technology. This paper is human brain cell structure modeling in order to neural networks realization for order language and computer embodiment of parallel processing. And it is shown that the usage extreme of time saving and correct judgement for business services, Overviews some of the currently popular neural networks architectures, and describes the current state of the neural networks technology.

• 한국산업정보학회:학술대회논문집
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• 한국산업정보학회 2002년도 춘계학술대회 논문집
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• pp.367-371
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• 2002

I construct a chaotically driven contraction system having some analogy with the information transfer mechanism in the brain system especially from CA1 cell to CA3 cell known from the empirical result. And I consider the properties of the response system on a state space according to the external input into the drive neuron by observing the fractal hierarchical structure. Then I induce the relation between the information about state transition of the chaotic time series and the spatial information on a fractal attractor to confirm the possibility of encoding of time series data to spatial information.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.88.2-88
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• 2001

In this paper Author introduce a new field named Artificial Life and its main directions of research. That is the research of evolutionary robot and artificial brain. Then author explored the advanced scientific thought hidden in them. Furthermore, the author tries intuitively to show a new type of control that is heuristically raised from artificial life research. It could be named as evolutionary control. This type of control is more like human body´s structure, and it is self-organized.