Browse > Article

Pulmonary adenocarcinoma with brain metastasis in a Miniature Pincher  

Kang, Min-Soo (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Kwon, Hyo-Jung (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Park, Mi-Sun (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Youn, Hwa-Young (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Han, Man-Gil (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Kim, Dae-Yong (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Publication Information
Korean Journal of Veterinary Research / v.44, no.4, 2004 , pp. 621-624 More about this Journal
Abstract
A 13-year-old female Miniature Pincher was euthanized after suffering from respiratory insufficiency and seizure. At necropsy, firm tan masses approsimately 4 to 5 cm in diameter were noted at the right caudal love and left cranial lobe of the lung. On cross sections of the cerebellum and the verebrum, several compressive firm round masses, 0.5 to 1 cm in diameter, were noted. similar looking nodules were also present in the mediastinal lymph nodes. Histopathologically, the neoplastic masses consisted of cuboidal shape epithelial cells that form glandular structure. The neoplastic cells have hyperchromatic nuclei with prominent nucleoli and moderate amount of cytoplasm. The degree of mitosis was high (4-6/400X). Multiple areas of necrosis, hemorrhage, and tumor emboli were also noted. Metastasis to the mediastinal lymph nodes, pancreas, and brain was confirmed. Based on the gross and histopathologic examinations, a diagnosis of primary metastatic pulmonary adenocarcinoma was made. Clinicaly recognized neurological signs were therefore due to brain metastasis.
Keywords
Dog; lung tumor; metastasis; brain;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Jones, T. C., Hunt, R. D. and King, N. W. Veterinary pathology, pp. 971-972. 6th ed. Williams & Wilkins, Maryland, 1997
2 Moore, J. A. and Taylor, H. W. Primary pulmonary adenocarcinoma with brain stem metastasis in a dog. J. Am. Vet. Med. Assoc. 1988, 192, 219-221
3 Hawkins, E. C., DeNicola, D. B. and Kuehn, N. F. Bronchoalveolar lavage in the evaluation of pulmonary disease in the dog and cat. State of the art. J. Vet. Intern. Med. 1990, 4, 267-274
4 Donald, J. M. Tumors in domestic animals, pp. 380-392. Iowa state press, Iowa, 2002
5 Stunzi, H., Head, M. W. and Nielsen, S. W. Tumors of the lung. Bull. World Health Organ. 1974, 50, 9-19
6 Hawkins, E. C., Morrison, W. B., DeNicola, D. B. and Blevins, W. E. Cytologic analysis of bronchoalveolar lavage fluid from 47 dogs with multicentric malignantlymphoma. J. Am. Vet. Med. Assoc. 1993, 203, 1418-1425
7 Redman, H. C., Hahn, F. F. and Muggenburg, B. A. Electroencephalographic correlates of a metastatic brain tumor in a beagle dog. Am. J. Vet. Res. 1973, 34, 681-684
8 Humphery, E. W., Ewing, S. L., Wrigley, J. V., Northrup, W. F. 3rd, Kersten, T. E., Mayer, J. E. and Varco, R. L. The production of malignant tumors of the lung and pleura in dogs from intratracheal asbestos instillation and cigarette smoking. Cancer. 1981, 47, 1994-1999
9 Sorjonen, D. C., Braund, K. G. and Hoff, E. J. Paraplegia and subclinical neuromyopathy associated with a primary lung tumor in a dog. J. Am. Vet. Med.Assoc. 1982, 180, 1209-1211
10 Gillett, N. A., Stegelmeier, B. L., Kelly, G., Haley, P. J. and Hahn, F. F. Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs. Vet. Pathol. 1992, 29, 46-52