• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.10a
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• pp.170-174
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• 2007

Although research efforts for brain waves have prospered in medicine and engineering, acupuncture still has a long way to go regarding researches on brain waves analysis. Thus this study set out to analyze brain waves stimulated by indirect mugwort moxibustion, which was part of acupuncture techniques, and to investigate their correlations with the automatic nervous system. For the experiments, stimulation was given to Jungwan, Shingwol and Gwanwon, which were some of the spots on the body suitable for acupuncture, through indirect mugwort moxibustion. The subjects' brain waves were measured before the stimulation, during the stimulation, and one hour and two hours after the stimulation. The measurements were analyzed with Matlab 7.0 for FFT and frequency power spectrum. Then the ${\alpha}$, ${\beta}$, ${\delta}$, and ${\theta}$ waves were analyzed and examined for changes to the percentage of each frequency and to the amplitude of vibration according to the stages of stimulation. The EEG data of the entire brain were translated into FFT to analyze the percentage of the ${\alpha}$, ${\beta}$, ${\delta}$, and ${\theta}$ waves. As a result, the ${\alpha}$ waves recorded a double increase after the stimulation. The power spectrum analysis results of the entire brain decreased the ${\alpha}$ and ${\beta}$ waves dropping in the energy level, which suggested that the parasympathetic nerves were activated. When the results of the study were compared with those of the previous study, it's confirmed that indirect moxibustion stimulation could cause changes to the automatic nervous system and bring stability to those who were nervous or under stress due to the proportionate increase of the ${\alpha}$ waves.

• Journal of Biomedical Engineering Research
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• v.28 no.5
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• pp.657-664
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• 2007

Stroke patients need regular medical treatments and rehabilitation training from their doctors. However, severe aftereffects caused by stroke allow them minimum activities, which make it difficult for them to visit doctor. Recently, electric brain stimulation treatment has been found to be better way compared to conventional ones and many are interested in using this method for the treatment of stroke. In this study, we have developed a remote medical treatment system using wireless electric brain stimulator that can help the stroke patients to get a treatment without visiting their doctors. The developed remote medical treatment system connects the doctors to the brain stimulator implanted in the patients via the internet and ZigBee communication built in the brain stimulator. Also, the system receives personal information of the connected patients and cumulates the total records of electric stimulation therapy in a database. Doctors can easily access the information for better treatment planning with the help of graphical visualization tools and management software. The developed remote medical treatment system can be applied to the electric stimulation treatments for other brain diseases with a minor change.

• Journal of Biomedical Engineering Research
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• v.44 no.6
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• pp.377-383
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• 2023

Purpose: There is increasing attention to the application of transcranial direct current stimulation (tDCS) for enhancing cognitive functions in subjects to aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD). Despite varying treatment outcomes in tDCS which depend on the amount of current reaching the brain, there is no general information on the impacts of anatomical features associated with AD on tDCS-induced electric field. Objective: The objective of this study is to examine how AD-related anatomical variation affects the tDCS-induced electric field using computational modeling. Methods: We collected 180 magnetic resonance images (MRI) of AD patients and healthy controls from a publicly available database (Alzheimer's Disease Neuroimaging Initiative; ADNI), and MRIs were divided into female-AD, male-AD, female-normal, and male-normal groups. For each group, segmented brain volumes (cerebrospinal fluid, gray matter, ventricle, rostral middle frontal (RMF), and hippocampus/amygdala complex) using MRI were measured, and tDCS-induced electric fields were simulated, targeting RMF. Results: For segmented brain volumes, significant sex differences were observed in the gray matter and RMF, and considerable disease differences were found in cerebrospinal fluid, ventricle, and hippocampus/amygdala complex. There were no differences in the tDCS-induced electric field among AD and normal groups; however, higher peak values of electric field were observed in the female group than the male group. Conclusions: Our findings demonstrated the presence of sex and disease differences in segmented brain volumes; however, this pattern differed in tDCS-induced electric field, resulting in significant sex differences only. Further studies, we will adjust the brain stimulation conditions to target the deep brain and examine the effects, because of significant differences in the ventricles and deep brain regions between AD and normal groups.

• Journal of Information Technology Applications and Management
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• v.9 no.4
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• pp.165-177
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• 2002

For measuring EEG with the international 10-20 electrode system on 16 channels, and to analyze the interrelationship between the original signals and the changed signals after the stimulation, we use the scent of lavender which stimulates the olfactory sense. Moreover, the effect of the scent stimulation to the brain is analyzed. The purpose of this analysis is to apply these results to the computerized mapping of the brain signals and to find possible ways of specifying the source of the brain signals through various medical applications.

• Science of Emotion and Sensibility
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• v.16 no.4
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• pp.481-492
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• 2013

This study sorted scores of individual characteristics and multiple intelligence by sex, handle, blood type and age through previous questionnaire with 462 adult males and females. Then electrode was attached to prefrontal lobes Fp1 and Fp2 with EEG measuring system and changes of concentration between no stimulation state and pure pink noise stimulation and their relations to multiple intelligence were examined. As a result of analysis of covariance, the mean concentration of all subjects was significantly higher in the pink noise stimulation compared to no stimulation. According to individual characteristics, concentration was significantly higher in left-hander, type A blood, and group in their thirties except for gender. Concentration in pink noise state strengthened the relation to spatial intelligence and made negative correlations with musical intelligence compared to no stimulation state. These results suggested that individual characteristics should be reflected on using pink noise for improving concentration.

• Journal of Korean Neurosurgical Society
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• v.54 no.2
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• pp.118-124
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• 2013

Objective : Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment of choice for patients with advanced idiopathic Parkinson's disease (PD) who have motor complication with medication. The objectives of this study are to analyze long-term follow-up data of STN DBS cases and to identify the factors related to outcomes. Methods : Fifty-two PD patients who underwent STN DBS were followed-up for more than 3 years. The Unified Parkinson's Disease Rating Scale (UPDRS) and other clinical profiles were assessed preoperatively and during follow-up. A linear regression model was used to analyze whether factors predict the results of STN DBS. We divided the study individuals into subgroups according to several factors and compared subgroups. Results : Preoperative activity of daily living (ADL) and the magnitude of preoperative levodopa response were shown to predict the improvement in UPDRS part II without medication, and preoperative ADL and levodopa equivalent dose (LED) were shown to predict the improvement in UPDRS part II with medication. In UPDRS part III with medication, the magnitude of preoperative levodopa response was a predicting factor. Conclusion : The intensity of preoperative levodopa response was a strong factor for motor outcome. And preoperative ADL and LED were strong factors for ADL improvement. More vigorous studies should be conducted to elucidate how levodopa-induced motor complications are ameliorated after STN DBS.

• The Journal of Korean Physical Therapy
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• v.19 no.4
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• pp.33-41
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• 2007

Purpose: To investigate environmental enrichment and nerve stimulation follows in application times with the change of BDNF & Trk-B receptor in the motor cortex and spinal cord. Methods: Experimental groups were divided into the five groups. Group I: normal control group, Group II: experiment control group, Group III: sciatic never electrical stimulation after MCAO, Group IV: application of only environmental enrichment after MCAO, Group V: never electrical stimulation with environmental enrichment after MCAO. Histologic observation and coronal sections were processed individually in goat polyclonal antibody phosphorylated BDNF and rabbit polyclonal antibody Trk-B receptor. Results: In immunohistochemistric response of BDNF and Trk-B, group II were showed that lower response effect at postischemic 1 days, 3 days, and 7 days. Group V were showed that increase response effect at postischemic 3 days, 7 days and 14 days. Specially showed that the most response effect at postischemic 14 days. In neurobehavioral assessment, group V were significantly difference from other groups on between-subject effects. Conclusion: The above results suggest that combined environmental enrichment with peripheral nerve electrical stimulation in focal ischemic brain injury were more improved that the change of BDNF & Trk-B receptor expression than non treatment.

• Sleep Medicine and Psychophysiology
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• v.28 no.1
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• pp.2-5
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• 2021

Hyperarousal or increased brain excitability is thought to play a key role in the pathophysiology of insomnia. Neuromodulation techniques are emergent complementary therapies for insomnia and can improve sleep by modulating cortical excitability. A growing body of literature support the idea that neuromodulation can be effective in improving sleep or treating insomnia. Recent evidence has revealed that neuromodulation methods can improve objective and subjective sleep measures in individuals with insomnia, although effects vary according to protocol. Different mechanisms of action might explain the relative efficacy of neuromodulation techniques on sleep outcomes. Further research testing different stimulation parameters, replicating existing protocols, and adding standardized sleep-related outcomes could provide further evidence on the clinical utility of neuromodulation techniques.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.153-161
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• 2007

Stroke is the second most significant disease leading to death in Korea. The conventional therapeutic approach is mainly based on physical training, however, it usually provides the limited degree of recovery of the normal brain function. The electric stimulation therapy is a novel and candidate approach with high potential for stroke recovery. The feasibility was validated by preliminary rat experiments in which the motor function was recovered up to 80% of the normal performance level. It is thought to improve the neural plasticity of the nerve tissues around the diseased area in the stroked brain. However, there are not so much research achievements in the electric stimulation for stroke recovery as for the Parkinson's disease or Epilepsy. This study aims at the developments of a wireless variable pulse generator using ZigBee communication for future implantation into human brain. ZigBee is widely used in wireless personal area network (WPAN) and home network applications due to its low power consumption and simplicity. The developed wireless pulse generator controlled by ZigBee can generate various electric stimulations without any distortion. The electric stimulation includes monophasic and biphasic pulse with the variation of shape parameters, which can affect the level of recovery. The developed system can be used for the telerehabilitation of stroke patient by remote control of brain stimulation via ZigBee and internet. Furthermore, the ZigBee connection used in this study provides the potential neural signal transmission method for the Brain-Machine Interface (BMI).

• Journal of Sensor Science and Technology
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• v.20 no.1
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• pp.19-24
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• 2011

Brain disorders such as epilepsy is a condition that affects an estimated 2.7 million Americans, 50,000,000 worldwide, approximately 200,000 new cases of epilepsy are diagnosed each year. Of the major chronic medical conditions, epilepsy is among the least understood. Scientists are conducting research to determine appropriate treatments, such as the use of drugs, vagus nerve stimulation, brain stimulation, and Peltier chip-based focal cooling. However, brain stimulation and Peltier chip-based stimulation processes cannot effectively stop seizures. This paper presents simulation of a novel heat enchanger network(HEN) technique designed to stop seizures by using a neural cooling probe to stop focal and spontaneous seizures by cooling the brain. The designed probe was composed of a U-shaped tube through which cold fluid flowed in order to reduce the temperature of the brain. The simulation results demonstrated that the neural probe could cool a 7 $mm^2$ area of the brain when the fluid was flowing atb a velocity of 0.55 m/s. It also showed that the neural cooling probe required 23 % less energy to produce cooling when compared to the Peltier chip-based cooling system.