• 한국정보전자통신기술학회논문지
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• 제12권4호
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• pp.413-418
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• 2019

뇌와 관련된 질병(치매, 조현병, 우울증, 파킨슨병 등)을 가진 환자의 치료 및 재활 정도의 진행을 확인하고자 하는 연구가 현재 활발히 진행되고 있는 추세이다. 그 중에서 경두개 자기 자극법(Transcranial magnetic stimulation, TMS)은 뇌 질환이 있는 환자에게 비 침습적으로 뇌 신경 조절에 사용되는 기법이기 때문에 치료에 많이 사용되고 있다. 경두개 자기 자극 시 정상인의 근피로도는 증가하는 경향을 확인할 수 있다. 따라서 본 논문에서는 경두개 자기 자극 시에 운동 신경 유발 응답 측정을 위한 근전도 측정 시스템을 구축하여 피실험자의 Raw Data를 RMS 기법으로 분석하고, RMS 그래프의 경향을 통해 운동 신경 유발 응답 측정 시스템을 확인하고자 하는 것이 목표이다. 실험 방법으로는 피실험자의 위팔두갈래근의 수축과 이완 운동을 통해 피로한 상황까지 도달하게 한 후, 표면 근전도 기기를 통해 받아들인 원신호를 RMS 기법으로 분석한다. 실험 결과, RMS 그래프가 상승하는 경향을 확인 하였고, 이를 통해 구축된 근전도 측정 시스템으로 운동 신경 유발 응답을 측정한 데이터를 고려하여 개개인에 맞는 자기자극 강도 결정에 활용될 수 있을 것으로 사료된다.

• 대한물리의학회지
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• 제8권3호
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• pp.351-360
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• 2013

PURPOSE: The purpose of this study was to investigate the effects of observed action gait training on stroke patients. METHODS: 22 subjects were randomized into two groups. The observed action gait training performed that watched a video of normal gait before gait training and the general gait training without watching it. The experimental group(n=11) performed observed action gait training and the control group(n=11) performed general gait training. Both group received gait training for 3 times per week during 8 weeks. RESULTS: The experimental group showed significant differences in the cadence, gait velocity, stride, step, single limb support, double limb support, stride length and step length(p<.05). The control group showed significant differences only in the stride(p<.05). CONCLUSION: The observed action gait training affected coordination and weight shift, as well as symmetry of the body. Plasticity of the brain was facilitated by repetitive visual and sensory stimulation. The observed action gait training promoted the normal gait by watching the normal gait pattern. In conclusion, motor learning through the sensory stimulation promotes brain plasticity that could improve motor function, and observed action gait training indirectly identified stimulated brain activities.

• 대한인간공학회지
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• 제32권4호
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• pp.345-353
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• 2013

Objective: This research measured physiological and psychological effects of Vibroacoustic stimulation(VA) to scapular and sacrum of supine position on the mattress. Background: When vibroacoustic stimulation applies to human body, it has a positive influence on physiological and psychological effects by stimulating the organs, tissues and cells of whole body. Method: This experiment was conducted to 10 normal males in two conditions: no stimulation and vibroacoustic stimulation. No stimulation experiment was executed as a supine position for 30 minutes without any vibrational stimulus, while vibroacoustic stimulation was transmitted by the vibrational speaker, which uses 40Hz frequency. Subjects had a laser Doppler flowmeter probe in scapular, sacrum, and also had 8 channel electroencephalogram(EEG) measurement sensor in the scalp. Blood pressure and skin temperature were measured in two conditions with an underlying posture for 30 minutes. Additionally, blood flow rate and EEG were measured before and after for two minutes on two conditions. Results: According to the vibroacoustic stimulation, blood flow rate and skin temperature were increased, while blood pressure was decreased. When using vibroacoustic stimulation compared to no stimulation, blood flow rate went approximately two times higher, and skin temperature also higher 3~4 times. Furthermore, the relative alpha power of brain wave was significantly increased when we applied to vibroacoustic stimulation. Conclusion: This experiment tested the VAT embedded in mattress in two conditions. According to this experiment, VAT decreases blood pressure, improves not only a physiological effect on blood flow rate as well as skin temperature, but also psychological functions by increasing relative alpha power. Application: The results of the publishing trend analysis might help physiological and psychological effects of vibroacoustic stimulation.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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• pp.85-85
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• 2003

Purpose： To investigate whether or not acupuncture of GB34 produces a significant response of the modulation of somatomotor areas by functional magnetic resonance imaging (fMRI) study. Materials and methods： The acupoint, GB34, located in the back of the knee, is known to be effective in recovering motor function after stroke. Using 3T MRI scanner, functional MR imaging of the whole brain was peformed in 12 normal healthy subjects during two stimulation paradigms; acupuncture manipulation on GB34 and sham points. This study investigates the activation of the motor cortex elicited by a soft and an intensified stimulation of GB 34.Three different paradigms were carried out to detect any possible modulation of the Blood Oxygenation Level Dependent (BOLD) response in the somatomortor area to motor stimulation through acupuncture.

• Journal of Ginseng Research
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• 제14권3호
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• pp.399-403
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• 1990

This study was undertaken to investigate the effect of ginseng total sapoin (GTS) on locomotor activity that had been increased by caffeine. Catecholamines, noradrenaline and dopamine, possible mediators for the locomotor activity, were measllred in the mouse whole brain, cortex and the re- mainder. The locomotor activity was measured in circlllar activity cages equipped with six light sources and photocells. The catecholamine contents in the mollse brain were determined by HPLC-fluorescence detection. GTS (50 and 100 mg/kg) reduced the increased locomotor activity by caffeine (25 mg/kg) dose-devendently. Caffeine increased the norevinephrint and dopamine in mouse whole brain and cortex dose-dependently. GTS reduced the norevinevhrine in the remainder, and reduced the dopamine in the cortex which had been increased by caffeine.

• 재활치료과학
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• 제1권2호
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• pp.5-13
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• 2012

본 문헌고찰의 목적은 뇌졸중을 경험하는 대상자들을 위한 체성감각 자극 중심치료의 효과와 관련된 지금까지의 문헌들을 확인하고, 본 문헌고찰에 근거하여 임상환경에서 보다 효과적으로 적용할 수 있는 이상적인 체성감각자극 훈련방법을 제안하고자 함이다. 먼저, 문헌연구를 통해 뇌졸중을 경험하는 대상자를 중심으로 지금까지 주로 적용되었던 전기적 체성감각자극 치료의 효과성과 제한점을 확인하고, 최근문헌에 근거하여 임상환경에서 보다 효율적 적용이 가능할 것으로 기대되는 앞으로의 치료적 발전방향성을 제시하였다. 본 문헌고찰 결과, 현재까지 뇌졸중을 경험하는 대상자의 기능회복을 위한 체성감각 중심훈련의 필요성을 강조하는 연구 결과가 어느 정도 축적되어 있었음에도 불구하고 실제 임상에서는 재활치료 시 치료적인 여건에 제한으로 인해 구체적인 체성감각 자극입력의 치료적 적용은 제한점이 많은 것으로 확인되었다. 뿐만 아니라, 현재 이용 되고 있는 치료도구 역시 체성감각 및 특수감각을 고려한 도구는 거의 없는 것이 현실이었다. 하지만 본 문헌고찰을 통해서 분명히 확인할 수 있었던 것은 적절한 체성감각과 특수감각의 통합적 적용은 뇌졸중을 경험하는 대상자의 기능회복에 매우 긍정적인 효과를 보여주었다는 점이다. 뿐만 아니라, 치료적 환경에서 적용 가능한 적절한 기계적 인터페이스의 적용은 향후 뇌 손상 환자의 재활에 매우 긍정적인 영향을 줄 수 있을 것이라고 기대된다.

• 대한의용생체공학회:의공학회지
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• 제33권1호
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• pp.47-52
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• 2012

The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: $60.6{\pm}7.4yrs$, H&Y stage: $3.1{\pm}0.2$) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing average speed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-way repeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater than those of Med-off/DBS-off and Med-off/DBS-on (p < 0.01) whereas RMS angle was not different among conditions (p = 0.06). Two way repeated measures ANOVA showed that only medication improved RMS angular velocity (p < 0.01), whereas both medication and DBS had no significant effect on RMS angle (p > 0.02). Effect size of RMS angular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication and DBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated with different functional aspects in PD.

• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.346-350
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• 2009

Objective : The purpose of this study was to analyze in detail the relationship between outcome and time course of effect in medically refractory primary cervical dystonia (CD) with phasic type that was treated by bilateral globus pallidus internus (Gpi) deep brain stimulation (DBS). Methods : Six patients underwent bilateral implantation of DBS into the Gpi under the guide of microelectrode recording and were followed for $18.7{\pm}11.1$ months. The mean duration of the CD was $5.8{\pm}3.4$ years. The mean age at time of surgery was $54.2{\pm}10.2$ years. Patients were evaluated with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and relief scale using patient self-reporting. Results : The TWSTRS total scores improved by 64.5%, 65.5%, 75.8%, and 76.0% at 3, 6, 12 months, and at the last available follow-up after surgery, respectively. Statistically significant improvements in the TWSTRS scores were observed 3 months after surgery (p=0.028) with gradual improvement up to 12 months after surgery, thereafter, the improvement was sustained. However, there was no statistically significant difference between the scores at 3 and 12 months. Subjective improvement reported averaged $81.7{\pm}6.8%$ at last follow-up. Mild dysarthria, the most frequent adverse event, occurred in 3 patients. Conclusions : Our results show that the bilateral Gpi-DBS can offer a significant therapeutic effect from 3 months postoperatively in patients with primary CD with phasic type, without significant side effects.

• Molecules and Cells
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• 제37권4호
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• pp.307-313
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• 2014

Cell migration requires a defined cell polarity which is formed by diverse cytoskeletal components differentially localized to the poles of cells to extracellular signals. Rap-GAP3 transiently and rapidly translocates to the cell cortex in response to chemoattractant stimulation and localizes to the leading edge of migrating cells. Here, we examined localization of truncated RapGAP3 proteins and found that the I/LWEQ domain in the central region of RapGAP3 was sufficient for posterior localization in migrating cells, as opposed to leading-edge localization of full-length Rap-GAP3. All truncated proteins accumulated at the leading edge of migrating cells exhibited clear translocation to the cell cortex in response to stimulation, whereas proteins localized to the posterior in migrating cells displayed no translocation to the cortex. The I/LWEQ domain appears to passively accumulate at the posterior region in migrating cells due to exclusion from the extended front region in response to chemoattractant stimulation rather than actively being localized to the back of cells. Our results suggest that posterior localization of the I/LWEQ domain of RapGAP3 is likely related to F-actin, which has probably different properties compared to newly formed F-actin at the leading edge of migrating cells, at the lateral and posterior regions of the cell.

• Journal of Korean Neurosurgical Society
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• 제37권5호
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• pp.325-328
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• 2005

Objective: Stereotactic thalamic procedure is well known to be a effective treatment for disabling upper limb tremor of essential tremor. However, the effect of this procedure for head tremor, which is midline symptom of that disease entity, has not been sufficiently established. The authors discuss the result of stereotactic thalamic operations for head tremor of their patients who suffered from essential tremor. Methods: We evaluated 4 patients of essential tremor who had head tremor combined with both upper limb tremor. One patient underwent unilateral ventralis intermedius thalamotomy, two patients had unilateral Vim deep brain stimulation(DBS) and one patient had unilateral Vim thalamotomy and contralateral DBS. Postoperative results of tremor were evaluated using our proposed scale. Results: Contralateral upper limb tremors to surgical side were markedly resolved in all patients but there was no meaningful effect for head tremor in 3 patients who underwent unilateral thalamic surgery. In a patient having simultaneously unilateral thalamotomy and contralateral DBS, remarkable improvement of head tremor was observed. Conclusion: Although it is difficult to evaluate the efficacy of thalamic surgery for axial symptom of essential tremor with a few cases, simultaneous unilateral thalamotomy and contralateral DBS would be expected to induce favorable outcomes for head tremor with significant economical advantages.