Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Effects of Medication and Deep Brain Stimulation on the Finger-tapping Speed and Amplitude of Parkinsonian Bradykinesia

파킨슨성 완서증의 손가락 마주치기 속도와 크기에 대한 약물과 뇌심부자극의 효과

  • Kim, Ji-Won (School of Biomedical Engineering, Konkuk University) ;
  • Kwon, Yu-Ri (School of Biomedical Engineering, Konkuk University) ;
  • Park, Sang-Hoon (School of Biomedical Engineering, Konkuk University) ;
  • Eom, Gwang-Moon (School of Biomedical Engineering, Konkuk University) ;
  • Koh, Seong-Beom (Department of Neurology, Korea University College of Medicine) ;
  • Jang, Ji-Wan (Department of Neurology, Korea University College of Medicine) ;
  • Lee, Hye-Mi (Department of Neurology, Korea University College of Medicine)
  • 김지원 (건국대학교 의학공학부) ;
  • 권유리 (건국대학교 의학공학부) ;
  • 박상훈 (건국대학교 의학공학부) ;
  • 엄광문 (건국대학교 의학공학부) ;
  • 고성범 (고려대학교 의과대학 신경과) ;
  • 장지완 (고려대학교 의과대학 신경과) ;
  • 이혜미 (고려대학교 의과대학 신경과)
  • Received : 2011.12.31
  • Accepted : 2012.03.23
  • Published : 2012.03.30
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Abstract

The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: $60.6{\pm}7.4yrs$, H&Y stage: $3.1{\pm}0.2$) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing average speed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-way repeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater than those of Med-off/DBS-off and Med-off/DBS-on (p < 0.01) whereas RMS angle was not different among conditions (p = 0.06). Two way repeated measures ANOVA showed that only medication improved RMS angular velocity (p < 0.01), whereas both medication and DBS had no significant effect on RMS angle (p > 0.02). Effect size of RMS angular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication and DBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated with different functional aspects in PD.

Keywords

References

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