• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.4 s.304
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• pp.95-102
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• 2005

In this paper, we propose a user friendly object-based image retrieval system using the interaction between cortex and hippocampus. Most existing ways of queries in content-based image retrieval rely on query by example or query by sketch. But these methods of queries are not adequate to needs of people's various queries because they are not easy for people to use and restrict. We propose a method of automatic color object extraction using CSB tree map(Color and Spatial based Binary をn map). Extracted objects were transformed to bit stream representing information such as color, size and location by region labelling algorithm and they are learned by the hippocampal neural network using the interplay between cortex and hippocampus. The cells of exciting at peculiar features in brain generate the special sign when people recognize some patterns. The existing neural networks treat each attribute of features evenly. Proposed hippocampal neural network makes an adaptive fast content-based image retrieval system using excitatory learning method that forwards important features to long-term memories and inhibitory teaming method that forwards unimportant features to short-term memories controlled by impression.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.12
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• pp.2349-2356
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• 2008

In this paper, we present the method to effectively extract and classify the EEG caused by only brain activity when a normal subject is in a state of mental activity. We measure the synchronous EEG on the auditory event when a subject who is in a normal state thinks of a specific task, and then shift the baseline and reduce the effect of biological artifacts on the measured EEG. Finally we extract only the mental task signal by averaging method, and then perform the recognition of the extracted mental task signal by computing the AR coefficients. In the experiment, the auditory stimulus is used as an event and the EEG was recorded from the three channel $C_3-A_1$, $C_4-A_2$ and $P_Z-A_1$. After averaging 16 times for each channel output, we extracted the features of specific mental tasks by modeling the output as 12th order AR coefficients. We used total 36th order coefficient as an input parameter of the neural network and measured the training data 50 times per each task. With data not used for training, the rate of task recognition is 34-92 percent on the two tasks, and 38-54 percent on the four tasks.

• Journal of Ginseng Research
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• v.46 no.6
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• pp.750-758
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• 2022

Background: Mild cognitive impairment (MCI) is a transitional condition between normality and dementia. Ginseng is known to have effects on attenuating cognitive deficits in neurogenerative diseases. Ginsenosides are the main bioactive component of ginseng, and their protein targets have not been fully understood. Furthermore, no thorough analysis is reported in ginsenoside-related protein targets in MCI. Methods: The candidate protein targets of ginsenosides in brain tissues were identified by drug affinity responsive target stability (DARTS) coupled with label-free liquid chromatography-mass spectrometry (LC-MS) analysis. Network pharmacology approach was used to collect the therapeutic targets for MCI. Based on the above-mentioned overlapping targets, we built up a proteineprotein interaction (PPI) network in STRING database and conducted gene ontology (GO) enrichment analysis. Finally, we assessed the effects of ginseng total saponins (GTS) and different ginsenosides on mitochondrial function by measuring the activity of the mitochondrial respiratory chain complex and performing molecular docking. Results: We screened 2526 MCI-related protein targets by databases and 349 ginsenoside-related protein targets by DARTS. On the basis of these 81 overlapping genes, enrichment analysis showed the mitochondria played an important role in GTS-mediated MCI pharmacological process. Mitochondrial function analysis showed GTS, protopanaxatriol (PPT), and Rd increased the activities of complex I in a dose-dependent manner. Molecular docking also predicted the docking pockets between PPT or Rd and mitochondrial respiratory chain complex I. Conclusion: This study indicated that ginsenosides might alleviate MCI by targeting respiratory chain complex I and regulating mitochondrial function, supporting ginseng's therapeutic application in cognitive deficits.

• BMB Reports
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• v.53 no.2
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• pp.100-105
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• 2020

While liver histopathology is heterogeneous in diabetes, the underlying mechanisms remain unclear. We investigated whether glycemic variation resulting from differential diets can induce heterogeneity in diabetic liver and the underlying molecular mechanisms. We generated end-stage non-obese diabetic model rats by subtotal-pancreatectomy in male Sprague-Dawley rats and ad libitum diet for 7 weeks (n = 33). The rats were then divided into three groups, and fed a standard- or a low-protein diet (18 or 6 kcal%, respectively), for another 7 weeks: to maintain hyperglycemia, 11 rats were fed ad libitum (18AL group); to achieve euglycemia, 11 were calorie-restricted (18R group), and 11 were both calorie- and protein-restricted with the low-protein diet (6R group). Overnight-fasted liver samples were collected after the differential diets together with sham-control (18S group), and histology and molecular changes were compared. Hyperglycemic-18AL showed glycogenic hepatopathy (GH) without steatosis, with the highest GSK-3β inactivation because of Akt activation during hyperglycemia; mitochondrial function was not impaired, compared to the 18S group. Euglycemic-18R showed neither GH nor steatosis, with intermediate GSK-3β activation and mitochondrial dysfunction. However, euglycemic-6R showed both GH and steatosis despite the highest GSK-3β activity and no molecular evidence of increased lipogenesis or decreased ApoB expression, where mitochondrial dysfunction was highest among the groups. In conclusion, heterogeneous liver histopathology developed in end-stage non-obese diabetic rats as the glycemic levels varied with differential diets, in which protein content in the diets as well as glycemic levels differentially influenced GSK-3β activity and mitochondrial function in insulin-deficient state.

• Journal of Intelligence and Information Systems
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• v.13 no.3
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• pp.17-29
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• 2007

Inference engine that performs the brain of software agent in next generation's web with various standards based on standard language of the web, XML has to understand SWRL (Semantic Web Rule Language) that is a language to express the rule in the Semantic Web. In this research, we want to develop a forward inference engine, SMART-F (SeMantic web Agent Reasoning Tools-Forward chaining inference engine) that uses SWRL as a rule express method, and OWL as a fact express method. In the traditional inference field, the Rete algorithm that improves effectiveness of forward rule inference by converting if-then rules to network structure is often used for forward inference. To apply this to the Semantic Web, we analyze the required functions for the SWRL-based forward inference, and design the forward inference algorithm that reflects required functions of next generation's Semantic Web deducted by Rete algorithm. And then, to secure each platform's independence and portability in the ubiquitous environment and overcome the gap of performance, we developed management tool of fact and rule base and forward inference engine. This is compatible with fact and rule base of SMART-B that was developed. So, this maximizes a practical use of knowledge in the next generation's Web environment.

• Archives of design research
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• v.18 no.2 s.60
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• pp.303-314
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• 2005

This study is intended to promote local woodcraft industry with revitalization of local festival in Inje-county. To do so, we propose the travel souvenir design with local identity and the plan for production and marketing based on the management of 'Design Hospital' and the building of production method through 'laser wood inlaying technique like puzzle style'. Research method is benchmarking analysis of successful cases of travel souvenir which is developed for cultural contents of local festival. The result of this study is the following. First, design outsourcing is done one of support in industry focused on old boy network, Through it, Special brain of design can be supplied without compensation. Also the difficulty of manpower problem is lessened and the ability of product development in short term can be guaranteed. On the basis of this, we are able to apply Mass Customization production by up to date digital production method. This enables us to maintain the production flexibility of cultural goods fit for the traits of local festival. This study is intended to present the best model guananteeing both profit of wood technological industry and the possibility of local cultural.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.150-166
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• 2020

Based on the theory of cognitive reserve, we undertook this study to develop a cognitive function training program for woman in menopausal transition with complaints of declining in cognitive function. The program was established by applying the analysis, design, and development stages of the network-based instructional system designed by Jung. The cognitive function training program developed by us is an was an 8-week program composed of cognitive and video training using a mobile application. The program consists of 24 sessions, each with 20-30 minutes of duration, to be completed 3 sessions per week. The contents of the cognitive function training comprise of memory, attention, language function, and scenario-based problem-solving for executive functions, all of which are cognitive areas found to be the most vulnerable for menopausal women. The educational contents were developed for eight subject areas, one subject area per week, including the definition of menopause, its causes and symptoms, menopause and brain function, etc. During the pilot test, the cognitive function training program was applied to 10 menopausal women who complained of cognitive function decline. The results indicated that, after eight weeks of training, the overall cognitive function of participants increased, revealing statistically significant differences (t=-3.04, p=.014) after the program was completed. The mobile app-based cognitive function training program might not only improve patients' memory functions but also potentially reduce the incidence of dementia.

• Molecules and Cells
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• v.37 no.7
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• pp.547-553
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• 2014

Glioblastoma multiforme (GBM) is one of the most common brain malignancies and has a very poor prognosis. Recent evidence suggests that the presence of cancer stem cells (CSC) in GBM and the rare CSC subpopulation that is resistant to chemotherapy may be responsible for the treatment failure and unfavorable prognosis of GBM. A garlic-derived compound, Z-ajoene, has shown a range of biological activities, including anti-proliferative effects on several cancers. Here, we demonstrated for the first time that Z-ajoene specifically inhibits the growth of the GBM CSC population. CSC sphere-forming inhibition was achieved at a concentration that did not exhibit a cytotoxic effect in regular cell culture conditions. The specificity of this inhibitory effect on the CSC population was confirmed by detecting CSC cell surface marker CD133 expression and biochemical marker ALDH activity. In addition, stem cell-related mRNA profiling and real-time PCR revealed the differential expression of CSC-specific genes, including Notch, Wnt, and Hedgehog, upon treatment with Z-ajoene. A proteomic approach, i.e., reverse-phase protein array (RPPA) and Western blot analysis, showed decreased SMAD4, p-AKT, 14.3.3 and FOXO3A expression. The protein interaction map (http://string-db.org/) of the identified molecules suggested that the AKT, ERK/p38 and $TGF{\beta}$ signaling pathways are key mediators of Z-ajoene's action, which affects the transcriptional network that includes FOXO3A. These biological and bioinformatic analyses collectively demonstrate that Z-ajoene is a potential candidate for the treatment of GBM by specifically targeting GBM CSCs. We also show how this systemic approach strengthens the identification of new therapeutic agents that target CSCs.

• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.286-294
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• 2010

This study was performed to identify the cerebral network associated with sensation through the tickling stimulation, which is distinctive from the rest of other networks processing normal stimulation and to investigate the difference of laughing mechanism which is closely related to tickling using functional MRI(fMRI). A 16 healthy volunteers (mean age: 28.9) on a 3.0T MR scanner during two sensation conditions. Counterbalanced stimulus were presented across the participants, and the stimulation was used block design. Acquired data was analyzed by the statistical parametric mapping (SPM 99). Subject and group analysis was performed. Individual analysis showed the activation of somatic sensation area in both tasks and the tickling sensation test showed more activated area in the Wernicke's area(BA40) compared to the normal sensation. The group analysis result shows that under normal stimulations, both sides of somatosensory cortices(BA 1,2 and 3) were activated and under tickling stimulation, not only the cortices but also those huge activation on thalamus, cingulate gyrus and insular lobe were detected. When the tickling was stopped, significant activations were shown in right cingulate gyrus, left MFG area and left insular lobe. A cerebral area responsible for recognizing tickling sensation was examined and the primitive stimulation such as tickling is much closely related to laugh, which is an important factor for various social activities.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.13 no.1
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• pp.19-22
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• 2017

Moyamoya disease is characterized by progressive bilateral narrowing of the internal carotid arteries(ICA) and their main branches, and formation of a fine vascular network (moyamoya vessels) at the base of brain. Mild intellectual or motor impairment, or both can be seen in moyamoya disease patient. Patients having intellectual disability usually have malocclusions associated with oral habits such as tongue thrusting, bruxism, or clenching. A patient with moyamoya disease and cerebral palsy visited Chonbuk National University hospital for dental examination. She showed mild openbite on anterior teeth, and had oral habits such as mouth breathing, tongue thrusting, and drooling. She was treated with myofunctional therapy(MFT) whose purpose was to strengthen orofacial muscles. Lip closing force and bite force were recorded to evaluate the muscle tone. Tongue crib was delivered to restrict tongue thrusting habit, since her compliance to the MFT was decreased after 6 months of treatment. With the MFT and tongue crib, the openbite was fairly improved. When myofunctional therapy has difficulty in obtaining good compliances, the treatment should not be effective enough. Although intellectually disabled patients are not compliant enough, thus a habit breaking device should be needed to treat the openbite caused by oral habits, dentist should make an effort to do MFT, since it could reduce a treatment period, and enhance the stability.