• International Journal of Oral Biology
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• 제43권3호
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• pp.113-121
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• 2018

Taste is closely related to intake of food. Taste perception is also influenced by type of food ingested, and nutrition and health status. Bitter taste plays an important role in the survival of human and animals to avoid probable toxic and harmful substances. Vertebrate animals recognize bitter taste through type 2 taste receptors (T2Rs). Several T2Rs have been expressed extra-oral such as the gastrointestinal tract, respiratory tract, urogenital tract, brain and immune cells, and parts of their functions are being revealed. This review will discuss physiological roles of T2Rs in relation to innate immunity, secretion and smooth muscle contraction expressed in extra-oral cells and tissues, and we summarize relationships between polymorphisms in T2Rs and general or oral diseases. It is not a coincidence that animals pay much genetic costs for taste and smell during evolution.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제28권1호
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• pp.1-21
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• 2024

This review comprehensively explores the evolution, theoretical underpinnings, variations, and applications of diffusion models. Originating as a generative framework, diffusion models have rapidly ascended to the forefront of machine learning research, owing to their exceptional capability, stability, and versatility. We dissect the core principles driving diffusion processes, elucidating their mathematical foundations and the mechanisms by which they iteratively refine noise into structured data. We highlight pivotal advancements and the integration of auxiliary techniques that have significantly enhanced their efficiency and stability. Variants such as bridges that broaden the applicability of diffusion models to wider domains are introduced. We put special emphasis on the ability of diffusion models as a crucial foundation model, with modalities ranging from image, 3D assets, and video. The role of diffusion models as a general foundation model leads to its versatility in many of the downstream tasks such as solving inverse problems and image editing. Through this review, we aim to provide a thorough and accessible compendium for both newcomers and seasoned researchers in the field.

• 대한소아치과학회지
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• 제34권3호
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• pp.532-542
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• 2007

연구 목적은 부정교합과 부분무치증 등의 치과 문제의 배경으로서 사람 진화에 따른 치열의 변화 양상을 고찰하는 것이었다. 사람은 분류학적으로 동물계, 척추문, 포유강, 영장목, 고등영장아목, Hominoid(상위인과), Hominid(인과), Homo(인속), sapiens(종)이다. 최초의 Hominid는 약 400만년 전에 출현한 Australopithecus로서 직립보행과 치열의 변화가 특징이었고, Homo속은 약 250만년 전에 출현한 최초의 석기 제작자 H. habilis를 시작으로, H. erectus, H. neanderthalensis 등이 나타났다가 사라지면서 현생 인류인 H. sapiens에 이르렀다. 원시포유류의 I3 C1 P4 M3의 치열은 원시영장류의 I2 C1 P4 M3, 고등영장류의 I2 C1 P3 M3, Hominoid의 I2 C1 P2 M3로 변화하였고 H. sapiens는 I2 C1 P2 M2의 치열로 변화하고 있다. Hominoid의 상자형 치열은 Australopithecus의 오메가형 치열을 거쳐 Homo의 포물선형 치열로 변화하였다. 치아의 크기가 계속 감소하였고 특히 견치의 크기와 성적 이형성이 감소하였다. 뇌 크기가 증가하고 악골의 크기가 감소함에 따라 치열은 두개관에 대해 후하방으로 이동하였다. 녹말이 풍부한 주식으로의 변화, 식품 가공, 요리 기술의 발달이 저작의 필요성을 감소시켜 치열 변화를 촉진하였다는 가설이 제기되었다. 지구 역사에서 극히 최근에 나타난 신종으로서 지구 전역에 퍼져 대량 멸종을 일으키고 있는 H. sapiens의 미래는 불투명하다. 부분무치증과 부정교합은 사람 진화에 따른 치열 변화와 관계가 있는 것으로 보이며 앞으로 증가할 가능성이 있다고 사료된다.

• 생명과학회지
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• 제22권3호
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• pp.293-297
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• 2012

분자 운동 단백질은 신경세포 내의 세포체에서 특정 목적지까지 소포를 이동시키는데 관여한다. 오징어의 거대 축삭은 간단한 제거조작으로 축삭을 분리 가능하기 때문에 신경세포내 물질이동기전 연구의 좋은 모텔로 활용 가능하다. 이전연구에서 오징어 거대축삭의 소포들은 미세소관을 따라 이동하는 키네신 항체에 의하여 운반됨이 확인되었다. 본 연구는 오징어 뇌에 존재하는 키네신들을 크로닝하고, 분리된 유전자의 분석을 행하기 위하여 키네신 운동 도메인에서 잘 보존된 아미노산 배열에 해당되는 영역에 DNA primer을 이용하여 새로운 6종류의 키네신을 분리하였다. 오징어의 키네신들과 생쥐의 키네신들의 motor 영역의 아미노산분석에서 보존된 영역이 존재하며, Maximum Parsimony (MP) 방법, Neighbor-Joining (NJ) 방법, Minimum Evolution (ME) 방법, 그리고 Maximum likelihood (ML) 방법을 기초로 한 계통분석에서 생쥐의 키네신과 높은 상동성을 나타내었으며, 또한 계통수에서도 높은 상관관계가 확인되었다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권8호
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• pp.299-308
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• 2014

신체 동작, 얼굴 표정과 같이 아주 복잡한 생체 패턴을 인식하고 분류하는 인간의 능력을 모방한 정보처리 컴퓨팅 관련 연구가 최근 다수 등장하고 있다. 특히 컴퓨터비전 분야에서는 인간의 뛰어난 인지 능력 중 상황정보 없이 시각시퀀스에서 동작을 분류하는 기능을 통해 시공간적 패턴 코딩과 빠른 인식 방법을 이해하고자 한다. 본 연구는 비디오 시퀀스상의 동작인식에 생물학적 시각인지과정의 영향을 받은 생체 기반 컴퓨터비전 모델을 제시하였다. 제안 모델은 이미지 시퀀스에서 동작을 검출하고 시각 패턴을 판별하는 데 생체 시각처리과정의 신경망 구조 단계를 반영하였다. 실험을 통해 생체 기반 동작인식 모델이 인간 시각인지 처리의 여러 가지 속성을 고려했을 뿐 아니라 기존 동작인식시스템에 비해 시간 정합성이 뛰어나며 시간 변화에 강건한 분류 능력을 보임을 알 수 있다. 제안 모델은 지능형 로봇 에이전트와 같은 생체 기반 시각정보처리 시스템 구축에 기여할 수 있다.

• 한국발생생물학회지:발생과생식
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• 제23권4호
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• pp.333-344
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• 2019

In vertebrate reproductive system, estrogen receptor (ER) plays a pivotal role in mediation of estrogenic signaling pathways. In the present study, we report the cDNA cloning, expression analysis, and transcriptional activity of ERβ1 subtype from medaka Oryzias dancena. The deduced O. dancena ERβ1 (odERβ1; 519 amino acids) contained six characteristic A/B to E/F domains with very short activation function 2 region (called AF2). A phylogenetic analysis indicated that odERβ1 was highly conserved among teleost ERβ1 subgroup. A conventional RT-PCR revealed that the odERβ1 transcripts were widely distributed in the multiple tissues, the ovary, brain, gill, intestine, kidney, and muscle. Further, the relatively higher odERβ1 expressions in the ovary and brain were clearly reproduced in RT-qPCR assay. When HA-fused odERβ1 expression vector was transfected into HEK293 cells, an immunoreactivity for odERβ1 was mainly detected in the nucleus part. Finally, an estrogen responsive element driven luciferase reporter assays demonstrated that the transcriptional activity of odERβ1 significantly increased by estradiol-17β (E2) in a dose dependent manner (p<0.05). However, fold-activation of odERβ1 in the presence of E2 was markedly weak, when it compared with those of O. latipes ERβ1. Taken together, these data suggest that odERβ1 represents a functional variant of teleost ERβ subtype and provides a basic tool allowing future studies examining the function of F domain of ERβ1 subtype and expanding our knowledge of ERβ evolution.

• Molecules and Cells
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• 제28권2호
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• pp.111-117
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• 2009

The CHRM3 gene is a member of the muscarinic acetylcholine receptor family that plays important roles in the regulation of fundamental physiological functions. The evolutionary mechanism of exon-acquisition and alternative splicing of the CHRM3 gene in relation to transposable elements (TEs) were analyzed using experimental approaches and in silico analysis. Five different transcript variants (T1, T2, T3, T3-1, and T4) derived from three distinct promoter regions (T1: L1HS, T2, T4: original, T3, T3-1: THE1C) were identified. A placenta (T1) and testis (T3 and T3-1)-dominated expression pattern appeared to be controlled by different TEs (L1HS and THE1C) that were integrated into the common ancestor genome during primate evolution. Remarkably, the T1 transcript was formed by the integration event of the human specific L1HS element. Among the 12 different brain regions, the brain stem, olfactory region, and cerebellum showed decreased expression patterns. Evolutionary analysis of splicing sites and alternative splicing suggested that the exon-acquisition event was determined by a selection and conservation mechanism. Furthermore, continuous integration events of transposable elements could produce lineage specific alternative transcripts by providing novel promoters and splicing sites. Taken together, exon-acquisition and alternative splicing events of CHRM3 genes were shown to have occurred through the continuous integration of transposable elements following conservation.

• 대한한의학원전학회지
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• 제33권1호
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• pp.197-205
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• 2020

Objectives : We analyzed the descriptions of Doek(德)·Qi(氣)·Saeng(生)·Jeong(精)·Sin(神)·Hon(魂)·Baek(魄)·Sim(心)·Ui(意)·Ji(志)·Sa(思)·Ji(智)·Ryeo(慮)·Ji(智) which are the concepts mentioned in the beginning of the ≪Lingshu·Benshen≫. Methods : We reinterpreted this verse in ≪Lingshu·Benshen≫ from the viewpoint of evolution and development of mental function and considered it in relation to the knowledge of modern psychology and brain science. Results & Conclusions : The reproductive essence of the parents are combined, primitive essence (元精) is created and simultaneously primitive spirit is born. Primitive spirit first differentiates into Hon and Baek. Hon and Baek are instinctive mental functions. Up to this point, because the process is completed before birth, primitive spirit, Hon, and Baek are innate spirit. Ui, Ji, Sa, Ryeo and Ji are the rational thinking abilities as mental functions that develop actively after birth. This is called conscious spirit and acquired spirit. Analyzing the contents of , it can be said that the mental function is divided into four layers of primitive spirit-Baek-Hon-conscious spirit.

• International Journal of Internet, Broadcasting and Communication
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• 제9권3호
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• pp.44-58
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• 2017

The purpose of this study is to prove the Korean Internet company, Kakao's resilience capacity. For it, this paper reviews the previous literatures regarding Kakao's business models and discusses 'resilience' theory. Then, it organizes the research questions based on the theoretical background and explains the research methodology. It investigates the case of Kakao's business and organization. The case analysis shows that five levers of resilience are a good indicator for a successful platform business evolution. The five levers are composed of coordination, cooperation, clout, capability, and connection: First lever, coordination that makes the company to restructure its silo governance in order to respond to actual business flow starting from the basic asset like game and music content; second lever, cooperation where the firm provides creative people with playground for startups such as KakaoPage; third lever, clout where the company shares its data by opening its API of AI and chatbot to $3^{rd}$ party developers; fourth lever, capability where the firm establishes AI R&D center, KakaoBrain as the function of multi-domain generalist for developing diverse platforms tackling customer needs; and the last fifth lever, connection where the firm continues to expand its platform business to the peripheries, O2O businesses such as KakaoTaxi, KakaoOrder, KakaoPay, and KakaoBank. In conclusion, this study proposes Internet companies to be a resilient platform utilizing those five levers of resilience in order to form successful platform. This study contributes to the agile innovation of Internet platform with ecological sense.

• Journal of Korean Neurosurgical Society
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• 제30권10호
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• pp.1220-1223
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• 2001

Authors experienced a unique case of craniopharyngioma which had evolved rapidly after 4 years of total resection for supratentorial meningioma. A 58-year-old woman presented with headache and visual deterioration. Previously, she had undertaken surgical removal of frontal convexity meningioma 4 years ago and had been well without any postoperative sequelae thereafter. Brain magnetic resonance imaging demonstrated a newly developed suprasellar mass. Pertinent operative procedure was performed and histological verification was made as an adamantinomatous craniopharyngioma. She has been showing unremarkable clinical course up to date. Possible pathogenic mechanisms of de novo development of craniopharyngioma are disscussed with review of case.