• Molecules and Cells
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• v.43 no.4
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• pp.331-339
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• 2020

Genetic modifications in noncoding regulatory regions are likely critical to human evolution. Human-accelerated noncoding elements are highly conserved noncoding regions among vertebrates but have large differences across humans, which implies human-specific regulatory potential. In this study, we found that human-accelerated noncoding elements were frequently coupled with DNase I hypersensitive sites (DHSs), together with monomethylated and trimethylated histone H3 lysine 4, which are active regulatory markers. This coupling was particularly pronounced in fetal brains relative to adult brains, non-brain fetal tissues, and embryonic stem cells. However, fetal brain DHSs were also specifically enriched in deeply conserved sequences, implying coexistence of universal maintenance and human-specific fitness in human brain development. We assessed whether this coexisting pattern was a general one by quantitatively measuring evolutionary rates of DHSs. As a result, fetal brain DHSs showed a mixed but distinct signature of regional conservation and outlier point acceleration as compared to other DHSs. This finding suggests that brain developmental sequences are selectively constrained in general, whereas specific nucleotides are under positive selection or constraint relaxation simultaneously. Hence, we hypothesize that human- or primate-specific changes to universally conserved regulatory codes of brain development may drive the accelerated, and most likely adaptive, evolution of the regulatory network of the human brain.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.181-184
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• 1998

CAM-Brain is a model to develop neural networks based in cellular automata by evolution, and finally aims at a model as and artificial brain,. In order to show the feasibility of evolutionary engineering to develop an artificial brain we have attempted to evolve a module of CAM-Brain for the problem to control a mobile robot, In this paper, we present some recent results obtained by analyzing the behaviors of the evolved neural module. Several experiments reveal a couple of problems that should be solved when CAM-Brain evolves to control a mobile robot. so that some modification of the original model is proposed to solve them. The modified CAM-Brain has evolved to behave well in a simulated environment, and a thorough analysis proves the power of evolution.

• Journal of the Korean Institute of Intelligent Systems
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• v.11 no.7
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• pp.680-688
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• 2001

In this paper, we propose a reliable method for searching the optimally performing generalized brain-state-in-a-box (GBSB) neural associative memory using an evolution program (EP) given a set of prototype patterns to be stored as stable equilibrium points. First, we exploit some qualitative guidelines necessary to synthesize the GBSB model. Next, we parameterize the solution space utilizing the limited number of parameters to represent the solution space. Then, we recast the synthesis of GBSB neural associative memories as two constrained optimization problems, which are equivalent to finding a solution to the original synthesis problem. Finally, we employ an evolution program (EP), which enables us to find an optimal set of parameters related to the size of domains of attraction (DOA) for prototype patterns. The validity of this approach is illustrated by a design example and computer simulations.

• Journal of Trauma and Injury
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• v.25 no.4
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• pp.209-216
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• 2012

Purpose: The objectives of this study are to classify chronic subdural hematomas based on brain computerized tomographic scan (CT scan) findings and to determine the mechanism of evolution and treatment methods. Methods: One hundred thirty-nine patients who were diagnosed with a chronic subdural hematoma and who available for follow up assessment 6 months post-surgery were analyzed retrospectively. The presence of trauma and past medical history were reviewed and evaluation criteria based on brain CT scan findings were examined. Results: Initial brain CT scans revealed a chronic subdural hematoma in 106 patients, a subdural hygroma in 24 patients, and an acute subdural hematoma in 9 patients. In all cases where the initial acute subdural hematoma had progressed to a chronic subdural hematoma, final was a hypo-density chronic subdural hematoma. In case where the initial subdural hygroma had progressed to a chronic subdural hematoma, the most cases of hematoma were hyper-density and mixed-density chronic subdural hematoma. In total, 173 surgeries were performed, and they consisted of 97 one burr-hole drainages, 70 two burr-hole drainages and 6 craniotomies. Conclusion: This study demonstrates that rebleeding and osmotic effects are mechanisms for enlarging of a chronic subdural hematoma. In most cases, one burr-hole drainage is a sufficient for treatment. However, in cases of mixed or acute-on-chronic subdural hematomas, other appropriate treatment strategies are required.

• The Korean Journal of Pain
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• v.23 no.3
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• pp.159-165
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• 2010

The evolution of brain imaging techniques over the last decade has been remarkable. Along with such technical developments, research into chronic pain has made many advances. Given that brain imaging is a non-invasive technique with great spatial resolution, it has played an important role in finding the areas of the brain related to pain perception as well as those related to many chronic pain disorders. Therefore, in the near future, brain imaging techniques are expected to be the key to the discovery of many unknown etiologies of chronic pain disorders and to the subjective diagnoses of such disorders.

• Korean Journal of Child Studies
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• v.26 no.5
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• pp.185-204
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• 2005

This paper demonstrated how application of evolutionary knowledge to developmental perspectives enhances understanding of human ontogeny. Evolutionary Developmental Psychology (EDP) explains human behavior through evolutionary principles and focuses on ontogeny rather than phylogeny. In this paper, the authors review concepts of evolution, adaptations, and the processes of evolution from EDP perspectives. The definition and basic assumptions of EDP are introduced, followed by explanations of how evolution happens in ontogeny by looking at developmental systems approaches, concepts of ontogenetic and deferred adaptations, evolution of childhood, and brain plasticity. Possible pathways of evolution in ontogeny are also discussed. Finally, some research methodology for applying EDP to child development is suggested with specific hypotheses and studies.

• Animal cells and systems
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• v.5 no.3
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• pp.231-236
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• 2001

SINE-R retroposons have been derived from human endogenous retrovirus HERV-K family and found to be hominoid specific. Both SINE-R retroposons and HERV-K family are potentially capable of affecting the expression of closely located genes. From cDNA library of human fetal brain, we identified seven SINE-R retroposons and compared them with sequences derived from GenBank database. The SINE-R retroposons from human feta1 brain showed 85∼97% sequence similarities with the human-specific retroposon SINE-R.C2. They also showed 88∼96% sequence similarities with the sequence of the schizo-cDNA clone that derived from postmortem frontal cortex tissue of a schizophrenic patient. Phylogenetic analysis using the neiqhbor-joining method revealed that the seven new SINE-R retroposons from cDNA library of the human feta1 brain have proliferated independently during human evolution. The data indicate that such SINE-R retroposons are expressed in human fetal brain and deserve further investigation as potential leads to understanding of neuropsychiatric diseases.

• Proceedings of the IEEK Conference
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• 1999.06a
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• pp.464-467
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• 1999

Rapid progress in the modeling of biological structures and simulation of their development has occurred over the last few years. Cellular automata (CA) and Lindenmayer-system(L-system) are the representative models of development/morphogenesis of multicellular organism. L-system is applied to the visualization of biological plant. Also, CA are applied to the study of artificial life and to the construction of an artificial brain. To design the L-system and CA automatically, we make this model evolve. It is necessary to code the developmental rules for evolution. In this paper, we propose a DNA coding method for evolution the models of development/morphogenesis of biological multicellular organisms. DNA coding has the redundancy and overlapping of gene and is apt for the representation of the rule. In this paper, we propose the DNA coding method of CA and L-system.

• Journal of Korean Neurosurgical Society
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• v.30 no.9
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• pp.1140-1143
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• 2001

The mortality of patients with brain abscess has decreased significaltly. This has been attributed to improved diagnostic imaging, the evolution of neurosurgical techniques and understanding of intracranial pressure pathophysiology, greater critical care understanding, and newer antibiotics. However, the mortality associated with intraventricular rupture of brain abscess remained consistently high at or above 80% once identified. A case of intraventicular rupture of thalamic abscess with good quality of survival is presented based on aggressive 4-component therapeutic plan used. The four components are 1) extraventricular drainage for 6 weeks, 2) lavage of the ventricular system using closed irrigation system, 3) intravenous antibiotics, 4) intraventricular gentamicin and vancomycin, twice and once daily, respectively.

• Journal of the Korea Computer Graphics Society
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• v.9 no.2
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• pp.19-26
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• 2003

본 논문은 두개의 날개를 가진 다양한 생명체들의 형상과 움직임을 복잡한 공기역학 없이 body-brain 공진화를 사용하여 생성하는 시스템을 기술한다. 인공생명 기술이 다양한 가상생명체들을 생성하는데 이용되었지만 제한된 기하학적 요소들을 사용한 날개 생성의 어려움과 매우 복잡한 공기역학으로 인하여 하늘의 생명체들을 탐색한 연구들은 매우 드물다. 본 논문의 진화된 생명체들은 시스템의 단순함에도 불구하고 심미적인 모습과 유기적인 날개침 동작을 보여준다. 진화 알고리즘을 위한 유전형 인코딩에 쓰인 자료구조는 제한된 리스트 구조로서 이는 방향그래프와 유사하나 더욱 쉽게 다루어질 수 있다. 본 시스템으로 진화된 생명체는 연속적인 삼각형 패치로 이루어진 두개의 대칭형 날개를 가지며, 새, 나비, 박쥐 혹은 상상적인 용이나 익룡 등을 연상시키는 다양한 모습과 기동을 보여준다.