• Archives of Reconstructive Microsurgery
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• 제14권1호
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• pp.50-56
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• 2005

There are limited treatment options in the reconstruction of the very large defect in the metaphyseal portion of distal femur and proximal tibia. Fibula is one of the most popular donor of the long bone reconstruction in reconstructive microsurgical field. It has many advantages such as very strong strut tubular bone, very reliable vascular anatomy with large vascular diameter and long pedicle. There are limited donor site problems such as transient peroneal nerve dysfunction. In those situations with the huge long bone defects in distal femur or proximal tibia, the defective bony shape and strength of the transplanted fibular bone is not enough if only one strut of the fibula is transferred. We performed 7 cases of "doule barrel" fibular transplantation on the metaphyseal portion of distal femur and proximal tibial large defects in which it is very difficult to fill the bony gap with conventional bone graft or callotasis methods. It takes averaged 8.3 months since that procedure to obtain bony union. After solid union of the transferred double barrelled fibular graft. There were no stress fracture in our series. So we can propose double barrel fibular graft is useful method in those cases with very large bone defect on the metaphysis of large long bone.

• Journal of the Korean Wood Science and Technology
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• 제43권4호
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• pp.528-537
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• 2015

폐기물의 재활용을 도모하기 위해 음식점이나 정육점에서 폐기되는 뼈(골분)를 합판용 접착제의 충전제로서 이용 가능성을 검토하였다. 현재 업계에서 합판의 제조에 사용되고 있는 3종의 접착제(UMF, UF 및 PF수지)에 대해 3종의 골분(소골분, 돼지골분 및 조개골분)을 첨가하여 제조한 라티에타파인 합판의 접착성능을 기존의 소맥분과 비교하였다. 3수지에서 모두 소맥분을 전부 소골분, 돼지골분 및 조개골분으로 각각 대체한 합판의 접착성능은 상태나 습윤 강도 및 목파율 모두 소맥분 첨가 합판보다 낮았다. 따라서 소맥분을 전혀 첨가하지 않고 골분으로 모두 대체하는 것은 곤란하였다. 그러나, 소맥분의 절반을 소골분과 돼지골분으로 각각 대체하여 제조한 합판의 성능은 소맥분을 사용한 합판과 거의 동등하거나 오히려 우수한 내수성능을 발휘하여 소맥분과 병용해서 사용하면 충분히 이용이 가능할 것으로 생각된다. 소맥분과 병용한 경우, 3종의 골분 중에는 조개골분을 첨가하여 제조한 합판 보다는 소골분과 돼지골분을 첨가한 합판의 성능이 우수하였으며, 소골분과 돼지골분 간에는 큰 차이가 없었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.127-128
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• 2006

• 대한치과교정학회지
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• 제37권1호통권120호
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• pp.5-15
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• 2007

본 연구는 스크류의 역학적인 특성을 알아보고자 세 종류의 self-drilling형의 교정용 미니 스크류 (Type A; 순수한 원통형, Type B; 내경이 증가하는 구간이 있는 부분적인 원통형, Type C; 원통형과 원추형이 함께 있는 복합형)를 피질골의 두께를 다르게 설정한 인공골 시편에 삽입하였다. 일정한 회전 속도와 수직력을 부여할 수 있는 구동식 토오크 시험기(Biomaterials Korea, Seoul, Korea)를 이용하여 삽입 토오크를 측정하고 만능시험기(Instron 3366, Instron, Norwood, MA, USA)를 이용하여 Pull-out 강도를 측정하여 다음과 같은 결과를 얻었다. 피질골 두께의 증가에 따른 최대 삽입 토오크(maximum insertion torque) 값은 Type A는 차이가 없는 반면(p > 0.05), Type B와 Type C에서는 유의한 증가가 관찰되었다 (p < 0.05). 모든 피질골 두께에서 Type C > Type A > Type B의 순으로 최대 삽입 토오크 값이 크게 나타났다 (p < 0.05). Pull-out 강도는 모든 경우에 Type A가 Type B와 Type C보다 낮게 측정되었다 (p < 0.05). Type별로 피질골 두께와 최대 삽입 토오크, Pull-out 강도 간에 통계적으로 유의한 상관관계가 있었다 (p < 0.05). 이상의 결과는 미니 스크류 식립을 위한 디자인 선택 시 식립부위의 피질골 두께를 고려해야 함을 시사한다.

• 한국재료학회지
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• 제15권10호
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• pp.652-656
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• 2005

The samples were prepared with hydroxyapatite(HAp) powder and Polycaboxylate (P.C/HAp=10, 15, 20, 25, 30, 35 $wt\%$). The hydroxyapatite green body with Polycaboxylate were obtained by compaction and drying at room temperature for 3hrs. The higher mechanical properties were observed in HAp sample with $35 wt\%$ Polycaboxylate. The average compressive ana bending strength in HAp with $35 wt\%$ Polycaboxylate are $302 kgf/cm^2$ and $213 kgf/cm^2$ respectively. This strength is higher compare to that of the cortical bone.

• The Journal of Korean Physical Therapy
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• 제24권5호
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• pp.313-318
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• 2012

Purpose: This study examined the effects of an exercise program involving the Proprioceptive Neuromuscular Facilitation (PNF) lower-extremity patterns on the Bone Mineral Density (BMD), balance and lower muscular strength in patients with osteoporosis. Methods: The participants were allocated randomly to 2 groups: experimental group and control group. To evaluate the effects of exercise, the subjects were evaluated using the BMD and Time Up & Go Test and One Leg Stance Test for balance, and the Sit To Stand for lower muscular strength. Results: After the 8 week study, the experimental group showed a significant difference in all items compared to the control groups. Conclusion: These results suggest that a PNF exercise program is effective in patients with osteoporosis. Furthermore, an exercise program involving these patterns can be used in a follow-up program for patients with osteoporosis. Overall, more study will be needed to develop and apply more efficient exercise programs for such patients.

• Journal of Oral Medicine and Pain
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• 제32권1호
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• pp.35-43
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• 2007

본 연구는 숙지황과 가시오가피 복합추출물 (OPB)이 난소절제 흰쥐의 골밀도 및 골대사 변화에 미치는 영향을 관찰하기 위하여 수행하였다. 13주된 20마리의 Sprague-Dawley 암컷 흰쥐를 대조군과 실험군으로 나누었고, OPB의 골밀도 및 골대사 변화에 대한 효과를 관찰하기 위하여 난소절제 후 3일 후부터 OPB를 100 mg/kg씩 8주 동안 경구투여 하였다. pQCT 방식으로 골밀도, 골함유량, 골강도를 측정하였고, 혈청 중 CTx (C-telopeptide of type I collagen)의 변화를 관찰하였다. 난소절제 후 대조군의 골밀도는 $-29.8{\pm}3.0%$로 현저히 감소하였으며, 이러한 감소는 OPB의 투여에 의해 $-21.4{\pm}2.3%$로 억제되었다. 골강도의 변화에서는 anti-fracture 값과 anti-twisting 값이 대조군에 비해 OPB 처리군에서 유의성 있는 차이를 나타냈다. 또한 혈청 중 골흡수 지표인 CTx 농도는 대조군에 비해 OPB 처리군에서 낮게 나타났다. 이상의 결과로 숙지황과 가시오가피의 복합 추출물인 OPB가 난소를 절제한 흰쥐에서 골 소실을 억제하므로 임상에서 난소절제 후 또는 폐경 후 골다공증의 개선제로 이용될 수 있으리라 여겨진다.

• BMB Reports
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• 제53권9호
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• pp.472-477
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• 2020

Osteoclasts are hematopoietic-derived cells that resorb bone. They are required to maintain proper bone homeostasis and skeletal strength. Although osteoclast differentiation depends on receptor activator of NF-κB ligand (RANKL) stimulation, additional molecules further contribute to osteoclast maturation. Here, we demonstrate that protocadherin-7 (Pcdh7) regulates formation of multinucleated osteoclasts and contributes to maintenance of bone homeostasis. We found that Pcdh7 expression is induced by RANKL stimulation, and that RNAi-mediated knockdown of Pcdh7 resulted in impaired formation of osteoclasts. We generated Pcdh7-deficient mice and found increased bone mass due to decreased bone resorption but without any defect in bone formation. Using an in vitro culture system, it was revealed that formation of multinucleated osteoclasts is impaired in Pcdh7-deficient cultures, while no apparent defects were observed in differentiation and function of Pcdh7-deficient osteoblasts. Taken together, these results reveal an osteoclast cell-intrinsic role for Pcdh7 in maintaining bone homeostasis.

• Preventive Nutrition and Food Science
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• 제10권2호
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• pp.156-160
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• 2005

Salvia miltiorrhiza Radix root extracts (SMR) was evaluated for inhibition of the progress of bone loss induced by ovariectomy (OVX) in rats. We measured body weight and bone histomorphometry in sham, OVX and SMR-administered OVX rats. From light microscopic analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMR-administered rats were composed of fine particles. The trabecular bone area and trabecular thickness in OVX rats were decreased by $50\%$ from those in sham rats, and these decreases were completely inhibited by administration of SMR for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMR for 7 weeks. In OVX rats, free $T_3$ was normal in all cases, whereas free $T_4$ was significantly increased. Although there was no difference between OVX and SMR-administered rat in $T_3$ levels, we have found significant difference between them in $T_4$ level. These results strongly suggest that SMR may be beneficial for preventing bone loss in OVX rats.

• The Korean Journal of Physiology and Pharmacology
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• 제26권3호
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• pp.207-218
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• 2022

Aging in mammals, including humans, is accompanied by loss of bone and muscular function and mass, characterized by osteoporosis and sarcopenia. Although resistance exercise training (RET) is considered an effective intervention, its effect is blunted in some elderly individuals. Fibroblast growth factor (FGF) and its receptor, FGFR, can modulate bone and muscle quality during aging and physical performance. To elucidate this possibility, the FGFR inhibitor NVP-BGJ398 was administrated to C57BL/6n mice for 8 weeks with or without RET. Treatment with NVPBGJ398 decreased grip strength, muscular endurance, running capacity and bone quality in the mice. FGFR inhibition elevated bone resorption and relevant gene expression, indicating altered bone formation and resorption. RET attenuated tibial bone resorption, accompanied by changes in the expression of relevant genes. However, RET did not overcome the detrimental effect of NVP-BGJ398 on muscular function. Taken together, these findings provide evidence that FGFR signaling may have a potential role in the maintenance of physical performance and quality of bone and muscles.