• Archives of Plastic Surgery
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• 제42권3호
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• pp.334-340
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• 2015

Background Full-thickness skin grafts (FTSGs) are generally considered unreliable for coverage of full-thickness finger defects with bone or tendon exposure, and there are few clinical reports of its use in this context. However, animal studies have shown that an FTSG can survive over an avascular area ranging up to 12 mm in diameter. In our experience, the width of the exposed bones or tendons in full-thickness finger defects is <7 mm. Therefore, we covered the bone- or tendon-exposed defects of 16 fingers of 10 patients with FTSGs. Methods The surgical objectives were healthy granulation tissue formation in the wound bed, marginal de-epithelization of the normal skin surrounding the defect, preservation of the subdermal plexus of the central graft, and partial excision of the dermis along the graft margin. The donor site was the mastoid for small defects and the groin for large defects. Results Most of the grafts (15 of 16 fingers) survived without significant surgical complications and achieved satisfactory functional and aesthetic results. Minor complications included partial graft loss in one patient, a minimal extension deformity in two patients, a depression deformity in one patient, and mild hyperpigmentation in four patients. Conclusions We observed excellent graft survival with this method with no additional surgical injury of the normal finger, satisfactory functional and aesthetic outcomes, and no need for secondary debulking procedures. Potential disadvantages include an insufficient volume of soft tissue and graft hyperpigmentation. Therefore, FTSGs may be an option for treatment of full-thickness finger defects with bone or tendon exposure.

• Imaging Science in Dentistry
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• 제50권4호
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• pp.273-279
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• 2020

This review presents an overview of some diagnostic imaging-related issues regarding medication-related osteonecrosis of the jaws(MRONJ), including imaging signs that can predict MRONJ in patients taking antiresorptive drugs, the early imaging features of MRONJ, the relationship between the presence or absence of bone exposure and imaging features, and differences in imaging features by stage, between advanced MRONJ and conventional osteomyelitis, between oncologic and osteoporotic patients with MRONJ, and depending on the type of medication, method of administration, and duration of medication. The early diagnosis of MRONJ can be made by the presence of subtle imaging changes such as thickening of the lamina dura or cortical bone, not by the presence of bone exposure. Most of the imaging features are relatively non-specific, and each patient's clinical findings and history should be referenced. Oral and maxillofacial radiologists and dentists should closely monitor plain radiographs of patients taking antiresorptive/antiangiogenic drugs.

• Toxicological Research
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• 제33권2호
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• pp.157-164
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• 2017

This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effects of caffeine on the long bones and testes in rats are different according to the age of the rat at the time of exposure, and might therefore be caused by changes to organ sensitivity and metabolic rate at different developmental stages. Although the long bones and testes are more susceptible to caffeine during puberty, caffeine has negative effects on body fat, bone minerals and the adrenal glands when exposure occurs during young adulthood. There is a need, therefore, to educate the public the potential dangers of caffeine consumption during puberty and young adulthood.

• 치과방사선
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• 제25권2호
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• pp.363-373
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• 1995

The aim of this study was to evaluate and compare observer performance between conventional radiographs and their digitized images for the detection of bone loss in the bifurcation of mandiblar first molar. One dried human mandible with minimal periodontal bone loss around the first molar was selected and serially enlarged 17 step defects were prepared in the bifurcation area. The mandible was radiographed with exposure time of 0.12, 0.20, 0.25, 0.32, 0.40, 0.64 seconds, after each successive step in the preperation and all radiographs were digitized with IBM-PC/32 bit-Dx compatible, video camera (VM-S8200, Hitachi Co., Japan), and color monitor(Multisync 3D, NEC, Japan). Sylvia Image Capture Board for the ADC(analog to digital converter) was used. The obtained results were as follows: 1. In the conventional radiographs, the mean score of the readability was higher at the condition of exposure time with 0.32 second. Also, as the size of artificial lesion was increased, the readability of radiographs was elevated (P<0.05). 2. In the digital images, the mean score of the readability was higher at the condition of exposure time with 0.40 second. Also, as the size of artificial lesion was increased, the readability of digital images was elevated(P<0.05). 3. At the same exposure time, the mean scores of readibility were mostly higher in the digitized images. As the exposure time was increased, the digital images were superior to radiographs in readability. 4. As the size of lesion was changed, the digital images were superior to radiographs in detecting small lesion. 5. The coefficient of variation of mean score has no significant difference between digital images and radiographs.

• 치과방사선
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• 제29권1호
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• pp.33-42
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• 1999

Geometrically standardized dental radiographs were taken. We prepared Digital Cu-Equivalent Image Analyzing System for quantitative assessment of mandible bone. Images of radiographs were digitized by means of Quick scanner and personal Mcquintosh computer. NIH image as software was used for analyzing images. A stepwedge composed of 10 steps of 0.1mm copper foil in thickness was used for reference material. This study evaluated the effects of step numbers of copper wedge adopted for calculating equation. kVp and exposure time on the coefficient of determination(r²)of the equation for conversion to Cu-equivalent image and the coefficient of variation and Cu-Eq value(mm) measured at each copper step and alveolar bone of the mandible. The results were as follows: 1. The coefficients of determination(r²) of 10 conversion equations ranged from 0.9996 to 0.9973(mean=0.9988) under 70kVp and 0.16 sec. exposure. The equation showed the highest r was Y=4.75614612-0.06300524x +0.00032367x² -0.00000060x³. 2. The value of r² became lower when the equation was calculated from the copper stepwedge including 1.0mm step. In case of including 0mm step for calculation. the value of r showed variability. 3. The coefficient of variation showed 0.11, 0.20 respectively at each copper step of 0.2, 0.1mm in thickness. Those of the other steps to 0.9 mm ranged from 0.06 to 0.09 in mean value. 4. The mean Cu-Eq value of alveolar bone was 0.14±0.02mm under optimal exposure. The values were lower than the mean under the exposures over 0.20sec. in 60kVp and over 0.16sec. in 70kVp. 5. Under the exposure condition of 60kVp 0.16sec.. the coefficient of variation showed 0.03. 0.05 respectively at each copper-step of 0.3, 0.2mm in thickness. The value of r² showed over 0.9991 from both 9 and 10 steps of copper. The Cu-Eq value and the coefficient of variation was 0.14±0.01mm and 0.07 at alveolar bone respectively. In summary. A clinical application of this system seemed to be useful for assessment of quantitative assessment of alveolar provided high coefficient of determination is obtained by the modified adoption of copper step numbers and the low coefficient of variation for the range of Cu-Equivalent value of alveolar bone from optimal kVp and exposure time for each x-ray machine.

• 대한간호
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• 제23권2호통권125호
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• pp.29-36
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• 1984

Bone marrow transplantation has been recognized as one of the best methods in the treatment of patients with severe aplastic anemia, acute leukemia, chronic myelocytic leukemia, congenital immune deficiency syndrome and radiation exposure. While there are

• 한국산학기술학회논문지
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• 제21권8호
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• pp.277-286
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• 2020

본 연구는 간호대학 여학생의 골 건강에 대한 인지 및 지식과 골질량 증진행위를 파악하기 위한 서술적 조사연구이다. 연구대상은 K시와 D시 소재의 3개 간호대학에 재학 중인 간호대학 여학생 172명을 대상으로 2020년 3월 16일부터 4월 4일까지 일반적 건강관련 특성, 골 건강 인지, 골 건강 지식, 골질량 증진행위 도구를 이용하여 온라인 설문조사를 실시하였다. 수집된 자료는 SPSS WIN 22.0을 이용하여 서술적 통계, t-test, ANOVA, Pearson's correlation, 위계적 다중회귀분석을 하였다. 간호대학 여학생의 건강 인지 수준은 1.79점이었으며, 골 건강 지식수준 8.86점, 골질량 증진행위 수준은 2.78점으로 나타났다. 골질량 증진행위는 골 건강 지식(r=-0.21, p=.005)과 초경연령(r=-0.21, p=.004), 하루 15분 햇빛노출(r=-0.44, p<.000)간에 유의한 음의 상관관계가 있었다. 골질량 증진행위에 영향을 주는 변수 3가지를 단계별 회귀분석으로 투입하였을 때 모델 1의 골 건강 지식(β=0.21, p=.005)과 모델 2의 초경연령(β=-0.20, p=.005)을 투입했을 때 보다 모델 3의 하루 15분 햇빛노출(β=-0.38, p<.000)이 투입되었을 때 골질량 증진행위에 대한 설명력이 증가하여 20.6%의 설명력이 나타났다. 본 연구결과 골질량 생성에 비타민 D는 음식과 햇빛을 통해 체내로 들어오므로 골량이 증가하는 여대생의 햇빛 노출은 골질량 증진행위에 중요한 요인이다.

• Molecules and Cells
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• 제26권5호
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• pp.486-489
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• 2008

Curcumin (diferuloylmethane), a pigment derived from turmeric, has anti-oxidant and anti-inflammatory activities. Accumulating evidence points to a biochemical link between increased oxidative stress and reduced bone density. Osteoclast formation was evaluated in co-cultures of bone marrow stromal cells (BMSC) and whole bone marrow cells (BMC). Expression of receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) was analyzed at the mRNA and protein levels. Exposure to curcumin led to dose-dependent suppression of osteoclastogenesis in the co-culture system, and to reduced expression of RANKL in $IL-1{\alpha}$-stimulated BMSCs. Addition of RANKL abolished the inhibition of osteoclastogenesis by curcumin, whereas the addition of prostaglandin $E_2$ ($PGE_2$) did not. The decreased osteoclastogenesis induced by curcumin may reduce bone loss and be of potential benefit in preventing and/or attenuating osteoporosis.

• Imaging Science in Dentistry
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• 제33권1호
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• pp.43-49
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• 2003

Purpose : To evaluate the differences in bone height, bone width, and visibility of posterior spiral tomographic images according to various exposure directions, image layer thickness, and inclination of the mandibular inferior border. Materials and Methods: Six partially and completely edentulous dry mandibles were radiographed using Scanora spiral tomography. Spiral tomography was performed at different exposure directions (dentotangential and maxillotangential projection), image layer thicknesses (2 mm, 4 mm and 8 mm), and at various inclinations to the mandibular border (+ 100, 00 and -10°). The bone height and width was measured using selected tomographic images. The visibility of mandibular canal, crestal bone, and buccal and lingual surfaces were graded as 0, 1, or 2. Results : The bone width at the maxillo-tangential projection was wider than at the dento-tangential projection (p < 0.05). The visibility of buccal and lingual surface at the maxillo-tangential projection was higher than at the dento-tangential projection (p<0.05). Thinner image layer thicknesses resulted in greater visibility of buccal and lingual surfaces (p < 0.05). Bone height was greatest in the -10° group, and at the same time the bone width of the same group was the narrowest (p < 0.05). The visibility of alveolar crest and buccal surface of the + 10° group was the highest, while the visibility of the mandibular canal was greatest in the 00 group. Conclusion: When spiral tomography is performed at the mandibular posterior portion for visualization prior to implant surgery, it is important that the inferior border of mandible be positioned as parallel as possible to the floor. A greater improvement of visibility can be achieved by maintaining a thin image layer thickness when performing spiral tomography.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.179-179
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• 2006

PLGA/HA composite scaffold fabricated by GF/PL method showed enhanced mechanical property, hydrophilicity and osteoconductivity compared with the SC/PL scaffolds, and this enhancement was most likely due to a higher extent of exposure of HA particles to the scaffold surface. The biodegradable polymer/bioceramic composite scaffolds fabricated by the GF/PL method could enhance bone regeneration efficacy for the treatment of bone defects compared with conventional composite scaffolds.