• 대한골관절종양학회지
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• 제11권2호
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• pp.160-167
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• 2005

목적: 거대세포종은 대부분 대퇴골 원위부 및 경골 근위부에 주로 발생하며, 병소 내 소파술에서 광범위 절제술까지 다양한 수술 방법들이 시행되고있다. 저자들은 수술이 어렵고 재발율이 높은 슬관절 부위의 거대세포종 환자에서 재발율을 포함한 치료 성적을 분석하고, 재발율과 관련된 인자를 규명하고자 하였다. 대상 및 방법: 병리학적으로 확진 되고, 고속 바(high-speed burring)와 골 시멘트를 이용한 병소내 소파술을 시행 한 41예의 슬관절 주위 거대세포종 환자를 대상으로 하였다. 재발율과 기능적 평가를 통한 치료 성적을 분석하였으며, 성별, 연령, 종양의 위치, 크기, 연골 하골의 침범과 관절 내 침범 유무 그리고 Campanacci 분류에 따른 인자들과 재발율과의 상관관계를 통계적으로 분석하였다. 평균 추시 기간은 50(12~122) 개월이었다. 결과: 최종 추시 상 재발율은 17%였고, 재발시기는 평균 술 후 10개월이었다. Musculoskeletal Tumor Society (MSTS) Grading System에 의한 술 후의 기능 평가점수는 평균 27.8(93%)로 78%에서 만족스러운 기능을 보였다. 성별, 연령, 종양의 위치, 크기, 연골 하침범, 관절 내 침범, Campanacci 분류 등은 종양의 국소 재발과 통계적으로 유의한 상관 관계를 보이지 않았다. 결론: 슬관절 주변 거대세포종의 재발과 관련된 인자를 찾지는 못하였다. 수술적 치료로서 고속 바를 이용한 세심한 소파술과 골시멘트 충진술을 이용한 국소 절제술 만으로도 만족할 만한 결과 및 재발율을 얻을 수 있었다.

• Journal of Radiation Protection and Research
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• 제15권2호
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• pp.41-49
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• 1990

Wistar rat에 $^{88}SrCl_2$를 꼬리 정맥에 주사하여 체내 기관과 혈액 내 분포, 잔존율을 조사하였고 착화제와 유기산을 투석하여 혈장 단백질에 결합하는 Sr 양의 변화를 측정하였다. 혈액내에서 Sr은 혈장에 60%, 세포에 40% 부착되어 이동하였다. 혈장에 존재하는 Sr 중 약 50%정도는 혈장 단백질과 결합한 상태였고, 세포에는 세포 표면에 가볍게 부착되어 있었다. Erythrocyte나 granulocyte보다 lymphocyte에 많은 양의 Sr이 부착되어 있었다. 투여후 초기 1시간 이내에 혈액 내에서 급격히 감소하여 뼈에 침착되었다. 이때 각 기관에서도 Sr의 잔존율은 24시간 이내에 크게 감소하였고, 뼈로 침착된 Sr은 24시간 이후에 서서히 감소하였다. 착화제 EDTA, EGTA 및 DTPA를 투여한 경우, 혈장 단백질에 결합하는 Sr의 양은 대조군의 57%에서 27-33%로 감소하였으며 citrate 및 oxalate의 투여시는 이 값이 19%와 40%로 각각 감소하였다.

• 대한의용생체공학회:의공학회지
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• 제38권6호
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• pp.321-329
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• 2017

This paper presents a bone metastasis Detection algorithm on abdominal computed tomography images for early detection using fully convolutional neural networks. The images were taken from patients with various cancers (such as lung cancer, breast cancer, colorectal cancer, etc), and thus the locations of those lesions were varied. To overcome the lack of data, we augmented the data by adjusting the brightness of the images or flipping the images. Before the augmentation, when 70% of the whole data were used in the pre-test, we could obtain the pixel-wise sensitivity of 18.75%, the specificity of 99.97% on the average of test dataset. With the augmentation, we could obtain the sensitivity of 30.65%, the specificity of 99.96%. The increase in sensitivity shows that the augmentation was effective. In the result obtained by using the whole data, the sensitivity of 38.62%, the specificity of 99.94% and the accuracy of 99.81% in the pixel-wise. lesion-wise sensitivity is 88.89% while the false alarm per case is 0.5. The results of this study did not reach the level that could substitute for the clinician. However, it may be helpful for radiologists when it can be used as a screening tool.

• 지역사회간호학회지
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• 제26권4호
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• pp.398-404
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• 2015

Purpose: This study was conducted to examine the effects of osteoporosis prevention education on Korean breast cancer patients' knowledge and health promoting behavior. Methods: The participants in this study included breast cancer patients who were registered at a self-help group organized by the Breast Cancer Center of a university hospital in Seoul, Korea. The intervention group received 60 minutes' didactic instruction followed by 30 minutes' interactive session, and reinforcement education with leaflets was given three weeks after the group intervention. In order to measure the effects of the intervention, this study used valid and reliable scales on the knowledge of osteoporosis and health promoting behavior for preventing osteoporosis. A post-test was conducted 12 weeks after the intervention. Results: The results showed significant improvement in three of the five factors of osteoporosis knowledge including bone physiology, the characteristics of osteoporosis, and preventive behaviors in the intervention group. Overall health promoting behavior for preventing osteoporosis had significantly increased in the intervention group compared to the control group. Conclusion: Osteoporosis preventive education improved breast cancer patients' knowledge of osteoporosis and health promoting behavior for preventing osteoporosis by inducing their voluntary participation in self-care activities.

• 대한골관절종양학회지
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• 제1권1호
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• pp.17-22
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• 1995

From Sept. 1986 to Dec. 1992, seventy three cases of Enneking's stage IIB osteosarcoma of extremities, which were proved histologically, took neoadjuvant chemotherapy and completed our protocol. Their average age was 16.7 years(7 to 57). For neoadjuvant chemotherapy, 37 cases took high dose methotrexate(HDMTX)-adriamycin(ADR)-cisplatin(CDDP) regimen(HDMTX group) and 36 cases took ADR-CDDP(ADR-CDDP group). The average follow up was 17 months(2-63). According to Kaplan-Meier's plot, 5-year continuously disease free survival for whole 73 cases of neoadjuvant group was 45.2%, for HDMTX group 68.4%, for ADR-CDDP group 26.6%. There was significant stastical difference between these two groups(p<0.001), with log-rank test. There can be a different survival according to the chemotherapeutic protocols. Better results can be achieved through refined protocol and effective chemotherapeutic agents.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1325-1332
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• 2016

Radioprotective effects of ginger essential oil (GEO) on mortality, body weight alteration, hematological parameters, antioxidant status and chromosomal damage were studied in irradiated mice. Regression analysis of survival data in mice exposed to radiation yielded LD50/30 as 7.12 and 10.14 Gy for control (irradiation alone) and experimental (GEO-treated irradiated) mice, respectively, with a dose reduction factor (DRF) of 1.42. In mice exposed to whole-body gamma-irradiation (6 Gy), GEO pre-treatment at 100 and 500 mg/kg b.wt (orally) significantly ameliorated decreased hematological and immunological parameters. Radiation induced reduction in intestinal tissue antioxidant enzyme levels such as superoxide dismutase, catalase, glutathione peroxidase and glutathione was also reversed following administration of GEO. Tissue architecture of small intestine which was damaged following irradiation was improved upon administration of GEO. Anticlastogenic effects of GEO were studied by micronuclei assay, chromosomal aberration and alkaline gel electrophoresis assay. GEO significantly decreased the formation of micronuclei, increased the P/N ratio, inhibited the formation of chromosomal aberrations and protected agaisnt cellular DNA damage in bone marrow cells as revealed by comet assay. These results are supportive of use of GEO as a potential radioprotective compound.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3715-3720
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• 2014

Background: It is controversial whether Tai Chi (TC) benefits breast cancer survivors (BCS) on quality of life (QoL). We therefore undertook a meta-analysis to assess this question. Materials and Methods: A computerized search through electronic databases was performed to identify relevant randomized controlled trials (RCTs). The primary outcome was QoL, while secondary outcomes included body mass index (BMI), bone mineral density (BMD), and muscle strength. Results: Five RCTs involving 407 patients were included in the meta-analysis. The pooled standardized mean differences were 0.10 (95% confidence interval (CI): -0.35-0.54) for physical well-being, 0.03 (95%CI: -0.18-0.25) for social/family well-being, 0.24 (95%CI: 0.02-0.45) for emotional well-being, 0.23 (95%CI: -0.03-0.49) for functional well-being, and 0.09 (95%CI: -0.19-0.36) for additional concerns. TC failed to improve BMI, BMD, and muscle strength. Conclusions: There is currently lack of sufficient evidence to support TC improving QoL and other important clinical endpoints.

• 대한두경부종양학회지
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• 제15권2호
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• pp.232-234
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• 1999

두경부 영역에서 발생하는 악성종양은 원격전이가 흔하지 않으나 최근 들어 국소전이에 대한 치료효과가 향상됨에 따라 원격전이가 재발과 사망의 주된 원인이 되고 있다. 원격전이중 뇌전이는 빈도는 적으나 이환시 높은 사망률을 보이므로 뇌전이를 의심하는 증상이 있을 때는 조기발견을 위한 적극적인 진단적 접근과 이에 대한 적절한 치료가 중요하다. 본 증례와 같이 고식적 수술후 국소전이에 대한 조절이 잘 되고 있는 환자에서 지속적인 두통 및 체중감소 등의 증상이 나타나는 경우 뇌전이를 의심하여 적절한 진단 방법을 통한 조기 진단과 치료가 중요하다고 생각된다.

• 혜화의학회지
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• 제9권2호
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• pp.223-239
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• 2001

A literature study on cancer therapy of warm-hot oriental medicine was done, and the results were as follows. 1. In oriental medicine, oncogens are six exopathogens, seven modes of emotion, overwork, pathogenic factors, and especially related with pathologic cold situation. 2. There are many capillaries in tuomr, and because temperature of inner space of tumor is higher than normal organization. Tumor cell has a character which is weak for high temperature. 3. Warm-hot herb drugs have effects of dissipating mass, warming kidney to reinforce yang and dispering, so it has a function of suppressing tumor as well as improving immunity in cancer therapy. 4. In traditional medical books, main prescriptions of cancer therapy are xinzhiyinyanggongjiwan(新製陰陽攻積丸), qianjinxiaoshiwan(千金硝石丸), feiqiwan(肥氣丸), xibenwan(息賁丸), fuliangwan(伏梁丸), beiqiwan, bentunwan(賁豚丸), zengsunwujiwan(增損五積丸), and these are composed of warm-hot herb drugs. 5. In current, the study of warm-hot drugs is progressed in immunological capacity, anti-tumor activity, stimulating bone marrow and regulating hormone secretion. It will be expected that advanced study of these must be accomplished in cancer patients.

• 대한골관절종양학회지
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• 제12권2호
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• pp.131-135
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• 2006

연골육종은 조직학적 소견에 따라 grade I, II, III로 나누어지며 예후와도 깊은 관련이 있다. Grade II 및 III의 연골육종의 수술 시 광범위 절제를 주로 시행하나 grade I 연골육종의 경우에는 소파술과 광범위 절제술 사이에 이견이 많다. 저자들은 상완골의 근위부에 grade I, 원위부에 grade II의 연골육종이 발생한 경우에 grade I은 소파술을, grade II는 광범위 절제술을 시행한 경험을 하였기에 보고하는 바이다.