• Molecules and Cells
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• 제39권1호
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• pp.6-19
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• 2016

Redox signalling comprises the biology of molecular signal transduction mediated by reactive oxygen (or nitrogen) species. By specific and reversible oxidation of redoxsensitive cysteines, many biological processes sense and respond to signals from the intracellular redox environment. Redox signals are therefore important regulators of cellular homeostasis. Recently, it has become apparent that the cellular redox state oscillates in vivo and in vitro, with a period of about one day (circadian). Circadian timekeeping allows cells and organisms to adapt their biology to resonate with the 24-hour cycle of day/night. The importance of this innate biological timekeeping is illustrated by the association of clock disruption with the early onset of several diseases (e.g. type II diabetes, stroke and several forms of cancer). Circadian regulation of cellular redox balance suggests potentially two distinct roles for redox signalling in relation to the cellular clock: one where it is regulated by the clock, and one where it regulates the clock. Here, we introduce the concepts of redox signalling and cellular timekeeping, and then critically appraise the evidence for the reciprocal regulation between cellular redox state and the circadian clock. We conclude there is a substantial body of evidence supporting circadian regulation of cellular redox state, but that it would be premature to conclude that the converse is also true. We therefore propose some approaches that might yield more insight into redox control of cellular timekeeping.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.498-502
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• 2004

In a link-motion mechanism, numerous links are interconnected and each link executes a constrained motion at a high speed. Due to the complicated constrained motions of the constituent links, dynamic unbalance forces and moments are generated and transmitted to the main frame. Therefore unwanted vibration is produced. This degrades productivity and precise work. Based on constrained multi-body dynamics, the kinematic analysis is carried out to enable design changes to be made. This will provide the fundamental information for significantly reducing dynamic unbalance forces and moments which are transmitted to the main frame. In this work, a link-motion punch press is selected as an example of a link-motion mechanism. To calculate the mass and inertia properties of every link comprising a link-motion punch press, 3-dimensional CAD software is utilized. The main issue in this work is to eliminate the first-order unbalance force and moment in a link-motion punch press. The mass, moment of inertia link length, location of the mass center in each link have a great impact on the degree of dynamic balancing which can be achieved maximally. Achieving good dynamic balancing in a link motion punch press is quite essential fur reliable operation at high speed.

• 대한한의학원전학회지
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• 제20권3호
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• pp.1-8
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• 2007

In "Hwangjenaegyeong", pathogenesis is explained based on theory of Yin and Yang. According to the theory, all environments surrounding us, physical and emotional both, are related to outbreak of diseases. This also reflects one of the major theories in oriental medicine, in which a human body is perceived as a correspondence to natural environment. In this theory, the main idea is to understand changes in the universe based on mutual correlations from within. This kind of perspective is easily criticized from scientific point of view. Whereas modern science pursue analytic thinking and objective information, the theories above seem rather vague. However, from a different angle, through a characteristic perspective of oriental medicine, actual significance can be found in the theory. Many diseases result from one's intemperate living habits. Therefore, much prevention can be made by self-control. Also, once disease occurs, the essential step to treatment is to find cause in the living environment and regain balance. Natural cure will take its' course when living habits recover moderate pace and are back in harmony with the environment.

• 기본간호학회지
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• 제13권2호
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• pp.200-207
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• 2006

Purpose: This study was done to identify factors influencing falls in inpatients. A comprehensive analysis of individual, disease, and environment related factors and an assessment of being in a risk factor group were included in the data. Method: The medical records of 325 inpatients were reviewed. Data were collected from January to July 2003. Frequencies, 1-test and $X^2-test$ were used to analyze the data and the SPSS program was used. Results: Individual-related factors for inpatients falls were age, drinking and weakness. Disease-related factors for inpatients falls were diagnostic department, admission from ER or OPD, admission by wheelchair or orther method and activity status. Environment-related factors for inpatient falls were re-education and side-rails. Assessment of the risk factor group related factors were age, history of falls, body balance, depression, communication, medication, chronic disease, urinary condition and total score for risk factors. Conclusion: Experienceing a fall among Korean inpatients was associated not only with individual factors, but also with disease and environmental factors. The findings of this study suggest that broad intervention programs should be provided to prevent inpatient falls.

• 대한약침학회지
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• 제24권3호
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• pp.138-141
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• 2021

Objectives: This study aims to describe the utilization of herbal formulas from Wenrejingwei by using network analysis and understand the treatment of acute exogenous febrile diseases. Methods: We constructed a matrix of high-frequency herbal combinations (HCs) from Wenrejingwei and Shang Han Lun and cluster networks based on cohesive analysis. Network analysis was performed to compare the results. Results: The results of the high-frequency HC network in Wenrejingwei showed cohesive patterns in three categories corresponding to dampness-heat and warm-fever treatment. Compared to the Shang Han Lun network, the Wenrejingwei network indicated a careful approach in the use of pungent and warm herbs such as Guizhitang. Moreover, the combination of Scutellaria baicalensis and Coptis chinensis along with the use of herbs strengthening yin, such as Ginseng Radix and Liriopes Radix, provide evidence of a holistic approach in the treatment of exogenous febrile diseases by considering the balance of the human body damaged by heat. Conclusion: The results of this study could help select appropriate herbal formulas and treatment methods for treating Onbyeong and modern acute febrile infectious diseases.

• 대한한의학원전학회지
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• 제34권3호
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• pp.21-39
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• 2021

Objectives : This paper compares and analyzes Liu Hejian's kidney fluid nourishing treatment methodology with Zhu Danxi's kidney tonifying treatment methodology. Methods : The two doctors' medical theories and treatment formulas were examined to study how their medical arguments manifested in clinical application. Results : Both doctors emphasized the kidney. Liu pursued the treatment of balance based on the theory of the original qi of the Taiyitianzhen(太乙天眞), while Zhu tried to prevent the frenetic stirring of the ministerial fire by restraining one's desires. In nourishing kidney fluid, Liu sometimes used hot medicinals to treat kidney deficiency patters, where medicinals that tonify the kidney fluid were not defined clearly. Zhu, on the other hand, defined formulas and medicinals that would tonify the kidney yin clearly. Conclusions : The tradition of emphasizing the body's yin qi based on the kidney has been continued from Liu Hejian to Zhu Danxi, during which the pathology of fire and heat were examined thoroughly. In clinical application, various and specific ways of controlling the fire heat were developed.

• 턱관절균형의학회지
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• 제8권1호
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• pp.6-10
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• 2018

In order to propose a fundamental and appliable theories for balancing therapy of temporomandibular joint (TMBT), evolutionary proofs and up-down theories in evolutionary biology and Korean medicine were investigated. Balancing therapy of temporomandibular joint treats disorder and diseases of the whole body through straightening of the abnormal linking between temporomandibular joint and axis. Although the mechanism of this therapy contains many merits like multicellular integrity and coadjustment, ease of balance and alert forward mobility by the bipedal stepping and evolution to Homo sapiens, increasing disadvantages of balancing pressure of right and left in the lengthened perpendicular axis and the balancing load of temporomandibular joint and axis following the reactional change of dental occlusion are deeply related and considered in this therapy. As for up-down theory, crossing of heavenly qi and earth qi centering on cervical joint is presented as the first mechanism for TMBT, and the other ones like in-out and up-down qi activity of tripple energizer, up-down of essence-qi-spirit in the three backbone barrier and three cinnabar field, up-down of yin-yang-water-fire of viscera and bowels can be related too.

• The Journal of Asian Finance, Economics and Business
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• 제8권4호
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• pp.69-81
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• 2021

The aim of this paper is to identify the key determinants in the Gulf Cooperation Council (GCC) countries for Foreign Direct Investment (FDI) inflows by using a balanced data panel for the period from 1995 to 2018. This study covers GCC countries in their entirety. The study uses ten explanatory variables, namely, trade ratio, gross domestic product, external balance, fuel exports, gross savings, international tourism, military expenditure, net foreign assets, services value added, and total natural resources. The authors have tried to find the best fit model from the differences methods considered such as OLS, GLS regression with the help of Hausman test, and country by country regressions as additional analysis. The study revealed a significantly positive association between inflation, trade ratio, gross domestic product, gross savings, and net foreign assets with FDI. On the contrary, international tourism was revealed to have a negative association with FDI. The sample of all GCC countries chosen for this study has not been considered widely by any earlier study. Moreover, this study covered many determinants of FDI that add to the previous literature. It is a significant contribution to the current research body and stresses the originality of this paper.

• PNF and Movement
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• 제11권2호
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• pp.57-65
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• 2013

Purpose : This purpose of this study was to investigate the effects of elastic band resistance exercise program in the falls prevention of elderly women. Methods : The subjects of this study, 46 people elderly women who participated in the exercise program of Jeollanamdo Y elderly welfare center were chosen as subjects and use the elastic band resistance exercise program for 12 weeks. Results : There was a significant increase on the physical function and fall efficacy of all the subjects in the experimental group and the control one after the experiment. Furthermore, the experimental group showed more meaningful improvement than the control one. Conclusion : Falls Efficacy of the experimental group before the experiment, after the changes in difference was noted. More results from the 12 weeks of using the elastic band resistance exercise program to increase the efficacy of body functions (power of lower extremity, muscle endurance, flexibility, balance, and agility), and falls efficacy of elderly women is considered as an effective fall prevention exercise program.

• PNF and Movement
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• 제10권2호
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• pp.47-54
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• 2012

Purpose : The purpose of this study was investigated to find the approach in the various method for patients with chronic low back pain. Methods : For research purposes that meet the search was focused papers. Treatments include PNF, chiropractic, joint mobilization, microcurrent, electroacupuncture, stabilizing exercise, resistance exercise, aquatic rehabilitation exercise, lumbar flexion and extension exercise were included as Gymball exercise. Results : Treatment with the three major manual therapy, electrical therapy and therapeutic exercise were divided. The result of applying manual therapy increased balance, increased strength, stability increased and decreased pain. The result of applying the electrical therapy increased flexibility, and decreased pain. The result of applying therapeutic exercise increases muscle strength, reduced pain, and decreased body fat. Conclusion : Previous studies by examining the effects of chronic low back pain treatment was intended to help in the selection and application Aquatic therapy, manual therapy, electrical therapy for patients with chronic low back pain with pain reduction was found to be effective.