• 대한한의학회지
• /
• 제16권1호통권29호
• /
• pp.403-418
• /
• 1995

In order to study the effects of Chungsimgangwhawhan on blood pressure in normal rats and rabbits, and hyperlipidemia induced by 1% cholesterol diet, triton WR-1339, and 75% fructose in mice and rats, the amount of total cholesterol, triglyceride, phospholipid and blood pressure were measured. The results were as follows : 1. After per os medication of Chungsimgangwhawhan, blood pressure in rats were increased but were not significant. 2. Chungsimgangwha-Whan showed strong effects on decreasing blood pressure, depending on the concentration in blood vessels of rabbits. 3. In the model of hyperlipidemia induced by 1% cholesterol diet in mice, Chungsimgangwhawhan showed decreasing effects on total cholesterol level in serum significantly (p<0.05) depending on the concentration, and on triglyceride (p<0.01) and phospholipid level (p<0.001) in serum. 4. In the model of hyperlipidemia induced by triton WR-1339 in rats, Chungsimgangwhawhan showed mild decreasing effects on total cholesterol level in serum, but was not significant. 5. In the model of hyperlipidemia induced by 75% fructose in rats, Chungsimgangwhawhan showed decreasing effects on total cholesterol and triglyceride level in serum significantly(p<0.01) depending on the concentration. According to the above results, Chungsimgangwhawhan showed significant decreasing effects on blood pressure and hyperlipidemia, and it is considered that it is appropriate to apply for hypertension and hyperlipidemia.

• Asian-Australasian Journal of Animal Sciences
• /
• 제7권4호
• /
• pp.459-466
• /
• 1994

Primordial germ cells (PGCs) in aves are the progenitor cells for the gametes. These cells first appear in the epiblast (Eyal-Giladi et al.. 1981). Then translocate and concentrate to endoderm of germinal crescent area in the junction of the area opaca and area pellucida lateral to the primitive streak in stage 4 through 7. They separate from the endoderm, temporarily circulate via the blood vascular system, leave the blood vessels, and finally settle down in the gonadal anlagen at stage 20-24 where they rapidly proliferate to form germ cells. Recently, several attempts have been made to introduce foreign gene into the avian genome to form a transgenic chicken. The stem cells most readily available as vehicles for genetic manipulation of germline in avian species are the PGCs. PGCs have recently been manipulated genetically and used successfully as a vector for gene transfer.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
• /
• pp.544-544
• /
• 2000

From ancient times. the diagnosis method of the oriental medicine has been Performed by curing diseases by means of rectifying and adjusting the unbalance in the Physiological function of the five viscera and the six bowels of a human body. Diseases have been diagnosed by the condition of blood circulation that cycles a human body through blood vessels by dint of the vitality of the heart, Based on such a systematic pulse diagnosis method, the article presents parameters that will be beneficial to clinical application on the basis of its analysis of the filtering for eliminating noises from pulse signals inputted from sensor group the digital hardware dealing with signals necessary for recognition algorithm. and the structure of diagnosis algorithm and components of pulse waveform.

• 생약학회지
• /
• 제18권4호
• /
• pp.241-248
• /
• 1987

Woohwangchungsim-Won has been widely used for the treatment of appoplexy, hypertension, arteriosclerosis, insomnia and cerebrovascular accident, etc in oriental hospital and pharmacy. In order to investigate the efficacy of Woohwangchungsim-Won, the water extract of it were bioassayed for isolated ileum, blood vessels, blood pressure, heart and diuresis. The results of this studies were as follows; Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contraction of isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were inhibited. Vaso-dilating action due to vascular smooth muscle relaxation in frogs and rabbits, and hypotensive action in anesthetized rabbits were noted. Negative inotropic action on the isolated frog heart and diuretic effect in rabbits were shown.

• 소성∙가공
• /
• 제24권2호
• /
• pp.89-94
• /
• 2015

Medical catheter tubes are disposable devices that are inserted into the body cavities such as the pleura, trachea, esophagus, stomach, urinary bladder, ureter, or blood vessels for surgical procedures. Each hole of the inner tube is called a lumen, which is used as a passage for drug injections, waste discharge, polypus removal, blood transport, or injection of a camera or sensor. The catheter tube is manufactured by extrusion. The flow in the inner extrusion die affects the thickness and diameter of the tube. In the current study computer simulation of flow in an extrusion die for catheter tubing was performed. Velocity, pressure, shear rate, and shear stress were investigated and the die design was examined.

• 대한의용생체공학회:의공학회지
• /
• 제10권1호
• /
• pp.25-32
• /
• 1989

In this study, Rheoencephalography( REG ) was designed and constructed. Using the cons- tructed instrument cerebral blood flow(CBF) of left and right brain, CBF change by posture, and reproducibility were studied. Followings are important results. Relative CBF could be measured noninvasively and continuously. Since reproducibility of the constructed REG was found to be quite high (4%), the accuracy of the instrument itself was proved. REG can be easily applied for testing the effect of drugs for the patients with cerebral vessel diseases since it is quite sensitive to the relative changes of CBF. Various cerebral diseases can be diagnosed by analyzing the REG waveforms. The area of restricted cerebral blood vessels can be located by arranging the electrode configuration. Comparative studies with the standard techinques of measuring CBF are needed to verify the accuracy of REG. Further studies on optimal electrode configuration and various artifacts are also necessary.

• Journal of Medicine and Life Science
• /
• 제16권3호
• /
• pp.55-59
• /
• 2019

Cerebral vessels are functionally and structurally specialized to provide adequate blood flow to brain which shows high metabolic rates. Cerebral hemorrhage or ischemic infarction due to cerebrovascular injury or occlusion can cause the immediate brain damage, and if not treated rapidly, can lead to serious or permanent brain damages, and sometimes life-threatening. Unlike these popular cerebrovascular diseases, there are diseases caused by genetic problems. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of them. CADASIL does not show the high incidence, but it is considered to be significantly affected by regional obstructiveness such as islands and therefore, to be an important genetic disease in Jeju. This paper aims to summarize the possibility of animal model research that can provide preclinical data for CADASIL disease research and to evaluate its applicability in future research plans.

• 사상체질의학회지
• /
• 제5권1호
• /
• pp.157-173
• /
• 1993

In order to investigate experimentally the clinical effects of Soeuminsohaphyangwon that was prescribed to cure the Wisunanrihanbyung of Soeum-In, the author experimented various activities of mixed extract from the Soeuminsohaphyangwon by the method prescribed in the experimental part. The results of the studies were summerized as follows : 1. Suppressive action was not shown on the convulsion induced by strychnine but significant effect was noted on the convulsion induced by picrotoxin and caffeine. 2. In acetic acid method experiment analgesic effect was noted. 3. A prolongation of anesthetic time by Pentobarbital sodium and antipyretic effect was observed. 4. Relaxing action was noted on the ileums of mice, also same effect was recognized on contraction of the ileums due to acetylcholine, barium chloride and histamine 2 HCl. 5. The expansion of blood vessels by relaxation of smooth muscle and fall of blood pressure were noted. According to the above results, effects based on oriental medical references were approximate to the actual experimental results.

• Journal of Chest Surgery
• /
• 제18권4호
• /
• pp.806-811
• /
• 1985

Pulmonary arteriovenous fistula is a rare congenital vascular malformation in the lung, resulting from erroneous capillary development, with incomplete formation or disintegration of the vascular septa that would normally divide the primitive connection between the venous and arterial plexus. The pathogenesis of its symptom is that unoxygenated and desaturated arterial blood enter into the pulmonary venous system directly. Recently we have experienced a case of multiple pulmonary arteriovenous fistula in a 15 year old male patient, who presented the symptom of cyanosis and dyspnea on exertion. The operation revealed well circumscribed and multilobulated aneurysmal lesion in left lower lobe with its subpleural and posterolateral basal location, and another aneurysmal lesion in inferior lingular segment of left lung. There was no abnormal connection between the fistula and systemic circulation. The left lower lobectomy was performed along with local extirpation of the inferior lingular segment of left lung. Both lesions showed angiomatous dilatation of the various sized vessels embedded in the parenchyma microscopically. Postoperative clinical course disclosed much improvement in symptoms and in the value of blood gas analysis. The patient was discharged without any complication.

• Journal of Chest Surgery
• /
• 제21권4호
• /
• pp.711-715
• /
• 1988

Pulmonary arteriovenous fistula is a congenital vascular malformation originated from abnormalities of capillary development. Fistulas may develop only in the lung or may be associated with similar abnormalities of the skin, mucous membrane, and the other organs. It may occur with hereditary hemorrhagic telangietasia[Rendu-Osier-Weber syndrome]. Recently we have experienced a case of the pulmonary arteriovenous fistula associated with Schwannoma in 20 year old male man. Tennis ball sized bright reddish mass which was composed of variable sized vascular channels filled with blood clots was located in the just subpleural portion of left lower lobe. Left lower lobectomy was done. Microscopic findings showed variable sized numerous blood vessels embedding in the parenchyma. There was a thumb-tip sized brown nodular mass which was turned out to be Schwannoma at the left 7th thoracic paravertebral area.