Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
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Physiological approach of CADASIL animal model and its predictable implication

CADASIL 동물모델의 생리학적 접근 및 연구적 가치의 예측

  • Jung, Sung-Cherl (Department of Physiology, Jeju National University School of Medicine) ;
  • Ko, Eun-A (Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine)
  • 정성철 (제주대학교 의과대학 생리학교실) ;
  • 고은아 (미국 네바다 주립대학교 생리학/세포생물학 교실)
  • Received : 2019.12.24
  • Accepted : 2020.01.07
  • Published : 2019.12.31
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Abstract

Cerebral vessels are functionally and structurally specialized to provide adequate blood flow to brain which shows high metabolic rates. Cerebral hemorrhage or ischemic infarction due to cerebrovascular injury or occlusion can cause the immediate brain damage, and if not treated rapidly, can lead to serious or permanent brain damages, and sometimes life-threatening. Unlike these popular cerebrovascular diseases, there are diseases caused by genetic problems. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of them. CADASIL does not show the high incidence, but it is considered to be significantly affected by regional obstructiveness such as islands and therefore, to be an important genetic disease in Jeju. This paper aims to summarize the possibility of animal model research that can provide preclinical data for CADASIL disease research and to evaluate its applicability in future research plans.

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References

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