• 대한수의학회지
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• 제22권2호
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• pp.197-209
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• 1982

This study was undertaken to clarify the histopathological changes of pigs naturally infected with hog cholera. Microscopic observations of the brain as well as clinical observations were carried out for the naturally and experimentally infected pigs with hog cholera viruses. Electron microscopically the vascular cuffings of the brain were also observed in the experiment. In addition, clinical and pathological studios were carried out in the rabbits inoculated with ALD, lapinized and isolated strain of hog cholera virus, respectively. The results obtained are as follows; Vascular cuffing of the brain was observed in about 97% of the natural cases and all of the experimental cases. Among the 496 cuffed blood vessels of natural cases, intramural cuffing (82.9%), intramural and perivascular cuffing (11.9%) and perivascular cuffing (5.2%) were seen, respectively. Electron microscopic findings on cuffed blood vessels of the brain were endothelial cellular degeneration, intramural separation and vacuolation, perivascular vacuolation and infiltration of pleomorphic lymphoid cells. In the rabbits dosed with tissue suspension of the lymphoid organs and isolated hog cholera virus, high body temperature and vascular cuffing of the brain were observed, meanwhile these changes were more significant in pre-injected cased with indian ink.

• 대한한의학방제학회지
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• 제18권2호
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• pp.15-23
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• 2010

The spice phenomenon therapy is to adhibit aromatic herbs or materials to the human body or clothing, for the purpose of preventing and treating diseases. Mankind found the fire, and found that some plants and trees give off smoke when they are burning. Then, they found that some of aromatic substances had certain actions after being absorbed through the respiratory organ, which was the beginning of the spice phenomenon therapy. The spice phenomenon therapy is effective to relieve the exterior syndrome, to eliminate dampness, to regulate Qi flow, and to induce resuscitation. It has two actions. One is that the aromas that permeated the body, refreshes the mind, stimulates the appetite, strengthens the spleen and the stomach, and makes a relaxing sleep. The other is that the aromatic substances, absorbed into the human body, have pharmacological actions. The volatile aromatic substances have various pharmacological actions such as stimulating cranial nerves, dilating cardiac blood vessels, promoting gastric secretion, relaxing and sleep-inducing. It has been proved that the spice phenomenon therapy is anti-inflammatory and anti-microbial and is effective to dilate cerebral blood vessels and to ease the pain. It is expected to be studied more aggressively.

• Biomolecules & Therapeutics
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• 제7권1호
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• pp.66-78
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• 1999

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10$^{-6}$ M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD$_{90}$ and V$_{max}$ at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.s.

• 대한기계학회논문집B
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• 제29권4호
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• pp.425-434
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• 2005

In order to analyze pulsating flows in elastic blood vessels, a method based on the ALE concept and finite volume method was reformed and modulated to include wall motion of elastic vessels and impedance phase angle(phase difference between wall motion and blood flow). Our study indicated wall shear rates(WSR) were significantly influenced by the wall motion and the impedance phase angle. For larger wall motion more than $5{\%},$ the computed WSR started to deviate from the results of the perturbation theory that assumed smaller wall motion. The study showed that oscillatory shear index increased as the impedance phase angle became more negative like $-70{\circ}\;or\;-80{\circ}$ due to reduced mean WSR and increased amplitude of WSR. This result indicated that hypertensive patients are more vulnerable to atherosclerosis than normal persons because of the role of more negative impedance phase angles usually observed in these patients.

• Imaging Science in Dentistry
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• 제48권4호
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• pp.295-300
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• 2018

This report presents a clinical case of trauma due to assault with a knife, and describes the importance of using the correct imaging modality in cases of facial penetrating trauma involving the superficial and deep anatomical planes. Penetrating wounds in the maxillofacial region are rare and poorly reported, but can result in serious complications that are difficult to resolve and may compromise the patient's quality of life, especially when large blood vessels or other vital structures are involved. Thus, it is essential to determine the extent of the affected blood vessels and the proximity of the retained object to the anatomical structures. In this case, digital subtraction angiography was the imaging modality chosen. The use of appropriate imaging examinations allows a proper map of the surgical field, reducing the chances of vascular damage during the surgical procedure.

• Archives of Plastic Surgery
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• 제50권3호
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• pp.311-314
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• 2023

In lower extremity reconstruction, the recipient vessel often requires long-range mechanical dilation because of extensive vasospasm or plaque formation induced by concomitant atherosclerosis. While a forceps dilator can be used to manipulate and dilate vessels approximately 1 cm from their end, a DeBakey vascular dilator can dilate long-range vessels. The authors successfully performed free flap reconstruction of the lower extremity using the DeBakey vascular dilator. Of the two patients who underwent lower extremity reconstruction, one had extensive vasospasm, and the other had plaques in the recipient arteries. Irrigation with 4% lidocaine and dilation of the lumen with a forceps dilator were insufficient to restore the normal arterial blood flow. Instead, a DeBakey vascular dilator with a 1-mm diameter tip was gently inserted into the lumen. Then, to overcome vessel resistance, the dilator gently advanced approximately 10 cm to dilate the recipient artery. Normal arterial blood flow was gushed out after dilating the vessel lumen using a DeBakey vascular dilator. The vascular anastomosis was performed, and intravenous heparin 5000 IU was administered immediately after anastomosis. Prophylactic low-molecular-weight-heparin (Clexane, 1 mg/kg) was administered subcutaneously to both patients for 14 days. The reconstructed flap survived without necrosis in either patient.

• 생명과학회지
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• 제24권5호
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• pp.573-587
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• 2014

혈관신생은 모든 조직의 성장과 발달, 그리고 상처회복 등에 매우 중요하다. 지방조직은 우리 몸에서 가장 혈관이 발달된 조직으로서 각 지방세포들은 모세혈관에 둘러싸여 있으며 신생혈관들은 지방세포에 영양분과 산소를 공급한다. 혈관의 내피세포들은 파라크린 신호경로, 세포외 성분, 세포들 간의 직접적인 작용을 통해 지방세포와 교류한다. 활성화된 지방세포들은 VEGF, FGF-2, leptin, HGF와 같은 혈관신생인자들을 생성하며, 이들은 단독으로 혹은 협력하여 혈관신생을 증가시키고 지방조직의 성장과 대사를 촉진한다. 따라서 혈관신생 억제제들은 비만과 비만관련 질환을 치료하는데 유용할 것으로 생각된다.

• Archives of Reconstructive Microsurgery
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• 제6권1호
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• pp.1-8
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• 1997

Recently prostaglandin $E_1(PGE_1)$ has been shown to ensure flap survival by producing vasodilation of the peripheral vessels and platelet disaggreation. However, direct observation and detailed quantitative studies of the effects of $PGE_1$ on the cutaneous microcirculation have not been reported. In the present study, we investigated cutaneous microcirculatory changes in the rabbit ear chamber(REC) with an intravital microscope following intravenous administration of $PGE_1$. The results obtained in this study indicate that $PGE_1$ administered intravenously at a rate of 200ng/kg/min might act directly on the vessels and cause dilatation of metarterioles and capillaries without affecting vasomotion and systemic blood pressure. Clinically in order to evaluate the effect of an intravenous administration of $PGE_1$ on the cutaneous microcirculation, cutaneous blood flow, skin temperature and transcutaneous $Po_2$ in the pedicle or free flap of operated patients were evaluated by the combination of several measurements following the administration of $PGE_1$. The present study suggests that improvement of cutaneous microcirculation by $PGE_1$ may enhance the survival rate of flap or replantation. Both vessel arterial ischemia and venous congestion are main factors of tissue necrosis in the flap surgery. Vasodilatory or antithrombotic agents have been used in salvage of flap necrosis. However, the therapeutic effects of those drugs are still not well elucidated. Recently prostaglandin $E_1(PGE_1)$ has been shown to ensure flap survival by producing vasodilatation of the peripheral vessels and platelet disaggregation[1-3]. Emerson and sykes[4] have obtained significant improvement in the flap survival in the rat using $PGI_2$. Suzuki et al.[5] have reported prolonged flap survival length by using $PGE_1$ in the rabbit and concluded that $PGE_1$ improved the microcircuration in the flap. However, direct observation and detailed quantitative studies of the effects of $PGE_1$ on the cutaneous microcirculation have not been reported. In the present study, we investigated microcirculatory changes in the rabbit ear chamber[6,7] with an intravital microscope following intravenous administration of $PGE_1$.

• 한국가축번식학회지
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• 제15권3호
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• pp.161-172
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• 1991

This study was conducted to research the endocrine mechanisms of postpartum anestrus and determine if the morphology of the CL could be related to function in Korean native goats. At parturition 48 goats were assigned to a nonsuckled group and a suckled group. Serum concentrations of luteinizing hormone(LH), follicle stimulating hormone(FSH), prolactin(PRL), estradiol-17$\beta$(E2) and cortisol were measured at various times after parturitionin the goats. The corpora lutea of pregnancy were examined by a light microscope on the 6th hour and the first, 3rd, 10th, 11th, and 21st days after parturition. The results were summarized as follows : Mean serum LH concentrations were lower after parturition in all treatments and increased gradually with the intervals after parturition(P<0.01). These values did not differ between groups. The levels of serum FSH were lower after parturition and tended to increase gradually between 2 and 21 days. The levels of serum FSH are not significantly different between the groups of goats. Two days after kidding mean levels of serum PRL began to fall in nonsuckling goats but increased in suckling goats. During 3 weeks serum PRL concentrations were different between nonsuckling and suckling goats(P<0.01). Three days after parturition the levels of serum E2 decreased in all treatments. From parturition to day 21 serum E2 concentrations were greater in nonsuckling than in suckling goats(P<0.01). At the sixth hour after parturition the structure of the CL was well preserved. At days 1 and 3 the blood vessels were sparcely distributed, whereas, at days 1 and 3 the blood vessels were sparcely distributed, whereas, at days 10, 11 and 21 tortuous larger vessels with thick walls were observed on the luteal tissue. At days 1, 3, 10, 11 and 21 after parturition the CL of pregnancy showed degeneration and the proportion of tissue occupied by intercelluar substances increased at days 21 postpartum. In conclusion, the present study has shown that regression of the CL of pregnancy is accelerated in the period after parturition and effectively completed within three weeks postpartum.

• 한국정보통신학회논문지
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• 제18권12호
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• pp.3029-3034
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• 2014

이 논문은 사람 눈의 공막컬러코드와 공막혈관징후패턴코드 생성에 의한 공막진단시스템 구현에 관한 연구이다. 시스템은 고성능 DSP 영상처리 프로세서를 기반으로 PGC 프로그램어불 게인제어 선처리 및 RISC SD프레임저장 메모리 등으로 구성된다. PGC는 RGB신호를 최적화하고 그래리 영상에서 에지가 검출된다. 판별 및 매칭 처리알고리듬은 공막컬러코드화 및 혈관징후패턴코드 생성을 실행된다. 공막컬러코드는 메모리 맵의 위치에서 YCbCr값을 구하고 허용오차 범위를 적용하여 생성된다. 혈관징후패턴코드는 24시간등분과 13환형등분 구역에 의해 디지털화 되고 중첩매칭과 허용오차 적용에 의해 코드화된다. 실험결과 성능에서 시스템은 40ms로 동작하고 진단오차는 컬러판별이 평균 약20%, 혈관징후패턴 매칭이 약 24%이다. 이 시스템 및 기술은 세분화와 환자데이터베이스화 하면 공막진단 의용시스템으로 사용 할 수 있다.