• 대한기계학회논문집B
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• 제26권5호
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• pp.629-639
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• 2002

In-vitro flow characteristics downstream of a polyurethane artificial heart valve and a Bjork-Shiley Monostrut mechanical valve have been comparatively investigated in pulsatile flow using particle image velocimetry (PIV). With a triggering system and a time-delayed circuit the velocity distributions on the two perpendicular measurement planes downstream of the valves are evaluated at any given instant in conjunction with the opening behaviors of valve leaflets during a cardiac cycle. The regions of stasis and high shear stress can be found simultaneously by examining the entire view of the instantaneous velocity and Reynolds shear stress fields. It is known that high shear stress regions exist at the interface between strong axial jet flows along the wall and vortical flows in the central area distal to the valves. In addition. there are large stagnation or recirculation regions in the vicinity of the valve leaflet, where thrombus formation can be induced by accumulation of blood elements damaged in the high shear stress zones. A correlation between the unsteady flow patterns downstream of the valve and the corresponding opening postures of the polyurethane valve membrane gives useful data necessary for improved design of the frame structure and leaflet geometry of the polyurethane valve.

• 대한한의학원전학회지
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• 제29권2호
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• pp.151-163
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• 2016

Objectives : Shanghanlon is based on the Hwangjenaegyeong(黃帝內經)'s theory. Therefore, the contents of the Naegyeong can interpret Shanghanlon's provision, Chengwuji(成無己) followed the same way. Therefore, I studied the relationship between the symptom of Shanghanlon and the defensive Gi(衛氣), I try to prove that the Naegyeong is the theoretical basis of Shanghanlon. Methods : Naegyeong explains that defensive Gi protects the outer parts of the body, and runs the outer parts of the body. So I will explain the spontaneous sweating(自汗) aversion to cold(惡寒) pain(痛症) fever(發熱) difficulty of urination(小便不利) using the function of defensive Gi. Results & Conclusions : The defensive Gi and the nutrient Gi(營氣) run together, if the defensive Gi is weak, can not protect the nutrient Gi. If the defensive Gi does not perform the function of inducing astringency(固攝), the symptom of spontaneous sweating appears. If aversion to cold is caused by the weak of defensive Gi, we use the treatment of warming the Yang(溫陽). If aversion to cold is caused by the defensive Gi can not run, we use the treatment of activating the Yang(通陽). If the Gi and Blood(氣血) is not feeding properly, the pain occurs. In this case, we use the treatment of activating the Yang(通陽). The fever is caused by the stagnation of defensive Gi. If the defensive Gi is weak, the symptom of difficulty of urination appears.

• 동의생리병리학회지
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• 제28권6호
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• pp.585-592
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• 2014

This study is to develop a standard tool for pattern identifications in Korean Medicine for Lung Cancer. The advisor committee for this study was organized by 12 Korean Medicine professors from the Korean Association of Traditional Oncology. The item and structure of instrument were based on review of published literature. We took the consultation twice from the advisor committee and additional advices by e-mail correspondences. We divided the symptoms and signs of lung cancer into 6 pattern identifications. - lung spleen both deficiency (肺脾兩虛), lung kidney both deficiency (肺腎兩虛), dampness phlegm obstructing the lung (濕痰蘊肺), qi stagnation blood stasis (氣滯血瘀), yin deficiency toxin heat (陰虛毒熱), and heat toxin accumulation (熱毒蘊結). We obtained the mean weights which reflected the standard deviations from each symptoms of the 6 pattern identifications which were scored on a 5-point scale by 12 experts. We designed the Korean medicine pattern identification tool for lung cancer. It was composed of 57 questions in the question-and-answer format. Though there are some limits that this study is not proved about validity and reliability, the instrument is meaningful and expected to be applied to the subsequent research.

• Journal of Acupuncture Research
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• 제23권5호
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• pp.115-125
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• 2006

Objectives & methods : This study aimed to investigate and compare the traditional acupuncture treatment and Sa-am acupuncture treatment of stroke. We investigated ${\ll}$Sa-am chimgujeongjeon(舍岩鍼灸正傳)${\gg}$ for Sa-am acupuncture treatment, and ${\ll}$Dongeuibogam(東醫寶鑑)${\gg}$ and ${\ll}$Chimgudaesung (鍼灸大成)${\gg}$ for traditional acupuncture treatment. Results & Conclusion : 1. In the traditional acupuncture treatment, acupoints on CV, GV, GB, LI, ST meridians to remove pathogens such as fire, damp, phlegm, blood stagnation and Ashi points (nearby points) are often used rather than acupoints according to the diagnosis of excess & deficiency in organs and meridians. 2. In ${\ll}$Sa-am chimgujungjeon(舍岩鍼灸正傳)${\gg}$, symptoms of stroke are classified into 21 and each symptoms are analyzed according to the diagnosis of excess & deficiency of organs and meridians, consequently treated using tonification & sedation of corresponding meridians. 3. For the treatment of stroke in ${\ll}$Sa-am chimgujungjeon(舍岩鍼灸正傳)${\gg}$, tonification & sedation of the acupoints on related meridian is often omitted, using only the acupoints on targeted meridian. 4. In ${\ll}$Sa-am chimgujungjeon(舍岩鍼灸正傳)${\gg}$, empirical points are preferably used for the treatment of stroke.

• 치위생과학회지
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• 제4권2호
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• pp.81-84
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• 2004

천연물로부터 치은에 생성되는 멜라닌의 양을 효과적으로 조절하여 치은 미백을 목표로 하는 물질을 분리하고자 문헌에 소개되고 있는 미백 효과를 가진 전통한약을 비롯하여, 민간에서 사용되고 있는 약 100여 종의 고등식물을 대상으로 B-16 mouse melanoma cell lines에서 melanin 생성 억제 효과를 screening하였다. 그 결과 천궁의 methylene chloride 분획에서 활성을 나타내어 실험재료로 선택하여 2개의 화합물을 분리하였으며 각종 spectral data를 검토하여 linoleic acid methyl ester(1), 1,3-dilinoleoyl-2-stearoyl glycerol(2)로 구조를 규명하였다. 이들 화합물은 B-16 mouse melanoma cell lines에서의 melanin 생성억제 활성을 Kojic acid를 비교 물질로하여 측정하였다. 2종의 화합물 중 1,3-dilinoleoyl-2-stearoyl glycerol은 높은 활성을 보이지 않았으나 linoleic acid methyl ester는 Kojic acid에 비하여 강한 활성을 나타내었다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.203-206
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• 1996

To understand the local fluid dynamics for different desists of Fontan operation, five models were made out of Pyrex glass to facilitate in-vitro study. Model I, II and III have same position of the center of the anastomosis of the IVC( inferior vena cava) with that of the SVC(superior vena cava), but Model IV and V have 10 mm offset between them. Also the anastomotic junction angles are different(Model I and $IV:90^{\circ}$, Model II and $V:70^{\circ}$, Model $III:45^{\circ}$). These models were then connected to a flow loop for flow visualization study. In Model I any dominant vortex was not seen in the central region of the juntion, but a large unstable vortex was created in the Model II and III. In Model IV and V a significant stagnation region was created in the middle of the offset region. It also showed that the flow direction from the IVC and SVC to the LPA(left pulmonary artery) and RPA(right pulmonary artery) highly depends on the offset of the junction rather than the anastomotic junction angle.

• 대한의료기공학회지
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• 제16권1호
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• pp.116-136
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• 2016

Objectives : The purpose of this study is to report a 67-year-old male patient with Herpes zoster(caseI) and a 38-year-old female patient with Herpes zoster(caseII), whose symptoms were relieved after Korean medicine treatment alone. Methods : Both patients took Yeonryeonggobondan and Pyungwee-san daily. Everytime they came to the hospital, they received acupuncture treatment, Hwidam's Su-Gi therapy and External Gigong Therapy. Acupuncture was applied by gall bladder seunggyeok(膽勝格, GB-), spleen jeonggyeok(脾正格, SP+), large intestine seunggyeok(大腸勝格, LI-) of Saam's Acupuncture Method. Hwidam's Su-Gi therapy was applied on neck. External Gigong Therapy was applied on skin lesion area. the patients' symptoms were evaluated with photographs and VAS. Results : The results were as follows: 1. In the case of a 67-year-old male patient, it took 14 days to recover the skin lesions and to reduce the pain after treatment started. And he visited 13 times during that period. 2. In the case of a 38-year-old female patient, it took 23 days to recover the skin lesions to reduce and the pain after treatment started. And she visited 10 times during that period. 3. Intensive treatment early in treating herpes zoster helped to shorten the treatment period. 4. Taking Yeonryeonggobondan and Pyungwee-san and receiving acupuncture treatment(SP+) can help to improve immunity and recover skin lesions in herpes zoster diagnosed with spleen deficiency with dampness encumbrance(脾虛濕困) and blood stasis due to qi stagnation (氣滯血瘀). 5. The combination of acupuncture treatment(GB-) and External Gigong Therapy was effective in controlling pain. 6. External Gigong Therapy is considered to be effective for the recovery of the skin as well as the pain of the herpes zoster. Conclusions : Korean medicine treatment alone has a great effect on the above two patients with herpes zoster. I hope the active research about Korean medicine treatment will be done not only for herpes zoster but also for various intractable pain diseases.

• 대한한방부인과학회지
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• 제30권4호
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• pp.175-202
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• 2017

Objectives: This study was conducted towards developing a screening tool for syndrome differentiation in the diagnosis of menopause in menopausal and perimenopausal women. Methods: We conducted a literature review of studies on menopausal diagnosis based on syndrome differentiation, and examined well-founded differentiated syndromes and their respective clinical symptoms. Based on the findings, we created a questionnaire through consultations with Oriental medicine experts in physiology, pathology, and diagnostics. Finally, the research team conducted an expert Delphi study on differentiated syndromes and the associated clinical symptoms. Results: Seven differentiated syndromes were selected, including Liver Depression (肝鬱), Kidney Yin Deficiency (腎陰虛), Kidney Yang Deficiency (腎陽虛), Liver and Kidney Yin Deficiency (肝腎陰虛), Kidney Yin and Yang Deficiency (腎陰陽兩虛), Heart-Kidney Noninteraction (心腎不交), and Dual Deficiency of Heart and Spleen (心脾兩虛); 4 disease locations, including liver (肝), heart (心), spleen (脾), and kidney (腎); and 3 disease natures, including Yin Deficiency (陰虛), Qi Stagnation (氣滯), and Blood Deficiency (血虛). In addition, we added 3 supplemental disease natures, including Yang Deficiency (陽虛), Qi Deficiency (氣虛), and Heat (火熱), in consideration of syndrome differentiation categories that may possibly be added in a follow-up clinical questionnaire. Conclusions: This resulted in a total of 7 differentiated syndromes, 4 disease locations, and 6 disease natures. We translated the clinical symptoms of these 17 categories into Korean Hangeul. After consulting with 5 Oriental medicine experts and a psychology expert, we produced a questionnaire for use in diagnosing menopause based on syndrome differentiation. The calculation of scores for the syndrome differentiation screening tool will be confirmed through clinical research based on the results of a review of existing literature.

• Integrative Medicine Research
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• 제3권2호
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• pp.60-66
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• 2014

Background: Medically unexplained symptoms (MUSs) are common in primary care. Atpresent, there are no proven, comprehensive treatments available in primary care forpatients with MUSs. However, MUS has parallels with "subhealth" or Mibyeong from tradi-tional East-Asian medicine, and thus, Mibyeong interventions could be effective in treatingMUS. Unfortunately, studies on Mibyeong and its intervention methods are relatively rare.Methods: We administered a web-based survey to 17,279 Korean medicine (KM) practitionersregistered with the Association of Korean Medicine. The response rate was 4.9% (n = 849).Based on the responses received, we assessed how much they agreed with concepts relatedto Mibyeong on a 7-point scale from "do not agree" to "strongly agree." Respondents werealso asked to indicate how frequently they encountered various subtypes and patterns ofMibyeong, and how frequently they use listed intervention methods.Results: Data from 818 respondents were analyzed after excluding those with no clinicalexperience. On average, respondents were male general practitioners aged between 30 yearsand 49 years, working or living in metropolitan areas such as Seoul, Incheon, and Gyeonggi-do. Responses did not differ by demographics. Respondents generally thought that Mibyeongreferred to subjective or borderline findings without certain disease, and that Mibyeong hasvarious subtypes and patterns. Subtypes included fatigue, pain, and digestion problems; pat-terns were either deficiencies (e.g., qi, blood, and yin deficiency) or stagnations (e.g., liver qidepression and qi stagnation). Decoction was the most frequently used type of interventionfor Mibyeong of all items listed, followed by acupuncture and moxibustion. Patient educa-tion was also recommended, suggesting healthy eating, promoting healthy environment,and exercise.Conclusion: We were able to provide preliminary results on KM practitioners' recognition ofand interventions for Mibyeong, but further research is needed to develop a detailed defi-nition of Mibyeong and its myriad subtypes and patterns, and evaluations of the efficacy ofMibyeong interventions.

• 한방비만학회지
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• 제21권2호
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• pp.80-94
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• 2021

Objectives: The purpose of this study is to re-evaluate the importance of questions of obesity syndrome differentiation (OSD) questionnaire based on real-world survey and to explore the possibility of simplifying OSD types. Methods: The OSD frequency was identified, and variance threshold feature selection was performed to filter the questions. Filtered questions were clustered by K-means clustering and hierarchical clustering. After principal component analysis (PCA), the distribution patterns of the subjects were identified and the differences in the syndrome distribution were compared. Results: The frequency of OSD in spleen deficiency, phlegm (PH), and blood stasis (BS) was lower than in food retention (FR), liver qi stagnation (LS), and yang deficiency. We excluded 13 questions with low variance, 7 of which were related to BS. Filtered questions were clustered into 3 groups by K-means clustering; Cluster 1 (17 questions) mainly related to PH, BS syndromes; Cluster 2 (11 questions) related to swelling, and indigestion; Cluster 3 (11 questions) related to overeating or emotional symptoms. After PCA, significant different patterns of subjects were observed in the FR, LS, and other obesity syndromes. The questions that mainly affect the FR distribution were digestive symptoms. And emotional symptoms mainly affect the distribution of LS subjects. And other obesity syndrome was partially affected by both digestive and emotional symptoms, and also affected by symptoms related to poor circulation. Conclusions: In-depth data mining analysis identified relatively low importance questions and the potential to simplify OSD types.