• International Journal of Industrial Entomology and Biomaterials
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• 제5권2호
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• pp.201-204
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• 2002

This study was undertaken to find effects of ethanol extracts from Bombyx mori on the hyperglycemia induced by streptozotocin in rats. Blood glucose level of rats increased depending on experimental days after streptozotocin treatment. But there was no difference in blood glucose level between the rats injected with ethanol extracts of B. mori and normal rats. There was no significant difference in the kidney fibrosis between the rats injected with ethanol extrscts of B. mori and normal rats at all ages examined. The transforming growth factor-$\beta$l ($TGF-{\beta}1$) protein was detected in the glomerulay endothelial cells and tubular epithelial cells of streptozotocin rats at 14 days of age. In the rats injected with ethanol extracts of B. mori to the kidneys, the $TGF-{\beta}1$ protein was detected very faintly. The $TGF-{\beta}1$ mRNA of streptozotocin rats increased at 14 days of age, and this was higher than the rats injected with ethanol extrscts of B. mori. Taken these together, the results suggest that the ethanol extracts of B. mori ameliorate hyperglycemia of the rats induced by streptozotocin.

• 한국어병학회지
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• 제35권1호
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• pp.121-128
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• 2022

Recent studies revealed that histone proteins are involved in innate immune responses during pathogen invasion as well as DNA packing. This study characterized the histone genes (H2A.V) of sevenband groupers and analyzed gene expression in NNV-infected sevenband groupers. The open reading frame (ORF) of H2A.V is 387 bp which encoded 128 amino acid residues. The deduced amino acid sequence of H2A.V harbor a highly conserved domain for H2A/H2B/H3 and H2A_C binding domain. Quantitative real-time PCR analysis showed that H2A.V had a high gene expression level in the brain and blood after being NNV-infected. An increase in extracellular histone protein in the blood has been identified as a biomarker for vascular function in humans. More research is required to understand histone's immune response at the protein level or in aquatic animals.

• 한국가금학회지
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• 제22권1호
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• pp.43-54
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• 1995

Effects of dietary protein sources and their amino acid compositions on the liver and plasma cholesterol levels in growing Single Comb white Leghorn male chicks were studied. A diet containing isolated soy protein (21% cp) was supplemented with 0.5% DL-methionine and 0.3% L-glycine. and another diet containing casein(21% cp) was supplemented with 1.5% L-arginine HCl, 0.4% DL-methionine. and 1.0% L-glycine. Plasma cholesterol level was markedly lower in groups force-fed the diets containing either soy protein or casein supplemented with amino acids compared to those found in birds fed corresponding diets without amino acids supplementation. The cholesterol lowering effect of the casein diet. when balanced with various supplemental amino acids appeared to be due to arginine instead of methionine or glycine. It is likely that amino acid balance rather than the composition of a specific amino acid is one of the major factors determining the effect of dietary protein sources on the blood cholesterol levels in chicks.

• 한국가금학회지
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• 제14권1호
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• pp.63-68
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• 1987

상품보존 차원에서 활용할 수 있는 생리적 기초자료를 얻고자 재래오골계를 대상으로 혈액상 및 혈액화학치를 조사하였던 바 그 결과는 다음과 같다. 1. 적혈구상 및 백혈구수에 있어서는 암수 모두 성장에 따른 유의한 차이를 보이지 않았고, 성간에도 역시 유의성이 인정되지 않았다. 2. 혈액화학치에 있어서 총단백량과 혈당치는 암수 각각 주령에 따라 다소 증가하였고, 콜레스테롤의 함량은 암수 모두 주령에 관계없이 일정한 수준을 나타내었으나 전반적으로 수컷에서 높은 경향이었다.

• 한국식품영양과학회지
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• 제25권4호
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• pp.601-607
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• 1996

Nineteen non-insulin-dependent diabetic(NIDD) and healthy control women were investigated to study the relationship between glycemic control and the level of calcium, zinc, and magnesium in the serum and urine. Urinary calcium, zinc and magnesium levels in the NIDD women were significantly higher(p<0.01) than those of the control women. There were no difference in serum magnesium and zinc levels between the two groups, but se겨m calcium level was lower(p<0.01) in the NIDD women compared to that of the control group. In the NIDD women, serum magnesium was negatively related to fasting blood glucose(r=-0.533 : p<0.05), urinary glucose(r=-0.767 ; P<0.001), urinary protein(r=-0.476 : p<0.05), and urine volume(r=-0.571 : p<0.05). The levels of zinc in both serum (r=0.515, p<0.05) and urine(r=0.623 : p<0.01) were related to urinary protein but only urinary zinc level(r=0.570 : p<0.01) was related to serum albumin. Urinary magnesium, not calcium was correlated with the urinary glucose(r=0.563 : p<0.05) and urinary protein(r=0.568 ; p<0.05). Fasting blood glucose was positively correlated with duration of diabetes, as well as dietary fat and calorie intake. The results of this study suggest that NIDD alters all magnesium, zinc, and calcium utilization, particularly magnesium is involved in glycemic control in this condition.

• 한국어병학회지
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• 제2권2호
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• pp.91-98
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• 1989

미야이리균(Clostridium butyricum Miyairi II 588)을 담수산 양식어류인 잉어, 틸라피아, 이스라엘잉어에 첨가하여 사육한 결과 다음과 같은 결과를 얻었다. 1. 잉어, 틸라피아, 이스라엘잉어에 대한 사육 실험 결과 0.1%의 미야이리균을 첨가한구에서 가장 효율적인 성장율을 나타내었다. 2. 각 어종의 혈액 검사를 실시하여 본 결과 혈액내의 적혈구수, 헤모글로빈량, 헤마토크릿트치에서는 이상을 발견할 수 없었으며, 혈청내 단백질의 증가와, 콜레스테롤의 감소, 글루코스의 증가가 나타났다. 3. 혈청내의 GOT와 GPT는 정상어제의 수치와 유사하게 나타났다.

• Nutrition Research and Practice
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• 제12권3호
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• pp.233-242
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• 2018

BACKGROUND/OBJECTIVES: The effects of fish consumption by subjects with prediabetes on the metabolic risk factors were examined based on the data from the $6^{th}$ Korea National Health and Nutrition Examination Surveys in 2015. SUBJECTS/METHODS: A total of 1,520 subjects who agreed to participate in a blood test and dietary intake survey were divided into a prediabetes group and normal blood glucose group, and the level of the subjects' fish consumption was divided into ${\leq}17.0g/day$, 18.0-93.0 g/day, and ${\geq}94g/day$. The correlation between the level of fish intake and the metabolic risk factors was evaluated by multinomial logistic regression analysis. RESULTS: A significant difference in the gender distribution was observed in the prediabetes group, which is a group with a high risk of non-communicable diseases, according to the fish intake, and there were significant differences in the total energy intake, protein intake, n-3 fatty acids intake, and the intakes of sodium and micro-nutrients according to the intake group (P < 0.05). In addition, the blood total cholesterol (TC) decreased 0.422 fold in model 1 (unadjusted) [95% confidence interval (CI): 0.211-0.845] and 0.422 fold in model 2 (adjusted for sex) (95% CI: 0.210-0.846) in those with a fish intake of 18.0-93.0 g/day (P < 0.05) compared to those with a fish intake of ${\leq}17.0g/day$. The blood TC decreased 0.555 fold (95% CI: 0.311-0.989) in model 1 and 0.549 fold (95% CI: 0.302-0.997) in model 2 in those with a fish intake of ${\geq}94g/day$ compared to those with a fish intake of ${\leq}17.0g/day$ (P < 0.05). CONCLUSION: Subjects with prediabetes or the metabolic risk factors can maintain their blood low density lipoprotein cholesterol (LDL-C) and blood TC concentrations at the optimal level by consuming fish (18.0-93.0 g/day).

• Journal of Animal Science and Technology
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• 제63권3호
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• pp.491-500
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• 2021

The objective of this study was to evaluate the effects of low protein diets added with protease on growth performance, nutrient digestibility, and blood profiles of weaned piglets and growing-finishing pigs. A total of 96 weaned pigs ([Yorkshire × Landrace] × Duroc) with average body weight (BW) of 6.99 ± 0.21 kg were used in a 20-week experiment. The dietary treatments were arranged in a 2 × 3 factorial design. Treatments were as follows: In phase 1 (1-2 weeks), two protein levels as high protein (HP; 19.0%), low protein (LP; 17.0%), and three protease (PT) levels (PT0, 0%; PT1, 0.3%; and PT2, 0.5%); in phase 2 (3-4 weeks), protein levels (HP, 18.05%; LP, 16.15%) and protease levels (0%, 0.3%, and 0.5%); in phase 3 (5-12 weeks), protein levels (HP, 17.1%; LP, 15.3%) and protease level (0%, 0.15%, and 0.3%); in phase 4 (13-20 weeks), protein levels (HP, 16.15%; LP, 14.45%) and protease level (0%, 0.15%, and 0.3%). At 4 weeks and 20 weeks after treatment, BW was higher (p < 0.050) in the PT2 group than PT0 group. From weeks 0 to 4, average daily gain (ADG) and feed efficiency (G/F) were higher (p = 0.006 and p = 0.014; p = 0.014 and p = 0.044, respectively) in the PT2 group than PT0 and PT1 groups. From weeks 16 to 20, ADG and G/F were higher (p < 0.001 and p = 0.009; p = 0.004 and p = 0.033, respectively) in the PT2 group than PT0 and PT1 groups. Crude protein (CP) digestibility was higher (p = 0.013, p = 0.014, and p = 0.035, respectively) in the low protein (LP) group than high protein (HP) group at weeks 4, 12, and 20. At weeks 4 and 20, the LP diet group had lower (p < 0.001 and p = 0.001, respectively) blood urea nitrogen (BUN) levels than the HP diet group. Therefore, a low CP diet added with protease could increase growth performance and CP digestibility of weaned piglets and growing-finishing pigs.

• 한국식품영양과학회지
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• 제12권3호
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• pp.273-283
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• 1983

흰쥐와 흰생쥐 암 수 각 30마리씩에 대한 실험개시기와 종료후의 결과로서 나타난 식이에 대한 사양실험, 대사실험, 혈액성분분석 실시 결과는 다음과 같다. 1. 증체량은 흰쥐 암 수 모두 동물성단백질 배합비율이 높아질수록 증가했다. 흰생쥐는 숫생쥐가 C식이에서 최대를, E식이에서 최저를 나타냈으나 암생쥐는 반대였다. 2. 식이효율은 흰쥐 암 수 모두 동물성 단백질 배합비율이 높아질수록 증가했으며 암쥐보다 숫쥐에서 높았다. 흰생쥐는 숫생쥐가 증체량과 같은 경향이었으나 암생쥐는 일정경향이 없었다. 암생쥐보다 숫생쥐의 식이효율이 높았다. 3. 단백질효율은 흰쥐 암 수 모두 동물성단백질 배합비율이 높아질수록 증가했다. 흰생쥐는 숫생쥐의 증체량, 식이효율은 같은 경향이나 암생쥐는 일정한 경향이 없었다. 4. 질소보유율은 흰쥐 암 수 모두 단백질수준이 같을때 섭취질소량에 비례함을 보였다. 흰생쥐는 숫생쥐가 동물성 배합비율이 높아질때 증가하였다. 암생쥐는 일정한 경향이 없었다. 질소축적율은 흰생쥐에서 높게 나타나 체내 단백질이용이 흰쥐보다 높음을 알 수 있었다. 5. 혈청성분에서는 혈청 총단백질량은 흰쥐 암 수 모두 차이가 없으나 동물성단백질 배합비율이높아질수록 증가하는 경향이었다. 흰생쥐는 암 수 모두 일정한 경향이 없었다. 혈청요소질소량은 흰쥐의 경우 암 수 모두 식물성단백질 배합비율이 높아질수록 증가했다. 흰생쥐는 알정한 경향이 없었다. 혈청콜레스테롤량은 흰쥐 암 수 모두 단백질배합비율에 관계없이 일정한 경향이 없었다. 흰생쥐는 숫생쥐가 식물성단백질 배합비율이 높아질수록 증가했으나 암생쥐는 일정한 경향이 없었다. 6. 위의 결과로 실험식이중의 동물성단백질 배합비율이 높은 A, B식이에서 흰쥐는 증체량, 사료효율, 단백질효율이 좋았다. 흰생쥐는 숫생쥐가 C식이, 암생쥐가 E식이에서 높게 나타났다. 이는 생쥐의 증체량이 이유에서부터 성숙기까지 큰 차이가 없다는 것과 흰쥐와는 다른 단백질수준이 요구된다고 생각된다.

• 대한지역사회영양학회지
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• 제13권1호
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• pp.100-110
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• 2008

Recently, a lot of epidemiological studies revealed that low HDL-cholesterol level was a better predictor of risk for coronary heart disease than total cholesterol. This study investigated the anthropometric parameters, clinical blood indices, and dietary factors influencing serum HDL-cholesterol level by using a cross-sectional study for Korean female college students. The subjects were 94 female college students. They were divided into three groups according to their serum HDL-cholesterol levels, low HDL-cholesterol (<50 mg/dL, n=20), medium HDL-cholesterol (50 $\leq$, < 60 mg/dL, n=39) high serum HDL-cholesterol groups (60 $\leq$ mg/dL, n = 35). This study examined their demographic data and dietary intake throughout a questionnaire. Clinical blood indices were measured using an automatic blood chemistry analyzer (Selectra E), after 12 hours of fasting. BMI, body weight, fat mass, and waist circumferences were significantly increased according to low serum HDL-cholesterol levels. Serum lipid analysis showed a significantly higher level of TG, LDL-/HDL-Ratio, atherogenic index in the low HDL-cholesterol group. Serum levels of GPT, uric acid and alkaline phosphatase in the low HDL-cholesterol group were significantly higher than in the other group. The average consumption of energy was 1627 kcal and 77.76% of estimated energy requirement (EER). The mean ratio of calories from carbohydrate: protein: fat was 57:15:28. The low HDL-cholesterol group was significantly higher than the other groups in eggs, fat and oils consumption. Interestingly, milk and diary products consumption of low HDL-cholesterol group was half (p < 0.05) of those of the other groups. In conclusion, serum HDL-cholesterol levels appeared to be decreased by increasing BMI, fat mass, waist circumference, and serum TG level. In addition, some dietary factors seemed to be related to serum HDL-cholesterol levels. However, further research is needed to elucidate the exact relationship between serum HDL-cholesterol level and dietary factors.