• The Korean Journal of Physiology
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• 제5권1호
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• pp.59-69
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• 1971

Studies were undertaken on the changes in the renal blood flow by relating them with the alterations in the amplitudes in the rheogram of rabbits. The changing pattern of the electrical conductivity was recorded by means of the needle electrodes inserted into the kidney and the surrounding aluminium foil which was grounded. The Impedance Rheograph manufactured by the Narco Company was used. The small artifact which persisted after ligation of the renal vessels was subtracted from the value obtained in each pulsatile wave in the rheogram. The animals were nembutalized intravenously, 30 mg/kg. A plastic canule was inserted into the carotid artery and the arterial blood pressure was monitored continuously with the pressure transducer connected to the physiograph. Stepwise bleedings were performed on the animal. The first bleeding was between 13 to 18 ml in the amount, and it was folowed by consecutive hemorrhages, 5 or 10 ml each time. The total amount of bleeding was summed as much as 1.5-2% of the body weight. Two minutes fter each bleeding th arterial blood pressure, ECG and the rheogram were taken. That was the necessary time to obtain the stabilized picture of each parameter. After closing the bleeding process, the shed blood was retransfused into the animal and the response in the renal blood flow was observed as well as the arterial blood pressure. Particularly the presence or absence of the autoregulatory mechanism in the situation of the hemorrhage was also studied. The results obtained were as follows: 1. In 7 cases out of 22, that was about one third of the total number of experiments, the autoregulatory mechanism of the renal blood flow persisted even in acute hemorrhage, and the decreases in the renal blood flow were less than 10% of the control values even when the arterial blood pressure dropped to 66-87% of the original value obtained before the bleeding. 2. Because of the stepwise bleeding the exact blood pressure at which the renal blood flow reduced as much as one third of the control value could not be obtained. However, the results revealed that the approximate pressure, expressed as percentage of the control value, was 50-60% in 3 cases, 61-70% in 4 cases and 71-80% in 8 cases. In one case the decrease in the renal blood flow exceeded one third of the control value before the pressure dropped to 80% of the control. 3. In 19 cases the decreases in the renal blood flow exceeded one half of the control values by hemorrhage. Then the arterial blood pressure revealed less than 40% of the control value in 6-cases. In 2 cases the pressure was 51-60% of the control pressure. In 5 cases the range of bleed pressure was 61-70%, and in e remaining 6 cases the pressure ranged from 71 to 80% of e control value. 4. Out of 15 cases of retransfusion after definite decreases in the renal blood flow loller·ing the hemorrhage, 9 cases restored their renal blood flow. On the contrary 6 cases showed low values even when the shed blood was retransfused. 5. Theories concerning the mechanism of the autoregulation of the renal blood flow were reviewed for the purpose of explanation of the results obtained. However, there are much to be done before greater satisfaction

• 대한의용생체공학회:의공학회지
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• 제24권4호
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• pp.329-337
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• 2003

선천적 혹은 후천적인 이유로 인하여 인체 특정 부위의 정맥과 동맥이 서로 관통하여 동맥계의 혈류가 말초 혈관계를 우회하여 정맥계로 흐르게 되는 동정맥루는 인체 심혈관계의 혈류 역학적 거동에 큰 영향을 미치게 된다. 본 연구에서는 lumped parameter 모델을 기반으로 하는 수치 해석 방법을 사용하여 우측 하지에 위치한 급성 동정맥루가 전체 심혈관계에 미치는 영향을 해석적으로 고찰하였다. 이를 위하여 동정맥루가 포함된 인체 심혈관계를 전기 회로 상사계로 구성하였으며. 부위별 혈압과 관련된 상미분 연립 방정식을 4차의 Runge-Kutta방법으로 풀어서 시간에 따른 혈류 역학적 변수들을 구하였다 이때 급성 동정맥루의 생성에 따른 혈류 역학적 보상작용을 분석하기 위하여 arterial baroreflex 제어계를 모델에 포함하였다.

• 전기학회논문지
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• 제60권8호
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• pp.1606-1616
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• 2011

The blood pressure measuring equipment, which is being supplied and used most widely by being recognized convenience and accuracy now generally, is oscillometric blood pressure monitor. However, a change in blood pressure is basically influenced by diverse elements such as each individual's physiological status and physical condition. Thus, the measurement of blood pressure, which used single element called oscillation in blood pressure of being conveyed to cuff, is not considered on physiological elements such as cardiovascular system status and blood vessel stiffness index, and on external elements, thereby being quite in error. Accordingly, this study detected diverse bio-signals and body informations in each individual as the measurement subject such as ECG, PPG, and Korotkoff Sound in order to enhance convenience and accuracy of measuring blood pressure in the complex measurement equipment, thereby having extracted regression method for compensation in error of oscillometric blood pressure measurement on the wrist, and having improved accuracy of measuring blood pressure. To verify a method of improving accuracy, the blood pressure value in each of SBP, DBP, MAP was acquired through 4-stage experimental procedure targeting totally 51 subjects. Prior to experiment, the subjects were divided into two groups such as the experimental group for extracting regression method and the control group for verifying regression method. Its error was analyzed by comparing the reference blood pressure value, which was obtained through the auscultatory method, and the oscillometric blood pressure value on the wrist. To reduce the detected error, the blood pressure compensation regression method was calculated through multiple linear regression analysis on elements of blood pressure, individual body information, PTT, HR, K-Sound PSD change. Verification was carried out on improving significance and accuracy by applying the regression method to the data of control group. In the experimental results, as a result of confirming error on the reference blood pressure value in SBP, DBP, and MAP, which were acquired through applying regression method, the results of $-0.47{\pm}7.45$ mmHg, $-0.23{\pm}7.13$ mmHg, $0.06{\pm}6.39$ mmHg could be obtained. This is not only the numerical value of satisfying the sphygmomanometer reference of AAMI, but also shows the lower result than the numerical value in SBP : $-2.5{\pm}12.2$ mmHg, DBP : $-7.5{\pm}8.4$ mmHg, which is the mean error in the experimental results of Brram's research for verifying accuracy of Omron RX-M, which shows relatively high accuracy among wrist sphygmomanometers. Thus, the blood pressure compensation could be confirmed to be made within significant level.

• 성인간호학회지
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• 제16권3호
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• pp.460-469
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• 2004

Purpose: The purpose was to investigate the physiological parameter and physical health status and health perception in the elderly, and to find the correlation between these variables. The subjects were 139 in Kyungi senior center. Method: The instruments for this study were physiological parameters, which were composed of vital capacity, blood pressure, pulse oxygenation, hand grip power, body fat and physical health status scale developed by researcher, and health perception scale developed by Ware(1976). The data were analyzed by the SPSS-PC 11.0 version. Results: 1) 7.9% of subjects were included in abnormal range of vital capacity, 40.3% were systolic hypertension and 11.5% were diastolic hypertension. And 92.1% were included in normal range of pulse oxygenation, 79.8% were weakened hand grip power, and 10.1% of subjects were included in normal range of body fat. 2) The total mean score of the physical health status was 26.34 of a possible maximum score of 45. The physical health status score of women was lower than man's. 3) The mean score of man's health perception was 24.52 and women's was 20.39 of a possible maximum score of 44. 4) There was a significant positive correlation between hand grip power and physical health status(r=.28, p=.001). And a significant correlation between physical health status and health perception was found (r=.24, p=.004). Conclusion: It is concluded that the blood pressure, hand grip power and body fat among the physiological parameters of elderly subjects in Kyungi senior center were included in abnormal range. The factors were related life style. therefore, it is suggested that the health education to change life style for the elderly is needed.

• 한국어류학회지
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• 제20권2호
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• pp.81-89
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• 2008

메기, Silurus asotus에서 포식과 기아가 생존과 성장, 내장괴지수, 간중량지수, 생식소중량지수, 외형계측형질 변화 및 혈액 parameter들에 미치는 영향을 파악하기 위해 80일동안 기아 실험을 수행하였다. 기아군의 생존과 성장은 포식군의 생존과 성장에 비해 낮았다(P<0.05). 기아는 체중성장률, 일간성장률과 비만도에서 성장 정지 효과를 나타낸 반면, 포식군은 지속적인 성장을 보였다. 외형 계측형질 중복강 부위 횡단길이 관련에서 포식군은 실험 시작시와 차이를 보이지 않았으나, 기아군은 차이를 나타냈다 (P<0.05). 실험 기간 중 혈액성상(cortisol, glucose, AST, ALT, RBC 및 hemoglobin)에서 포식군과 기아군 사이에 유의한 차이를 보였다. 본 연구 결과, 포식과 기아 파악에 사용된 모든 parameter들은 본 종의 영양 상태 확인의 지표로 유용하며, 양식 메기의 성장 시기 평가 결정에 유용하리라 사료된다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.489-492
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• 2005

Even though the blood pressure is one of the most widely used index for the healthcare monitoring of hypertensive and normotensive persons, there is no non-intrusive measurement method which is commercialized until now. Pulse Arrival Time (PAT) is known that it has close relation with the systolic blood pressure (SBP) and arterial stiffness. In this study, SBP estimation methods by non-intrusive measurement of PAT are suggested. For the unconstrained measurement of PAT, the first method used the electrically non contact electrocardiogram (ENC-ECG) technique and the reflective type of Photoplethysmography (PPG) sensor on the computer mouse. In the second method, ENC-ECG and the air pressure sensor in the seat cushion on a chair were measured. The third method used ECG electrodes and PPG sensors on the toilet seat cover. The validation and regression analysis of the relationship of PAT and SBP are summarized. These methods have considerable errors to be used for all people. But these can be applied for each subject after the parameter customization within acceptable error. So, it is feasible for suggested methods to be used for monitoring of SBP in daily life in non-intrusive way when there is personal identification system of each subject.

• 동의생리병리학회지
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• 제21권6호
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• pp.1646-1654
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• 2007

The aim of this study was to investigate the effects of several herbal prescriptions in patients with allergy or atopic disease, such as atopic dermatitis, asthma and allergy rhinitis and others, on the blood immunological parameters and to verify the safety of long-term use of herbal medicine. Eighty one patients with allergy or atopy disease who taken herbal medicine at least for 2 months were compared with patients who taken same medicine with no allergy & atopy disease (n=14) and normal healthy subjects (n=22). According to the comparison of immunological parameters change, the data showed that herbal medicine decreased IgE (P=0.003), Eosinophil ratio (P<0.001) and count (P<0.001) of White Blood Cell (WBC) and did not affect to the liver cell enzymes in blood. This results indicated that herbal medicine decreased immune hypersensitivity and improved chronic inflammation related to blood immunological parameters of allergy or atopy diseases. In addition, herbal medicine seemed to be safe to the liver function for long-term use.

• Genomics & Informatics
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• 제8권3호
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• pp.122-130
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• 2010

Abnormal hematological values are associated with various disorders including cancer and cardiovascular, metabolic, infectious, and immune diseases. We report the copy number variations (CNVs) in clinically relevant hematological parameters, including hemoglobin level, red and white blood cell counts, platelet counts, and red blood cell (RBC) volume. We describe CNVs in several loci associated with these hematological parameters in 8,842 samples from Korean population-based studies. The data that we evaluated included four RBC parameters, one platelet parameter, and one associated with total white blood cell (WBC) count, exceeding the genome-wide significance. We show that CNVs in hematological parameters are associated with some loci, different from previously associated loci reported in single nucleotide polymorphism (SNP) association studies.

• 대한의용생체공학회:의공학회지
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• 제27권1호
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• pp.1-5
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• 2006

In this paper, we propose a subject-independent regression model to estimate systolic blood pressures (SBP) conveniently and continuously. There have been several researches on estimating SBP with pulse transit time (PTT) and they showed promising results. However, previous studies used only PTT as the estimation parameter, and their models were generated with just one person's PTT data which is not applicable to estimating other person's SBP. Therefore, we collected several additional biometric parameters with 202 healthy subjects. After statistical analysis of measured biometric parameters with SBP, we chose final estimating parameters including PTT to generate a multiple linear regression model for estimating SBP. Comparing the results of our study with approvable standards of automated sphygmomanometers developed by Association for the Advancement of Medical Instrumentation and approved by American National Standards Institute (ANSI/AAMI) indicates that our proposed method for continuously blood pressures monitoring gives an acceptable error.

• 대한의생명과학회지
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• 제13권2호
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• pp.83-89
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• 2007

Effects of alkaline reduced water (ARW) on the scavenging of reactive oxygen species (ROS) and diabetes were recently reported. However, no studies have yet been investigated on general drinking effects. In this study, we examined 100 patients hospitalized for senile disease treatment and recuperation. All examines received the ARW for 2 months. WBC level was decreased from $6.34\pm1.9(\times10^9/L)$ to $5.66\pm1.7(\times10^9/L)$. SGPT level was decreased from 27.47$\pm$14 Ut to 23.95$\pm$8.8 U/L. Cholesterol level was increased from 167.9$\pm$32 mg/dl to 176.21$\pm$42 mg/dl within normal range. However, the levels of potassium, adiponectin, SGOT and blood pressure showed no significant difference. The levels of growth hormone and homocysteine and mini-mental state examination also showed no significant difference. We suppose that the slight blood parameter trends indicate an improved physical condition induced by the ARW. Furthermore, we could found no harmful effect of the ARW in this study.