• The Journal of Korean Medicine
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• v.20 no.4
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• pp.69-81
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• 2000

Etiology and pathogenesis of hyperlipidemia are considered as 'difficiency in origin' of liver, spleen and kidney combined with 'excess in superficiality' of phlegm stagnancy and blood stasis. The prescription of Semyung-Gangji-tang, designed for the treatment of hyperlipidemia and atherosclerosis, consists of herbs effective at treating blood stasis and phlegm stagnancy. It invigorates the liver, kidney and spleen. Its medical nature is not too cold or too hot and it increases human vital energy. The purpose of this study is to examine the currative effects of Semyung-Gangji-tang on hyperlipidemia in rabbits. Twenty-four male NZW rabbits, around 2kg of B.W., were divided into 3 groups. Group I was served as the normal group. Group II was served as the hyperlipidemic control group fed with 1 % cholesterol diet for 8weeks and with normal diet for the next 4weeks. Group III was served as the treatment group, treated the same as the control group and medicated with Semyung-Gangji-tang for the last 4weeks. Blood samples were collected from each of the animals at a, 3, 6, 8, 10, 12 weeks and used for the blood chemical analysis. Animals were sacrificed at 8 and 12weeks and chemical analyses were performed on the collected liver samples. The serum total cholesterol value of treatment group ($938.60{\pm}95.07{\;}mg/dl$) at l2weeks was significantly decreased (P<0.00l) compared with the value of control group ($1375{\pm}37.82{\;}mg/dl$) at 12weeks. The serum LDL-cholesterol value of the treatment group ($838.00{\pm}89.52 mg/dl$) at l2weeks was significantly decreased(p<0.00l) compared with the value of the control group ($1249.60{\pm}37.63{\;}mg/dl$) at l2weeks. These results indicate that Semyung-Gangji-tang has the effects of lowering serum lipid in experimentally induced hyperlipidemic rabbits.

• Journal of Society of Preventive Korean Medicine
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• v.8 no.2
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• pp.65-80
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• 2004

Objectives : CRATAEGII FRUCTUS(山査) is known as the substance which delays aging by the antioxidant effects. The purpose of this study is to investigate the effects of CRATAEGII FRUCTUS(山査) on antioxidant enzyme activities such as Thiobarbituric acid reactive substance(TBARS), Superoxide dismutase(SOD), Catalase(CAT), Glutathione peroxidase (GSH-px) in rat erythrocytes and blood plasma. Methods : Sprague-Dawley rats were divided into 3 groups, Normal group (supplied enough water and feeds only, Normal Group), D-galatose administered group(injected D-galatose 50mg/kg, 1time/day for 6 weeks, Control Group) and CRATAEGII FRUCTUS(山査) administered group (D-galactose 50mg/kg and CRATAEGII FRUCTUS(山査) extracts 85.0mg/200g 1time/day for 6 weeks, SS Group). Rats were sacrificed and TBARS, SOD, CAT, GSH-px, neutral fat and cholesterol were measured in rat erythrocytes and blood plasma. Results : There was no significant difference in the level of TBARS in the blood plasma between each experimental group. Red blood cell SOD activities were significantly different in each group. They were significantly decreased in the Control group compared to those of Normal and there was an increasing phenomenon in the SS group compared to the Control group. There was a significant difference in the activities of the red blood cell - glutathione peroxides in each group. There was a significant increase in the SS group compared to the Control group. Red blood cell catalase activities was no significant difference in each group. Plasma total lipid concentration was significantly different in each group. It was significantly increased in the Control group compared with the Normal group and it was decreasing in the SS group compared to the control group. Plasma triglyceride was not significantly different in each group. Plasma total cholesterol and Plasma HDL -cholesterol concentrations in the blood plasma were not significantly different in each group. Conclusions : According to the above results, it is considered that CRATAEGII FRUCTUS(山査) is effective in inhibiting lipid peroxides and increasing the activities of antioxidative(anti aging) enzyme in D-galactose induced aging rat.

• The Journal of Internal Korean Medicine
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• v.35 no.1
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• pp.24-36
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• 2014

Objectives : This study was performed to evaluate the effects of moxibustion on cerebral blood flow, peripheral blood flow and blood pressure. Methods : We designed a randomized, cross-over study that included 20 healthy, male volunteers who were randomly assigned to one of two groups (the moxibustion group or the control group). The initial trial was followed by a washout period of one week before the groups were switched and the trial repeated. The cerebral blood flow and peripheral blood flow of the volunteers in both groups were measured by mean velocity (Vm), peak systolic velocity (Vs), pulsatility index (PI), perfusion units (PU) and mean blood pressure (BP) before the intervention (baseline), 30 minutes after the intervention, and again 60 minutes after the intervention. Results : 1. The Vm increased significantly in the moxibustion group. The Vs also constantly increased in moxibustion group, but there was no significant difference. 2. The PI decreased significantly in the control group at 0-30 minutes and in the moxibustion group at 30-60 minutes. 3. The PU constantly decreased in moxibustion group. In control group, the PU decreased at 30 minutes and increased slightly at 60 minutes. 4. The mean blood pressure did not show any significant difference between the two groups. Conclusions : This study shows that moxibustion at CV12 increased the cerebral blood flow. Based on this result, we can suggest that moxibustion at CV12 might be helpful in improving the functional recovery of stroke patients. However, further research needs to be conducted on a larger numbers of subjects in order to confirm these effects.

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.105-116
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• 2000

The purpose of this study is to evaluate the relationship of blood pressure with dietary habit and level of physical fitness of middle-aged male workers by age. The study subjects included 511 male employees who have worked at a company in C City, whose age was more than 40 years old. Between April 10 and May 30. 1998, all of the study subjects measured physical fitness (Balance, strength, power, agility, flexibility and endurance) and blood pressure. A questionnair was administered for dietary habit and socio-demographic characteristics. The average age (SD) of the study subjects was 46.61(3.98) years. The study subjects were classified by age into 3 groups; 40-44 aged group(34.6%), 45-49 aged group(41.3%), and 50-54 aged group (24.1%). The score of dietary habit of 40-44 aged group was $69.77{\pm}5.82$. that of 45-49 aged group was $69.77{\pm}5.83$, and that of 50-54 aged group was $71.85{\pm}6.82$(p=0.005). But age of health physical fitness tend to weaken in the age of 40-44. Systolic(p=.011) and Diastolic blood pressure (p= .011) were significantly increased with age increment. Diastolic blood pressure and dietary habit of 45-49 aged group showed the significant negative-correlation(r= .280. P<0.05). and Diastolic blood pressure and age of health physical fitness of 40-44 aged group showed the significant positive-correlation(r= .182. P<0.05). On the basis of the results of this study. I hope occupational nurses should play an active role to improve dietary habit and physical fitness for prevention of hypertension with increase of age in middle-aged male workers.

• The Journal of Korean Medicine
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• v.24 no.2
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• pp.12-18
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• 2003

Objectives : Hypertension is very prevalent disease, and causes serious cardiovascular complications. Nowadays optimal hypertension treatment is emphasized to reduce the incidence of cardiovascular complications. Auricular acupuncture therapy is economical, safe and effective. Its clinical application is various, and it can be used to control blood pressure. So The effect of auricular acupuncture therapy was investigated. Daily variation of blood pressure during needle-embedded period and variation of blood pressure by blood pressure classification were observed. Methods : The auricular acupuncture points we used were Gangapjeom (降壓點), Sinmun (神門), Gyogam (交感), Sim(心), and Icheom (耳尖). Auricular acupuncture needles were embedded for three days. Blood pressure was checked four times per day and the mean obtained. Results : The following results were obtained : 1. During needle-embedded period, systolic and diastolic blood pressure decreased. Blood pressure decreased most significantly 2 days after treatment. 2. The change of blood pressure in the higher blood pressure group was more remarkable than that of the lower blood pressure group. Conclusions : Through this research, auricular acupuncture therapy is considered as an effective and safe method to lower blood pressure.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.6
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• pp.1339-1348
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• 1999

In present study possible hypolipidemic effects of garlic were investigated in an experimental model which consisted of 4 groups of Wistar rats(three weeks old): CO group received a basal diet(as a standard diet) contained 6.3% of corn oil. LO group was taken the experimental diet in which only 6.3% corn oil in basal diet was substituted by 12.6% of lard oil. So the experimental diet was somewhat high saturated fat diet. LG1 group was treated orally with garlic juice as 1% of raw garlic in the diet together with the same diet as the diet for LO group. LG2 group was taken 2% of garlic under the same dietary condition as that of LG1 group. The rat body weights prior and posterior to the experimental period were measured and the amount of the experimental dietary intake was determined at every 3 day interval. After the experimental dietary period of 30 days the blood obtained from all the sacrificed rats were analyzed for the biochemical parameters. Over the one month period of experiment there was no abnormality or apparent change in appearance and activity or diet consumption in all experimental rat groups. LO group fed a diet rich in lard showed significantly increased body weight gain rate by 30% and also elevated levels of triglyceride, total cholesterol and LDL cholesterol by 29.9%, 27.4% and 62.3% respectively and no significant difference in the levels of HDL cholesterol, GOT, GPT, blood glucose and blood urea nitrogen as compared to those of control group. So it seemed that the high calorie diet in LO group mainly contributed to the significant increase in body weight gain rate and other biochemical parameters. In spite of 1% garlic treatment LG1 group had significantly increased body weight gain rate by 25.2%, levels of triglyceride, total choesterol and LDL cholesterol by 25.2%, 24.6% and 50.5% respectively as compared to control and LO group, and no increase in the levels of HDL cholesterol, blood glucose and blood urea nitrogen. At garlic 1% diet there was no hypolipidemic efficacy in rat serum. Under the treatment with garlic 2% in diet LG2 group showed significantly increased body weight gain rate by 19.7% as compared to control and elevated levels of GOT, GPT and BUN by 85.8~96.4%, 127~148% and 88% respectively as compared to control, but LG2 group had significantly reduced levels of triglyceride, total cholesterol and LDL cholesterol as compared to LOand LG1 group. In present study there were no significant change in HDL cholesterol and blood glucose value. In LG2 group GOT, GPT and blood urea nitrogen values were slightly increased presumably due to the inhibiting effects of garlic on the hepatic or renal function of rats. Nevertheless in this study garlic may have some demonstrable hypolipidemic effects in rat.

• Journal of Nutrition and Health
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• v.30 no.4
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• pp.451-457
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• 1997

This study was designed to investigate the effect of the ratio of energy from carbohydrate to total calories on dietary intake, obesity index, blood pressure, and blood lipid content in cardiovascular disease patients over 35 years old. A total of 552(227 male, 325 female) subjects were divided into three groups according to carbohydrate/total energy ratio : carbohydrate ratios below 25 percent were in the low carbohydrate group( <61.1%), between 25 and 75 percent carbohydrate were medium($\geq$61.1-<74.7%), and higher than 75 percent were in the high carbohydrate group($\geq$74.7%). The anthropometric data, nutrient intake, serum lipid levels, and blood pressure of each group were compared with one another. For men and women with high carbohydrate intakes, Inadequate nutritional intake was observed. Abdominal fat accumulation and blood TC level for men in the high carbohydrate group were higher than in medium or low carbohydrate groups. Therefore, it seems that high carbohydrate intake may produce adverse effects on abdominal fat accumulation and blood lipid patterns. Blood pressure, however, was significantly higher for women in low and high carbohydrate groups than in medium carbohydrate group. These results suggest that extremely high and low carbohydrate intake may raise the risk of cardiovascular disease and that it is necessary to consume nutritionally balanced meals. This can be done by controlling the ratio of dietary carbohydrate at a medium level in order to prevent and/or to reduce the risk.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.4 no.2
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• pp.240-247
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• 1994

To identify normal levels of ethanol, acetaldehyde and alcohol dehydrogenase(ADH) activity in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood were measured in 97 subjects(male : 36, female : 61), 45 subjects(male : 21, female : 24) were not exposed to organic solvents and any other chemicals. Fifty two subjects(male : 15, female : 37) were exposed to organic solvents including toluene and xylene. The results were summerized as follows : 1. The blood ADH was not detected in exposed and non-exposed group. 2. The average blood ethanol level of non-exposed group was 0.0490 mg/dl, and exposed group was 0.0363 mg/dl. They were statistically significant(p<0.05). 3. The blood acetaldehyde levels in exposed group were significantly higher than that of non-exposed group was not statistically significant (p>0.05). 4. The average blood ethanol level of males in both groups was significantly higher than that of females, however, they were not statistically significant (p>0.05).

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.2
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• pp.81-84
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• 2004

It is well known that malignant tumor have hypoxic cell fraction, which is radio resistant and is one of the most important cause of local recurrence after radiotherapy. One of the causes of hypoxia in tumor is blood flow decrease due to increase in blood flow resistance and one of the causes of increased blood flow resistance could be attributed to the increase in blood viscosity. For the evaluation of the change of blood viscosity in oral cancer, experiments were carried out to test the change of blood viscosity among the normal control and xenografted oral cancer nude mice. Relative viscosity measured against distilled water was $3.30{\pm}0.14$ for normal control, and $3.67{\pm}0.62$ for tumor bearing mice at the first time of blood sampling in experimental period ($100mm^3$ $200mm^3$). There was no statistically significant difference between the control group and experimental group (p>0.05). However, as the tumor grew, significant difference of blood viscosity was detected at the third time of blood sampling (control group:$3.37{\pm}0.59$, and experimental group: $4.31{\pm}0.41\;300mm^3$

• Preventive Nutrition and Food Science
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• v.7 no.1
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• pp.72-77
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• 2002

The purpose of this study was designed to observe the effects of Zizyphus jujuba seed extract on the concentrations of the lipids and blood glucose in the S.D. rats fed the experimental diets for 4 weeks. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, triglyceride (TG), phospholipid (PL) and blood glucose in serum were significantly higher in the cholesterol administration groups (group 2 (cholesterol+water), group 3 (cholesterol+Zizyphus jujuba seed extract)) than those in the control group (group 1, basal diet+water). But the concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum ware remarkably lower in the group 3 than those in the group 2. In the ratio of HIDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Zizyphus jujuba seed extract administration group was higher percentage than in the group 2. The activities of aspartate aminotransferase (AST), alanine amino-transferase (ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in serum were rather lower in the Zizyphus jujuba seed extract administration group (group 3) than in the cholesterol diet group (group 2). From the above research, Zizyphus jujuba seeds were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic rats. And particularly, Zizyphus jujuba seeds were more effective as a therapeutic regimen for the control of metabolic derangements in adult disease.