• 대기
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• 제19권4호
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• pp.345-370
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• 2009

Numerical experiments using the Weather Research and Forecasting (WRF) model were done to identify the role of the mountain ranges in the northern part of the Peninsula (referred as "the northern mountain complex"), in the occurrence of two heavy snowfall events over the Yeongdong region on 7-8 December 2002 and 20-21 January 2008. To this end, control simulations with the topography of the northern mountain complex and other simulations without the topography of the mountain complex were performed. It was revealed that the amount of snowfall over the Yeongdong region from the control simulation much more exceeded that of the simulation without the topography of the mountain complex. This increase of the snowfall amount over the Yeongdong region can be explained as follows: As the upstream flow approached the northern mountain complex, it deflected around the northern mountain complex due to the blocking effect of the mountains with a low Froude number less than ~0.16. This lead to the strengthening of northeasterly over the East Sea and over the Yeongdong region. The strong northeasterly is accompanied with much more snowfall over the Yeongdong region by intensifying air-mass modification over the sea and the orographic effect of the Taeback mountains. Thus, it was concluded that the topography of the northern mountain complex is one of the main factors in determining the distribution and amount of precipitation in the Yeongdong region when there is an expansion of the Siberian High toward the East Sea.

• Journal of Plant Biotechnology
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• 제44권3호
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• pp.229-234
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• 2017

Photoperiod is one of the factors affecting productivity of cucumber plant by inducing ethylene hormone production and so triggering flower sex differentiation into female flower. However, only few studies have been perfomed in order to reveal the effect of photoperiod in molecular level in relation to the flower differentiation. Therefore, in this study, Mercy cultivar of cucumber (andromonoecious) was treated with photoperiod of 8, 12, 16 hours of light, while control received no treatment of additional light. Photoperiod of 8 hours was achieved by blocking the sunlight with shade net and 16 hours by giving longer light exposure using white LEDs. Cucumber's flowers were quantified and the apical and lateral shoots were extracted to evaluate the gene profile related to the photoperiod, ethylene production, and female flower differentiation, which were CsACS2, CsETR1, CsCaN, and CsPIF4 using PCR method. Photoperiod of 8 hours affected the production of female flower with average number of 6.7 flowers in main stem and 8.0 flowers in lateral stem, compared to photoperiod of 12 and 16 hours which produced 3.7 and 2.0 flowers in main stem with 7.0 and 11.3 in lateral stem, respectively. In silico studies in this experiment resulted in proposed model of signal transduction that showed the connection between ethylene production and flower differentiation. PCR analysis confirmed the expression of CsACS2, CsETR1, and CsCaN, that was positively correlated with numbers of female flowers in cucumber, but the expression of CsPIF4 that represent photoperiod haven't been confirmed correlated with the ethylene production and flower differentiation.

• 한국통신학회논문지
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• 제31권10C호
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• pp.921-926
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• 2006

초광대역(UWB) 시스템은 높은 시간분해능으로 인해 복잡한 다중경로 환경에서도 정밀한 위치추적을 가능하게 한다. 그러나 송수신 채널에 존재할 수 있는 장애물로 인해서 정밀한 위치추적 성능이 저하될 수 있다. 첫째로 장애물은 다중경로의 구조를 복잡하게 만들어 직선경로 신호 성분의 도착시간 추정을 어렵게 만든다. 둘째로 전파시간에 초과시간지연을 초래하여 거리추정의 정확도를 저하시킬 수 있다. 본 논문에서는 광선추적법을 사용하여 두번째 원인에 의해 발생하는 거리추정 오차를 줄이는 기법을 소개한다. 이를 위하여 통계적인 접근방식과 지도를 이용한 위치인식기법을 사용하였다. 통계적인 접근방식에서는 매질에 의해서 발생하는 초과시간지연들의 분포를 광선추적법을 사용하여 구하고, 이에 근거하여 오차의 하계를 구하였다. 또한 건물의 도면을 이용한 위치인식 방법에도 광선추적 법을 사용하였으며, 그 성능을 사무실 환경에서 측정된 데이터를 사용하여 검증하였다.

• 생약학회지
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• 제51권3호
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• pp.178-185
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• 2020

In this study, the effect of complex hot water extracts of Cirsium jaonicum, Artemisia annua and Curcuma longa (CAC) on the improvement of non-alcoholic fatty liver disease (NAFLD) was investigated. CAC inhibited fatty acid synthesis and lipid accumulation in HepG2 cells cultured with free fatty acid (FFA). In the NAFLD animal model, CAC extract suppressed the increase in body weight, liver, and epididymis fat weight, and suppressed the increase in hepatocyte fat and blood triglyceride. In addition, by blocking the Nrf2/HO-1 signaling pathway, cells were protected from oxidative stress in hepatocytes. Moreover, CAC inhibited the expression of COX-2, iNOS, TNF-α and IL-17 in hepatocytes. These results suggest the possibility that CAC extract can be applied in the field of health functional foods and pharmaceuticals for improvement and prevention of NAFLD.

• 한국공간정보시스템학회 논문지
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• 제10권1호
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• pp.51-63
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• 2008

USN의 중계경로에 대한 연구는 주로 비공간 데이터를 위주로 이루어지고 있으며 지도 중첩법에 의한 공간분석이 이루어지지 않아 신뢰성에서 한계를 노출하고 있다. 본 연구는 공간변수별로 가중치를 부여하고 전파 확산 예측모델과 연계하여 전계강도를 산출하고 이에 의거하여 중계망의 분포를 지도화하였다. 전파장애에 개입되는 다양한 공간 변수를 통합하여 제작된 컴퓨터 지도는 기존에 조사지점에만 국한된 통계 수치정보가 지닌 한계를 극복하고 시청각 효과를 이용하여 광역적인 중계망 변화 추이를 시각적으로 제시하였다. 개별 셀과 연구지역 전체에 대해 전파중계망에 대한 정량적인 근거는 다양한 자료처리능력, 신속성을 바탕으로 지금까지는 불가능했던 전파 중계망에 대한 실시간 지도화 기능을 제공하였고 노드의 장애가 발생하였을 경우 대안을 마련하기 위한 보조수단으로서 활용가치가 매우 높을 것으로 사료된다.

• 약학회지
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• 제40권1호
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• pp.102-111
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• 1996

LB10522 is a new parenteral broad spectrum cephalosporin with a catechol moiety at C-7 position of beta-lactam ring. This compound can utilize tonB-dependent iron transp ort system in addition to porin proteins to enter bacterial periplasmic space and access to penicillin-binding proteins (PBPs) which are the lethal targets of ${\beta}$-lactam antibiotics. The chelating activity of LB10522 to metal iron was measured by spectrophotometrically scanning the absorbance from 200 to 900nm. When $FeCl_3$ was added, optical density was increased between 450 and 800nm. LB10522 was more active against gram-negative strains in iron-depleted media than in iron-replete media. This is due to the increased expression of iron transport channels in iron-depleted condition. LB10522 showed a similar activity against E. coli DC2 (permeability mutant) and E. coli DCO (wild type strain) in both iron-depleted and iron-replete media, indicating a minimal permeaility barrier for LB10522 uptake. LB10522 had high affinities to PBP 3 and PBP 1A, 1B of E. coli. By blocking these proteins, LB10522 caused inhibition of cell division and the eventual death of cells. This result was correlated well with the morphological changes in E. coli exposed to LB10522. Although the in vitro MIC of LB10522 against P. aeruginosa 1912E mutant (tonB) was 8-times higher than that of the P. aeruginosa 1912E parent strain, LB10522 showed a similar in vivo protection efficacy against both strains in the mouse systemic infection model. This result suggested that tonB mutant, which requires a high level of iron for normal growth, might have a difficulty in surviving in their host with an iron-limited environment.

• 대한의용생체공학회:의공학회지
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• 제17권3호
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• pp.337-346
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• 1996

The patency of small size vascular grafts is poor, and the blood flow characteristics in the artery graft anastomosis are suspected as one of the important factors influencing intimal hyperplasia. Disturbed flow patterns caused by sixte and compliance mismatch generate unfavorable flow environment which promotes intimal thickening. Tapered vascular yuts are suggested in order to reduce sudden expansion near the anastomosis. The photochromic flow visualization method is used to measure the flout fields in the end-to-end anastomosis model under the carotid and femoral artery flow wave form. The results show that flow disturbance near the anastomosis is diminished in the tapered grafts comparing to the tubular graft. As the divergent ang1e decreases, we can reduce the low and oscillatory wall shear stress zone which is prone to intimal hyperplasia. The flow wave form effects the wall shear rate dis- tribution significantly. The steep deceleration and back flow in the femoral flow wAve form cause low mean wall shear rate and high oscillatory shear index.

• 한국안전학회지
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• 제27권3호
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• pp.153-160
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• 2012

Various social problems such as traffic congestion, car accidents and environmental problems(air pollution, noises etc.) have been happening in the Seoul metropolitan area that has the car oriented traffic system providing cars continuously. Along with this, the financial burden caused by current oil price anxiety made paradigm shift from caroriented to public transportation-oriented. Its typical example is an arterial branch bus system changing(bus lane through the center of main road) started in Seoul in July, 2004. But study on safety analysis of bus lane and characteristic of accidents are not sufficient enough to now. The bus lanes are expanded to provide roads for better traffic operation and accidents between buses and pedestrians or ordinary vehicles are considered main problems. This study divided each bus route of median bus lane(bus-only lane through the center of main roads) and bus lane at roadside by intersection and collected and analysed data about influence variables of bus accidents chosen in each section. We constructed a logistic model using collected data. As a result, bus lane at roadside are used by both buses and other kinds of vehicles differently from median bus lane and showed such characteristic in accident influence. Therefore access management to factors causing conflict and improvement of operation management are required. In case of median bus lane, the more buses moving general vehicle lane and traffic volume of section were, the more accidents happened. In case that stop line of center lane is not backward, view blocking of vehicles turning left caused accidents.

• 약학회지
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• 제49권2호
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• pp.140-146
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• 2005

Candida albicans, a polymorphic fungus, causes systemic and local infections. Recent reports show that the fungus is a main etiological agent for the arthritis. For trea tment, antifungal drugs and/or rheumatoid drugs are used, but resistance and side effects limit application of the drugs. In search of new sources for treatment of the fungal arthritis, we choose Egb 761 (extract of Ginkgo leaves 761), one of the most popular over-the-counter herbal medicines. The Egb 761 contains two major ingredients such as terpene and flavonoid. In the present study, we examined if the terpene portion of Egb 761 had anti-inflammatory activity against C.albicans-caused arthritis. The terpene was extracted with combination of methanol and water from the Egb 761, followed by gel-permeation chromatography. Presence of terpene was determined by the Salkowski colorimetric method and HPLC analysis. For an animal model of inflammation induction, mice were given an emulsion form of C.albicans cell wall mixed with Complete Freund's Adjuvant (CFA) by footpad-injection. Results showed that intraperitoneal administration of the water-soluble portion that contained terpene and flavonoid reduced the inflammation. Whereas the terpene had anti-inflammatory activity, flavonoid portion had no such activity, For determination of possible mechanism of the activity, the terpene seemed to be suppression of nitric oxide (NO) production from LPS-treated macrophages. Taken together the Ginkgo terpene may have anti-inflammatory effect against C.albicans-caused arthritis, possibly by blocking NO production.

• 한국재료학회지
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• 제11권3호
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• pp.207-214
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• 2001

실리카 유리는 매우 우수한 광도파 소재이지만 비선형 광특성이 거의 없다. 그러나 이런 실리카 유리에 금속 전극과 같은 차단전극을 이용하여 강한 전기장을 장시간 가하게 되면 공간 전하 분극이 발생하게 되고 이에 의해 비선형 광특성이 나타나게 된다는 것은 실험적으로 알려져 왔다. 본 연구에서는 전기분극 시 실리카 유리에서 나타나는 비선형 광특성의 경시적인 변화를 공간적인 위치와 시간에 따라 정확히 예측할 수 있는 수치해석적인 모델을 제시하고자 하였다. 이를 위해서 지금가지 실험들에서 실리카 유리의 비선형 광특성 발생의 원인으로 밝혀진 공간전하분극을 전기분극 기구의 전산모사를 통하여 규명하였다. 비정질 실리카를 전해질 용액과 같은 특성을 지니는 매질로 가정하고 전하운반체가 단지 $Na^{+}$ 밖에 없다는 가정 하에 유한 차분법 (finite difference method)을 이용하였다. 원래의 복잡한 함수들을 표준화 변수들을 이용하여 간단한 식으로 변환하여 $Na^{+}$의 농도와 전기장의 분포를 표준화된 시편의 길이와 인가된 전압의 세기만으로 구할 수 있도록 하였다.