• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.192-192
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• 1996

Endothelin has $ET_{A}$ type and $ET_{B}$ type receptors, and it has been thought that ET-1 proves vasoconstriction effect via $ET_{A}$ receptor and vasodilation via $ET_{B}$ receptor. Recently, it has been reported that $ET_{B}$ receptor is also related to the vaso-constriction. Bosentan is a $ET_{A+B}$ receptor antagonist, and proves it's effect on trauma and ischemia. We already announced that the level of Endothelin-1 increase in the brain and spinal cord of EAE-induced lewis rat and showed the origin of ET-1 is activated macrophages. Intracisternal injection of Bosentan, $ET_{A+B}$ receptor antagonist, (300nmol/body) was done for observing the role of endothelin-1 on the pathogenesis of EAE. Bosentan ameliorated the severity of clinical score of EAE and decreased the histologically observed inflammatory region. The blocking effect on the progression of EAE model suggests that Bosentan is a physiological antagonist in terms of development of the sign of multiple sclerosis.

• Journal of Environmental Science International
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• v.25 no.8
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• pp.1191-1206
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• 2016

Transported deposit was accumulated in a grit chamber built at the mouth of Yeocheoncheon in 1987 with the intention of blocking the influx of sediment into the Ulsan-harbor. This study attempted to analyze the effects of the transported deposit on the water quality at Yeocheoncheon. Only one episode of dredging has been performed in the approximately 25 years since the grit chamber were built, leading to the formation of stagnant water in the grit chamber due to a large amount of transported deposit. The deposit has a relatively high organic content, in the range of 11.7-25.9% (mean 18.3%). It appears that the main reason for the upstream transport of water pollution from the mouth of the Yeocheoncheon is the tides. The effects of organic content and stagnant water on water quality were analyzed using WASP. Moreover, the changes in water quality arising due to the removal of the grit chamber were analyzed. Results indicated that BOD improved by 18.8-100%, while T-P improved by 90.0-617.4%, between the grit chamber and Hanbi-Gyo, which is located 1.3 km away from the grit chamber.

• Journal of Information Processing Systems
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• v.2 no.2
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• pp.107-113
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• 2006

It is essential to guarantee a handoff dropping probability below a predetermined threshold for wireless mobile networks. Previous studies have proposed admission control policies for integrated voice/data traffic in wireless mobile networks. However, since QoS has been considered only in terms of CDP (Call Dropping Probability), the result has been a serious CBP (Call Blocking Probability) unfairness problem between voice and data traffic. In this paper, we suggest a new admission control policy that treats integrated voice and data traffic fairly while maintaining the CDP constraint. For underprivileged data traffic, which requires more bandwidth units than voice traffic, the packet is placed in a queue when there are no available resources in the base station, instead of being immediately rejected. Furthermore, we have adapted the biased coin method concept to adjust unfairness in terms of CBP. We analyzed the system model of a cell using both a two-dimensional continuous-time Markov chain and the Gauss-Seidel method. Numerical results demonstrate that our CAC (Call Admission Control) scheme successfully achieves CBP fairness for voice and data traffic.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2015.07a
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• pp.464-465
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• 2015

본 논문은 HEVC(High Efficiency Video Coding) 기반의 3차원 비디오 부호기에서 깊이 비디오 부호화의 효율 증대를 위한 디블록킹 필터(deblocking filter)를 제안한다. 디블록킹 필터는 블록 왜곡(blocking artifact)을 보정하기 위한 필터인데 원래 색상 영상의 특성에 맞게 설계되어서 비슷한 목적을 지닌 SAO(Sample Adaptive Offset)와 더불어 기존 방법의 깊이 비디오 부호화에서는 사용되지 않는다. 제안 방법은 디블록킹 필터의 사전 실험 통계에 기반하여 기여도가 낮은 normal 필터를 제외시킨다. 또한, 깊이 비디오의 특성을 고려하여 임펄스 응답(impulse response)를 변형하였다. 이 변형된 디블록킹 필터를 깊이 비디오 부호화에만 적용하고 색상 비디오 부호화에는 기존 디블록킹 필터를 사용하였다. 3D-HTM(HEVC Test Model) 13.0 참조 소프트웨어에 구현하여 실험한 결과, 기존 방법에 비해 깊이 비디오 부호화 성능이 5.2% 향상되었다. 색상-깊이 비디오 간 참조가 있기 때문에 변형된 깊이 비디오 부호화가 색상 비디오 부호화 효율에 영향을 끼칠 수도 있지만 실험 결과 색상 비디오 부호화 성능은 유지되었다. 따라서 제안 방법은 성공적으로 깊이 비디오 부호화의 효율을 증대시켰다.

• The Journal of the Korea Contents Association
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• v.5 no.1
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• pp.147-155
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• 2005

In this paper, communication channels for the transmission of multimedia packets are modeled and evaluated. The multimedia packet traffic characterized by on-off and MMPP process for voice and data, respectively, dynamic channel allocation, queueing of data packets due to unavailability of channels and dropping of queued data packets over timeout, and guard channel for voice packets are modeled. The performance indices adopted in the evaluation of SRN model includes blocking and dropping probabilities. The SRN uses rewards concepts instead of the complicate numerical analysis required for the Markov chain. It is shown that our SRN modeling techniques provide an easier way to carry out performance analysis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.11
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• pp.2897-2908
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• 1996

This paper presents an effective call admission control algorithm using the Common Pool on the virtual path in ATM networks. Call admission control decides whether or not to accept a new call, so as to ensure the service quality of both individiual existing calls and of the new call itself. In the proposed algorithm, a new call is accepted when the sum of the bandwidths of existing calls and of the new call will not exceed lind capacity. If the sum of their bandwidths exceed link capacity, reserved bandwidth of Common Pool is considreed to accept the new call. Computer simulation results using a simuple network model are algorithm given to evaluate accuracy and call blocking probability by the proposed method.

• Natural Product Sciences
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• v.20 no.4
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• pp.262-268
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• 2014

Rutaecarpine is one of the major alkaloids present in the fruits of Evodia rutaecarpa. In this study, rutaecarpine was evaluated, both in vitro and in vivo, for its hepatoprotective properties against thioacetamide (TAA)-induced hepatic fibrosis. The results showed that rutaecarpine inhibited TAA-induced cytotoxicity, reduced the expression of the fibrogenic cytokine transforming growth factor ${\beta}1$ ($TGF-{\beta}1$), and induced the expression of bcl-2. To evaluate its in vivo effects, animal models with TAA-induced hepatic fibrosis were utilized. Levels of liver tissue injury-associated enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were monitored. $TGF-{\beta}1$ and the ${\alpha}$-smooth muscle actin (${\alpha}$-SMA) were measured as markers of the protective effects on hepatic fibrosis. The AST and ALT levels in blood were greatly enhanced by TAA and completely blunted by rutaecarpine. Rutaecarpine led to the down-regulation of $TGF-{\beta}$ and Bax mRNA expression, as well as the up-regulation of Bcl-2 and $Bcl-X_L$ mRNA levels. In conclusion, rutaecarpine inhibited TAA-induced hepatic fibrosis and apoptosis by inducing the expression of Bcl-2 while blocking $TGF-{\beta}1$ in our TAA-intoxicated model.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.39-44
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• 2018

In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the only source of nutrient, it can serve for both biosynthesis and energy production. However, a series of studies revealed that the cancer cell consumes glucose for biosynthesis through fermentation, not for energy supply, under physiological conditions. Recently, a new observation was made that there is a metabolic symbiosis in which glycolytic and oxidative tumor cells mutually regulate their energy metabolism. Hypoxic cancer cells use glucose for glycolytic metabolism and release lactate which is used by oxygenated cancer cells. This study challenged the Warburg effect, because Warburg claimed that fermentation by irreversible damaging of mitochondria is a fundamental cause of cancer. However, recent studies revealed that mitochondria in cancer cell show active function of oxidative phosphorylation although TCA cycle is stalled. It was also shown that blocking cytosolic NADH production by aldehyde dehydrogenase inhibition, combined with oxidative phosphorylation inhibition, resulted in up to 80% decrease of ATP production, which resulted in a significant regression of tumor growth in the NSCLC model. This suggests a new theory that NADH production in the cytosol plays a key role of ATP production through the mitochondrial electron transport chain in cancer cells, while NADH production is mostly occupied inside mitochondria in normal cells.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.34S no.4
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• pp.1-11
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• 1997

In this paper, modeling of the communication channel occupancy characteristics at the base station in the wide area radio trunking syste has been performed. Using the results, mathematical analysis for the switching capacity at the network switch has also been done. Specificatlly, we propose a G/M/m queueing model for the single service area modeling, and analyze changes in call blockingprobabilities accoridng to changes in the burstness characteristics of group paging calls. As a result, we have observe dthat the channel occupancy variations become larger as the burstness characteristics become more apparent, to make the call blocking probability higher. Next, based on the single service area analysis, we have anayzed mathematically the average switching capacity required to serve mobile subscribers for a wide area radio trunking sytem, where multiple switching port assignments are required when the people in the same group are distributed over several base stations. Accordingly, we have observed that the average and the variance of switching channel occupancy are closely related to the mobility characteristics of subscribers, and that we need a netowrk switch having bigger capacity as subscribers show wider distribution. Especially, with the call dropping probability within 0.2%, a switch having about 5 to 6 times bigger can be required, compared with the one when the mobility of subscribers is mostly restricte dto a single service area.

• 전자공학회논문지 IE
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• v.45 no.3
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• pp.50-55
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• 2008

In CDMA system, the number of mobile stations which can be served simultaneously in a base station is limited by the amount of total interference received. Considering the facts, the call admission control method using the effective bandwidth concept is employed in this paper. The bandwidth for a new call and a handoff call is allocated by considering the number of mobile station being served and dynamically assigned by taking account of the blocking rate of new calls and the dropping rate of handoff calls. Also, there is reserved resource for handoff call. We analyze the performance of system according to reserved resource by a simulation study. The more a resource reserved, the less it is the dropping rate of handoff.