• The korean journal of orthodontics
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• v.39 no.2
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• pp.105-111
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• 2009

Objective: To estimate the effects of bracket material type on enamel decalcification during orthodontic treatment, this study analyzed the adhesion level of mutans streptococci (MS) to orthodontic bracket materials in vivo. Methods: Three different types of orthodontic bracket materials were used: stainless steel, monocrystalline sapphire, and polycrystalline alumina. A balanced complete block design was used to exclude the effect of positional variation of bracket materials in the oral cavity. Three types of plastic individual trays were made and one subject placed the tray in the mouth for 12 hours. Then, the attached bacteria were isolated and incubated on a mitis salivarius media containing bacitracin for 48 hours. Finally, the number of colony forming units of MS was counted. The experiments were independently performed 5 times with each of the 3 trays, resulting in a total of 15 times. Mixed model ANOVA was used to compare the adhesion amount of MS. Results: There was no difference in colony forming units among the bracket materials irrespective of jaw and tooth position. Conclusions: This study suggested that the result of quantitative analysis of MS adhesion to various orthodontic bracket materials in vivo may differ from that of the condition in vitro.

• Journal of the Korean Geographical Society
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• v.46 no.1
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• pp.67-80
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• 2011

Choropleth mapping of population distribution is based on the assumption that people are uniformly distributed throughout each enumeration unit. Dasymetric mapping technique improves choropleth mapping by refining spatially aggregated data with residential information. Further, pycnophylactic interpolation can upgrade dasymetric mapping by considering population distribution of neighboring areas, while preserving the volumes of original units. This study proposed a combined solution of dasymetric mapping and pycnophylactic interpolation to improve the accuracy of population density distribution. Specifically, the dasymetric method accounts for the spatial distribution of population within each census unit, while pycnophylactic interpolation considers population distribution of neighboring area. This technique is demonstrated with 1990 census data of the Athens, GA. with land use land cover information derived from remotely-sensed imagery for the areal extent of populated areas. The results are evaluated by comparison between original population counts of smaller census units (census block groups) and population counts of the grid map built from larger units (census tracts) aggregated to the same areal units. The estimated populations indicate a satisfactory level of accuracy. Population distribution acquired by the suggested method can be re-aggregated to any type of geographic boundaries such as electoral boundaries, school districts, and even watershed for a variety of applications.

• Journal of the Korean GEO-environmental Society
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• v.10 no.2
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• pp.21-28
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• 2009

A grouting method has been widely used in construction of large-scale structure to reduce permeability and reinforce the ground. If cement and grout material were not mixed well in the injection tip equipment, an opposite flow and interception state of the chemical grouting can occur. McG (Multi-mixing counterflow prevented Grouting, McG) method installed a special grouting device to allow better mixing of the grouting material(above fineness $6,000cm^2/g$) and prevent backward flow. The block of nozzle also diversify powder rate of cement. YSS (Youngil Special Silicate, YSS) that lowers $Na_2O$ and thereby increases durability was developed by gel-forming reaction material. The seepage state and unconfined compressive strength of the injection material using the special injection tip equipment was tested in this study. The results of this study showed that the uniaxial compressive strength, permeability, N-value, TCR and RQD were improved by this method. Engineering characteristics obtained by the special injection tip method will be compared with those by the other method through various field tests from now on.

• Journal of Dental Rehabilitation and Applied Science
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• v.25 no.3
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• pp.255-265
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• 2009

Recently many studies have been published on application of immediate loaded implants. However, the immediate loading protocol has not been well documented. The purpose of the present study was to evaluate the stress distribution between bone-implant interfaces and the effect of implant length in the anterior maxilla using 3 dimensional finite element analyses. The diameter 4.0 mm threaded type implants with different length(8.5 mm, 10.0 mm, 11.5 mm, 13.0 mm, 15.0 mm) were used in this study. The bone quality of anterior maxillary bone block was assumed to D3 bone. Bone-implant interfaces of immediately loaded implant were constructed using a contact element for simulating the non osseointegration status. For simplification of all the processing procedures, all of the material assumed to be homogenous, isotropic, and linearly elastic. The 178 N of static force was applied on the middle of the palatoincisal line angle of the abutment with $120^{\circ}$ angle to the long axis of abutment. Maximum von Mises stress were concentrated on the labial cortical bone of the implant neck area, especially at the cortical-cancellous bone interfaces. Compared the different length, highest peak stress value was observed at the 8.5 mm implants and the results indicated a tendency towards favorable stress distribution on the bone, when the length was increased. Presence of cortical bone was very important to immediate loading, and it appears that implants of a length more than 13 mm are preferable for immediate loading at the anterior maxilla.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.6
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• pp.691-699
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• 2012

In this paper, we present a Vt-DRO with a low phase noise, which is achieved by improving the coupling structure between the dielectric resonator and microstrip line. The Vt-DRO is a closed-loop type and is composed of 3 blocks; dielectric resonator, phase shifter, and amplifier. We propose a mathematical estimation method of phase noise, using the group delay of the resonator. By modifying the coupling structure between the dielectric resonator and microstrip line, we achieved a group delay of 53 nsec. For convenience of measurement, wafer probes were inserted at each stage to measure the S-parameters of each block. The measured S-parameter of the Vt-DRO satisfies the open-loop oscillation condition. The Vt-DRO was implemented by connecting the input and output of the designed open-loop to form a closed-loop. As a result, the phase noise of the Vt-DRO was measured as -132.7 dBc/Hz(@ 100 kHz offset frequency), which approximates the predicted result at the center frequency of 5.3 GHz. The tuning-range of the Vt-DRO is about 5 MHz for tuning voltage of 0~10 V and the power is 4.5 dBm. PFTN-FOM is -31 dBm.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Molecules and Cells
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• v.38 no.7
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• pp.663-668
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• 2015

hBMSCs are multipotent cells that are useful for tissue regeneration to treat degenerative diseases and others for their differentiation ability into chondrocytes, osteoblasts, adipocytes, hepatocytes and neuronal cells. In this study, biodegradable elastic hydrogels consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(${\varepsilon}$-caprolactone) (PCL) scaffolds were evaluated for tissue engineering because of its biocompatibility and the ability to control the release of bioactive peptides. The primary cultured cells from human bone marrow are confirmed as hBMSC by immunohistochemical analysis. Mesenchymal stem cell markers (collagen type I, fibronectin, CD54, $integrin1{\beta}$, and Hu protein) were shown to be positive, while hematopoietic stem cell markers (CD14 and CD45) were shown to be negative. Three different hydrogel scaffolds with different block compositions (PEG:PCL=6:14 and 14:6 by weight) were fabricated using the salt leaching method. The hBMSCs were expanded, seeded on the scaffolds, and cultured up to 8 days under static conditions in Iscove's Modified Dulbecco's Media (IMDM). The growth of MSCs cultured on the hydrogel with PEG/PCL= 6/14 was faster than that of the others. In addition, the morphology of MSCs seemed to be normal and no cytotoxicity was found. The coating of the vascular endothelial growth factor (VEGF) containing scaffold with Matrigel slowed down the release of VEGF in vitro and promoted the angiogenesis when transplanted into BALB/c nude mice. These results suggest that hBMSCs can be supported by a biode gradable hydrogel scaffold for effective cell growth, and enhance the angiogenesis by Matrigel coating.

• Journal of Internet Computing and Services
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• v.21 no.2
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• pp.1-8
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• 2020

Recently, the number of APT(Advanced Persistent Threats) attack using malware has been increasing, and research is underway to prevent and detect them. While it is important to detect and block attacks before they occur, it is also important to make an effective response through an accurate analysis for attack case and attack type, these respond which can be determined by analyzing the attack group of such attacks. Therefore, this paper propose a framework based on genetic algorithm for analyzing malware and understanding attacker group's features. The framework uses decompiler and disassembler to extract related code in collected malware, and analyzes information related to author through code analysis. Malware has unique characteristics that only it has, which can be said to be features that can identify the author or attacker groups of that malware. So, we select specific features only having attack group among the various features extracted from binary and source code through the authorship clustering method, and apply genetic algorithm to accurate clustering to infer specific features. Also, we find features which based on characteristics each group of malware authors has that can express each group, and create profiles to verify that the group of authors is correctly clustered. In this paper, we do experiment about author classification using genetic algorithm and finding specific features to express author characteristic. In experiment result, we identified an author classification accuracy of 86% and selected features to be used for authorship analysis among the information extracted through genetic algorithm.

• Journal of architectural history
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• v.16 no.3
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• pp.75-94
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• 2007

There were many researches on marine transportation and granaries, most of which focused on the historical establishment and organization of the marine transportation. However, a few researches were conducted on the architectural aspects. Hence the purposes of this study are to investigate the following matters: first, documents and relics concerning the tribute granary castle at Cape Gongse in Asan, a typical granary during the Joseon Dynasty, were investigated to academically understand the castle's establishment and historical background; second, the dispositional characteristics of the granary and the castle, including its adjacent facilities, were investigated to review its archaeological value; finally, basic materials were provided for systematical preservation and management these relics. As for the research method, the author referred to and analyzed sundry records and old maps, and ascertained in detail historical evidence through residential testimonies and the on-the-spot surveys. In addition, the author investigated the dispositional characteristics of the tribute granary castle at Cape Gongse by analyzing its exact size and shape, based on the old documents and an actual survey of the castle remains. The characteristics of the tribute granary castle at Cape Gongse may be summarized as follows. First, tribute granary at cape Gongse is a only tribute granary which has a granary and castle. second, the tribute granary castle at Cape Gongse has a curvilinear shape, like a gourd dipper; a large circle surrounding the village and a small circle surrounding the area of Mt. Shinpoong both meet up with it. Third, the construction type of the tribute granary castle at Cape Gongse is in a style similar to a town castle or a battle camp castle located in the coastal regions. As for its locational conditions, however, the east gate, presumably an incoming and outgoing route to the granary for vessels, was a feature unique to the marine granary castle. Fourth, the tribute granary at Cape Gongse had a granary of eighty kan in 1523 and, in addition, there were also Bongsang-cheong, Sa-chang, Joseon-sobakcheo, Chimhae-dang, and more, not to mention many privates houses in the castle. The granary is located in the center of the tribute granary castle, where Gongse Nonghyub is currently located. The location of the government offices seemed to be on the northern ridge. Fifth, the tribute granary castle at Cape Gongse is a valuable relic that offers insight into marine transportation, tribute granaries, and tribute granary castles during the Joseon Dynasty. It has special archaeological value because it was one of only a few tribute granary castles that served to protect the tribute granaries.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.2
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• pp.19-24
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• 2007

With recent advancement of high-speed, multi-gigabit data transmission capabilities, serial links have been more widely adopted in industry than parallel links. Since the parallel link design forces its transmitter to transmit both the data and the clock to the receiver at the same time, it leads to hardware's intricacy during high-speed data transmission, large power consumption, and high cost. Meanwhile, the serial links allows the transmitter to transmit data only with no synchronized clock information. For the purpose, clock and data recovery circuit becomes a very crucial key block. In this paper, a 5.4Gbps half-rate bang-bang CDR is designed for the applications of high-speed graphic DRAM interface. The CDR consists of a half-rate bang-bang phase detector, a current-mirror charge-pump, a 2nd-order loop filter, and a 4-stage differential ring-type VCO. The PD automatically retimes and demultiplexes the data, generating two 2.7Gb/s sequences. The proposed circuit is realized in 66㎚ CMOS process. With input pseudo-random bit sequences (PRBS) of $2^{13}-1$, the post-layout simulations show 10psRMS clock jitter and $40ps_{p-p}$ retimed data jitter characteristics, and also the power dissipation of 80mW from a single 1.8V supply.